|1.||Kaetzel, David M: 5 articles (01/2011 - 04/2004)|
|2.||Bohr, Vilhelm A: 5 articles (03/2007 - 08/2002)|
|3.||McCorkle, Joseph R: 4 articles (01/2011 - 04/2004)|
|4.||Yang, Mengmeng: 4 articles (01/2011 - 08/2006)|
|5.||Wilson, David M: 3 articles (01/2013 - 12/2004)|
|6.||Cox, Lynne S: 2 articles (12/2012 - 06/2008)|
|7.||Novak, Marian: 2 articles (01/2011 - 09/2009)|
|8.||Zhang, Qingbei: 2 articles (01/2011 - 08/2006)|
|9.||Jarrett, Stuart G: 2 articles (09/2009 - 01/2009)|
|10.||Choudhury, Sibgat A: 2 articles (10/2007 - 04/2005)|
04/17/2013 - "These new lipid-ODN conjugates, which have been characterized on the basis of their physicochemical properties, showed an improved resistance to exonucleases and were able to lower the VEGF-mRNA expression in human SH-SY5Y neuroblastoma cells more effectively than the relevant free antisense-ODN did."
11/26/2002 - "We show that this mutation inactivates the 3' --> 5' exonuclease of poldelta and causes a mutator and cancer phenotype in a recessive manner. "
01/01/2013 - "Our data indicate that except for the endometrial cancer-associated APE1 variant R237C, the polymorphic variants Q51H, I64V and D148E, the rare population variants G241R, P311S and A317V, and the tumor-associated variant P112L exhibit normal thermodynamic stability of protein folding; abasic endonuclease, 3'-5' exonuclease and REF-1 activities; coordination during the early steps of base excision repair; and intracellular distribution when expressed exogenously in HeLa cells. "
05/01/2002 - "In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. "
02/01/2002 - "Proofreading function by the 3'-->5' exonuclease of DNA polymerase delta (pol delta) is consistent with the observation that delta efficiency of the associated exonuclease can lead to a strong mutation phenotype, high error rates during DNA replication, and ultimately cancer. "
02/08/2002 - "Werner syndrome is a premature aging and cancer-prone hereditary disorder caused by deficiency of the WRN protein that harbors 3' -->5' exonuclease and RecQ-type 3' --> 5' helicase activities. "
|3.||Neoplasm Metastasis (Metastasis)
01/01/2011 - "These studies provide the first demonstration that the 3'-5' exonuclease activity of NM23-H1 is necessary for metastasis suppressor function and further indicate cooperativity of the 3 enzymatic activities of the molecule on suppression of the metastatic process."
01/01/2011 - "Metastasis suppressor function of NM23-H1 requires its 3'-5' exonuclease activity."
09/01/2009 - "We have employed a site-directed mutagenesis approach to demonstrate that the 3'-5' exonuclease activity of NM23-H1 is required for its metastasis suppressor function. "
08/01/2006 - "As 3'-5' exonucleases are generally required for maintenance of genome integrity, this activity represents a plausible candidate mediator of the metastasis suppressor properties of the NM23-H1 molecule. "
08/01/2006 - "NM23-H1 is a metastasis suppressor protein that exhibits 3'-5' exonuclease activity in vitro. "
|4.||Myotonic Dystrophy (Dystrophia Myotonica)
10/02/2006 - "We report here on the study of the role of flap endonuclease 1 (Fen1), a structure-specific nuclease with both 5' flap endonuclease and 5'-3' exonuclease activity, in the somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat of the DMPK gene in a mouse model for myotonic dystrophy type 1 (DM1). "
01/01/2015 - "3'-5' Exonuclease activities play key roles in maintaining genome stability, so the detection of 3'-5' exonuclease activity is very important for diseases diagnosis and drug development. "
12/01/2012 - "Several exonucleases have been recently discovered, with potentially critical roles in genome stability and ageing. "
05/01/2014 - "The 3'-5' exonuclease proofreading activity is able to correct DNA synthesis errors and helps protect against genome instability. "
06/05/2012 - "Enzymes containing 3'-5' exonuclease activities play vital roles in maintaining genome stability. "
03/12/2004 - "We report here a novel interaction of the BLM protein with the human 5'-flap endonuclease/5'-3' exonuclease (FEN-1), a genome stability factor involved in Okazaki fragment processing and DNA repair. "
|1.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|2.||Messenger RNA (mRNA)
|6.||DNA (Deoxyribonucleic Acid)
|7.||protein-histidine kinase (histidine kinase)
|8.||DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)
|9.||RNA (Ribonucleic Acid)
|1.||Drug Therapy (Chemotherapy)