A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Also Known As:
Heme Synthetase; Protoheme Ferro-Lyase; Zinc Chelatase; Chelatase, Porphyrin-Metal; Chelatase, Zinc; Ferro-Lyase, Protoheme; Porphyrin Metal Chelatase; Protoheme Ferro Lyase; Synthetase, Heme; Porphyrin-Metal Chelatase