Favism

Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.

Also Known As:

Networked: 191 relevant articles (1 outcomes, 20 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Anemia
2.	Reticulocytosis
3.	Hyperbilirubinemia
4.	Glucosephosphate Dehydrogenase Deficiency
5.	Hemolysis

Experts

1.	Arbid, Mahmoud S: 4 articles (03/2018 - 01/2013)
2.	Koriem, Khaled M M: 4 articles (03/2018 - 01/2013)
3.	Vandenberg, Albert: 2 articles (01/2021 - 10/2018)
4.	Cai, Wangwei: 2 articles (04/2018 - 01/2016)
5.	Du, Guankui: 2 articles (04/2018 - 01/2016)
6.	Xiao, Man: 2 articles (04/2018 - 01/2016)
7.	Al-Kahlout, Mustafa S: 2 articles (07/2017 - 01/2016)
8.	Al-Tayeb, Jamal M: 2 articles (07/2017 - 01/2016)
9.	Prchal, Josef T: 2 articles (07/2017 - 01/2016)
10.	Reading, N Scott: 2 articles (07/2017 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Favism:

1.	glucose-6-phosphate dehydrogenase A-IBA 01/01/2016 - "We have found by comparison to the general population (485 adults and 466 newborns) that children with favism, in terms of relative frequency, G6PD A- was under-represented, whereas G6PD Med was over-represented. " 11/01/1994 - "The most common variants are G6PD A- (46%) and G6PD Mediterranean (23%), both of which were associated with favism. " 01/01/2016 - "We have investigated the hematological features of acute favism in the Palestinian Gaza community that is characterized by the polymorphic coexistence of three different G6PD deficiency genes (G6PD A-, G6PD Cairo, G6PD Med). " 10/01/1997 - "By using this procedure, 9 new mutations have been identified, five of them have been also found in other geographical areas and were associated with favism (G6PD A-376G/968C, G6PD Santamaria 376G/542T, G6PD Aures 143C and G6PD Chatham 1003A) or chronic haemolytic anaemia (G6PD Tomah 1153C). " 05/01/2011 - "We discuss the pathophysiology of severe methemoglobinemia when associated with acute hemolysis, favism, and the common African G6PD A-variant [G6PD, VAL68MET, ASN126ASP]. "
2.	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 02/09/1970 - "[Family studies of erythrocyte glucose-6-phosphate dehydrogenase in favism]." 04/01/2011 - "Favism is an acute hemolytic syndrome occurring in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals after the consumption of fava beans. " 02/01/2006 - "Glucose-6-phosphate dehydrogenase variants associated with favism in Thai children." 07/01/2000 - "Favism is an acute hemolytic syndrome occurring in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals after the consumption of fava beans. " 10/01/1999 - "Susceptibility to favism is conferred by a genetic deficiency in erythrocytic glucose-6-phosphate dehydrogenase (G6PD) activity. "
3.	EnzymesIBA 01/01/2014 - "The aim of this study was to compare the direct costs of favism treatment on patients and health system with G6PD enzyme screening test. " 10/01/2006 - "The aim of the present study was to determine the normal values of G6PD and deficiency prevalence of this enzyme in different age groups of people living in the western region of Turkey and accordingly inform and educate about favism to those asymptomatic carriers who usually are not aware of their G6PD deficient status. " 01/01/2014 - "The cost of G6PD enzyme screening in Rasht is substantially lower than the cost of treating hospitalized patients with Favism." 01/01/2014 - "Medical expenses of patients with Favism admitted to 17th Shahrivar Hospital compared to G6PD enzyme screening cost, in north of Iran." 11/01/1996 - "None of the subjects studied displayed any sign of favism, a condition usually associated with G6PD Mediterranean, which is characterized by a very low intracellular enzyme activity."
4.	Glutathione (Reduced Glutathione)IBA 04/01/1960 - "[The instability of erythrocytic reduced glutathione in the pathogenesis of ictero-hemoglobinuric favism]." 07/01/1957 - "[Instability of blood glutathione in favism; utilization of a selective test and introduction of the genetic problem]." 06/01/1956 - "[Early determinations of serum glutathione in favism]." 04/01/1958 - "Studies on glutathione stability in erythrocytes of cases with past history of favism or sulfa-drug-induced hemolysis." 05/17/2011 - "Here, we investigated the hypothesis that favism is caused by toxic Vicia faba substances, which in some ACP(1) phenotypes cause increased phosphorylation and consequently increased glycolysis, with strong reduction in reduced glutathione production, resulting in hemolysis. "
5.	divicineIBA 10/01/1999 - "Favism: divicine hemotoxicity in the rat." 07/01/1993 - "Divicine has long been thought to be a mediator of an acute hemolytic crisis, known as favism, in susceptible individuals who ingest fava beans (Vicia faba). " 07/01/1984 - "Activity of divicine in Plasmodium vinckei-infected mice has implications for treatment of favism and epidemiology of G-6-PD deficiency." 08/01/2001 - "Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins." 01/01/1989 - "3. Toxic substances of Vicia faba and their mechanism of action: treatment of G6PD-deficient RBC with divicine or isouramil (redox substances present in fava beans) provokes the same changes as observed during favism. "
6.	vicineIBA 12/01/2006 - "In the case of faba bean (Vicia faba L.), a breeding priority is the absence vicine and convicine (v-c); responsible for favism in humans and for the reduced animal performance or low egg production in laying hens. " 09/23/2022 - "However, they also produce the anti-nutritional compounds, vicine and convicine (v-c), that when enzymatically degraded into reactive aglycones can potentially lead to hemolytic anemia or favism. " 01/01/1991 - "Vicine and convicine as natural occurring toxic compounds in Vicia faba are involved in the formation of hemolytic anemia (favism). " 05/14/1984 - "Active principles which are responsible for the haemolysis ( Vicine and Convicine ) were isolated from broad beans and their effects on GSH levels of blood were 99% and 81%, respectively, in favism sensitive subjects and 33.3% and 19% in normal subjects." 01/01/1973 - "These observations are consistent with the results of laboratory studies, which incriminate vicine, divicine, and DOPA in the etiology of favism."
7.	Oxidoreductases (Dehydrogenase)IBA 06/01/1969 - "[Experimental studies of favism in animals with G-6-P dehydrogenase deficiency in connection with 8 cases of favism]." 04/30/2018 - "Favism is an acute hemolytic syndrome caused by the ingestion of fava bean (FB) in glucose 6-phosphate dehydrogenase (G6PD) deficient individuals. " 01/01/2016 - "Favism is a life-threatening hemolytic anemia resulting from the intake of fava beans by susceptible individuals with low erythrocytic glucose 6-phosphate dehydrogenase (G6PD) activity. " 06/08/1968 - "[Glucose-6-phospate dehydrogenase deficiency (favism) and acute kidney failure]." 05/02/2013 - "Glucose 6-phosphate dehydrogenase (G6PD) deficiency, known as favism, is classically manifested by hemolytic anemia in human. "
8.	Oxidants (Oxidizing Agents)IBA 01/01/1989 - "However, favism is a unique natural model of oxidant damage in vivo, useful for the study of senescent or damaged red blood cells (RBC) clearance from circulation. " 02/01/2013 - "Due to abnormalities were seen in the liver function tests of these patients, we suggest that these tests be regularly performed for favism patients who are constantly exposed to oxidant agents." 10/01/2012 - "Acute hemolysis by fava bean ingestion in G6PD deficient individuals (favism) is described being the best-studied natural model of oxidant damage. " 01/01/2013 - "Also, it is better to test for G6PD deficiency in all of the neonates, to detect its presence and to prevent its complications such as favism and oxidant drug-induced hemolysis, since the test has a low cost." 06/01/1987 - "These findings support the role of procalpain in protecting G6PD-deficient RBC from oxidant-induced Heinz body formation and imply that exhaustion of the procalpain-calpain system is an important step in the mechanisms of RBC damage and destruction in favism."
9.	DNA (Deoxyribonucleic Acid)IBA 03/01/1996 - "DNA analyses showed that seven (three boys, four girls) of these 20 (35%) had G6PD Aures (nt 143 T - > C), a variant associated with favism which was recently reported in an Algerian. " 09/01/2006 - "We performed DNA analysis on 68 G6PD deficient children, 52 school boys and 16 children with the history of favism and hemolytic anemia using a combination of PCR-RFLP technique, single strand conformation polymorphism (SSCP) analysis and DNA sequencing. " 01/01/2016 - "Favism also induced deoxyribonucleic acid (DNA) damage and prior treatment of anise oil maintained liver DNA content. " 09/01/2022 - "Almond oil restored blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism." 09/01/2022 - "Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism."
10.	AntioxidantsIBA 05/01/2013 - "Oxidative stress and antioxidant defense in Egyptian favism patients." 04/01/1988 - "[Erythrocyte antioxidant enzymatic systems and serum beta-glucuronidase in subjects with favism. " 01/01/2007 - "The role of G6PD as an antioxidant enzyme has been recognized in erythrocytes for a long time, as its deficiency is associated with neonatal jaundice, drug- or infection-mediated hemolytic crisis, favism and, less commonly, chronic non-spherocytic hemolytic anemia. " 09/01/2022 - "Almond oil restored blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism." 09/01/2022 - "Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism."

Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions) 01/01/2021 - "Blood transfusion was conducted in 36.36% of the cases and the mean of blood administered was 18.9 cc/kg. In this study, hydration therapy was performed in most of the children presenting favism. " 07/01/2019 - "Leukocytosis in patients with favism and association with blood transfusion." 05/01/2013 - "Blood samples were collected from children with favism (n = 55) between age (2-12 years) on EDTA tubes divided into 3 groups: group 1 control group (n = 15), group 2 before blood transfusion (during hemolytic action) (n = 20) and group 3 after blood transfusion (treated) (n = 20). " 07/01/2019 - "The aim of this study is to analyze the effect of blood transfusion in leukocytosis patients with favism as compared to patients treated with antibiotics or combination of both. "
2.	Therapeutics 01/01/2021 - "Blood transfusion was conducted in 36.36% of the cases and the mean of blood administered was 18.9 cc/kg. In this study, hydration therapy was performed in most of the children presenting favism. " 02/01/1995 - "This is the first application of haptoglobin therapy for acute favism and the first reported case of Japanese G6PD deficiency with typical favic crisis. " 02/01/1995 - "Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara." 07/31/2020 - "All subjects must be aged ≥18 years, male or female, must be willing and able to give informed consent and must not have any contraindications to take hydroxychloroquine (intolerance or previous toxicity for hydroxychloroquine/chloroquine, bradycardia or reduction in heart rhythm with arrhythmia, ischemic heart disease, retinopathy, congestive heart failure with use of diuretics, favism or glucose-6-phosphate dehydrogenase (G6PD) deficiency, diabetes type 1, major comorbidities such as advanced chronic kidney disease or dialysis therapy, known history of ventricular arrhythmia, any oncologic/hematologic malignancy, severe neurological and mental illness, current use of medications with known significant drug-drug interactions, and known prolonged QT syndrome or current use of drugs with known QT prolongation). "
3.	Anesthesia 05/01/2006 - "We report a case of a 30-year-old female patient with favism and review the disease and anesthesia-related implications." 01/01/2009 - "Keywords used were glucose-6-phosphate dehydrogenase (G6PD) deficiency, anesthesia, analgesia, anxiolysis, management, favism, hemolytic anemia, benzodiazepines, codeine, codeine derivatives, ketamine, barbiturates, propofol, opioids, fentanyl, and inhalation anesthetics. "
4.	Drug-Eluting Stents 11/01/2008 - "Drug-eluting stents in a patient with favism: is the aspirin administration safe?"
5.	Cochlear Implants (Cochlear Implant) 07/01/2009 - "Eight out of one thousand and three hundred patients who received cochlear implants in PUMC hospital were diagnosed with other assident particular diseases besides SNHL, which included hypopotassaemia, hemophilia, idiopathic thrombocytopenic purpura (ITP), favism, abnormal blood coagulation factor, abnormally high alkaline phosphatase. "