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Ferrochelatase (Heme Synthetase)

A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Also Known As:
Heme Synthetase; Protoheme Ferro-Lyase; Zinc Chelatase; Chelatase, Porphyrin-Metal; Chelatase, Zinc; Ferro-Lyase, Protoheme; Porphyrin Metal Chelatase; Protoheme Ferro Lyase; Synthetase, Heme; Porphyrin-Metal Chelatase
Networked: 235 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Taketani, Shigeru: 8 articles (01/2013 - 05/2002)
2. Schneider-Yin, X: 7 articles (11/2010 - 08/2000)
3. Deybach, Jean-Charles: 6 articles (01/2015 - 01/2002)
4. Gouya, Laurent: 6 articles (01/2015 - 01/2002)
5. Bloomer, Joseph R: 6 articles (07/2011 - 06/2002)
6. Elder, G H: 6 articles (03/2010 - 12/2001)
7. Deybach, J C: 6 articles (01/2009 - 08/2000)
8. Minder, E I: 5 articles (11/2010 - 10/2000)
9. Badminton, Michael N: 5 articles (03/2009 - 01/2006)
10. Gouya, L: 5 articles (01/2009 - 08/2000)

Related Diseases

1. Conversion Disorder (Astasia Abasia)
2. Erythropoietic Protoporphyria
3. Porphyrias
4. Neoplasms (Cancer)
5. Malaria

Related Drugs and Biologics

1. Heme (Haem)
2. protoporphyrin IX
3. Iron
4. Messenger RNA (mRNA)
5. 1-phenyl-3,3-dimethyltriazene (PDT)
6. Transferrin Receptors (Transferrin Receptor)
7. Enzymes
8. Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)
9. Protoporphyrinogen Oxidase (Protox)
10. Complementary DNA (cDNA)

Related Therapies and Procedures

1. Photochemotherapy (Photodynamic Therapy)
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)