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Factor XII (Hageman Factor)

Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Also Known As:
Hageman Factor; Coagulation Factor XII; Blood-coagulation factor XII
Networked: 458 relevant articles (8 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Renné, Thomas: 24 articles (09/2015 - 07/2005)
2. Gailani, David: 12 articles (03/2014 - 07/2005)
3. Kleinschnitz, Christoph: 9 articles (01/2014 - 03/2006)
4. Nieswandt, Bernhard: 9 articles (02/2012 - 07/2005)
5. Bork, Konrad: 7 articles (01/2015 - 05/2006)
6. Stoll, Guido: 7 articles (02/2012 - 03/2006)
7. Björkqvist, Jenny: 5 articles (08/2015 - 02/2011)
8. Maas, Coen: 5 articles (08/2015 - 09/2008)
9. Tucker, Erik I: 5 articles (03/2014 - 01/2009)
10. McCarty, Owen J T: 5 articles (03/2014 - 01/2009)

Related Diseases

1. Hemorrhage
2. Thrombosis (Thrombus)
3. Stroke (Strokes)
4. Inflammation
5. Habitual Abortion (Recurrent Miscarriage)

Related Drugs and Biologics

1. Factor XI (Plasma Thromboplastin Antecedent)
2. Proteins (Proteins, Gene)
3. High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)
4. Plasma Kallikrein
5. Aspirin (Acetylsalicylic Acid)
6. Complement C1s (C1 Esterase)
7. bismuth subgallate
8. Prekallikrein
9. Thrombin
10. Antithrombin III

Related Therapies and Procedures

1. Thrombolytic Therapy
2. Intravenous Injections
3. Transplants (Transplant)
4. Renal Dialysis (Hemodialysis)
5. Aftercare (After-Treatment)