Volatile Fatty Acids

Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.

Also Known As:

Fatty Acids, Volatile; Acid, Short-Chain Fatty; Acid, Volatile Fatty; Fatty Acid, Short-Chain; Fatty Acid, Volatile; Fatty Acids, Short Chain; Short Chain Fatty Acid; Short-Chain Fatty Acids; Fatty Acids, Short-Chain; Short-Chain Fatty Acid; Volatile Fatty Acid

Networked: 3052 relevant articles (179 outcomes, 332 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052

Experts

1.	Chen, Wei: 14 articles (06/2022 - 02/2005)
2.	Zhang, Hao: 13 articles (06/2022 - 02/2017)
3.	Nyman, Margareta: 12 articles (02/2022 - 01/2013)
4.	Tain, You-Lin: 11 articles (04/2022 - 09/2018)
5.	Zhao, Jianxin: 11 articles (10/2021 - 02/2017)
6.	Wang, Gang: 10 articles (06/2022 - 02/2017)
7.	Hsu, Chien-Ning: 10 articles (04/2022 - 09/2018)
8.	Mackay, Charles R: 9 articles (01/2022 - 07/2015)
9.	Hou, Chih-Yao: 9 articles (12/2021 - 09/2018)
10.	Zhang, Yi: 8 articles (04/2022 - 01/2020)

Related Diseases

1.	Inflammation (Inflammations) 11/08/2023 - "DOP also effectively regulates disordered intestinal flora and enhances the production of short-chain fatty acids, which is also beneficial in modulating gut internal environmental homeostasis, inhibiting inflammation, and restoring the intestinal barrier. " 05/01/2020 - "PS and PSF also modulated the gut microbiota composition, abundance and diversity of HFD rats, increased the relative abundance of short chain fatty acid (SCFA) producing bacteria and increased SCFA production, reduced intestinal permeability, relieved gastrointestinal inflammation, and improved lipid metabolism. " 01/01/2022 - "SCE effectively improved liver inflammation and oxidative/nitrosative stress, strengthened intestinal barrier function, and regulated the composition of IM and the content of short-chain fatty acids (SCFAs) in AH mice. " 11/01/2021 - "PIDF mainly relieved the toxicity of Cd by increasing the production of short chain fatty acids with anti-inflammatory functions and repressing the liver and kidney inflammation mediated by the TLR4/ MyD88/NF-κB pathway. " 10/21/2019 - "Secondary outcomes include evaluating the efficacy of the intervention in influencing infant and maternal stool microbial composition and short chain fatty acid concentrations, epigenetic profile, and markers of inflammation and stress, as well as changes in maternal dietary intake and well-being. "
2.	Dysbiosis 01/01/2019 - "This study demonstrated LC supplementation improved high-fat diet (HFD)-induced gut microbiota dysbiosis and significantly enhanced short-chain fatty acid (SCFA)-producing bacteria (e.g., Blautia) along with SCFA content accumulation in the gut. " 08/01/2022 - "plantarum strains improved dysbiosis and enhanced the abundance of beneficial bacteria related to short-chain fatty acids (SCFAs) production. " 06/01/2022 - "Furthermore, LWE significantly improved microbiota dysbiosis via an increase in gut microbiota diversity and an abundance of the microbiota that produce short chain fatty acids (SCFAs), such as Ruminococcaceae, Faecalibaculum, Intestinimonas, and Alistipes. " 01/24/2022 - "Besides, A-FBTP supplementation effectively improved CTX-induced gut microbiota dysbiosis, including promoting the abundance of beneficial bacteria (e.g., Lactobacillus) and short chain fatty acid (SCFA)-producing bacteria (e.g., Lachnospiraceae, Prevotellaceae and Ruminococcaceae), along with reducing the growth of potentially pathogenic microbes (e.g., Desulfovibrionaceae and Helicobacter). " 01/01/2022 - "laterosporus BL1 intervention significantly improved HFD-induced gut flora dysbiosis, as evidenced by a reverse in the relative abundance of Bacillota and Bacteroidota, as well as an increase in the relative abundance of bacteria that produce short-chain fatty acids (SCFAs), which in turn increased SCFAs levels. "
3.	Colitis 07/01/2010 - "The increased short chain fatty acids levels in the feces of mice fed with LAB indicate that the probiotics have protective effects against DSS-induced colitis via modulation of the gut microbiota. " 12/28/2022 - "cristatum improved the intestinal homeostasis of colitis mice, especially increased the proportion of Lactobacillus, followed by an obvious increase in fecal short-chain fatty acids (SCFAs). " 01/01/2020 - "TRF and IER also improved the short chain fatty acid formation in colitis mice. " 01/01/2023 - "Results: This study showed that prior colonization with ST4 conferred protection from DSS-induced colitis through elevating the abundance of beneficial bacteria, short-chain fatty acid (SCFA) production and the proportion of Foxp3+ and IL-10-producing CD4+ T cells. " 01/01/2021 - "This study was aimed at investigating the effect of NAM on the gut microbiota and short-chain fatty acids (SCFAs) in mice with chronic colitis. "
4.	Insulin Resistance 11/05/2022 - "Several studies have demonstrated a strong association between short chain fatty acid receptor FFAR3 and insulin sensitivity. " 06/08/2023 - "Short-chain fatty acids and insulin sensitivity: a systematic review and meta-analysis." 05/30/2017 - "casei CCFM419 had the potential ability to ameliorate insulin resistance and hyperglycaemic in type 2 diabetic mice through underlying PI3K/Akt signalling pathway and short-chain fatty acids/gut microbiota pathways." 11/01/2014 - "In addition, we analyzed fecal short chain fatty acids (SCFAs) as a proxy of colonic fermentation, and indices of insulin sensitivity from blood samples. " 10/01/1995 - "Splanchnic infusions of short chain fatty acids do not change insulin sensitivity of pigs."
5.	Ulcerative Colitis 03/10/2022 - "Studies investigating the changes in short-chain fatty acids (SCFAs) in patients with ulcerative colitis (UC) have yielded inconsistent results. " 10/01/2015 - "The use of short chain fatty acids to modulate gastrointestinal inflammatory conditions such as ulcerative colitis has produced encouraging results either in animal models or also in clinical trials. " 04/01/1997 - "Short chain fatty acid rectal irrigation for left-sided ulcerative colitis: a randomised, placebo controlled trial." 11/01/1996 - "This study showed trends towards a beneficial effect of topical short-chain fatty acids in active ulcerative colitis, but more patients are needed to demonstrate this effect with sufficient statistical power." 10/17/2023 - "Analysis of metabolites indicated that DP counteracted metabolic disturbances and augmented the levels of short-chain fatty acids in ulcerative colitis-affected mice. "

Related Drugs and Biologics

1.	Butyrates (Butyrate)
2.	Butyric Acid (Butanoic Acid)
3.	Dietary Fiber
4.	Lipids
5.	Propionates
6.	Prebiotics
7.	Bile Acids and Salts (Bile Acids)
8.	Acetates (Acetic Acid Esters)
9.	Lipopolysaccharides
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Therapeutics
3.	Fecal Microbiota Transplantation
4.	Total Parenteral Nutrition
5.	High-Protein Diet