Farnesol

A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

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Networked: 162 relevant articles (23 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nickerson, Kenneth W: 6 articles (01/2017 - 04/2007)
2.	Ahn, Kwang Seok: 5 articles (01/2021 - 05/2015)
3.	Sultana, Sarwat: 5 articles (02/2012 - 01/2005)
4.	Mo, Huanbiao: 4 articles (01/2018 - 12/2003)
5.	Jetten, Anton M: 4 articles (10/2015 - 08/2007)
6.	Joo, Joung Hyuck: 4 articles (10/2015 - 08/2007)
7.	Huang, Han Hsiang: 3 articles (02/2020 - 04/2018)
8.	Kuo, Shyh Ming: 3 articles (02/2020 - 04/2018)
9.	Wu, Guan Xuan: 3 articles (02/2020 - 04/2018)
10.	Kovács, Renátó: 3 articles (01/2020 - 04/2016)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2013 - "Remarkably, none of these genes conferred resistance to farnesol, indicating that this compound may be useful for the treatment of otherwise drug-resistant and refractory tumors expressing these mechanisms of resistance. " 07/01/2013 - "Farnesol exhibits cytotoxic activity against tumor cells in vitro and in vivo, implying that novel treatment strategies may be devised independent of Ras farnesylation. " 08/01/2022 - "This seems promising in that farnesol harms cancer cell lines but does not cause significant damage to healthy cells. " 08/01/2022 - "Farnesol acted in a concentration-dependent manner at the dose ranges studied for cancer cell lines, and while at certain doses it reduced proliferation, interestingly at higher concentrations it induced growth more than the control. " 08/01/2022 - "The investigation of in vitro effects of farnesol at different cancer cell lines."
2.	Body Weight (Weight, Body) 02/01/2012 - "To determine the protective effects of farnesol, it was administered orally at 2 doses (100 and 200 mg/kg body weight [b.w.]) once daily for 14 days. " 04/15/2005 - "No deaths occurred during the study, and farnesol had no significant effects on body weight, food consumption, clinical signs, or hematology/coagulation parameters. " 01/01/2015 - "The results showed that there were no significant differences in body weight, feed intake, and visceral organ weights between the farnesol supplementation and dietary control groups. " 04/01/1999 - "Unlike pharmacological Ca2+ channel blockers, farnesol blocked Ca2+ currents in the resting state: initial block was 63+/-8% in A7r5 cells and 50+/-9% in CHOC9 cells at a holding potential of -80 mV. We then gave 500 mg/kg body weight farnesol by gavage to Sabra hypertensive and normotensive rats and found that farnesol reduced blood pressure significantly in the hypertensive strain for at least 48 hours. " 11/01/2018 - "Compared with controls, m-farnesol- but not m-nerolidol-treated animals consumed more food and lost less body weight. "
3.	Oral Candidiasis (Thrush) 07/01/2008 - "Protective effects of farnesol against oral candidiasis in mice." 01/01/2021 - "The in vivo efficacy of farnesol combined with antifungals for oral candidiasis remains unknown. " 09/01/2021 - "Development, characterization and in vitro-in vivo evaluation of Farnesol loaded niosomal gel for applications in oral candidiasis treatment." 02/01/2009 - "Farnesol, a quorum-sensing molecule, regulates virulence and morphogenesis in Candida albicans and is involved in various human pathologies including oral candidiasis. " 07/01/2008 - "Farnesol treatment in a dose ranging between 1.125 and 9 micromol/mouse showed a protective effect against oral candidiasis in a dose-dependent manner, at least as estimated by symptom scores of tongues. "
4.	Wounds and Injuries (Trauma) 11/25/2008 - "Histopathological findings correlate with cellular and biochemical parameters of the lungs and potentiate the protective role of farnesol against CSE induced lung inflammation and injuries. " 06/24/2021 - "In sum, the slow release of farnesol from hydrogel membranes can be beneficial in the repair of RC injuries." 11/25/2008 - "In this study we report the protective efficacy of farnesol against massive lung inflammation, oxidative stress and consequent injuries caused by cigarette smoke toxicants. " 02/01/2012 - "Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol." 12/01/2009 - "Here, the model was exposed to the following biofilm effectors: xylitol, salicylic acid, farnesol, erythritol and two proprietary, semi-solid, wound-dressing formulations currently under development (Sanguitec gels). "
5.	Inflammation (Inflammations) 11/17/2023 - "Here, we expand on our initial findings, showing that farnesol profoundly alters the peritoneal cavity microenvironment promoting innate inflammation. " 03/17/2015 - "We show that farnesol is able to enhance inflammation by inducing activation of neutrophils and monocytes. " 01/01/2015 - "Overall, our results suggest that farnesol supplementation may be beneficial to improve the Th2-skewed allergic asthmatic inflammation. " 11/12/2015 - "Farnesol quells oxidative stress, reactive gliosis and inflammation during acrylamide-induced neurotoxicity: Behavioral and biochemical evidence." 07/31/2009 - "These findings revealed that oxidative stress, inflammation, Ras/Raf/ERK1/2 pathway and apoptosis collectively played a crucial role in the chemopreventive activity of farnesol to inhibit the murine skin tumorigenesis."

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3.	Terpenes (Terpenoids)
4.	Lanosterol
5.	Collagen
6.	Smoke
7.	Iron
8.	Azoxymethane
9.	ferric nitrilotriacetate
10.	nerolidol

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Fluid Therapy (Oral Rehydration Therapy)
5.	Aftercare (After-Treatment)