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Euthyroid Sick Syndromes (Euthyroid Sick Syndrome)

Conditions of abnormal THYROID HORMONES release in patients with apparently normal THYROID GLAND during severe systemic illness, physical TRAUMA, and psychiatric disturbances. It can be caused by the loss of endogenous hypothalamic input or by exogenous drug effects. The most common abnormality results in low T3 THYROID HORMONE with progressive decrease in THYROXINE; (T4) and TSH. Elevated T4 with normal T3 may be seen in diseases in which THYROXINE-BINDING GLOBULIN synthesis and release are increased.
Also Known As:
Euthyroid Sick Syndrome; Low T3 High T4 Syndrome; Low T3 and Low T4 Syndrome; Low T3-High T4 Syndrome; Low T3-Low T4 Syndrome; Non-Thyroidal Illness Syndrome; Sick Euthyroid Syndrome; High T4 Syndromes; Low T3 Low T4 Syndrome; Non Thyroidal Illness Syndrome; Syndrome, Non-Thyroidal Illness; Syndrome, Sick Euthyroid; Syndromes, Non-Thyroidal Illness; High T4 Syndrome; Low T3 Syndrome
Networked: 407 relevant articles (5 outcomes, 32 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Nephrotic Syndrome (Syndrome, Nephrotic)
2. Myocardial Infarction
3. Sepsis (Septicemia)
4. Infarction (Infarctions)
5. Hypothyroidism

Experts

1. Iervasi, Giorgio: 4 articles (11/2021 - 02/2013)
2. Lado-Abeal, Joaquin: 4 articles (11/2020 - 04/2013)
3. Wajner, Simone Magagnin: 3 articles (07/2021 - 01/2012)
4. Xu, Gaosi: 3 articles (10/2018 - 10/2014)
5. Kumar, K V S Hari: 3 articles (07/2016 - 05/2015)
6. Iervasi, G: 3 articles (03/2010 - 08/2001)
7. Fukumura, Y: 3 articles (07/2001 - 03/2000)
8. Kanda, T: 3 articles (07/2001 - 03/2000)
9. Kobayashi, I: 3 articles (07/2001 - 03/2000)
10. Kotajima, N: 3 articles (07/2001 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Euthyroid Sick Syndromes:
1. Triiodothyronine (Liothyronine)FDA LinkGeneric
2. Thyroid HormonesIBA
3. Insulin (Novolin)FDA Link
4. Thyroxine (Levothyroxine)FDA LinkGeneric
5. Hemoglobins (Hemoglobin)IBA
6. NAD (NADH)IBA
7. Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
8. Interleukin-6 (Interleukin 6)IBA
9. CytokinesIBA
10. Growth Hormone (Somatotropin)IBA

Therapies and Procedures

1. Therapeutics
2. Cardiopulmonary Bypass (Heart-Lung Bypass)
3. Critical Care (Surgical Intensive Care)
4. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
11/01/2019 - "The present study enrolled high-risk patients undergoing coronary artery bypass grafting from 1 January 2017 to 31 December 2017 in Beijing Anzhen hospital, including 387 (58.7%) patients with coronary artery bypass grafting-associated euthyroid sick syndrome and 272 (41.3%) patients without coronary artery bypass grafting-associated euthyroid sick syndrome. "
11/01/2019 - "Advanced age, higher euroscore II, and moderate and poor left ventricular ejection fraction were independent risk factors for coronary artery bypass grafting-associated euthyroid sick syndrome."
11/01/2019 - "Coronary artery bypass grafting-associated euthyroid sick syndrome exerted detrimental effects on short-term clinical outcomes in high-risk patients undergoing isolated coronary artery bypass grafting. "
11/01/2019 - "Multivariate logistic regression analysis on the total patients revealed that the independent risk factors for coronary artery bypass grafting-associated euthyroid sick syndrome were advanced age (odds ratio = 1.07, 95% confidence interval = 1.05-1.09, p < 0.0001), higher euroscore II (odds ratio = 1.06, 95% confidence interval = 1.01-1.11, p = 0.013), and moderate and poor left ventricular ejection fraction (odds ratio = 2.26, 95% confidence interval = 1.61-3.18, p < 0.0001). "
11/01/2019 - "The purpose of this cohort study was to investigate the independent relationship between euthyroid sick syndrome and in-hospital outcomes in high-risk patients undergoing isolated coronary artery bypass grafting, and we also examined the direct correlation between pre- or intra-operative variables and the incidence of coronary artery bypass grafting-associated euthyroid sick syndrome. "
5. Kidney Transplantation