Premature Rupture Fetal Membranes

Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.

Also Known As:

Fetal Membranes, Premature Rupture; PROM (Pregnancy); Premature Rupture of Fetal Membranes; Preterm PROM (Pregnancy); Preterm Premature Rupture of Fetal Membranes; Membrane Premature Rupture (Pregnancy); Membrane Premature Ruptures (Pregnancy); PROM, Preterm (Pregnancy); Premature Rupture of Membrane (Pregnancy)

Networked: 99 relevant articles (0 outcomes, 11 trials/studies)

Disease Context: Research Results

Urogenital Diseases: 126
- Female Urogenital Diseases and Pregnancy Complications
  - Pregnancy Complications: 2961
    - Obstetric Labor Complications: 62
      - Premature Rupture Fetal Membranes: 99
        Chorioamnionitis: 2091
        Preterm Premature Rupture of the Membranes: 878

Related Diseases

1.	Pregnancy Complications
2.	Premature Obstetric Labor (Premature Labor)
3.	Congenital Abnormalities (Deformity)
4.	Placenta Previa
5.	Hypertension (High Blood Pressure)

Experts

1.	Abdelazim, Ibrahim A: 5 articles (01/2022 - 02/2013)
2.	Dołegowska, Barbara: 3 articles (01/2015 - 01/2009)
3.	Kwiatkowski, Sebastian: 3 articles (01/2015 - 01/2009)
4.	Rzepka, Rafał: 3 articles (01/2015 - 01/2009)
5.	Torbé, Andrzej: 3 articles (01/2015 - 01/2009)
6.	Chlubek, Dariusz: 2 articles (09/2009 - 01/2009)
7.	Czajka, Ryszard: 2 articles (09/2009 - 01/2009)
8.	Gupta, Meruka: 2 articles (01/2005 - 10/2004)
9.	Kalish, Robin B: 2 articles (01/2005 - 10/2004)
10.	Perni, Sriram C: 2 articles (01/2005 - 10/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Premature Rupture Fetal Membranes:

1.	Insulin-Like PeptidesIBA 04/01/2014 - "This study was designed to detect the accuracy of the insulin-like growth factor binding protein-1 (IGFBP-1) in diagnosing premature rupture of fetal membranes. " 06/01/2013 - "This study was designed to compare the accuracy of placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) to diagnose premature rupture of fetal membranes (PROM). " 04/01/2014 - "Insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes." 06/01/2013 - "Placental alpha microglobulin-1 (AmniSure test) versus insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes."
2.	CollagenIBA 11/01/1990 - "Short communication: placental collagen and premature rupture of fetal membranes." 01/01/1988 - "Premature rupture of fetal membranes changes in collagen type." 01/01/2006 - "This electron microscopy study focused on collagen fibril orientation and unusual shapes in the dermis of Ehlers-Danlos syndrome (EDS) and related entities, including spontaneous cervical artery dissection syndrome and recurrent preterm premature rupture of fetal membranes syndrome. " 07/01/2009 - "To detect the expression of collagen III, CTGF and TNF-alpha in human fetal membranes with premature rupture of fetal membranes (PROM) and non-PROM, and explore their roles in the pathogenesis of PROM. " 04/01/2003 - "Collagen synthesis during pregnancy, vitamin C availability, and risk of premature rupture of fetal membranes."
3.	Leukocyte Elastase (Neutrophil Elastase)IBA 02/01/1993 - "[Importance of plasma PMN granulocyte elastase concentration determination in pregnant patients with premature rupture of fetal membranes]." 01/01/2009 - "[The assessment of neutrophil elastase measurements usefulness in pregnant women with premature rupture of fetal membranes and chorioamnionitis suspicion]." 10/01/2003 - "The aim of the study was to evaluate and compare the usefulness of determination granulocyte elastase, (EG) C-reactive protein (CRP) and white blood cell count (WBC) in prediction of chorioamninitis in pregnant women after premature rupture of fetal membranes. " 01/01/1989 - "[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]."
4.	Fibronectins (Fibronectin)IBA 02/01/2013 - "This study was designed to detect the accuracy of the fetal fibronectin (Quick Check fFN test(®)) in diagnosing premature rupture of fetal membranes. " 09/01/2014 - "To compare accuracy of fetal fibronectin (fFN) versus placental alpha microglobulin-1 for detection of premature rupture of fetal membranes (PROM). " 09/01/2014 - "Fetal fibronectin (Quick Check fFN test) versus placental alpha microglobulin-1 (AmniSure test) for detection of premature rupture of fetal membranes." 02/01/2013 - "The Quick Check fFN test(®) for detection of the fetal fibronectin in the vaginal fluid is a simple bedside test, more sensitive, and specific than Ferning and Nitrazine tests, it can be used as complimentary test to confirm the clinical diagnosis of premature rupture of fetal membranes." 02/01/2013 - "Fetal fibronectin (Quick Check fFN test(®)) for detection of premature rupture of fetal membranes."
5.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 01/01/1992 - "[Fibrin glue in premature rupture of fetal membranes]." 01/01/2021 - "An electronic search was conducted using the keywords "fetal membranes," "premature rupture," "amnion," "tissue engineering," "fibrin tissue adhesive," "regenerative medicine," "tissue adhesive," "wound healing," and "fetoscopy" through the MEDLINE, Embase, and Cochrane CENTRAL databases, with the limitation of English-language studies. "
6.	C-Reactive ProteinIBA 10/01/2003 - "The aim of the study was to evaluate and compare the usefulness of determination granulocyte elastase, (EG) C-reactive protein (CRP) and white blood cell count (WBC) in prediction of chorioamninitis in pregnant women after premature rupture of fetal membranes. " 01/01/1989 - "[The value of leukocytes, C-reactive protein and granulocyte elastase in patients with premature rupture of fetal membranes and amniotic infection]."
7.	Matrix Metalloproteinase 2 (Gelatinase A)IBA 06/01/2000 - "Induction of matrix metalloproteinase 2 may be a function of p53 gene expression increase in premature rupture of fetal membranes." 06/01/2000 - "Increased matrix metalloproteinase 2 expression and activity are associated with premature rupture of fetal membranes. " 06/01/2000 - "Quantitative competitive polymerase chain reaction documented a 10-fold increase in the expression of the gene for matrix metalloproteinase 2 in premature rupture of fetal membranes with respect to term and preterm labor. " 06/01/2000 - "This study was undertaken to investigate the expression pattern of apoptotic elements in pregnancy complications that may cause increased expression of the gene for matrix metalloproteinase 2. Amniochorial membranes were collected from the following groups of women: (1) women with premature rupture of fetal membranes, (2) women with preterm labor and intact membranes, and (3) women with term labor after vaginal delivery. "
8.	Tissue Adhesives (Tissue Adhesive)IBA 01/01/2021 - "An electronic search was conducted using the keywords "fetal membranes," "premature rupture," "amnion," "tissue engineering," "fibrin tissue adhesive," "regenerative medicine," "tissue adhesive," "wound healing," and "fetoscopy" through the MEDLINE, Embase, and Cochrane CENTRAL databases, with the limitation of English-language studies. "
9.	Kynurenic Acid (Kynurenate)IBA 12/01/2001 - "The aim of the study was to evaluate the influence of premature rupture of fetal membranes on kynurenic acid (KYNA) levels in venous and arterial umbilical cord blood of neonates. " 12/01/2001 - "[Influence of premature rupture of fetal membranes on kynurenic acid concentration in umbilical cord blood]."
10.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 01/01/2017 - "Purpose This study aimed to evaluate and validate the qualitative human chorionic gonadotropin β subunit (β-hCG) test of the vaginal fluid washings of pregnant women with premature rupture of fetal membranes (PROM). " 01/01/2017 - "Qualitative Determination of Human Chorionic Gonadotropin in Vaginal Washings for the Early Diagnosis of Premature Rupture of Fetal Membranes."

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 09/01/1991 - "[Maternal morbidity after abdominal cesarean section in relation to bacterial amniotic fluid colonization and premature rupture of fetal membranes]." 01/01/1990 - "[Clinical, histopathological and bacteriological evaluation of the sequelae of premature rupture of fetal membranes in parturients after cesarean section]." 01/01/2022 - "MDT continuous care was associated with a significantly lower incidence of premature rupture of fetal membranes, cesarean section, premature delivery, macrosomia, and hypoglycemia versus routine nursing. " 03/01/1988 - " There was no difference between the study groups and the controls in premature rupture of fetal membranes, placenta previa, cesarean sections, manual removal of placenta, retained secundine, postpartum hemorrhage, low birth weight, Apgar score less than 6, congenital abnormalities, or perinatal mortality. " 01/01/1988 - "[Preventive administration of antibiotics before cesarean section conducted after premature rupture of fetal membranes]."
2.	Prenatal Care (Care, Prenatal) 04/01/1990 - "It is concluded that upon premature rupture of fetal membranes, prenatal care should focus on oligohydramnios, because if this condition is prolonged, the risk of pulmonary hypoplasia increases accordingly." 01/04/2022 - "In this study, low Antenatal care (ANC) visits, being anemic, premature rupture of membrane, pregnancy-induced hypertension, not getting dietary supplementation, and physical abuse were determinants of adverse birth outcomes. " 01/04/2022 - "Low antenatal care visit, being anemic, premature rupture of membrane, pregnancy-induced hypertension, not getting dietary supplementation, and physical abuse were determinants of adverse birth outcomes. " 11/01/2016 - "Correlation analysis showed that the differences in mother's age, family income, education degree, harmful factors in contact environment, prenatal care, history of adverse pregnancy, unhealthy metal factor, gestational diabetes, diseases history in pregnancy, drug history in pregnancy, sexually transmitted disease, pregnancy hypertension, premature rupture of fetal membranes, and circular of umbilical cord performed statistical significance (P<0.05). " 10/01/2001 - "Factors with positive and negative associations with severe intracranial hemorrhage are listed in order of decreasing statistical significance: gestational age (negative), surfactant (positive), antenatal indomethacin (positive), neonatal transport (positive), cesarean birth (negative), poor prenatal care (positive), 5-minute Apgar score of < 7 (positive), chorioamnionitis (positive), antenatal terbutaline (negative), preterm premature rupture of fetal membranes (negative), and abruption (positive). "
3.	Induced Labor 04/01/1988 - "[Optimal time for labor induction in premature rupture of fetal membranes after the 37th week of pregnancy]." 01/01/1985 - "[Pregnancy monitoring and labor induction following premature rupture of fetal membranes]." 07/01/1983 - "[Clinical evaluation of the effect of prostin E2 in labor induction in pregnancy complicated by premature rupture of fetal membranes]." 08/01/1990 - "[Reflex labor induction in premature labor complicated by premature rupture of fetal membranes]." 06/18/2010 - "Factors significantly associated with pre-term delivery were low socio-economic class, previous pre-term delivery, antepartum hemorrhage, premature rupture of fetal membranes, urinary tract infection, pregnancy induced hypertension, induced labor, and booking elsewhere outside the teaching hospital."
4.	Conservative Treatment 03/01/2000 - "[Premature rupture of fetal membranes at term: sequelae of conservative management. " 01/01/1991 - "Preterm premature rupture of fetal membranes in a low socioeconomic population: results of conservative management." 09/01/1982 - "Comparison of aggressive and conservative management of premature rupture of fetal membranes." 05/01/1982 - "Conservative management of patients with premature rupture of fetal membranes."
5.	Therapeutics 07/01/1999 - "[Artificial amniotic fluid instillation in premature rupture of fetal membranes and extreme prematurity as alternative therapy]." 02/01/2015 - "[A case study regarding the use of antibiotic therapies for the treatment of preterm premature rupture of fetal membranes, and emergence of antibiotic resistant bacteria]." 09/01/2003 - "Duration of antibiotic therapy after preterm premature rupture of fetal membranes."