|2.||Neuralgia (Stump Neuralgia)
|4.||Major Depressive Disorder (Major Depressive Disorders)
|5.||Low Back Pain (Lumbago)
|1.||Arnold, Lesley M: 42 articles (07/2015 - 02/2002)|
|2.||Clauw, Daniel J: 38 articles (05/2015 - 01/2004)|
|3.||Häuser, Winfried: 29 articles (10/2015 - 06/2008)|
|4.||Derry, Sheena: 21 articles (01/2015 - 01/2008)|
|5.||Mease, Philip J: 21 articles (06/2014 - 04/2005)|
|6.||Moore, R Andrew: 20 articles (01/2015 - 01/2008)|
|7.||Palmer, Robert H: 19 articles (01/2015 - 11/2008)|
|8.||Müller, W: 19 articles (10/2006 - 01/2000)|
|9.||Stratz, T: 18 articles (10/2006 - 01/2000)|
|10.||Russell, I Jon: 17 articles (05/2013 - 05/2002)|
|1.||duloxetine (Cymbalta)FDA Link
12/01/2010 - "To investigate the efficacy of flexible dose duloxetine 60-120 mg/day on changes in fibromyalgia (FM) symptoms assessed by the Patient Global Impression of Improvement (PGI-I) scale. "
05/01/2006 - "Duloxetine effective for fibromyalgia in some women."
09/01/2007 - "Duloxetine has been shown to be an effective and safe treatment for many of the symptoms associated with fibromyalgia, particularly for women. "
07/01/2013 - "Clinical trials have demonstrated the analgesic efficacy of duloxetine for PDN and fibromyalgia in addition to improvements in quality-of-life measurements. "
06/01/2011 - "Data were pooled across 12-week treatment periods from 4 randomized, double-blind, placebo-controlled studies designed to evaluate the safety and efficacy of duloxetine for the treatment of fibromyalgia. "
|2.||pregabalin (Lyrica)FDA Link
07/01/2015 - "Pregabalin significantly improved Hospital Anxiety and Depression Scale-Anxiety (difference -0.95, p < 0.0001) and -Depression (difference -0.88, p = 0.0005) scores, Fibromyalgia Impact Questionnaire total score (difference -6.60, p < 0.0001), and sleep quality (difference 0.57, p < 0.0001), but not EuroQol 5-Dimensions score (difference 0.02, p = 0.3854). "
10/01/2014 - "Time to LTR was significantly longer with pregabalin CR versus placebo in fibromyalgia patients who initially showed improvement with pregabalin CR, indicating maintenance of response. "
01/01/2010 - "These results suggest that pregabalin may be beneficial in patients with fibromyalgia who have had an unsatisfactory response to treatment with other medications."
07/01/2010 - "For PGIC, administration of pregabalin resulted in an increase in the proportion of patients reporting improvement with an ED50 of 228 mg. The analyses support the recommended dose of pregabalin in patients with fibromyalgia of 300 to 450 mg/d."
01/01/2008 - "Pregabalin is, therefore, a valuable option in the first-line treatment of patients with fibromyalgia."
|3.||milnacipran (Ixel)FDA Link
02/01/2008 - "Further studies are needed to evaluate the safety and efficacy of milnacipran, determine optimal dosing, confirm if beneficial effects are sustained, and clarify the drug's role relative to, and in conjunction with, other treatments for fibromyalgia."
01/01/2010 - "In adults, milnacipran was generally effective in the treatment of fibromyalgia in four well designed trials of 3 or 6 months' duration. "
01/01/2013 - "To investigate whether milnacipran is safe and effective in improving cognitive function in patients with fibromyalgia. "
01/01/2013 - "Continuing efficacy of milnacipran following long-term treatment in fibromyalgia: a randomized trial."
08/01/2010 - "The clinical safety and efficacy of milnacipran 100 and 200 mg/day in individuals with fibromyalgia has been investigated in four large, randomized, double-blind, placebo-controlled studies and three long-term extension studies. "
|4.||Serotonin (5 Hydroxytryptamine)IBA
01/01/2004 - "To determine the efficacy of a serotonin receptor (5-HT(3)) antagonist in the treatment of fibromyalgia (FM) in a prospective, randomized, double-blind, placebo-controlled, multicentre trial. "
12/01/2011 - "This study aimed to investigate the genetic influence of the T102C polymorphism of the 2A serotonin receptor gene (HTR2A) and its interaction with environmental aspects, such as exposure to noise, traffic, climate, and opportunities to acquire new information, physical protection, and security, among others, as possible risk factors for developing fibromyalgia syndrome (FMS). "
08/01/2004 - "Sequence variants of the serotonin receptor subunit genes HTR3A and HTR3B indicate no obvious significance in the aetiology of fibromyalgia, yet they represent the basis for future studies on their pharmacogenetic relevance."
03/01/1997 - "To investigate the association of serum serotonin with fibromyalgia (FM), and to study the relationship of serotonin to clinical variables associated with FM. "
11/01/2013 - "Effects of physical exercise on serum levels of serotonin and its metabolite in fibromyalgia: a randomized pilot study."
|5.||Antidepressive Agents (Antidepressants)IBA
12/01/2002 - "Are antidepressants effective in fibromyalgia?"
01/01/2001 - "Are antidepressants effective in the treatment of fibromyalgia, and is this effect independent of depression?"
09/15/2008 - "To systematically review the efficacy of treatment of fibromyalgia syndrome (FMS) with antidepressants. "
09/01/2000 - "To systematically review the efficacy of antidepressants in the treatment of fibromyalgia and examine whether this effect was independent of depression. "
03/01/2000 - "Randomized, controlled trials of antidepressants for treatment of fibromyalgia were reviewed by methodology, results, and potential predictors of response. "
|6.||Norepinephrine (Noradrenaline)FDA LinkGeneric
02/28/1996 - "However, no rise in blood noradrenaline concentration during exercise was found in fibromyalgia patients as compared with a many-folded rise in healthy subjects. "
10/01/2013 - "Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inhibit the norepinephrine reuptake transporter (NRI). "
01/01/2002 - "Fibromyalgia patients have norepinephrine-evoked pain. "
01/01/2002 - "Our objective was to define if fibromyalgia patients have norepinephrine-evoked pain. "
01/01/2002 - "Norepinephrine-evoked pain in fibromyalgia. "
|7.||Amitriptyline (Elavil)FDA LinkGeneric
10/01/2015 - "Data from individual studies as well as from systematic reviews indicate that low doses (10-75 mg/day) of amitriptyline are effective for the treatment of fibromyalgia and, despite the limited quality of the data, they do not seem to be associated with relevant tolerability or safety issues. "
07/01/2009 - "Therapy with amitriptyline or physiotherapy is equally effective in improving outcome in patients of fibromyalgia over a period of six months."
07/01/2009 - "We compared the efficacy of physiotherapy and amitriptyline in disability reduction in patients of fibromyalgia syndrome in a rural tertiary care hospital in Central India. "
10/01/2015 - "Amitriptyline has been evaluated in placebo-controlled studies, and it has served as an active comparator to other therapeutic interventions in the treatment of fibromyalgia. "
01/01/2012 - "A standard battery of noninvasive autonomic function tests comprising of lying to standing test, hand grip test, cold pressor test, deep breathing test, and Valsalva maneuver was performed both before and after amitriptyline therapy to study the autonomic reactivity of the patients with fibromyalgia. "
01/01/2004 - "Although tropisetron proved to be efficacious in a group of fibromyalgia patients, the dose-response curves cannot yet be explained in a fully satisfactory manner, which may encourage research focusing on possible subgroups of FM."
01/01/2001 - "Short-term treatment of fibromyalgia patients with 5 mg tropisetron for 10 days proved to be efficacious and well tolerated. "
01/01/2000 - "We conclude that administration of tropisetron in fibromyalgia patients could be useful in the management of this difficult and incurable syndrome."
01/01/2000 - "This study demonstrates the efficacy of short-term treatment with 5 mg tropisetron once daily in primary fibromyalgia. "
01/01/2004 - "Previous studies evaluating the efficacy and tolerance of tropisetron for the treatment of fibromyalgia (FM) used the drug either intravenously or orally, and at different dosage levels ranging from 2 mg to 15 mg daily. "
|9.||salicylhydroxamic acid (SHAM)IBA
03/01/2007 - "Most importantly, this pilot suggests single points, smaller groups of points, or sham points may be as effective in diagnosing fibromyalgia as the use of all 18 points, and suggests methodologies to definitively test that hypothesis."
01/01/2015 - "Fibromyalgia-related daily functioning improved in the active tDCS group compared with the sham group. "
04/08/2014 - "This study provides Class II evidence that rTMS compared with sham rTMS improves QoL in patients with fibromyalgia."
12/01/2012 - "The effect of repetitive transcranial magnetic stimulation on fibromyalgia: a randomized sham-controlled trial with 1-mo follow-up."
10/01/2009 - "Low-frequency pulsed electromagnetic field therapy in fibromyalgia: a randomized, double-blind, sham-controlled clinical study."
|10.||venlafaxine (Effexor)FDA LinkGeneric
02/01/2015 - "In the context of these limitations, venlafaxine appears to be at least modestly effective in treating fibromyalgia. "
01/01/2007 - "Effective treatment of fibromyalgia comorbid with premenstrual dysphoric disorder with a low dose of venlafaxine."
02/01/2015 - "Studies assessing the efficacy of venlafaxine in the treatment of fibromyalgia to date have been limited by small sample size, inconsistent venlafaxine dosing, lack of placebo control and lack of blinding. "
02/01/2015 - "Accordingly, we systematically reviewed the efficacy of venlafaxine for treatment of fibromyalgia. "
02/01/2015 - "A systematic review of the efficacy of venlafaxine for the treatment of fibromyalgia."
|1.||Psychology Biofeedback (Biofeedback)
01/01/2013 - "Efficacy of EMG- and EEG-Biofeedback in Fibromyalgia Syndrome: A Meta-Analysis and a Systematic Review of Randomized Controlled Trials."
09/01/2002 - "The aim of the present study was to investigate the efficacy of EMG-biofeedback in female fibromyalgia patients with and without abnormality in the MMPI. "
03/01/2007 - "A pilot study of the efficacy of heart rate variability (HRV) biofeedback in patients with fibromyalgia."
09/01/2002 - "Efficacy of an EMG-biofeedback therapy in fibromyalgia patients. "
08/01/2007 - "Management of patients with fibromyalgia using biofeedback: a randomized control trial."
01/01/2013 - "The aim of this study was to determine whether balneotherapy with mineral waters and mineral-water containing mud is effective in the management of fibromyalgia. "
01/01/2011 - "The efficacy of balneotherapy and physical modalities on the pulmonary system of patients with fibromyalgia."
07/01/2012 - "Balneotherapy in fibromyalgia: a single blind randomized controlled clinical study."
09/01/2004 - "The aim of this study was to compare pool-based exercise and balneotherapy in fibromyalgia syndrome (FMS) patients. "
06/01/2002 - "This study shows that balneotherapy is effective and may be an alternative method in treating fibromyalgia patients."
|3.||Drug Therapy (Chemotherapy)
04/01/2009 - "A comprehensive disease management strategy including patient education, pharmacotherapy, cognitive-behavioral therapy, and aerobic and other forms of exercise can be beneficial for many patients with fibromyalgia."
04/01/2001 - "It is concluded that CES is as effective as the drug therapies in several trials, with no negative side effects, and deserves further consideration as an additional agent for the treatment of fibromyalgia."
05/01/2009 - "Thorough medical and psychiatric evaluations are necessary after confirming a diagnosis of fibromyalgia, and a multidisciplinary treatment strategy including patient education, aerobic exercise, and cognitive-behavioral therapy as well as pharmacotherapy has been shown to be effective in alleviating fibromyalgic symptoms."
05/01/2009 - "Advances have occurred in the pharmacotherapy of fibromyalgia (FM) and the methodology of clinical trial design in FM in parallel with improved understanding of the underlying pathophysiologic mechanisms. "
07/01/2015 - "To evaluate the association of financial conflicts of interest (FCOI) with the characteristics, outcome and reported methodological quality of fibromyalgia drug therapy randomized controlled trials (FM-RCTs). "
04/01/2015 - "Overall, most styles of massage therapy consistently improved the quality of life of fibromyalgia patients. "
07/01/2010 - "Additional rigorous research is needed in order to establish massage therapy as a safe and effective intervention for fibromyalgia. "
04/01/2002 - "Massage therapy has been observed to be helpful in some patients with fibromyalgia. "
04/01/2015 - "Ten randomized and non-randomized controlled trials investigating the effects of massage alone on symptoms and health-related quality of life of adult patients with fibromyalgia were included. "
01/01/2014 - "Although some studies evaluated the effectiveness of massage therapy for fibromyalgia (FM), the role of massage therapy in the management of FM remained controversial. "
|5.||Transcutaneous Electric Nerve Stimulation (TENS)
04/01/2013 - "To assess the efficacy of high-frequency transcutaneous electrical nerve stimulation (TENS) as an adjuvant therapy to aerobic and stretching exercises, for the treatment of fibromyalgia. "
03/01/2013 - "Efficacy of supervised exercise combined with transcutaneous electrical nerve stimulation in women with fibromyalgia: a prospective controlled study."
01/01/2015 - "The purpose of this study will be to complete a long-term, multicenter study to assess the effects of TENS in women with fibromyalgia. "
11/01/2013 - "Thus, the current study suggests TENS has short-term efficacy in relieving symptoms of fibromyalgia while the stimulator is active. "
11/01/2013 - "The current study used a double-blinded randomized, placebo-controlled cross-over design to test the effects of a single treatment of TENS with people with fibromyalgia. "