|1.||Macular Degeneration (Age-Related Maculopathy)
|2.||Optic Nerve Diseases (Optic Neuropathy)
|4.||Retinitis Pigmentosa (Pigmentary Retinopathy)
|1.||Chew, Emily Y: 20 articles (08/2015 - 02/2003)|
|2.||Mares, Julie A: 16 articles (11/2015 - 02/2004)|
|3.||Clemons, Traci E: 16 articles (08/2015 - 02/2003)|
|4.||Dana, Reza: 15 articles (06/2015 - 12/2008)|
|5.||Klein, Michael L: 14 articles (11/2015 - 02/2004)|
|6.||Tsubota, Kazuo: 14 articles (01/2015 - 02/2005)|
|7.||Age-Related Eye Disease Study Research Group: 12 articles (07/2015 - 05/2000)|
|8.||Pflugfelder, Stephen C: 12 articles (09/2014 - 12/2004)|
|9.||Tinker, Lesley: 11 articles (11/2015 - 08/2006)|
|10.||Ferris, Frederick L: 11 articles (07/2015 - 06/2003)|
|1.||Cyclosporine (Ciclosporin)FDA LinkGeneric
03/01/2013 - "Topical cyclosporine was beneficial in the treatment of severe dry eye disease in liver transplanted patients with FAP."
08/01/2010 - "In addition, compared with the vehicle, cyclosporine significantly improved 2 objective dry eye disease signs: corneal staining at weeks 4 (P = 0.025) and 8 (P = 0.050) and the Schirmer test at week 4 (P = 0.035). "
12/01/2009 - "We retrospectively identified a cohort of patients with severe dry eye disease who had shown inadequate response to at least a 4-month course of treatment with twice-daily use of topical cyclosporine 0.05% but who showed significant improvement to more frequent dosing. "
09/01/2002 - "In a naturalistic clinical setting, topical cyclosporin A therapy improved the signs and symptoms of dry eye disease, resulting in high patient satisfaction, fewer patients with chronic dry eye visiting the ophthalmologist, and less ancillary drug use."
10/01/2010 - "Cyclosporine A reduced complaints and improved major ocular signs in patients with moderate-to-severe dry eye disease. "
|2.||Ophthalmic Solutions (Eye Drops)IBA
04/01/2000 - "CsA 0.05% treatment also gave significantly greater improvements (P < 0.05) in three subjective measures of dry eye disease (blurred vision, need for concomitant artificial tears, and the physician's evaluation of global response to treatment). "
01/01/2015 - "Dobesilate administered as eye drops was well tolerated and effective in treating both the objective signs and subjective symptoms of dry eye disease in this 2-week study. "
02/01/2005 - "Autologous serum eyedrops were found effective in the treatment of severe dry eye disease, as evidenced by improvement of tear stability and ocular surface vital staining scores."
10/01/2010 - "CONCLUSION|: A few small-sized studies with short-term follow-up demonstrated that PEG/PG with HP-guar is a safe and effective lubricant eye drops for the treatment of dry-eye disease. "
12/01/2014 - "Fifty percent AS eye drops seem to be a safe and effective long-term treatment for dry eye disease, especially in patients with severe disease who have exhausted all other conventional forms of treatment."
02/01/2010 - "Targeting AD-liked changes in the retina has been recently shown to be effective in the reduction of retinal neuronal degeneration and loss in eye diseases. "
09/01/2015 - "Intrinsic optical signal (IOS) imaging promises to be a noninvasive method for high-resolution examination of retinal physiology, which can advance the study and diagnosis of eye diseases. "
06/01/2015 - "Intermediate-stage AMD was determined from enrollment retinal photographs by graders at a centralized Reading Center, using the Age-Related Eye Disease Study grading system. "
01/01/2015 - "Retinal images were taken from participants of the Nakuru Eye Disease Study in Kenya in 2007/08 (n = 4,381 participants [NW6 Topcon Digital Retinal Camera]). "
07/01/2014 - "Participants of the Blue Mountains Eye Study (BMES; whites, n = 3508) and the Singapore Epidemiology of Eye Disease Study (SEED; Malay, n = 3280, Indian, n = 3400, and Chinese, n = 3353) underwent examinations, including retinal photography. "
12/01/1996 - "The improvement in the eye disease was found immediately after the pulse therapy, prior to the start of the following therapy by oral steroids and/or orbital irradiation. "
09/01/2014 - "Steroids are often used as medical therapy for active thyroid eye disease (TED). "
03/01/2011 - "Two patients were excluded due to surgery or eye disease, and previous use of topical steroids over the past three months. "
10/01/2010 - "Steroids in thyroid eye disease."
10/01/2005 - "For GO, 70% recommend a wait-and-see policy; intervention, preferably with steroids, is advocated by two-thirds of respondents in cases of worsening or still-active eye disease despite euthyroidism."
08/01/2008 - "Based on the scientific rationale, these carotenoids may be effective in the prevention of age-related eye diseases. "
11/01/2015 - "Women 50 to 79 years of age in the Carotenoids in Age-Related Eye Disease Study with exposure and AMD data (n = 1663). "
08/01/2013 - "Replication analysis was performed in the TwinsUK and Carotenoids in Age-Related Eye Disease Study (CAREDS) cohorts. "
03/01/2013 - "To investigate genetic determinants of macular pigment optical density in women from the Carotenoids in Age-Related Eye Disease Study (CAREDS), an ancillary study of the Women's Health Initiative Observational Study. "
03/01/2013 - "Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study."
|6.||Hyaluronic Acid (Hyaluronan)IBA
06/01/2012 - "Efficacy of 0.18% hypotonic sodium hyaluronate ophthalmic solution in the treatment of signs and symptoms of dry eye disease."
09/01/2014 - "The goal of this study is to determine the functional and dynamic effects of hyaluronic acid (HA) gel injection into the levator plane for improving upper eyelid retraction in patients with thyroid eye disease (TED). "
07/01/2013 - "Effectiveness of sodium hyaluronate eye gel in patients with dry eye disease: a multi-centre, open label, uncontrolled study."
09/01/2014 - "Hyaluronic acid gel injection for upper eyelid retraction in thyroid eye disease: functional and dynamic high-resolution ultrasound evaluation."
07/01/2013 - "To assess the effectiveness of sodium hyaluronate Eye Gel in Dry Eye Disease (DED) patients Methods: A Multi-center, Open-label, Uncontrolled clinical trial was conducted in different centers of Pakistan. "
|7.||Botulinum Toxins (Botulinum Toxin)IBA
06/01/2002 - "This subconjunctival method of botulinum toxin injection provides an effective treatment for upper eyelid retraction associated with thyroid eye disease that is easy to administer and well tolerated by patients with few side effects."
02/01/2013 - "In this study, we examined the protective effects on dry eye disease in a Botulinum toxin A (BTX-A) induced mouse model, using a cell-permeable PEP-1-FK506BP protein. "
05/01/1998 - "The aim of this study was to evaluate the use of botulinum toxin A reversible chemodenervation of the glabellar muscles as adjunctive treatment in the rehabilitation of patients with thyroid eye disease. "
05/01/2014 - "To compare the efficacies of punctal plug insertion and Botulinum toxin injection in dry eye disease not responding to topical medications. "
03/01/2005 - "[Botulinum toxin injection-treatment of upper lid retraction in thyroid eye disease]."
|8.||Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric
02/01/1986 - "Although difficulties exist in evaluating clinical trials in allergic eye disease, both open and controlled studies have shown ocular sodium cromoglycate to be very effective in relieving the subjective symptoms and clinical signs of the above ocular disorders. "
01/01/1992 - "It is well established that 2% Sodium Cromoglycate is an effective treatment for a number of allergic eye diseases. "
02/01/1987 - "Thirty-one patients with allergic eye diseases were treated three times daily for 4 weeks in a double-blind trial comparing sodium cromoglycate eye ointment with placebo. "
02/01/1987 - "Double-blind group comparative trial of sodium cromoglycate eye ointment and placebo in the treatment of allergic eye diseases."
01/01/2005 - "Ophthalmologic preparation of sodium cromoglycate can be successfully employed both as a preventive means and as a treatment of allergic eye diseases. "
|9.||Azathioprine (Imuran)FDA LinkGeneric
11/01/1991 - "Azathioprine at a dose of 2.5 mg/kg/day has been shown to control the progression of existing, and the development of new, eye disease. "
01/01/2008 - "The CIRTED trial is the first study to evaluate the role of radiotherapy and azathioprine as part of a long-term, combination immunosuppressive treatment regime for Thyroid Eye Disease. "
04/01/2013 - "Reactivation of Darier's disease following Azathioprine treatment for thyroid eye disease."
11/01/1991 - "Cyclosporin A is also beneficial in controlling active eye disease and although it has a more rapid action than azathioprine, its toxicity limits its long term use. "
10/01/2008 - "Ninety patients with inflammatory eye disease were treated with methotrexate, 38 patients were treated with azathioprine, and 129 patients were treated with mycophenolate. "
07/01/2012 - "Diquafosol was effective in the treatment of dry eye disease at an optimal dose of 3% six times a day. "
01/01/2014 - "Three percent diquafosol ophthalmic solution appears to be effective in the treatment of ocular surface disease in this age-related dry eye disease mouse model."
06/01/2006 - "The P2Y2-agonist diquafosol is used for the treatment of the dry eye disease. "
11/01/2004 - "Diquafosol has a favorable risk/benefit profile in a broad spectrum of patients with dry eye disease and is a novel topical treatment of dry eye."
08/01/2002 - "INS365 significantly suppressed corneal damage at concentrations of more than 0.1% w/v. These results suggest that this P2Y2 agonist is a good candidate for the treatment of dry eye disease."
05/01/2004 - "On the long run, though, decompression surgery is actually regarded as the most effective treatment of thyroid eye disease."
03/01/2010 - "Ultrasonic bone removal is a safe and effective alternative to high-speed burring during lateral orbital decompression for thyroid eye disease."
03/01/2015 - "Endoscopic medial orbital decompression including removal of the medial floor of the orbit is a safe and effective procedure for treatment of thyroid eye disease. "
01/01/1998 - "We suggest endoscopic orbital decompression is an effective and safe treatment for dysthyroid eye disease."
03/01/2010 - "To evaluate the efficacy of ultrasonic bone removal during lateral orbital decompression for thyroid eye disease. "
04/01/2004 - "The development of prodrug formulations and permeability enhancers, sustained-release drug delivery devices, novel injectable medications and new and improved vectors, both viral and non-viral, for delivery of genes to all segments of the eye has greatly increased the chances of success in treating eye diseases. "
12/02/2013 - "Thus, NPinPMP is a novel sustained release system for protein drugs to reduce frequency of protein injections in the therapy of back of the eye diseases. "
01/01/1956 - "[Treatment of eye diseases by subconjunctival injections of eutizone]."
08/10/1950 - "[Retrobulbar injections of alcohol in treatment of painful eye diseases]."
06/01/2013 - "Regimens containing systemic anti-CMV therapy were associated with a 50% reduction in mortality (adjusted hazard ratio [HR], 0.5; 95% confidence interval [CI], 0.3-0.7; P = 0.006), a 90% reduction in new visceral CMV disease (adjusted HR, 0.1; 95% CI, 0.04-0.4; P = 0.004), and among those with unilateral CMV retinitis at presentation, an 80% reduction in second eye disease (adjusted HR, 0.2; 95% CI, 0.1-0.5; P = 0.0005) when compared with those using only intraocular therapy (implants or injections). "
01/01/2008 - "Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial."
01/01/2015 - "To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). "
09/01/2012 - "Orbital radiotherapy for thyroid eye disease."
01/01/2012 - "To assess the effectiveness and adverse events of orbital radiotherapy in thyroid eye disease. "
01/01/2012 - "Orbital radiotherapy is an anti-inflammatory treatment used in the treatment of active thyroid eye disease. "
|4.||Drug Therapy (Chemotherapy)
01/01/2014 - "Recent advances in the understanding of dry eye disease (DED) have revealed previously unexplored targets for drug therapy. "
11/01/2009 - "Systemic pharmacotherapy for specifically treating eye diseases is discouraged as side effects may exacerbate preexisting conditions in patients with a debilitating systemic disease. "
06/01/2006 - "Pharmacotherapy of allergic eye disease."
06/01/2006 - "We also examine surgery's role as a treatment modality for diabetic eye disease among the other accepted and developing treatment options, such as systemic and intravitreal pharmacotherapy. "
01/01/1997 - "The association with this malignant eye disease as well as the effect of irradiation and multi-agent chemotherapy on second tumour induction are evaluated."
08/01/2008 - "To study the in vivo response of mononuclear phagocytes (i.e., dendritic cells [DCs] and macrophages [MPhis]) in the posterior eye segment after laser-induced injury, and to gain a better understanding of the role of these cells in inflammatory eye disease. "
01/01/2006 - "Based on a proposed two-photon laser scanning ophthalmoscope, TPEF imaging of the living retina may be valuable for diagnostic and pathological studies of age related eye diseases."
01/01/2006 - "The current study provides a qualitative exploration of visual symptoms, levels of self-reported visual impairment, and general description of the areas of impact or restriction that patients experienced due to their eye disease, both pre- and post-laser treatment."
01/01/2003 - "The results of this study emphasise that RNFL evaluation using scanning laser polarimetry should be interpreted with caution in the study of eye diseases that lead to axonal loss predominantly in the nasal and temporal areas of the optic disc."
02/01/1989 - "The epidemiology of diabetic eye disease has been well described in population-based studies and the effects of laser treatment have been tested in randomized controlled trials. "