Fetal Resorption

The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).

Also Known As:

Networked: 193 relevant articles (8 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cleft Palate (Palate, Cleft)
2.	Fetal Weight
3.	Body Weight (Weight, Body)
4.	Proteinuria
5.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)

Experts

1.	Shoenfeld, Yehuda: 3 articles (09/2004 - 05/2003)
2.	Shoenfeld, Y: 3 articles (01/2003 - 07/2000)
3.	Blank, M: 3 articles (01/2003 - 07/2000)
4.	Wells, Peter G: 2 articles (12/2013 - 09/2006)
5.	Schneider, Steffen: 2 articles (06/2013 - 06/2013)
6.	Stinchcombe, Stefan: 2 articles (06/2013 - 06/2013)
7.	Fegert, Ivana: 2 articles (06/2013 - 06/2013)
8.	Strauss, Volker: 2 articles (06/2013 - 06/2013)
9.	Fussell, Karma C: 2 articles (06/2013 - 06/2013)
10.	Rey Moreno, Maria Cecilia: 2 articles (06/2013 - 06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fetal Resorption:

1.	Estrogens (Estrogen)FDA Link 06/01/2013 - "The present study demonstrates that both the placental degeneration and the increased incidence of late fetal resorptions are due to decreased levels of estrogen, since estrogen supplementation ameliorates the former and abolishes the latter." 06/01/2013 - "The clarification of the human relevance of the estrogen-related mechanism behind EPX-mediated late fetal resorptions in rats warrants further studies. " 04/01/1986 - "To reveal the biology and endocrinology of pregnancy in aging females, we performed a longitudinal study in a group of multiparous rats bred once every 2 mo. Beginning at 4 mo and continuing through 12 mo of age in the same individual females, we determined the chronological changes in estrous cyclicity and fertility; examined the number of implantation scars; estimated the fetal resorption rate; and assessed the patterns of progestin, androgen, and estrogen secretion during 5 consecutive gestations. " 05/01/1992 - "The study provides evidence of post-implantation fetal resorption, occurring primarily between days 10 and 19 post-coitum, in rats treated with a potent antiestrogen before or immediately after the prenidatory estrogen secretion.(ABSTRACT TRUNCATED AT 250 WORDS)" 05/01/1992 - "Fetal resorption in rats treated with an antiestrogen in relation to luteal phase nidatory estrogen secretion."
2.	Immunoglobulins (Immunoglobulin)IBA 06/01/1995 - "The following studies were carried out: autoantibody profile (ELISA), clinical manifestations including erythrocyte sedimentation rate (ESR), white blood cell and platelet count, immunoglobulin deposits in the kidneys, and fetal resorptions. " 06/01/1995 - "Following treatment with IVGG or IVGG F(ab')2, a complete clinical remission, manifested as normal ESR and leukocyte counts, and lack of proteinuria or immunoglobulin deposits in the kidneys in the mice with experimental SLE, normal activated partial thromboplastin time, and fetal resorption rate in the mice with experimental primary APS was achieved. " 11/01/2002 - "Autoantibodies from sera of SLE/APS patients affect reproductive outcome in pregnant mice, as was studied in vivo, where injection of immunoglobulin (Ig)G purified from patients with APS to mice caused fetal resorptions and growth retardation. " 04/01/2001 - "Intravenous immunoglobulin (IVIG) therapy has prevented pregnancy loss in some women with APS and has reversed fetal resorption rates in murine models of pregnancy loss. "
3.	Interleukin-3 (Interleukin 3)IBA 04/01/1993 - "Given our preliminary findings of low IL-3 in mice with APLS and the efficacy of IL-3 in preventing fetal loss in a strain of mice prone to fetal resorption, our aim in the present study was to examine the effect of murine recombinant IL-3 (mrIL-3) on pregnant mice induced with experimental APLS. "
4.	Cardiolipins (Cardiolipin)IBA 05/01/1995 - "In mice immunized with monoclonal or polyclonal anti-cardiolipin antibody we observed a significant increase in the number of fetal resorptions and a significant reduction of the mean weights of the embryos and the placentas. " 07/01/2000 - "Immunization of naive mice with this unique affinity purified anti-cardiolipin antibody resulted in the induction of experimental APS (thrombocytopenia, prolonged coagulation timed and fetal resorptions). " 08/01/1995 - "BALB/c mice were immunized with anti-cardiolipin monoclonal antibody (MoAb) named CAM and developed elevated serum titres of anti-phospholipid Abs accompanied by prolonged activated partial thromboplastin time, thrombocytopenia and a high percentage of fetal resorptions. " 12/01/1999 - "Elevated titers of mouse anti-cardiolipin (aCL), anti-beta(2)GPI, associated with lupus anticoagulant activity, thrombocytopenia, prolonged activated partial thromboplastin time and a high percentage of fetal resorptions were detected, in the CAM scFv group and in the scFv composed of CAM V(H) groups. " 10/01/2011 - "We previously showed that passive transfer of CIC15, a monoclonal antiphospholipid antibody binding to cardiolipin and annexin A5 that was isolated from a patient with primary antiphospholipid syndrome, induces fetal resorption in pregnant mice. "
5.	Freund's AdjuvantIBA 08/01/1991 - "Our recent data show that immunopotentiation of maternal immune system by Complete Freund Adjuvant significantly improves pregnancy rate in CBA x DBA/2 mouse combination with high percentage of fetal resorptions. " 11/01/1990 - "Nonspecific immunopotentiators and pregnancy loss: complete Freund adjuvant reverses high fetal resorption rate in CBA x DBA/2 mouse combination." 01/01/1989 - "To test the hypothesis that immunopotentiation of the maternal immune system is beneficial for the developing embryo, we examined (1) the effect of specific preimmunization with paternal leucocytes in women and BALB/c splenocytes in CBA/J x DBA/2J mice (which show increased % fetal resorption) and (2) the influence of non-specific potentiators such as complete Freund's adjuvant and thymus humoral factor on the abortion rate in CBA/J mothers. "
6.	thymic humoral factorIBA 11/01/1990 - "The injection of Thymus Humoral Factor known to be a potent T cell stimulator did not reduce the number of fetal resorptions. " 01/01/1989 - "To test the hypothesis that immunopotentiation of the maternal immune system is beneficial for the developing embryo, we examined (1) the effect of specific preimmunization with paternal leucocytes in women and BALB/c splenocytes in CBA/J x DBA/2J mice (which show increased % fetal resorption) and (2) the influence of non-specific potentiators such as complete Freund's adjuvant and thymus humoral factor on the abortion rate in CBA/J mothers. "
7.	Ritonavir (Norvir)FDA Link 01/01/2007 - "The exposure of pregnant rats at term to a 1:2 association of zidovudine plus ritonavir resulted in a significant reduction in maternal body weight gain and increased rate of fetal resorption."
8.	Zidovudine (Retrovir)FDA LinkGeneric 01/01/2007 - "The exposure of pregnant rats at term to a 1:2 association of zidovudine plus ritonavir resulted in a significant reduction in maternal body weight gain and increased rate of fetal resorption."
9.	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 11/01/1988 - "Data indicate that at 10% and 20% levels, DMSO affords an apparent dose-related protection against SAD-induced cleft palate, whereas 30% DMSO enhanced fetal resorption with no reduction in the incidence of cleft palate. "
10.	Dihydrotachysterol (AT 10)IBA 11/01/1988 - "Data indicate that at 10% and 20% levels, DMSO affords an apparent dose-related protection against SAD-induced cleft palate, whereas 30% DMSO enhanced fetal resorption with no reduction in the incidence of cleft palate. "

Therapies and Procedures

1.	Induced Abortion (Induced Abortions) 01/01/1996 - "Whereas the administration of 1 microgram of LPS to CFW female x CFW male pregnant mice on day 7 of gestation induced complete fetal resorption, prior immunization with 20 micrograms of LPS completely prevented LPS induced abortion as long as the anti-LPS antibody titers remained above a threshold value of about 1/500. " 10/01/1994 - "While an increase in fetal resorption and the abortion rate during the first trimester is well documented, a second-trimester intervention is assumed to be relatively safe. " 01/01/1993 - "In addition, cabergoline usually induced abortion through fetal resorption (75% of cases), without any clinical sign other than some vaginal discharge." 01/01/1989 - "To test the hypothesis that immunopotentiation of the maternal immune system is beneficial for the developing embryo, we examined (1) the effect of specific preimmunization with paternal leucocytes in women and BALB/c splenocytes in CBA/J x DBA/2J mice (which show increased % fetal resorption) and (2) the influence of non-specific potentiators such as complete Freund's adjuvant and thymus humoral factor on the abortion rate in CBA/J mothers. "
2.	Immunotherapy 01/01/1994 - "This study was designed to examine the influence of age, environment, and lymphocyte immunotherapy on fetal resorption rates in the CBA/J x DBA/2J mouse model. " 01/01/1994 - "Preimmunization with various preparations and dosages of lymphocytes was performed 1 wk before mating with DBA/2J males, and fetal resorption rates were measured to investigate the effect of immunotherapy. "
3.	Injections 10/01/1992 - "injections demonstrated significant reductions in fertilization rate and number of viable fetuses and an increased rate of fetal resorption when compared with non-immunized and control-immunized mice. " 10/01/1991 - "A 10-mug dose of the antibody produced 33% of fetal resorption or stillborn fetuses, whereas control injections resulted in only 4.4% of fetal loss. " 07/01/1991 - "Animals received daily injections from day 1 to day 16, and on day 17 of gestation the maternal condition, litter size, fetal resorption rates, and fetal/placental unit weights were determined. " 05/01/1994 - "The number of animals with fetal resorption in the adrenalectomized 1C group was significantly lower after daily injections of 4 mg progesterone from day 12 to day 17 of pregnancy. "
4.	Transplants (Transplant) 07/01/2009 - "Experimental data show that doses roughly equivalent to those used clinically in transplant patients may cause fetal resorption and malformations in pregnant rats and rabbits. "
5.	Vagotomy 05/01/1978 - "We suggest that these effects were caused by a direct effect of vagotomy on LH secretion which in turn lowers 3beta-HSD activity and progesterone levels in ovarian tissue and plasma, leading to fetal resorption." 05/01/1978 - "Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption."