Femur Head Necrosis

Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and LEGG-CALVE-PERTHES DISEASE.

Also Known As:

Avascular Necrosis Of Femoral Head, Primary; Femoral Head, Avascular Necrosis Of; Ischemic Necrosis Of Femoral Head; Femur Head Necroses; Head Necrosis, Femur; Necrosis, Femur Head; Aseptic Necrosis of Femur Head; Avascular Necrosis of Femur Head; Necrosis, Aseptic, of Femur Head; Necrosis, Avascular, of Femur Head

Networked: 96 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sepsis (Septicemia)
2.	Abdominal Pain (Pain, Abdominal)
3.	Nausea
4.	Femur Head Necrosis
5.	Necrosis

Experts

1.	Zhang, Changqing: 2 articles (01/2021 - 03/2005)
2.	Tong, Pei-jian: 2 articles (07/2013 - 03/2013)
3.	Bai, Yanjie: 1 article (01/2022)
4.	Jia, Xiaowei: 1 article (01/2022)
5.	Li, Xinle: 1 article (01/2022)
6.	Liang, Chunyong: 1 article (01/2022)
7.	Ma, Jiali: 1 article (01/2022)
8.	Sun, Yuting: 1 article (01/2022)
9.	Yang, Lei: 1 article (01/2022)
10.	Zhang, Ping: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Femur Head Necrosis:

1.	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/01/2021 - "This study aims to study the potential protective effects of Alendronate in the early stage of femur head necrosis. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 04/01/1998 - "[Aseptic femur head necrosis--sequelae of systemic corticosteroid therapy?]." 11/13/1969 - "[Femur head necrosis during systematic corticosteroid therapy]." 08/04/2023 - "At this time, he developed bilateral femur head necrosis and underwent surgery after discontinuation of the corticosteroid but developed respiratory failure postoperatively. " 01/01/1977 - "[Bilateral femur head necrosis in the course of corticosteroid treatment for viral hepatitis]." 04/06/1985 - "[Bilateral femur head necrosis following high dosage corticosteroid therapy for chorioretinitis]."
3.	TantalumIBA 06/01/2011 - "The tantalum screw implantation is simple and effective for the treatment of adult early femur head necrosis, and can effectively avoid collapse of necrotic area, the results were satisfactory in the near future." 07/01/2013 - "With development of science, tantalum rod implanting combined with correlative biotechnology should raise the effect in treating femur head necrosis." 07/01/2013 - "But reasons that the difficult diagnosis of early femur head necrosis, localized effect of tantalum rod, different experience of medical worker,caused the contentions about effect of tantalum rod implanting. " 07/01/2013 - "The structure and mechanics characteristics of tantalum rod is similar to bone tissue, it higher strength and can adapt the internal environment of organism, so it has a large potency in treating femur head necrosis. " 07/01/2013 - "[Progress on tantalum rod implanting for the treatment of femur head necrosis]."
4.	Cyclosporine (Ciclosporin)FDA LinkGeneric 07/01/2004 - "Although conventional immunosuppressive therapy regimens proved effective in controlling disease activity, all of the administered drugs were accompanied by serious side effects: bilateral femur head necrosis with corticosteroids, allergic skin reaction in response to azathioprine, nephrotoxicity with cyclosporine, nausea and abdominal pain with mycophenolate mofetil and life-threatening septicemia with cyclophosphamide treatment. "
5.	Mycophenolic Acid (Cellcept)FDA LinkGeneric 07/01/2004 - "Although conventional immunosuppressive therapy regimens proved effective in controlling disease activity, all of the administered drugs were accompanied by serious side effects: bilateral femur head necrosis with corticosteroids, allergic skin reaction in response to azathioprine, nephrotoxicity with cyclosporine, nausea and abdominal pain with mycophenolate mofetil and life-threatening septicemia with cyclophosphamide treatment. "
6.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/01/2004 - "Although conventional immunosuppressive therapy regimens proved effective in controlling disease activity, all of the administered drugs were accompanied by serious side effects: bilateral femur head necrosis with corticosteroids, allergic skin reaction in response to azathioprine, nephrotoxicity with cyclosporine, nausea and abdominal pain with mycophenolate mofetil and life-threatening septicemia with cyclophosphamide treatment. "
7.	Azathioprine (Imuran)FDA LinkGeneric 07/01/2004 - "Although conventional immunosuppressive therapy regimens proved effective in controlling disease activity, all of the administered drugs were accompanied by serious side effects: bilateral femur head necrosis with corticosteroids, allergic skin reaction in response to azathioprine, nephrotoxicity with cyclosporine, nausea and abdominal pain with mycophenolate mofetil and life-threatening septicemia with cyclophosphamide treatment. "
8.	SteroidsIBA 11/26/2022 - "Studies have shown that miR-145 is a key regulatory molecule of BMSC cells, but its mechanism in steroid-induced femur head necrosis remains unclear. " 12/01/2005 - "Experimental study on gufusheng in treatment of steroid-induced ischemic necrosis of femoral head in rabbits." 12/01/2005 - "To explore the mechanisim of compound Gufusheng in treatment of steroid-induced ischemic necrosis of femoral head (SINFH). " 11/01/1984 - "[Aseptic femur head necrosis in patients after long-term treatment with steroids]." 01/01/2004 - "[Femur head necrosis in haemophilia and after prolonged steroid therapy--description of two cases]."
9.	GlucocorticoidsIBA 06/01/2009 - "To probe into the mechanism of Chinese drugs for promoting blood circulation and eliminating blood stasis in the prevention and treatment of glucocorticoid-induced ischemic necrosis of femoral head. " 01/01/2021 - "Associations between glucocorticoids, antiphospholipid antibodies and femur head necrosis in patients with SLE: a directed acyclic graph-based multicentre study." 12/01/2004 - "The experimental study on treatment of glucocorticoid-induced ischemic necrosis of femoral head by gu fu sheng capsule." 06/01/2009 - "Chinese drugs for promoting blood circulation and eliminating blood stasis can improve the microcirculation of femoral head in rabbits with glucocorticoid-induced ischemic necrosis of femoral head by promoting the expression of VEGF." 06/01/2009 - "Effect of Chinese drugs for promoting blood circulation and eliminating blood stasis on vascular endothelial growth factor expression in rabbits with glucocorticoid-induced ischemic necrosis of femoral head."
10.	Antiphospholipid AntibodiesIBA 01/01/2021 - "Associations between glucocorticoids, antiphospholipid antibodies and femur head necrosis in patients with SLE: a directed acyclic graph-based multicentre study."

Therapies and Procedures

1.	Decompression 05/01/2000 - "[The value of core decompression in treatment of femur head necrosis]." 09/01/1997 - "The application of core decompression in the treatment of ischemic necrosis of femoral head (INFH) is to preserve the joint at early stage of the disease. " 03/01/1997 - "[Initial nuclear magnetic resonance tomography results of the treatment course of avascular femur head necrosis after femoral core decompression]." 03/01/1993 - "[Results of medullary space decompression in the early stage of so-called idiopathic femur head necrosis]." 08/01/1990 - "[Role of core decompression as treatment method for ischemic femur head necrosis]."
2.	Bone Transplantation (Bone Grafting) 12/01/2017 - "The Medical Subject Headings used were "femur head necrosis" and "bone transplantation." The relevant words in title or abstract included but not limited to "fibula flap," "fibular flap," "vascularized fibula," "vascularized fibular," "free fibula," "free fibular," "femoral head necrosis," "avascular necrosis of femoral head," and "ischemic necrosis of femoral head." The methodological index for nonrandomized studies was adopted for assessing the studies included in this review. "
3.	Moxibustion 06/04/2021 - "The medical subject titles used are "Osteonecrosis of the femoral head" and "acupuncture and moxibustion." Related words in the title or abstract including but were not limited to "necrosis of the femoral head," "avascular necrosis of the femoral head," "ischemic necrosis of the femoral head," "caput femoris necrosis," "bone paralysis," "bone erosion," and "bone atrophy." Nine randomized controlled trials were identified in this meta-analysis that included 630 subjects. "
4.	Braces 09/01/1969 - "[Studies on the frequency of femur head necroses following the use of braces and various conservative therapeutic technics in congenital hip displasia and hip luxation]."
5.	Therapeutics 11/10/1994 - "[Diagnosis and therapy of idiopathic femur head necrosis]." 09/01/1988 - "[Vascular pedicled iliac bone graft in therapy of femur head necrosis in the adult. " 09/01/1988 - "[Idiopathic femur head necrosis in the adult--results of surgical therapy]." 07/01/1987 - "[Superselective angiography as a therapy control of femur head necrosis treated with a vascular pedicled pelvic bone graft]." 02/01/1985 - "[Femur head necrosis--value of so-called radiologic early signs for diagnosis and therapy]."