|1.||Steinberg, Martin H: 24 articles (01/2015 - 06/2002)|
|2.||Gambari, Roberto: 15 articles (12/2015 - 08/2003)|
|3.||Sebastiani, Paola: 12 articles (04/2014 - 04/2005)|
|4.||Ware, Russell E: 12 articles (01/2014 - 01/2002)|
|5.||Sankaran, Vijay G: 12 articles (03/2013 - 02/2008)|
|6.||Orkin, Stuart H: 11 articles (10/2015 - 02/2008)|
|7.||Thein, Swee Lay: 10 articles (01/2015 - 08/2006)|
|8.||Chui, David H K: 10 articles (01/2014 - 01/2007)|
|9.||Bianchi, Nicoletta: 9 articles (12/2015 - 08/2003)|
|10.||Borgatti, Monica: 9 articles (12/2015 - 08/2003)|
|1.||Sickle Cell Anemia (Hemoglobin S Disease)
01/01/2014 - "Decades of research have established that the most effective treatment for sickle cell disease (SCD) is increased fetal hemoglobin (HbF). "
02/01/2008 - "Increasing hemoglobin F (HbF) appears to be beneficial for patients with sickle cell anemia. "
10/01/2004 - "Increased levels of fetal hemoglobin (HbF) are clinically beneficial in patients with sickle cell disease. "
03/15/1999 - "High levels of fetal hemoglobin (Hb F) protect from many of the complications of sickle cell disease and lead to improved survival. "
07/01/2009 - "Inducers of fetal hemoglobin (HbF) have shown considerable promise in the treatment of sickle cell disease (SCD). "
|2.||beta-Thalassemia (Cooley's Anemia)
04/01/2015 - "Polymorphic variations influencing fetal hemoglobin levels: association study in beta-thalassemia carriers and in normal individuals of Portuguese origin."
08/15/2010 - "The aim of this study was to analyze in 57 beta-thalassemia intermedia patients with very various genotypes the effects on fetal hemoglobin levels of SNPs lying in three genes or chromosome regions which include the XmnI (G)gamma polymorphism at position -158 of the HBG2 promoter (rs7482144), two SNPs located in the BCL11A region (rs4671393 and rs11886868) and three SNPs located in the HBS1L-MYB region (rs28384513, rs9399137 and rs4895441). "
04/01/2006 - "A molecular study was carried out of beta-thalassemia intermedia patients, compound heterozygotes for mutations usually found in beta-thalassemia major, with high levels of HbF in the absence of hereditary persistence of fetal hemoglobin (HPFH) syndrome. "
11/01/1992 - "Family studies revealed a combination of hereditary persistence of fetal hemoglobin (HPFH) and beta zero-thalassemia minor. "
02/01/1985 - "Studies of the ability of Plasmodium falciparum to grow in vitro in the red blood cells of subjects with certain beta-thalassemia syndromes are often difficult to interpret because of the known inhibitory effect of an elevated cellular content of human fetal hemoglobin (HbF). "
08/01/2001 - "rHuEpo promotes the differentiation and proliferation of erythroid cells, induces the production of fetal hemoglobin (HbF), and could be useful in the treatment of some selected transfusion-dependent thalassemia patients. "
12/01/2014 - "It has been reported that in patients with β-thalassemia in the presence of Xmn 1(G)γ polymorphic site the level of fetal hemoglobin (HbF) is increased thereby reducing the severity of disease. "
01/01/1981 - "In contrast to adults, the hemoglobin F level seems to be helpful for the diagnosis of thalassemia trait. "
06/01/2013 - "Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-β(0) thalassemia."
01/01/2013 - "Two key modifiers, an innate ability to produce fetal hemoglobin and coinheritance of α-thalassemia, both derived from family and population studies, affect the pathophysiology of both disorders at the primary level. "
04/01/2014 - "Increased fetal hemoglobin (HbF) expression is beneficial for β-hemoglobinopathy patients; however, current inducing agents do not possess the ideal combination of efficacy, safety and ease of use. "
09/01/2011 - "An improved understanding of the regulation of the fetal hemoglobin genes holds promise for the development of targeted therapeutic approaches for fetal hemoglobin induction in the β-hemoglobinopathies. "
01/01/2012 - "To address how low titer, variable expression, and gene silencing affect gene therapy vectors for hemoglobinopathies, in a previous study we successfully used the HPFH (hereditary persistence of fetal hemoglobin)-2 enhancer in a series of oncoretroviral vectors. "
01/01/2015 - "Fetal hemoglobin (HbF) is the major modulator of the phenotype of the β hemoglobinopathies. "
01/01/2015 - "Fetal hemoglobin (Hb F) is an important genetic modulator of the beta-hemoglobinopathies. "
01/01/2015 - "In STZ-diabetic animals treated with submerged culture mycelium powder, an increase in the number of erythrocytes in the bloodstream (an antianemic effect), erythrocyte resistance to acid hemolysis, and the normalization of fetal hemoglobin concentrations, along with the intensification of erythropoiesis were observed. "
05/01/2010 - "The role of chronic hemolysis was further strengthened by multivariate analysis showing a correlation between estimated GFR and a low plasma fetal hemoglobin level, a young age, and a high reticulocyte count (r(2) = 0.54). "
02/01/2010 - "We hypothesize that inhibition of sickling by genetic manipulation to enhance antisickling fetal hemoglobin (HbF) expression will have an ameliorating effect on oxidative stress by decreasing intravascular sickling and hemolysis and enhancing NO bioavailability. "
07/01/1986 - "Two sets of normal reference values for optical density at 450 nm and fetal hemoglobin at 16 to 36 and 16 to 25 weeks were established from 475 amniotic fluid and 153 fetal blood samples obtained from pregnancies not complicated by fetal hemolysis. "
05/01/2015 - "Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state."
|9.||Messenger RNA (mRNA)
|2.||Chelation Therapy (Therapy, Chelation)
|4.||Drug Therapy (Chemotherapy)
|5.||Blood Transfusion (Blood Transfusions)