|2.||Ventricular Premature Complexes (Premature Ventricular Contraction)
|1.||Antzelevitch, Charles: 6 articles (11/2013 - 01/2003)|
|2.||Curtis, Michael J: 3 articles (12/2015 - 03/2006)|
|3.||Liu, Zhi Jun: 3 articles (01/2013 - 01/2010)|
|4.||Liu, Zhao Lan: 3 articles (01/2013 - 01/2010)|
|5.||Liu, Jian Ping: 3 articles (01/2013 - 01/2010)|
|6.||Yan, Gan-Xin: 3 articles (09/2011 - 08/2004)|
|7.||Razumov, A N: 3 articles (03/2009 - 07/2002)|
|8.||Klemenkov, S V: 3 articles (03/2009 - 07/2002)|
|9.||Verrier, Richard L: 3 articles (10/2008 - 08/2004)|
|10.||Dianat, Mahin: 2 articles (03/2015 - 01/2015)|
|1.||Propafenone (Rythmol)FDA LinkGeneric
05/01/1991 - "The aim of this study was to evaluate plasma concentrations of propafenone (P) and 5-hydroxy-propafenone (5-OH-P) at steady state in 36 patients with ventricular premature beats, Lown class greater than or equal to 2, submitted to antiarrhythmic treatment with propafenone either in acute administration (AA) (300-450 mg) or in chronic administration (CA) (150-300 mg t.i.d. "
09/01/1989 - "In a multicentre study efficacy and safety of propafenone 450 mg day-1 and 750 mg day-1 was studied in 97 patients with frequent ventricular premature beats (VPB greater than 30 h-1). "
04/01/2006 - "Propafenone showed better effect in reducing atrial premature beats than that of Oxy (P < 0.05), while the two had similar effect on ventricular premature beats (P > 0.05). "
02/01/2001 - "The effect of YFOL was observed in treating 30 patients with different kinds of extrasystole and compared with that in 30 patients treated by propafenone. "
02/01/1993 - "In addition, at the end of the second week, a further significant reduction of the number of premature beats compared to the first week was found in patients for whom L-carnitine had been added to propafenone treatment."
04/01/2014 - "The purpose of this study was to compare the efficacy of radiofrequency catheter ablation (RFCA) versus antiarrhythmic drugs (AADs) for treatment of patients with frequent ventricular premature beats (VPBs) originating from the right ventricular outflow tract (RVOT). "
07/01/1994 - "Nevertheless no trial confirmed that hypothesis and CAST showed an increase in mortality in patients treated with antiarrhythmic drugs able to suppress ventricular premature beats. "
02/01/1987 - "The proarrhythmic effects of class IA antiarrhythmic drugs were prospectively evaluated during programmed ventricular stimulation in 24 consecutive patients with frequent ventricular premature beats whose baseline study, performed while no antiarrhythmic drugs were being taken, showed no inducible sustained ventricular arrhythmias. "
07/09/2010 - "We evaluated predictors of fat replacement (FR) in the right-ventricular-myocardium (RVM) determined by MSCT in atherosclerotics not receiving anti-arrhythmia drugs and evaluated the relationship between the presence of FR in the RVM and the occurrence of ventricular premature beats (VPB). "
01/01/1994 - "Seven responders of 8 patients treated had less frequent episodes of cardiac fibrillation the severity of which decreased, they suffered no more from high-grade extrasystoles, were put on reduced doses of antiarrhythmic drugs. "
|3.||Amiodarone (Amiodarona)FDA LinkGeneric
07/01/2006 - "It was found that both acute and chronic amiodarone treatment decreased the amplitude of extrasystoles. "
08/16/1991 - "In anaesthetized animals subject to 25 min of coronary artery occlusion, the rats which had received amiodarone had fewer ischaemia-induced ventricular premature beats than the controls (381 +/- 106 compared with 815 +/- 215, P = 0.070). "
10/01/1983 - "This finding suggests that the beneficial effect of amiodarone on CMT is primarily based on the prevention of the CMT-initiating premature beat. "
07/01/2012 - "[Supraventricular extrasystole after cardioversion with amiodarone]."
01/01/1983 - "[Characteristics of action and efficacy of cordarone in permanent auricular fibrillation and extrasystole in elderly and aged patients]."
|4.||Caffeine (No Doz)FDA LinkGeneric
10/01/1996 - "Caffeine restriction has no role in the management of patients referred with symptomatic idiopathic ventricular premature beats."
10/01/1996 - "However, there were no significant changes in palpitation scores or ventricular premature beat frequencies during the intervention weeks and no significant correlations were found between these variables and serum caffeine concentrations. "
10/01/1996 - "To assess the role of caffeine restriction in the management of patients with symptomatic idiopathic ventricular premature beats. "
10/01/1996 - "Caffeine restriction has no role in the management of patients with symptomatic idiopathic ventricular premature beats."
04/01/2007 - "No drug therapy is usually needed for the management of supraventricular or ventricular premature beats, but potential stimulants, such as smoking, caffeine, and alcohol should be eliminated. "
|5.||Flecainide (Tambocor)FDA LinkGeneric
11/01/1981 - "Clinical electrophysiologic study of antiarrhythmic properties of flecainide: acute intraventricular delayed conduction and prolonged repolarization in regular paced and premature beats using intracardiac monophasic action potentials with programmed stimulation."
10/01/1996 - "Flecainide abolished premature beats at a concentration of 1 mumol/l or higher. "
01/01/1983 - "Effects of flecainide on atrial and ventricular stimulation thresholds to repetitive extrasystoles and fibrillation and on "2nd Phase" ventricular arrhythmias in dogs."
04/01/2013 - "At the baseline exercise test before flecainide, 6 patients had ventricular tachycardia and 5 patients had bigeminal or frequent ventricular premature beats. "
03/01/2006 - "Randomized and blinded switch of perfusion to flecainide at 90 min caused no increase over baseline in the incidence of VF, tachycardia (VT) or premature beats (VPB) during the following 150 min of ischaemia, or during reperfusion (begun 240 min after the onset of ischaemia). "
|6.||Mexiletine (Mexitil)FDA LinkGeneric
05/01/1987 - "[Clinical study of the effectiveness of mexitil in the treatment of patients with extrasystole in old and advanced age]."
04/01/1986 - "[Clinical study of the effectiveness and characteristics of the action of mexitil in the treatment of extrasystole in middle-aged and elderly patients]."
01/01/1980 - "In both trials mexiletine was shown to have a good antiarrhythmic efficacy on chronic ventricular premature beats. "
10/01/1994 - "On 60 post-MI patients with > 100 ventricular premature beats per hour, signal-averaged ECGs were recorded before and after a constant infusion of Mexiletine (7 mg/kg) for 1 h and again after 4 days of oral Mexiletine therapy (Mexiletine SR, 360 mg twice daily). "
10/01/1994 - "Signal-averaged ECG in prediction of the short-term suppression of ventricular premature beats by Mexiletine."
|7.||Quinidine (Chinidin)FDA LinkGeneric
11/01/1990 - "We conclude that the administration of quinidine before electrical CV has the following advantages: 1) 12% of patients reverted to normal sinus rhythm before electrical CV; 2) quinidine reduced the amount of electrical energy necessary for the CV, and 3) quinidine reduced the incidence of atrial premature beats after electrical CV. "
11/01/1990 - "At the time of electrical CV (100 procedures in the control group and 44 in the quinidine group), the patients who received quinidine required a lower amount of electrical energy, and showed a lower incidence of atrial premature beats as compared with the control group (11.3% versus 28%, p less than 0.05). "
09/01/1987 - "Treatment with oral quinidine abolished fascicular extrasystoles without worsening of AV conduction."
01/01/1984 - "Relationship between saliva and serum quinidine concentrations and suppression of ventricular premature beats."
10/01/1980 - "Ventricular premature beat (VPB) frequency during quinidine therapy was compared to the baseline VPB frequency. "
|8.||Isoproterenol (Isoprenaline)FDA LinkGeneric
05/01/1986 - "Arguments suggesting that sympathetic drive should be tempered for a better protection against SD come from various observations: transient ischaemia preceding the terminal event, increasing heart rate preceding lethal or life-threatening arrhythmias, persistent arrhythmias inducibility with isoprenaline or exercise when they had apparently been controlled, the positive correlation between the number of premature beats and the sinus rate at Holter monitoring and the consistent sinus acceleration before a variety of arrhythmias at Holter monitoring. "
01/01/1997 - "As a result, isoproterenol caused arrhythmias and extrasystoles as it was observed in clinical studies. "
12/01/1999 - "In several family members tested, ventricular premature beats and then rapid polymorphic ventricular arrhythmias occurred whenever the sinus rate exceeded 130 beats/min. Emotional stress, isoproterenol infusion and exercise all elicited similar arrhythmias. "
03/01/1998 - "Infusion of isoproterenol induced QT prolongation (QTc=0.62 sec) and frequent occurrence of multiform ventricular premature beats. "
01/01/2016 - "Post-procedure IRAPB was defined as frequent atrial premature beats (≥6/min) under isoproterenol infusion (5 μg/min), monitored for 10 min after internal cardioversion, and we ablated mappable IRAPBs. "
01/01/2014 - "Allapinin, class 1C antiarrhythmic drug, is highly effective in treatment of patients with ventricular premature beats (VPB). "
01/01/2014 - "[Efficiency and safety of allapinin in short- and long-term treatment of patients with normal heart and ventricular premature beats]."
07/01/1989 - "Allapinine was found to be beneficial both in ventricular and supraventricular premature beats. "
11/01/1988 - "[Comparative study of the effectiveness of allapinin in patients with frequent and stable extrasystole]."
09/01/1988 - "Pharmacokinetics and pharmacodynamics of a new antiarrhythmic drug allapinin was studied in patients with frequent ventricular and supraventricular extrasystoles. "
01/01/2009 - "These results build on findings in isolated hearts and demonstrate that biventricular response to extrasystoles and subsequent contractile recovery is both linear and correlated, suggesting that intracellular calcium regulation in a given heart across contractile state is static."
08/01/2006 - "Calcium increased repolarization heterogeneity (interlead precordial T-wave heterogeneity, 95 +/- 15 to 264 +/- 33 microV, P < 0.006; T(peak)-T(end), an index of transmural dispersion of repolarization, 37 +/- 3 to 76 +/- 6 ms, P < 0.05) and lowered repetitive extrasystole threshold (RET; 24 +/- 2 to 13 +/- 1 mA, and following NTG, 32 +/- 4 to 18 +/- 1 mA, P < 0.0001). "
03/01/2006 - "Late-phase 3 EAD-induced triggered extrasystoles represent a new concept of arrhythmogenesis in which abbreviated repolarization permits "normal SR calcium release" to induce an EAD-mediated closely coupled triggered response, particularly under conditions permitting intracellular calcium loading. "
06/01/2000 - "Extrasystoles (ES) were used to assess transsarcolemmal (TSL) calcium flux and were measured at 300 milliseconds, 400 milliseconds, and 500 milliseconds after the preceding stimulus. "
05/01/2000 - "The aim was to investigate relations between intracellular calcium ([Ca2+]i) and force when a stimulus protocol, with three extrasystoles (ESs) at various intervals, was used. "
|1.||Drug Therapy (Chemotherapy)
04/01/2011 - "Usually, no drug therapy is needed for the management of supraventricular or ventricular premature beats but potential promoting factors should be eliminated. "
03/01/1996 - "Individualized antiarrhythmic drug therapy for patients with ventricular tachyarrhythmias may be selected by the noninvasive approach (suppression of spontaneous ventricular premature beats) or the invasive approach (suppression of ventricular tachyarrhythmias induced at an electrophysiologic study). "
01/21/1984 - "Drug therapy of ventricular arrhythmias in patients with cardiac disease sets out to lower the incidence of sudden death and should be used only for dangerous arrhythmias (ventricular premature beats of Lown classes 3 to 5) and in patients with significant heart disease. "
04/01/1988 - "Multivariate regression analysis identified 4 variables as independent predictors of sudden cardiac death: rales (p = 0.009), the number of runs of VT during exercise testing while receiving antiarrhythmic drug therapy (p = 0.0003), a history of congestive heart failure (p = 0.0009) and the number of premature beats on Holter monitoring (p = 0.01). "
01/01/2009 - "Anthracycline chemotherapy, which represents the treatment of choice for many hematologic and metastatic cancers, unfortunately carries with it the possibility of both early cardiotoxic phenomena, occuring during chemotherapy, and also late cardiotoxic manifestations, occuring even months or years from the completion of treatment.THE CLINICAL MANIFESTATIONS OF EARLY CARDIOTOXICITY COMMONLY INCLUDE: ventricular premature beats, supraventricular tachycardia, cardiomyopathy and sudden death.This"
07/01/2002 - "Those who took baths and exercised for 6 months benefited from the treatment most as their muscular performance and coronary heart reserve increased; mean daily number of ventricular extrasystoles reduced by 73.3%, supraventricular extrasystoles--by 72.2%; intraventricular conduction was not damaged."
11/01/1995 - "68 patients with CHD and stable angina pectoris class 1-2 in the presence of extrasystole were examined (spiro-bicycle ergometry, Holter ECG monitoring) before and after a course of general iodobromide baths (38 patients) or general fresh-water baths (30 patients). "
01/01/2003 - "To study effects of combined use of general artificial nitric baths and bicycle exercise for 6 months on physical performance (PP) and extrasystole (ES) in patients with coronary heart disease (CHD) and stable angina pectoris (SAP) of functional class I-II. A total of 129 CHD with SAP patients entered the study. "
11/01/1995 - "General iodobromide baths exerted marked antiarrhythmic effect in coronary heart disease with stable angina pectoris, the occurrence of ventricular, supraventricular extrasystoles reduced at least by half. "
11/01/1995 - "[The effect of iodobromide baths on the physical work capacity and extrasystole in patients with ischemic heart disease and stable stenocardia]."
11/01/1991 - "One week after LAD ligation, programmed stimulation produced nonstimulated extrasystoles of presumably reentrant origin in six dogs. "
02/01/1987 - "The doses of 1 and 2 mg kg-1 decreased ectopic activity 24-48 h after coronary artery ligation without complete suppression of extrasystoles. "
02/01/1988 - "During 30 minutes of left main coronary artery ligation, all 13 control hearts developed ventricular premature beats (number of beats, 225 +/- 51) and ventricular tachycardia (duration, 123 +/- 21 seconds); five hearts developed ventricular fibrillation. "
03/01/2011 - "Thirty minutes after medication, electrocardiogram was conducted and the time of arrhythmia occurrence, times of ventricular premature beat (VP), and incidence rates of ventricular tachycardia (VT) and ventricular fibrillation (VF) were recorded in the model dogs with arrhythmia induced by ligation of coronary artery. "
01/01/2012 - "Acute administration of G-CSF before coronary ligature in rats reduces the incidence of ventricular premature beats and ventricular tachycardia, suggesting a possible direct electrophysiological effect of this cytokine independently of its genomic effects. "
|4.||Cardiopulmonary Bypass (Heart-Lung Bypass)
10/01/2014 - "The most common complications in mono-lumen CVCs was hearth arrhythmias, in 20 cases as extrasystoles and they were registered in 16 catheter insertions (30.18%). "
07/01/2011 - "This port catheter was responsible for premature beats, which induced incessant AVNRT. "
05/01/2011 - "Accordingly, flow profile and wave intensity (WI) analyses were performed at baseline and during brief flow increases accompanying an extrasystole (ES) in 10 anesthetized late-gestation fetal sheep instrumented with PT, DA, and left pulmonary artery (PA) micromanometer catheters and transit-time flow probes. "
08/01/2009 - "Accordingly, beat-by-beat WI analysis was performed during brief increases in ventricular contractility accompanying an extrasystole (ES) in nine anesthetized late-gestation fetal sheep instrumented with PT and left PA micromanometer catheters to measure pressure (P) and transit-time flow probes to obtain blood velocity (U). "
02/01/2006 - "Intracardiac electrograms recorded from a basket catheter deployed around the crista terminalis during triggered atrial premature beats exhibited low-amplitude potentials which were suggested to reflect focal ectopic activity, preceding high-frequency atrial potentials. "