Fasciitis (Fascitis)

Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.

Also Known As:

Networked: 554 relevant articles (22 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Myositis (Idiopathic Inflammatory Myopathies)
2.	Eosinophilia
3.	Pain (Aches)
4.	Septic Shock (Toxic Shock Syndrome)
5.	Arthritis (Polyarthritis)

Experts

1.	Chou, Margaret M: 5 articles (12/2018 - 01/2014)
2.	Oliveira, Andre M: 4 articles (12/2018 - 01/2016)
3.	Furuya, Kazuhiro: 4 articles (01/2018 - 12/2010)
4.	Kurosaka, Daitaro: 4 articles (01/2018 - 12/2010)
5.	Ukichi, Taro: 4 articles (01/2018 - 12/2010)
6.	Yoshida, Ken: 4 articles (01/2018 - 12/2010)
7.	Henrich, Ian C: 3 articles (12/2018 - 01/2016)
8.	Quick, Laura: 3 articles (12/2018 - 01/2016)
9.	Young, Robert: 3 articles (12/2018 - 01/2016)
10.	Nather, Aziz: 3 articles (01/2018 - 05/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fasciitis:

1.	Proteins (Proteins, Gene)FDA Link 10/20/2018 - "Ischemic Fasciitis of the Left Buttock in a 40-Year-Old Woman with Beta-Propeller Protein-Associated Neurodegeneration (BPAN)." 07/01/2017 - "Overexpression of the above proteins may be associated with the pathogenic mechanism of ischemic fasciitis. " 03/01/2008 - "Sonography (Sonosite-Titan, 5 to 10 MHz, L-38) was performed on a patient (age, 26 years; body mass index, 38 kg/m2) with protein fasciitis. " 03/01/2008 - "We observed fasciitis due to the protein supplement Pure Whey, which has not been reported previously. " 07/01/2017 - "In this study, we examined the expression of ischemia-associated proteins in ischemic fasciitis by immunohistochemical and genetic methods. "
2.	Prednisolone (Predate)FDA LinkGeneric 03/01/2011 - "Prednisolone was effective in treating both gastroenteritis and fasciitis." 01/01/2008 - "Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome."
3.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2008 - "Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome." 01/01/1991 - "A 54 year old woman presented with an intra-abdominal adenocarcinoma of primary coelomic origin and a syndrome of palmar fasciitis and arthritis, which was exacerbated during treatment by combination chemotherapy with intravenous carboplatin 300 mg/m2 and cyclophosphamide 750 mg/m2, while the tumour responded well."
4.	Tryptophan (L-Tryptophan)FDA Link 05/01/1991 - "Study of 18 biopsy specimens in 11 patients with L-tryptophan-related eosinophiliamyalgia (fasciitis) syndrome showed hyaline sclerodermoid changes. " 04/01/1990 - "Tryptophan use and fasciitis." 04/01/1993 - "Long-term follow-up of patients with diffuse fasciitis and eosinophilia associated with L-tryptophan ingestion." 12/01/1991 - "[Contribution of MRI in the evaluation of fasciitis with eosinophilia induced by L-tryptophan. " 08/02/1991 - "A fasciitis-sclerodermia-eosinophilia syndrome developed in four female patients, aged between 55 and 75 years, after the ingestion of tryptophan, 1.5-6.0 g daily, for 13 months to 7 years. "
5.	incobotulinumtoxinAFDA Link 07/28/2023 - "Therefore, BoNT-A presents a promising alternative treatment option for fasciitis (PROSPERO 2022: CRD42022382805)." 07/28/2023 - "Subgroup analysis revealed that BoNT-A was particularly effective in treating plantar fasciitis (MD = -3.34 [95% CI, -4.08, -2.78]; P < .00001; I2 = 75%), lumbar back fasciitis (MD = -2.17 [95% CI, -3.82, -0.52]; P = .001; I2 = 93%), and neck and shoulder fasciitis (MD = -1.49 [95% CI, -2.76, -0.22]; P = .02; I2 = 61%). " 07/28/2023 - "By synthesizing the findings from multiple studies, we aimed to provide a comprehensive evaluation of the current evidence regarding the efficacy of BoNT-A in the treatment of fasciitis pain. " 07/28/2023 - "The overall effectiveness of BoNT-A in reducing fasciitis pain was significant, with a mean difference (MD) in visual analog scale score of -2.59 (95% confidence interval [CI], -3.36, -1.82); P < .00001; I2 = 88%. " 07/28/2023 - "We included only randomized controlled trials that examined the therapeutic effects of BoNT-A on fasciitis pain, with the primary outcome measure being the visual analog scale. "
6.	Anti-Bacterial Agents (Antibiotics)IBA 07/01/2015 - "Despite aggressive antibiotic treatment, early and repeated surgical débridement may be required to remove nonviable tissue in patients with the necrotizing form of retroperitoneal fasciitis. " 01/01/1998 - "Even in the era of broad-spectrum antibiotics, necrotising fasciitis is still a life-threatening disease. " 10/01/1982 - "Postoperative fasciitis occurred when prophylactic antibiotics were omitted or used inappropriately during clean-contaminated or contaminated procedures and when primary skin closure was done in the presence of intra-abdominal contamination. " 11/24/2022 - "Spider envenomation must be considered in patients with sudden onset, rapidly progressive necrotising fasciitis unresponsive to antibiotic therapy." 08/01/2020 - "The fasciitis was treated with multiple fasciotomies, antibiotics and hyperbaric oxygen therapy. "
7.	Adrenal Cortex Hormones (Corticosteroids)IBA 10/01/2009 - "Necrotising fasciitis after corticosteroid injection for trigger finger: a severe complication from a 'safe' procedure." 11/01/2006 - "Functional assessment used as indicating objective could, in partnership with follow-up of the biological inflammatory syndrome, lead to decreased use of corticoids in iosinophilic fasciitis. " 06/01/2004 - "Cranial fasciitis treated with intralesional corticosteroids." 03/01/1999 - "Nodular fasciitis: response to intralesional corticosteroids." 06/11/1982 - "Under systemic corticosteroid administration all symptoms of fasciitis quickly disappeared."
8.	CytokinesIBA 01/01/2005 - "The mechanism of the development of fasciitis is based on impairments in the microcirculatory bed due to the action on the cytokine endothelium. " 01/01/2017 - "For this purpose, we investigated the association between cytokine levels and the Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC)-score, disease severity and mortality in NSTI patients. " 03/01/1999 - "The superantigens produce an excessive stimulation of the immune system, with a subsequent outpouring of inflammatory cytokines causing the multiorgan failure that characterises both streptococcal necrotising fasciitis as well as streptococcal toxic shock syndrome. " 12/01/1999 - "Because tissue damage in streptococcal and post-streptococcal sequelae might be the end result of a distinct synergism between streptococcal and host-derived proinflammatory agonists it is proposed that only cocktails of anti-inflammatory agents including distinct inhibitors of SLS (phospholipids), gamma globulin, inhibitors of reactive oxygen species, proteinases, cationic proteins cytokines etc., will be effective in inhibiting the multiple synergistic interactions which lead to fasciitis, myositis and the flesh-eating syndromes, and often develop into sepsis, septic shock and multiple organ failure. "
9.	Prednisone (Sone)FDA LinkGeneric 10/01/1989 - "Treatment with moderate dosages of prednisone resulted in a prompt and complete remission of both the fasciitis and the selective marrow aplasia." 10/01/1977 - "The main signs are the acute painful onset after an unusual physical exertion, the development of fasciitis, and (or) myositis, and (or) scleroderma of limbs, the absence of Raynaud's phenomenon, visceral involvement, constant eosinophilia and hypergammaglobulinemia; the prognosis is good with an improvement sometimes spontaneous or coincident with prednisone therapy. " 02/01/2003 - "The patient was treated with cyclosporine and prednisone, which resulted in much improvement of her symptoms and signs related to the fasciitis. "
10.	tocilizumab (atlizumab)FDA Link 01/01/2020 - "Effectiveness of Tocilizumab in the Treatment of Fasciitis with Eosinophilia: Two Case Reports." 03/01/2015 - "Development of necrotising fasciitis in a patient treated for rheumatoid arthritis with tocilizumab." 11/01/2017 - "Tocilizumab is effective in a familial Mediterranean fever patient complicated with histologically proven recurrent fasciitis and myositis."

Therapies and Procedures

1.	Therapeutics 12/01/2021 - "Simple excision of ischemic fasciitis without margins may be inadequate therapy. " 02/15/2012 - "In this report, we describe the clinical case of a 30-year-old woman with two metachronous proliferative fasciitis occurring firstly in the orbit and, after 18 months, in the forearm; we also review the available literature on this topic, outlining guidelines for therapy and the follow-up of these patients." 06/13/2011 - "Necrotising fasciitis was diagnosed and despite aggressive supportive therapy the patient died within hours. " 06/01/2011 - "The occurrence of a documented fasciitis during anti EGFR-therapy is original and raises the question of underlying mechanism. " 03/01/2008 - "Sonography proved to be an effective method to visualize and confirm the fasciitis and to follow the course and therapy."
2.	Extracorporeal Shockwave Therapy 10/02/2017 - "Extracorporeal shock wave therapy (ESWT) has shown promising results in treating epicondylitis lateralis humeri and fasciitis plantaris. " 08/01/2012 - "De-focused low energy extracorporeal shock wave therapy (ESWT) has been widely used in various clinical and experimental models for the treatment of painful conditions such as epicondylitis and plantar fascitis and also bone and wound healing. " 08/01/2007 - "Shock wave therapy (SWT) refers to the use of focused shock waves for treatment of musculoskeletal indications including plantar fascitis and dystrophic mineralization of tendons and joint capsules. " 12/01/2023 - "Extracorporeal shock wave therapy (ESWT) is an effective treatment for musculoskeletal pain, tendinopathy, and fasciitis with an anti-inflammatory effect. "
3.	Moxibustion 01/01/2023 - "At present, many studies have summarized the efficacy of acupuncture and moxibustion in the treatment of low back fasciitis, but few have been summarized from the perspective of acupuncture alone. " 06/01/2014 - "[Dragon moxibustion for 32 cases of low back muscle fasciitis]." 07/01/2006 - "Scraping therapy and warming acup-moxibustion have obvious effect on fasciitis of back muscles, and it is a better therapy for this disease." 07/01/2006 - "[Observation on therapeutic effects of scraping therapy and warming acupuncture-moxibustion on 50 cases of fasciitis of back muscles]."
4.	Drug Therapy (Chemotherapy) 01/01/2016 - "Therefore, we finally diagnosed the lesion as TB fasciitis that improved with anti-TB drug therapy. " 02/01/2017 - "We report a case of a 70-year-old man with an anaplastic large-cell lymphoma who presented with inconclusive signs of necrotising fasciitis following a neutropenic phase after chemotherapy. " 09/01/1999 - "Recurrent inflammation in a site of previous necrotising fasciitis during intravenous CMF chemotherapy." 06/01/1993 - "Mortality remains high in patients with necrotising fasciitis despite use of modern powerful antimicrobial drug therapy and advances in the care of the critically ill. " 09/01/1999 - "We present the case history of a patient with breast carcinoma who developed repeated inflammation at the site of previous necrotising fasciitis following each cycle of intravenous CMF chemotherapy. "
5.	Acupuncture Therapy 07/13/2016 - "Necrotising fasciitis after acupuncture treatment in an immunocompetent patient." 12/01/2012 - "[Flat-acupotomy for 32 cases of back muscles fasciitis]." 01/01/2023 - "In the treatment of low back fasciitis, simple acupuncture therapy is superior to Western medicine therapy in improving treatment efficiency and low back muscle dysfunction, but slightly inferior to other traditional Chinese medicine therapies. " 04/01/2004 - "We report a case of life-threatening necrotising fasciitis that developed after acupuncture treatment for osteoarthritis of the knee in a 55-year-old diabetic woman. "