Fetal Alcohol Syndrome

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334 relevant articles (4 outcomes, 31 trials/studies) found for this Disease

Description: A condition occurring in FETUS or NEWBORN due to in utero ETHANOL exposure when mother consumed alcohol during PREGNANCY. It is characterized by a cluster of irreversible BIRTH DEFECTS including abnormalities in physical, mental, and behavior development (such as FETAL GROWTH RETARDATION; MENTAL RETARDATION; ATTENTION DEFICIT AND DISRUPTIVE BEHAVIOR DISORDERS) with varied degree of severity in an individual.

Also Known As:

Fetal Alcohol Syndromes

Relationship Network

Disease Context: Research Results

Female Urogenital Diseases and Pregnancy Complications

Pregnancy Complications: 552

Fetal Diseases: 584

Fetal Alcohol Syndrome: 334

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 449

Fetal Diseases: 584

Fetal Alcohol Syndrome: 334

Disorders of Environmental Origin

Substance-Related Disorders: 6011

Alcohol-Related Disorders: 36

Alcohol-Induced Disorders: 5

Fetal Alcohol Syndrome: 334

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
2.	Neoplasms (Cancer)
3.	Alcoholic Liver Diseases (Alcoholic Liver Disease)
4.	Gout
5.	Asthma (Bronchial Asthma)

Experts

1.	Spong, Catherine Y: 4 articles (03/2007 - 10/2002)
2.	Roberson, Robin: 2 articles (03/2007 - 03/2006)
3.	Abebe, Daniel: 2 articles (03/2007 - 03/2006)
4.	Toso, Laura: 2 articles (03/2007 - 03/2006)
5.	Auth, Jonathan: 2 articles (09/2005 - 10/2002)
6.	Vink, Joy: 2 articles (09/2005 - 10/2002)
7.	Abebe, Daniel T: 2 articles (09/2005 - 10/2002)
8.	Brenneman, Douglas E: 2 articles (09/2005 - 10/2002)
9.	Wozniak, D F: 2 articles (01/2001 - 02/2000)
10.	Olney, J W: 2 articles (01/2001 - 02/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fetal Alcohol Syndrome:

1.	Ethanol (Ethyl Alcohol)IBA 01/01/2003 - "These effects in vitro may help to explain the devastating effects of prenatal ethanol exposure in vivo, which contribute to the fetal alcohol syndrome." 09/01/2008 - "As maternal drinking is known to cause fetal alcohol syndrome (FAS) or malformation of the fetal brain during pregnancy, the objective of the present study was to investigate whether maternal ethanol exposure alters the PCD-related Bax and Bcl-2 protein expression during fetal brain development. " 09/01/2005 - "CONCLUSIONS: Impaired structural and functional development of VYS may contribute to the teratogenic action of ethanol in mice, which may also provide a clue to the study of fetal alcohol syndrome in humans." 11/01/1999 - "The decreased electrical activity in midbrain DA neurons could contribute to the prenatal ethanol exposure-induced reduction in DA content and metabolites observed in previous studies and the attention/hyperactivity problems reported in children with fetal alcohol effects/fetal alcohol syndrome." 02/01/1998 - "This study partially characterized the mechanism of ethanol-induced neural crest cell death in a chick embryo model of fetal alcohol syndrome. " Order ALL the reference details at left...
2.	XenobioticsIBA 02/01/2004 - "The variants have also been studied for association with alcoholic liver disease, cancer, fetal alcohol syndrome, CVD, gout, asthma and clearance of xenobiotics. " Order ALL the reference details at left...
3.	Amphetamine (Amfetamine)FDA LinkGeneric 05/01/2001 - "This mechanism may contribute to the therapeutic effects of amphetamine-like stimulants in attention problems observed in children with fetal alcohol syndrome." 05/01/2001 - "Amphetamine-like stimulants are effective in treating attention deficit/hyperactivity disorder (ADHD), which is a major symptom in fetal alcohol syndrome. " Order ALL the reference details at left...
4.	AcetaldehydeIBA 01/01/1979 - "The teratogenic effect of acetaldehyde: implications for the study of the fetal alcohol syndrome." 01/01/1996 - "These results clearly show that acetaldehyde may participate in the development of the Fetal Alcohol Syndrome." 10/01/1995 - "Experiments have provided evidence that supports and refutes the idea that acetaldehyde is responsible for the teratogenic effects observed in fetal alcohol syndrome. " 01/01/1984 - "Acetaldehyde may be important in the pathogenesis of the fetal alcohol syndrome." 07/23/1983 - "Acetaldehyde and the fetal alcohol syndrome." Order ALL the reference details at left...
5.	ZincIBA 01/01/1990 - "Because alcohol has an adverse effect on zinc homeostasis, this study was designed to study if zinc content of the diet modifies the severity of fetal alcohol syndrome in a mouse model. " 04/01/2001 - "BACKGROUND: Alcohol-induced zinc deficiency is one of the mechanisms proposed as a cause of developmental brain damage associated with fetal alcohol syndrome. " 01/01/1990 - "These results suggest that zinc intake should be optimized during pregnancy but that zinc supplementation above the Recommended Dietary Allowance does not reduce the incidence or severity of fetal alcohol syndrome." 01/01/1990 - "Zinc nutrition in fetal alcohol syndrome." 06/01/1988 - "Neonatal and maternal hair zinc levels in a nonhuman primate model of the fetal alcohol syndrome." Order ALL the reference details at left...
6.	Insulin (Novolin)FDA Link 01/01/2009 - "In a multiple regression model, age, low birth weight (LBW), insulin-like growth factor binding protein-3, and high risk for fetal alcohol syndrome were independent predictors of height SDS. " 06/01/2007 - "Cerebellar hypoplasia in experimental fetal alcohol syndrome (FAS) is associated with impaired insulin-stimulated survival signaling. " 09/01/2006 - "In fetal alcohol syndrome (FAS), cerebellar hypoplasia is associated with impaired insulin-stimulated survival signaling. " 05/01/2005 - "The present work explores the mechanisms of impaired insulin signaling in a rat model of fetal alcohol syndrome. " 05/01/2002 - "To determine the relevance of these findings to fetal alcohol syndrome, we examined mechanisms of insulin-stimulated neuronal survival and mitochondrial function using a rat model of chronic gestational exposure to ethanol. " Order ALL the reference details at left...
7.	PeptidesIBA 09/01/2005 - "CONCLUSION: The peptides, NAPVSIPQ+SALLRSIPA, prevented the alcohol-induced spatial learning deficits and attenuated alcohol-induced proinflammatory cytokine increase in a model of fetal alcohol syndrome. " 09/01/2005 - "Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome." 03/01/2007 - "In a model for fetal alcohol syndrome, neuroprotective peptides prevented fetal death and learning deficits. " 03/01/2006 - "OBJECTIVE: Vasoactive intestinal peptide (VIP)-related peptides prevented the learning deficit in the offspring in a model for fetal alcohol syndrome. " 06/01/2004 - "Combined administration of peptides was tested in a model of fetal alcohol syndrome and in a model of learning impairment: apolipoprotein E knockout mice. " Order ALL the reference details at left...
8.	SALLRSIPAIBA 10/15/2002 - "Previous work has demonstrated that peptide agonists (SALLRSIPA and NAPVSIPQ) from downstream mediators that are regulated by VIP were able to prevent the alcohol-induced fetal death, growth restriction and microcephaly associated with fetal alcohol syndrome. " 09/01/2005 - "OBJECTIVE: Previously, the novel peptides NAPVSIPQ and SALLRSIPA were shown to prevent alcohol-induced fetal death and growth abnormalities in a mouse model of fetal alcohol syndrome. " 03/01/2007 - "STUDY DESIGN: With a model for fetal alcohol syndrome, timed pregnant C57B16/J mice were treated on gestational day 8 with alcohol (25% alcohol) or control (saline solution) or alcohol plus peptides NAPVSIPQ + SALLRSIPA (NAP + SAL; 20 microg). " 05/01/2001 - "Two peptides [NAPVSIPQ (NAP) and SALLRSIPA (ADNF-9)], that are associated with novel glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome. " Order ALL the reference details at left...
9.	TolueneIBA 02/01/1997 - "A pattern of teratogenicity similar to that of the fetal alcohol syndrome is prevalent in all human studies of excessive in utero exposure to toluene. " 02/01/1997 - "The overlap of features following in utero toluene abuse with those of fetal alcohol syndrome suggests a possible common pathway of craniofacial teratogenesis. " 02/01/1994 - "Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome." 02/28/2002 - "A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria." 02/01/1994 - "Data from the patients herein described and the available scientific literature suggest that the mechanism of alcohol craniofacial teratogenesis may be nonspecific, with a variety of teratogens, including toluene, giving rise to phenotypic facial abnormalities similar to those of the fetal alcohol syndrome. " Order ALL the reference details at left...
10.	Glucose (Dextrose)FDA LinkGeneric 01/01/1986 - "Fetal alcohol syndrome: glucose and liver metabolism in term rat fetus and neonate." 01/01/1988 - "The role of altered glucose metabolism in the growth retardation associated with the Fetal Alcohol Syndrome has been difficult to assess because previously used experimental procedures have frequently substituted ethanol for dietary carbohydrate. " 01/01/1999 - "However, using an in vitro model system of fetal alcohol effects/fetal alcohol syndrome, this study examines the neuroprotective effects of nerve growth factor, brain-derived neurotrophic factor, or glial cell line derived neurotrophic factor against EtOH treatment (0, 200, 400, 800, or 1, 600 mg/dl) combined with acute ischemia (2-hour hypoxia in EtOH-containing glucose-free media) followed by chronic hypoglycemia (16-hour glucose deprivation in EtOH-containing media). " Order ALL the reference details at left...

Therapies and Procedures

1.	Prenatal Care 11/01/1995 - "The proportion of mothers of children with fetal alcohol syndrome was statistically significantly greater (as determined by exact binomial 95 percent confidence limits) than the proportion of all mothers for the following characteristics: black race (0.23 versus 0.05), unmarried (0.55 versus 0.22), not employed during pregnancy (0.86 versus 0.43), and started prenatal care in the third trimester (0.18 versus 0.04). " 01/01/1992 - "A range of critical health problems will require our attention if the goals are to be met, such as availability of prenatal care, infant mortality, inadequate nutrition during pregnancy or early childhood, or both, disease prevention by immunization, infants who have been exposed to drugs, fetal alcohol syndrome, and the emotional and mental disorders of early childhood, to name a few. " Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 06/11/1999 - "One child's development is retarded due to a fetal alcohol syndrome resulting from the mother's post-transplantation alcohol abuse during pregnancy. " 04/01/2008 - "Furthermore, to develop a novel method for reconstruction of the neural network damaged by ethanol, we tried to analyze the usefulness of intravenous NSC transplantation in fetal alcohol syndrome spectrum disorder (FASD) model rats. " Order ALL the reference details at left...
3.	Corneal Transplantation (Keratoplasty) 04/15/1993 - "These three siblings, who had mild systemic features of fetal alcohol syndrome, underwent corneal transplantations, and their specimens were examined by light and electron microscopy. " Order ALL the reference details at left...
4.	Lasers (Laser) 08/01/2008 - "OBJECTIVES: Use three-dimensional (3D) facial laser scanned images from children with fetal alcohol syndrome (FAS) and controls to develop an automated diagnosis technique that can reliably and accurately identify individuals prenatally exposed to alcohol. " Order ALL the reference details at left...
5.	Day Care (Partial Hospitalization) 06/01/1992 - "Fetal alcohol syndrome and its implications for the day care provider." Order ALL the reference details at left...

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