|1.||Dewhirst, Mark W: 36 articles (05/2014 - 03/2003)|
|2.||Romanovsky, Andrej A: 29 articles (01/2015 - 01/2002)|
|3.||Lin, Mao-Tsun: 29 articles (09/2011 - 10/2003)|
|4.||Roth, Joachim: 28 articles (06/2015 - 01/2002)|
|5.||Raoult, Didier: 27 articles (09/2015 - 01/2002)|
|6.||Kobayashi, Takeshi: 25 articles (02/2015 - 02/2002)|
|7.||Ishikawa, Takaki: 22 articles (11/2015 - 05/2005)|
|8.||Michiue, Tomomi: 22 articles (11/2015 - 05/2005)|
|9.||Maeda, Hitoshi: 22 articles (11/2015 - 05/2005)|
|10.||Gerstberger, Rüdiger: 22 articles (06/2015 - 01/2002)|
|1.||Anti-Bacterial Agents (Antibiotics)IBA
05/01/1989 - "Two courses of BHAC-DMP regimen induced complete remission in October, while marked pyrexia resistant to antibiotics remained. "
05/01/2012 - "However, there was no significant difference between the two investigated groups in the duration of the treatment with intravenous antibiotics, the time of fever remission calculated from admission, and the days of hospital stay. "
09/01/2010 - "The patient continued to have fevers while receiving intravenous antibiotics and underwent bilateral myringotomies; his clinical course subsequently improved significantly. "
08/01/2001 - "These findings were associated with a significant reduction in the median days of intravenous antibiotics in patients with fever [8.5 (0-30) versus 14 (0-34), P = 0.04] and hospital stay [27 (8-51) versus 34 (24-78), P < 0.05]. "
05/05/2001 - "The treatment was considered successful if fever and clinical signs resolved and/or pathogens were cleared without adding further antibiotics at 72 h. "
|2.||Acetaminophen (Paracetamol)FDA LinkGeneric
02/01/1986 - "By contrast among 1,1-dioxide derivatives the most effective in preventing pyrogen-induced fever was the ethyl ester (V:c) of benzoic series which appeared to be as active as paracetamol. "
01/01/2013 - "In the intent-to-treat population, paracetamol reduced the incidence of fever ≥38°C, but this reduction was only significant for the infant series, with computed efficacy of 43.0% (95% confidence interval [CI]: 17.4, 61.2), and not significant after the toddler dose (efficacy 15.9%; 95% CI: -19.9, 41.3); results were similar in the per protocol (PP) population. "
12/01/2011 - "The combination of IBU and APAP produces significantly greater fever control than APAP alone, with trends favoring the combination over IBU alone and IBU over APAP alone."
09/01/1997 - "A significantly greater and more rapid reduction of fever was demonstrated with paracetamol than with tepid sponging. "
04/01/2014 - "Recent trials have shown the efficacy of more aggressive approaches to fever reduction, whereas a large randomized trial showed the relative ineffectiveness of acetaminophen alone for fever control. "
|3.||Ibuprofen (Motrin)FDA LinkGeneric
01/01/2011 - "The difference in antipyretic efficacy of ibuprofen in the high fever group was statistically significant in the 3rd and 4th hours, and in the low-grade fever group, in the 3rd hour after medication. "
11/01/1998 - "A significant reduction in temperature (0.7 degrees C) after fever onset in the ibuprofen group compared with the placebo group was demonstrated if all 555 fever episodes were considered. "
01/01/2008 - "Ibuprofen is effective in reducing the time with fever. "
11/01/2000 - "Ibuprofen is effective in the treatment of fever in children. "
11/01/2000 - "Both ibuprofen formulations were effective in reducing fever and may be considered clinically bioequivalent."
|4.||Prednisolone (Predate)FDA LinkGeneric
08/01/2015 - "To our knowledge, the use of prednisolone for the treatment and prevention of further dabrafenib-associated pyrexia is not published; however, it is a low risk and low cost option that was very effective in this case. "
01/01/2013 - "After administration of prednisolone, haematological findings improved and the fever resolved; however, the patient developed persistent fever after 6 months. "
04/01/2010 - "His symptoms improved remarkably; however, he had recurrence of symptoms, such as fever, meningial irritation and oral aphtae, with attempted taper of prednisolone. "
04/01/2009 - "Administration of prednisolone at a dose of 20 mg/day promptly relieved the fever and the myalgia as well. "
12/01/2000 - "Administration of 60 mg prednisolone daily improved fever. "
|5.||Cisplatin (Platino)FDA LinkGeneric
03/01/1994 - "Optimal timing and doses of hyperthermia and cisplatin, or adding biochemical modulators to enhance the effects of cisplatin, will need to be determined to increase the efficacy of CHPP, with or without the concomitant administration of cisplatin."
05/01/2015 - "In conclusion, pretreatment with cisplatin (50 μg/ml) combined with hyperthermia (42 °C) for 60 min effectively eliminated HepG2 cells from IBS but did not significantly affect erythrocytes in vitro. "
09/01/1997 - "The data showed that cisplatin (1 or 3 micrograms/ml for 1 hour) combined with mild hyperthermia (40 degrees C for 1 hour) was effective for radiosensitization to LDRI in the parental cell line whether given before or after irradiation. "
01/01/1999 - "Radiation therapy, cisplatin and hyperthermia in combination prove to be effective and safe in management of these patients."
01/01/2015 - "Our aim was to study the effects of hyperthermia on cisplatin (cPt) sensitivity and to determine whether MLH1 and MSH2 associate with Hsp27 and Hsp72 in MMR-deficient(-)/-proficient(+) cells. "
|6.||Doxorubicin (Adriamycin)FDA LinkGeneric
07/01/2014 - "The aim of this study was to evaluate the enhancement of the efficacy of systemic doxorubicin by pulsed high-intensity focused ultrasound (HIFU)-induced, localized mild hyperthermia. "
01/01/2010 - "Preclinical data demonstrates enhanced therapeutic efficacy with liposomal encapsulation of doxorubicin combined with hyperthermia (HT). "
03/01/1983 - "Tumour growth was similar in groups 2 and 4. These data demonstrate that multiple treatments with Adriamycin and systemic hyperthermia were effective in decreasing the rate of tumour growth in rat tumour models, whereas a single exposure had no effect."
06/01/2003 - "Several in vitro studies have reported on the efficacy of combined liposomal encapsulated doxorubicin (Doxil or Caelyx, MedEquip, UK) and hyperthermia over Doxil alone. "
11/01/2007 - "The efficacy of caelyx and hyperthermia for anticancer treatment."
|7.||Adrenal Cortex Hormones (Corticosteroids)IBA
03/01/1998 - "With the addition of corticosteroids, 11 of 12 patients experienced a rapid improvement in symptoms, with diminished or resolved fevers and night sweats, and an increased sense of well-being and energy. "
02/01/1997 - "The early use of corticosteroids compared to supportive treatment resulted in: (1) significant reduction of the period of fever (4.0 +/- 1.9 vs 9.5 +/- 4.2 days P = 0.01); (2) reduction of the period of acute eruption (7.0 +/- 3.3 versus 9.8 +/- 3.0 days P = 0.08); and (3) milder signs of prostration. "
09/01/2005 - "Corticosteroids are effective in lowering the fever and reversing changes in the chest radiograph but have the caveat of encouraging viral replication. "
01/01/2013 - "After the anti-TB drugs were discontinued and the dose of the corticosteroids was increased, the CT findings and fever improved considerably. "
04/01/1993 - "The diagnosis was supported by slight fever, elevated inflammatory parameters, and improvement when oral corticosteroids were given. "
10/01/2001 - "At first, piperacillin sodium (PIPC) was started, but a spiking fever persisted. "
04/01/1993 - "A 43-year-old woman was treated with piperacillin (PIPC) for spiking fever. "
01/01/1988 - "Although emergence of resistance was not seen, one isolate had an increase in minimum inhibitory concentration from 8 to 128 micrograms/ml. There were no serious adverse reactions to piperacillin; only one patient developed fever possibly related to piperacillin. "
11/01/1986 - "The pooled data indicated that the piperacillin treatment group did not differ from the combined cephalosporin treatment groups with respect to prophylactic response, presence of febrile morbidity, fever index, duration of postoperative hospitalization and incidence of reported adverse experiences."
03/01/1985 - "The fever resolved shortly after the piperacillin treatment was stopped, as did the widespread rashes in the two patients who developed them. "
|9.||Ceftazidime (Fortum)FDA LinkGeneric
09/01/1999 - "Ceftazidime in combination with a glycopeptide antibiotic provides an effective and safe first-line therapy for patients with neutropenic fever following PBSC-supported high-dose therapy."
10/26/1988 - "In a preliminary study of 21 febrile episodes in neutropenic patients ceftazidime used as empirical treatment in doses of 3 grams per day succeeded in controlling fever in 74 per cent of the cases. "
11/01/2013 - "This article reviews the literature regarding ceftazidime therapy for the treatment of high-risk neutropenic patients with fevers. "
11/01/2013 - "Ceftazidime for neutropenic fevers: is it still an appropriate choice?"
01/01/2006 - "Twenty-five (66%) patients responded with clinical improvement and complete resolution of fever within 48 h after initiation of ceftazidime therapy. "
09/01/2006 - "PETS-liposomes were found to be highly efficacious carriers for the in vivo delivery of anticancer drugs, and to have potential anticancer applications in combination with hyperthermia."
09/01/2004 - "Thus, thermosensitive liposomes release their contents in response to mild hyperthermia and this combination therapy has a greater therapeutic efficacy for malignant brain tumours. "
06/01/2015 - "In this study, we report on the design, fabrication, and characterization of an ultrasound-guided focused ultrasound (USgFUS) cMUT probe dedicated to preclinical evaluation of targeted therapy (hyperthermia, thermosensitive liposomes activation, and sonoporation) at low frequency (1 MHz) with simultaneous ultrasonic imaging and guidance (15 to 20 MHz). "
02/01/2015 - "The objectives of this study were to formulate liposomes encapsulating thrombolytics and assess thrombolytic activity following hyperthermia. "
01/28/2014 - "The aim of our study is to apply a clinically available mild hyperthermia (HT) treatment with thermosensitive liposomes (TSL) to tackle both issues. "
|1.||Drug Therapy (Chemotherapy)
09/01/1992 - "In all three tumours, the best results were obtained associating chemotherapy with hyperthermia. "
10/15/1983 - "The clonogenic assay and in vitro evaluation of drug-heat interaction may prove helpful for selecting those patients in whom hyperthermia should be used as an adjunct to chemotherapy, and may help determine the most effective drug/heat scheduling. "
09/01/1981 - "Hyperthermia has great potential as an antineoplastic agent because: (a) it is effective against relatively radioresistant hypoxic cells and cells in S phase; (b) unlike most chemotherapeutic agents, it is effective against poorly vascularized and metabolically quiescent tissues; (c) as a physical agent, its biological effect is related to the duration and intensity of its application; (d) it seems to have no cumulative toxicity; and (e) it potentiates the effects of both chemotherapy and ionizing radiation at the cellular level. "
01/01/2013 - "We hypothesized that patients admitted for neutropenic fever, particularly if in complete remission (CR) or about to enter CR following the chemotherapy course associated with neutropenic fever, might be safely discharged earlier (ED). "
10/01/2005 - "Radiant whole body hyperthermia (WBH) at 41.8-42.2 degrees C may enhance the efficacy of systemic chemotherapy in patients with advanced malignancies, but is associated with marked physical stress. "
11/01/1980 - "Radiotherapy combined with hyperthermia by electromagnetic radiation to create complete remission in 11 patients without morbidity."
11/01/2014 - "The combination of hyperthermia and radiotherapy is synergistic, importantly allowing a reduction in X-ray dose with improved therapeutic results. "
10/01/2006 - "Hyperthermia is effective in improving clinical radiotherapy results."
01/01/1984 - "Therapeutic efficacy was assessed after 4 weeks and compared to the results in a similar group of 74 patients who received radiotherapy by the same scheme but without hyperthermia. "
04/01/2007 - "An improved response has been seen in several studies where hyperthermia was added to radiotherapy. "
07/01/1998 - "The level of cTnI before i.v.GG treatment was increased in 42.9% (18/42), but 89% (16/18) were in the normal range after treatment as shown by improved clinical symptoms and signs; 9.5% (4/42) were treated twice with i.v.GG because of recurrent high fever, with a positive level of cTnI in the second test. "
07/01/2015 - "Compared with the control group, the fever clearance time was shortened, CRP levels decreased, GCS score and efficacy of EEG was alleviated in the treatment group after treatment with statistical difference (P < 0.05). "
04/01/2013 - "Cows were defined as cured when their rectal temperature was <39.5 °C 4 days after treatment and fever did not rebound over 39.4 °C until the end of the screening period which was DIM 10. "
04/01/2013 - "In the current study, our data showed that the apoptosis rate of MKN28 cells increased relatively rapidly to 13.4% by 24 h after treatment with hyperthermia (42°C for 1 h) compared to 5.1% in control cells (P < 0.05). "
01/01/2003 - "Effects of hyperthermia on the rat bladder: a pre-clinical study on thermometry and functional damage after treatment."
|4.||Induced Hyperthermia (Thermotherapy)
01/01/1987 - "Based on an analysis of the data it appears that the hyperthermia induced by microwave exposure may be more effective in increasing survival in infected mice than hyperthermia produced by conventional methods (ie, high ambient temperature). "
01/01/2015 - "Our findings show that Hsp72 contributes to the protective effects of mild hyperthermia (40°C) against hyperthermia-induced ER stress and apoptosis. "
01/01/2012 - "The thorough study of the response of the inner membrane of heart and liver mitochondria to hyperthermia was performed in order to establish the pattern of the hyperthermia-induced changes in the membrane barrier function. "
10/01/2008 - "The aims of this study were to determine (i) the effect of passive hyperthermia on motor drive and cognitive function, and (ii) whether head cooling can limit the hyperthermia-induced alterations. "
05/01/2007 - "The results of the present study should be useful for further studies aimed at elucidation of the physiological mechanisms underlying thermotherapy and hyperthermia."
07/01/1992 - "One of the most promising ways to increase the efficacy of brachytherapy is to combine it with hyperthermia. "
06/01/1996 - "Several pilot studies demonstrated that the combination of interstitial hyperthermia and interstitial radiotherapy (interstitial thermoradiotherapy) is safe and effective. "
01/01/1990 - "Interstitial RF hyperthermia in conjunction with brachytherapy appears to be a relatively safe and effective modality, but must be tested prospectively to compare its efficacy to interstitial irradiation alone."
10/01/2001 - "Present observations suggest that endovascular brachytherapy of restenosis potentiated by hyperthermia is a technically feasible and well-tolerated treatment. "
06/01/2015 - "The primary aim of this prospective phase II study combining Iridium-192 brachytherapy with interstitial hyperthermia (IHT) is to analyze toxicity of the combined treatment; a secondary aim is to define the efficacy (bNED, DFS, OS) of salvage brachytherapy. "