Ethylnitrosourea (N-Ethyl-N-nitrosourea)

12/01/1977 - "Of four nitrosoureas administered to F344 rats that were offspring of mothers treated with ethylnitrosourea during pregnancy, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and its methyl derivative were particularly effective in blocking tumor development."
03/01/2021 - "Purpose: The objective of this study is to quantitatively evaluate terahertz (THz) imaging for differentiating cancerous from non-cancerous tissues in mammary tumors developed in response to injection of N-ethyl-N-nitrosourea (ENU) in Sprague Dawley rats. "
10/01/2017 - "In this study, we correlated tumor incidence in B6C3F1 mice during the period after exposure to N-ethyl-N-nitrosourea (ENU) with the persistence of ENU-induced mutant clones in transgenic gpt delta B6C3F1 mice. "
05/01/2006 - "In the present study, we used microarray analysis to compare the gene expression patterns of magnetic resonance imaging (MRI)-localized N-ethyl-N-nitrosourea (ENU)-induced tumors in rat brains with those of uninvolved contralateral side and normal brains. "
01/16/2006 - "In our previous study, microarray analysis was performed on N-ethyl-N-nitrosourea (ENU)-induced forestomach tumors in transgenic mice carrying the human prototype c-Ha-ras gene (ras H2 mice). "

04/01/1988 - "A combined dominant cataract-recessive specific locus mutation experiment for fractionated exposure to ethylnitrosourea (2 X 80 mg/kg, 24-h fractionation interval) was designed to determine if lower doses of ethylnitrosourea are more effective in inducing dominant cataract mutations as suggested by previous results. "
08/01/1986 - "These present results confirm previous results, which indicate that ethylnitrosourea is effective in inducing both recessive specific-locus and dominant cataract mutations although the per locus mutation rate to recessive alleles was observed to be approximately 6 times greater than the per locus mutation rate to dominant alleles. "
05/01/2009 - "This study analyzed genes associated with the morphology and regulation of ethylnitrosourea (ENU)-induced cataract mouse. "
05/01/2009 - "Characteristics of ethylnitrosourea-induced cataracts."
09/30/2008 - "A mouse with cataract, Kec, was generated from N-ethyl-N-nitrosourea (ENU) mutagenesis. "

03/01/1985 - "Cells which had been sublethally UV irradiated prior to infection, were able to overcome about 20% of the delayed lethal hits inflicted to ethylnitrosourea-treated H-1. "
11/01/2015 - "In the present study, the response to malaria infection was examined in a mutant mouse line, Tfrc(MRI24910), identified during an N-ethyl-N-nitrosourea (ENU) screen. "
04/01/1980 - "Influence of chronic Toxoplasma infection on ethylnitrosourea-induced central nervous system tumors in rats."
08/01/2005 - "flake (flk), an N-ethyl-N-nitrosourea-induced recessive germ line mutation of C57BL/6 mice, impairs the clearance of skin infections by Streptococcus pyogenes and Staphylococcus aureus, gram-positive pathogens that elicit innate immune responses by activating Toll-like receptor 2 (TLR2). "
02/01/2005 - "Our own N-ethyl-N-nitrosourea mutagenesis effort, which recently showed that components of Toll-like receptor signaling are essential constituents of the arsenal against MCMV infections, validated the forward genetic approach as a powerful tool to define the resistome."

01/01/2012 - "Mice with ethylnitrosourea- (ENU) induced leukemia were here used to monitor the therapeutic efficacy of lipopolysaccaride (LPS), Bacillus Calmette Guerin (BCG) and sheep erythrocytes (SRBC). "
01/01/2016 - "The present study deals with the characterization of N-N' Ethylnitrosourea (ENU) induced mouse model of leukemia by peripheral blood hemogram, bone marrow cytology, histology, cytochemical staining (MPO) and scanning electron microscopic study. "
07/01/1986 - "Spontaneous colony-forming activity in vitro and comparative histological studies on ethylnitrosourea-induced leukemia in Sprague-Dawley rats."
07/01/1982 - "Histological and cytological study on ethylnitrosourea-induced panmyelosis and acute leukemias in Sprague-Dawley rats."
04/01/1974 - "[Leukemia L 5222 of the rat strain BD IX. An ethylnitrosourea-induced monocytic-myeloic transplantable form for cytochemical and chemotherapeutic studies]."

05/01/2006 - "A point mutation of the neu/erbB-2 gene diagnostic of N-ethyl-N-nitrosourea-induced rat schwannomas is an early marker of Schwann precursor cells at high risk of subsequent malignant transformation. "
09/01/2000 - "Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain."
12/01/1999 - "Activation of neu by missense point mutation in the transmembrane domain in schwannomas induced in C3H/HeNCr mice by transplacental exposure to N-nitrosoethylurea."
10/01/1999 - "neu mutation in schwannomas induced transplacentally in Syrian golden hamsters by N-nitrosoethylurea: high incidence but low allelic representation."
09/01/1995 - "Ethylnitrosourea (ENU) given transplacentally to rats induces schwannomas of the cranial, spinal and peripheral nerves with a high frequency of mutation in the neu proto-oncogene. "