Fibrinopeptide B

Two small peptide chains removed from the N-terminal segment of the beta chains of fibrinogen by the action of thrombin. Each peptide chain contains 20 amino acid residues. The removal of fibrinopeptides B is not required for coagulation.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dai, Chen: 1 article (04/2018)
2.	Fan, Yi-Man: 1 article (04/2018)
3.	Xu, Jian-Ya: 1 article (04/2018)
4.	Yuan, Bin: 1 article (04/2018)
5.	Zhou, Li-Hua: 1 article (04/2018)
6.	Allen, Beth: 1 article (10/2008)
7.	Barder, Tim: 1 article (10/2008)
8.	Bujold, Emmanuel: 1 article (10/2008)
9.	Chaiworapongsa, Tinnakorn: 1 article (10/2008)
10.	Dalmasso, Enrique A: 1 article (10/2008)

Related Diseases

1.	Glomerulonephritis 06/01/1985 - "Plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 concentrations were determined by radioimmunoassay in 46 patients with glomerulonephritis and the nephrotic syndrome. " 06/01/1985 - "Plasma concentrations of fibrinopeptide A and fibrinopeptide B beta 15-42 in glomerulonephritis and the nephrotic syndrome." 10/01/1986 - "A study on the significance of the measurement of fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (FPB beta) in urine and plasma before and after urokinase (UK) administration in patients with chronic glomerulonephritis is described. " 10/01/1986 - "Levels of fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 (FPB beta) in urine and plasma after urokinase administration in patients with chronic glomerulonephritis." 06/01/1985 - "[The levels of fibrinopeptide A and fibrinopeptide B beta in the urine from patients with chronic glomerulonephritis during urokinase therapy]."
2.	Thrombosis (Thrombus) 08/24/1988 - "The novel action of fibrinopeptide B to reduce the platelet inhibitory effect of PGI2 and PGD2 may also contribute to the control of thrombus formation." 03/01/1981 - "First fibrinopeptide A and fibrin I are formed and then fibrinopeptide B (B beta 1-14) and fibrin II. Since it is postulated that fibrin II is important in the genesis of thrombosis, it is of interest to measure fibrinopeptide B in peripheral blood samples. " 04/01/2004 - "For a long time fibrinopeptide A(FPA), fibrinopeptide B(FPB), D-dimer, FM test, serum FDP, and thrombin anti-thrombin complex(TAT) are being used as molecular markers to for sure diagnose hypercoagulable state and thrombus formation. "
3.	Neoplasms (Cancer) 03/01/1996 - "Fibrin II (des-fibrinopeptide B-type fibrin) was easily identified in a direct apposition to the surface membranes of viable carcinoma cells, predominantly at the host-tumor interface and in the regions immediately adjacent to the zones of angiogenesis. " 04/20/1989 - "In 12 patients (38 courses) with gynecological malignancies who had been treated with remission induction chemotherapy, we measured the levels of ESR, Platelet, PT, APTT, Hepa T, AT III, alpha 2 PI, FDP and D-dimer, and we also measured such molecular markers as Fibrinopeptide A (FPA), Fibrinopeptide B beta 1-42 (FPB beta 1-42), and Fibrinopeptide B beta 15-42 (FPB beta 15-42) before and after chemotherapy. "
4.	Inflammation (Inflammations) 04/01/2018 - "Particularly, fibrinopeptide B (FpB) and heparin cofactor II (HCII) were evaluated as important nodes in the interaction network, which was closely involved in coagulation and inflammation. " 03/01/1986 - "To explore whether fibrin(ogen)-derived peptides exert direct effects upon cells involved in inflammation and tissue repair we examined the capacity of human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts. "
5.	Renal Insufficiency (Renal Failure) 03/01/1984 - "When the changes in these patients were compared with those occurring in patients undergoing intraamniotic hypertonic saline infusion, it was noted that: (1) patients with severe preeclampsia/eclampsia usually presented when plasmin action on fibrinogen exceeded that of thrombin; (2) in patients with preeclampsia/eclampsia the increase in fibrinopeptides lasted from 3 to 7 days, rather than for several hours as occurred after the infusion of hypertonic saline, indicating a more persistent stimulus to intravascular coagulation in preeclampsia/eclampsia; (3) severe thrombocytopenia and increased platelet protein levels were seen in these patients and were disproportionate to the degree of increase in the fibrinopeptide A level, suggesting that a mechanism other than thrombin must have contributed to the platelet changes; and (4) in two patients with severe preeclampsia/eclampsia, high desarginyl fibrinopeptide B levels preceded renal insufficiency, possibly reflecting fibrin II formation in renal vessels."

Related Drugs and Biologics

1.	Fibrinopeptide A
2.	Urokinase-Type Plasminogen Activator (Urokinase)
3.	Fibrin
4.	Thrombin
5.	Fibrinolysin
6.	Fibrinogen (Factor I)
7.	fibrin fragment D (D-dimer)
8.	Antigens
9.	formycin diphosphate (FDP)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Remission Induction
2.	Drug Therapy (Chemotherapy)
3.	Sclerotherapy
4.	Therapeutics