|3.||Dyspnea (Shortness of Breath)
|5.||Breast Neoplasms (Breast Cancer)
|1.||Bruera, Eduardo: 35 articles (09/2015 - 11/2003)|
|2.||Cella, David: 32 articles (10/2015 - 01/2002)|
|3.||Watanabe, Yasuyoshi: 27 articles (01/2015 - 11/2002)|
|4.||Jacobsen, Paul B: 23 articles (03/2014 - 04/2002)|
|5.||Bleijenberg, Gijs: 20 articles (11/2014 - 06/2002)|
|6.||Westerblad, Håkan: 19 articles (01/2015 - 02/2002)|
|7.||Maes, Michael: 19 articles (01/2015 - 10/2006)|
|8.||Bower, Julienne E: 19 articles (01/2015 - 07/2002)|
|9.||Morrow, Gary R: 18 articles (02/2016 - 05/2002)|
|10.||Newton, Julia L: 18 articles (05/2015 - 07/2006)|
|1.||modafinil (armodafinil)FDA Link
06/01/1997 - "Although modafinil has proven to be a safe and effective countermeasure to the effects of extensive SD on cognitive task performance, we encourage a more comprehensive understanding of the relation between its subjective and performance enhancing effects before the drug is recommended as a viable fatigue countermeasure."
10/01/2015 - "While there was no overall significant effect on fatigue, those with greater baseline fatigue experienced improved QOL and reduced fatigue when using armodafinil. "
01/01/2014 - "Use of the wake-promoting agent modafinil results in significant improvement in subjective measures of excessive daytime sleepiness, but not of fatigue. "
02/01/2013 - "After eight weeks of therapy, there was a significant improvement in the Fatigue Assessment Scale during armodafinil treatment (median -4.5, range -20, 5) compared with placebo treatment (median 3.5, range -9, 14, P<0.05) and for the FACIT-F (armodafinil: median 9, range -12, 26 vs. placebo: median -5, range -17, 11, P<0.005). "
09/01/2012 - "After correcting for multiple comparisons of the 8 neuropsychological dependent measures, we found that the patients had significantly improved delayed memory on a list-learning task after they took armodafinil (P = 0.0005), but no improvement on measures of executive function, visual memory, processing speed, or self-reported fatigue. "
|2.||Methylphenidate (Ritalin)FDA LinkGeneric
08/01/2013 - "Previous studies have noted that the addition of a psychostimulant such as methylphenidate to the therapeutic regimen of patients with TRD or those depressed patients with comorbid fatigue, advanced age, or a major medical illness showed significant improvement within two weeks. "
09/01/2011 - "Research on fatigue has focused on its epidemiology with only a single report of a beneficial treatment trial, which used methylphenidate. "
11/01/2015 - "The within-group analysis showed a significant improvement in fatigue scores in the methylphenidate arm (P = 0.008) but not in the placebo arm (P = 0.82). "
05/01/2014 - "Overall, no significant improvement in fatigue level was observed after methylphenidate, though benefits were shown in subgroups with age ≤ 65 and higher baseline BFI-C values. "
11/01/2010 - "A significantly greater number of subjects in the methylphenidate group versus the placebo group demonstrated clinically significant improvement in fatigue on total Brief Fatigue Inventory scores (7 of 10 vs 3 of 13) and Brief Fatigue Inventory severity scores (8 of 10 vs 3 of 13). "
09/01/2005 - "At the end of the exercise program, we observed significant improvement in spirometric values, peak oxygen uptake, time to fatigue, peak power output and minute ventilation compared with pre-training values for the patients."
05/01/2002 - "Our results show that: (1) for all subjects, the mean energy spectrum did not change throughout the free-pace runs, suggesting that velocity variability did not increase with fatigue (2-way ANOVA, P=0.557); (2) the kinetic of oxygen uptake and its asymptote were not changed during the free-pace runs compared to the constant-velocity run; (3) performance was not significantly improved by free-pace average velocity [mean (SD) 4.22 (0.47) compared to 4.25 (0.52) m x s(-1) for constant and free-pace respectively, t=-0.58, P=0.57]. "
10/01/2013 - "Fatigue resistance of two cements was greatly improved by use of a primer and an oxygen-inhibiting gel, as recommended by their respective manufacturers. "
05/01/2009 - "There was an 18% improvement in volitional time to fatigue (P= 0.02) and 17% improvement in peak oxygen uptake (VO(2peak)) (P= 0.01). "
03/01/2007 - "Mechanisms for this effect may be improved blood/oxygen supply to the brain or reduced fatigue and illness."
11/01/2009 - "Compared with placebo, D-MPH-treated subjects demonstrated a significant improvement in fatigue symptoms at Week 8 in the FACIT-F (P=0.02) and the Clinical Global Impression-Severity scores (P=0.02), without clinically relevant changes in hemoglobin levels. "
04/01/2006 - "Improved hemoglobin levels were significantly associated (P < 0.001) with improved fatigue. "
06/01/2010 - "Although no improvement in FACT-fatigue subscale score from baseline to the end of the treatment phase was confirmed for any dose group, there was a correlation between FACT-fatigue subscale score and hemoglobin concentration. "
08/15/2009 - "Improvement in hemoglobin level was independently associated with improvements in physical function and fatigue."
04/01/2006 - "These analyses evaluate the effect of hemoglobin level on fatigue and examine the relationship between improved fatigue and HRQOL. "
09/01/2015 - "In these long-standing RA patients, fatigue levels were high and mainly explained by HAQ and psychological distress but improved with treatment indicating a link with disease activity. "
03/01/2013 - "In particular, a significant improvement in function and fatigue indices (HAQ and FACIT) was found since T1 to T4 as compared to T0. "
10/01/2006 - "Treatment group QoL improved significantly more than placebo on the HAQ and fatigue indices, as well as seven of the eight SF-36 scales and SF-36 physical and mental summary scores. "
12/01/2015 - "At baseline, current smokers had lower Body Mass Index (27 kg/m(2) (23-30)/28 kg/m(2) (24-31)) (median (IQR)), shorter disease duration (3 years (1-8)/5 years (2-10)), lower swollen joint count (2 (0-5)/3 (1-6)), higher visual-analogue-scale (VAS) patient global (72 mm (54-87)/68 mm (50-80)), VAS fatigue (72 mm (51-86)/63 mm (40-77)) and Health Assessment Questionnaire (HAQ) score (1.1 (0.7 to 1.5)/1.0 (0.5 to 1.5)) than never smokers (all p<0.05). "
09/01/2015 - "Fatigue was mainly related to functional status (HAQ score), depression and anxiety, both before and after TCZ treatment. "
01/01/2015 - " primary objective of this study is to compare the efficacy of an intravenous high single-dose of iron isomaltoside 1000 with standard medical care on physical fatigue in women with postpartum haemorrhage. "
07/01/1992 - "By the end of the study, a statistically significant improvement in three subjective parameters, ie, lassitude, the ability to concentrate in school, and mood was reported by the girls who ingested iron compared with the controls. "
09/22/2011 - "In this issue of Blood, Krayenbühl et al provide strong evidence that women complaining of fatigue who were not anemic but who had reduced or absent iron stores were symptomatically improved after receiving parenteral iron. "
09/22/2011 - "Intravenous administration of iron improved fatigue in iron-deficient, nonanemic women with a good safety and tolerability profile. "
08/01/2001 - "Treatment of iron deficiency with either supplementation or a high iron diet results in improved mental health and decreased fatigue among women of childbearing age."
|7.||Amantadine (Aman)FDA LinkGeneric
06/01/1999 - "amantadine) have proven effective in therapy of fatigue. "
11/01/1995 - "Amantadine-treated patients showed a significantly greater reduction in fatigue, as measured by the MS-FS, than did patients treated with placebo (p = 0.04). "
09/01/2009 - "Amantadine is one of the medications prescribed for fatigue in MS. Some previous studies have demonstrated a positive influences of amantadine on fatigue in MS. The aim of this study was to determine the efficacy of amantadine on Persian MS patients. "
06/01/1989 - "A double-blind, controlled study of fatigue treatment was conducted to evaluate the efficacy of amantadine hydrochloride in treating MS-associated fatigue. "
12/01/2013 - "One month treatment with amantadine improved fatigue in patients with relapsing-remitting MS as evaluated by MFIS. "
|8.||Hydrocortisone (Cortisol)FDA LinkGeneric
10/23/2007 - "Compared with the control group, the experimental group of 40 undergraduate Chinese students given 5 days of 20-min integrative training showed greater improvement in conflict scores on the Attention Network Test, lower anxiety, depression, anger, and fatigue, and higher vigor on the Profile of Mood States scale, a significant decrease in stress-related cortisol, and an increase in immunoreactivity. "
03/01/2011 - "salivary cortisol and improved emotional well-being and fatigue scores. "
07/01/2015 - "We evaluated fatigue severity scale (FSS), visual analog scale (VAS) for overall fatigue, revised Chalder fatigue scale (RCFS), World Health Organization quality of life scale abbreviated version (WHOQOL-BREF), Buzhongyiqi-Tang questionnaire (BZTQ), and salivary cortisol level at baseline (week 0) and at the end of the study (week 2) in the two groups. "
04/01/2015 - "This study examined salivary cortisol levels in couples in which one member had unexplained chronic fatigue (CF). "
01/01/2015 - "The aim of this study was to clarify whether there are differences in the circadian rhythms of shift-working nurses by assessing depression, fatigue and salivary cortisol levels. "
|9.||Carnitine (L-Carnitine)FDA LinkGeneric
01/01/2003 - "In contrast, patients treated with IFN + carnitine show a marked and early significant reduction of fatigue levels. "
01/01/2013 - "Carnitine group showed significant improvement in maximum fused tetanic tension, maximum fused tetanic tension after fatigue protocol and recovery from fatigue after 5 minutes of rest period compared to the diabetic group. "
11/01/2012 - "A separate analysis of patients who were carnitine-deficient at baseline did not show statistically significant improvement in fatigue or other outcomes after L-carnitine supplementation. "
11/01/2012 - "L-carnitine supplementation resulted in significant carnitine plasma level increase by week 4. The primary outcome, fatigue, measured using the BFI, improved in both arms compared with baseline (L-carnitine: -0.96, 95% CI, -1.32 to -0.60; placebo: -1.11, 95% CI -1.44 to -0.78). "
04/01/2009 - "However, an exploratory covariate analysis that excluded these two protocol violators and included outcome data from both the double-blind and open-label phases demonstrated significantly improved fatigue on the FACT-An fatigue subscale (P<0.03), and significantly improved FACT-An functional well-being subscale (P<0.03), and KPS (P<0.003), in the group that started with L-carnitine during the double-blind phase. "
|10.||Polymethyl Methacrylate (Sol)IBA
06/01/1985 - "In response to fatigue, the denervated SOL showed a marked decrease in resistance to fatigue at 1 day but a relatively normal response thereafter, whereas the denervated EDL showed an increase in resistance to fatigue at and beyond the 28-day period. "
01/01/1999 - "The fatigue properties of poly(methyl methacrylate) (PMMA) bone cement were significantly improved through 13.56-MHz radio frequency plasma treatments on the X-ray opaque powder and on the reinforcing fibers. "
09/01/1995 - "The fatigue strength of both SRC-PMMA samples was significantly greater (P < 0.001) at 80 MPa (10(6) cycles) compared with bone cement and PMMA, both of which had fatigue strengths of about 18 MPa. "
03/01/1995 - "For the non-notched specimens, at all stress levels, C-R-PMMA had significantly greater fatigue life than either C-PMMA or R-PMMA (except C-PMMA at 30 MPa). "
01/01/1996 - "The aim of the present study was to examine the influence of SSC-induced metabolic fatigue and muscle damage on the efficacy of stretch reflexes, as judged by the electromyograph (EMG) response of two shank muscles (lateral gastrocnemius LG, soleus SOL) to controlled ramp stretches. "
|1.||Drug Therapy (Chemotherapy)
11/01/2010 - "Participants in the experimental group reported a significant reduction in fatigue and improvement in sleep quality from the second session of chemotherapy and continued to improve during the study period. "
11/01/2013 - "A significant improvement in the global health and fatigue scores was recorded for group A post-chemotherapy compared to pre-chemotherapy (P<0.05). "
04/01/2013 - "After adjusting for treatment with chemotherapy, age, marriage, education and children at home, there was a significant improvement in physical, mental and total fatigue (FQ), cognitive function, body image and future perspective (EORTC QLQ C30 and BR23) in the intervention group compared with controls. "
11/01/2009 - "D-MPH produced significant improvement in fatigue in subjects previously treated with cytotoxic chemotherapy. "
10/01/2008 - "After adjusting for performance status, concomitant diseases and chemotherapy type, an increase in Hb level was significantly associated with an improvement in Fatigue subscale (+1.9 points per 1 g/dL). "
10/01/2010 - "Thermal treatment did not affect the surface morphology but resulted in significant changes in the instrument bulk with the appearance of an R-phase and an improved fatigue resistance; indeed after treatment at 500 °C, N(f) increased up to 829 and 474 for EP and Non-EP instruments, respectively. "
01/01/2010 - "Immediately after treatment (at 20 weeks), patients allocated to pragmatic rehabilitation (n=95) had significantly improved fatigue (effect estimate -1.18, 95% confidence interval -2.18 to -0.18; P=0.021) but not physical functioning (-0.18, 95% CI -5.88 to +5.52; P=0.950) compared with patients allocated to treatment as usual (n=100). "
09/23/2006 - "After treatment, the studied population showed significant improvement in fatigue, experienced disability and physical function. "
01/01/2006 - "After treatment, the total CIS score and the sub-scores for fatigue, concentration, motivation and activity improved significantly. "
01/01/2011 - "Better improvement of fatigue after treatment on day 1 was associated with more improvement with fatigue on day 8 as assessed by FACIT-F (p = .0004) and ESAS (p = .0001). "
02/01/2015 - "Analysis of three non-randomized trials and three before-and-after studies showed that self-administered foot reflexology resulted in significant improvement in subjective outcomes such as perceived stress, fatigue, and depression. "
10/01/2014 - "Compared with the control group, our meta-analysis showed that patients receiving regular use of massage had significantly greater reductions in anger and fatigue symptoms. "
08/01/1995 - "The results showed that massage after exercise fatigue significantly improved quadriceps performance compared to rest (p = 0.001). "
03/01/2015 - "It seems that both interventions were effective in reducing fatigue, but the effects of reflexology on reducing fatigue were more than those of relaxation. "
08/01/2009 - "More than 75% reported that massage therapy was effective in reducing fatigue, creating a general feeling of wellness, and improving sleep quality and their ability to think clearly. "
10/01/2013 - "A search for studies published from 2000-2010 was carried out in Pubmed, Scielo and Bireme databases, using the descriptors fatigue and radiotherapy and their correlates in Portuguese. "
08/01/2012 - "Dosimetric explanations of fatigue in head and neck radiotherapy: an analysis from the PARSPORT Phase III trial."
01/01/2010 - "The present study indicates a link between fatigue and intestinal injury during pelvic radiotherapy. "
01/01/2010 - "This study was designed to investigate a possible linkage between fatigue and intestinal injury during pelvic radiotherapy. "
01/01/2010 - "This study attempts to identify the magnitude of fatigue and its implication on the quality of life during radiotherapy. "
|5.||Activities of Daily Living (ADL)
06/01/2003 - "While most studies were small and underpowered, the results are consistent in showing measurable improvement in fatigue, exercise capacity, muscle strength, and the performance of activities of daily living. "
08/01/2013 - "Findings showed the significant decrease in the mean scores of fatigue (p<0.001) and significant improvement in mean scores of ADL (p<0.001) and QOL (p<0.001) after home-based nursing pulmonary rehabilitation in the case group. "
08/01/2009 - "At the end of the study period, patients in the intervention group improved in the 6MRT and ADL field test compared with those patients in the control group (p = 0.018 and p = 0.010, respectively) with reduced perception of fatigue (p <or= 0.006). "
05/01/1996 - "All patients improved after their operations, but four patients were minimally disabled from activities of daily living; six patients experienced shoulder fatigue at work; and four patients had difficulty with sports activities. "
08/01/1995 - "After one month of therapy, 16 patients (64%) reported a reduction in fatigue on the Hare fatigue scale; three of 16 showed improvement on the modified Barthel index for activities of daily living, and two of 16 experienced improvement on a modified Klingman mobility index. "