HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Ethylmaleimide (N-Ethylmaleimide)

A sulfhydryl reagent that is widely used in experimental biochemical studies.
Also Known As:
N-Ethylmaleimide; N Ethylmaleimide; 1H-Pyrrole-2,5-dione, 1-ethyl-
Networked: 150 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ivanov, V V: 3 articles (09/2016 - 12/2010)
2. Stepovaya, E A: 3 articles (09/2016 - 12/2010)
3. Kim, J A: 3 articles (12/2001 - 04/2001)
4. Lee, Y S: 3 articles (12/2001 - 04/2001)
5. Nosareva, O L: 2 articles (09/2016 - 01/2016)
6. Novitsky, V V: 2 articles (09/2016 - 12/2010)
7. Ryazantseva, N V: 2 articles (09/2016 - 01/2016)
8. Shakhristova, E V: 2 articles (09/2016 - 01/2016)
9. Yakushina, V D: 2 articles (09/2016 - 01/2016)
10. Krishnan, K S: 2 articles (09/2012 - 09/2001)

Related Diseases

1. Neoplasms (Cancer)
06/01/2000 - "The purpose of this study was to examine whether N-ethylmaleimide (NEM) can enhance phosphatidylserine (PS) externalization on the outer surface of cancer cells, and PS-externalized cancer cells can be phagocytosed immediately by macrophages. "
01/01/2016 - "The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases. "
03/01/1990 - "Treatment with the alkylating agent N-ethylmaleimide induced a disappearance of the high-affinity state of the D2 receptor in the adenoma and a reduction in receptor concentration, but did not have any effect on the affinity of receptors present in DA-resistant tumors. "
06/21/2022 - "By stimulated emission depletion SRM we imaged nanoscale patterns of six different platelet proteins; four different SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) mediating protein secretion by membrane fusion of storage granules, and two angiogenesis regulating proteins, representing cargo proteins within these granules coupled to tumor progression. "
12/01/1968 - "Female mice bearing the Ehrlich carcinoma or P388 lymphocytic leukemia tumors in ascites form were given sublethal doses of whole-body x-irradiation and the thiol binding agents N-ethylmaleimide, hydroxy-mercuribenzoate, or iodoacetamide, injected intraperitoneally prior to irradiation, as a single treatment. "
2. Ulcer
10/01/2015 - "In male Sprague Dawley rats, ulcers were induced in the colon 6 cm from the anus by enema of 50 μl of 3% N-ethylmaleimide, a sulfhydryl alkylator. "
02/07/1989 - "The anti-ulcer effects of nitrendipine were not reversible with indomethacin, sodium meclofenamate or N-ethylmaleimide. "
10/25/1986 - "N-ethylmaleimide pretreatment of this gradient fraction uncovered a vesicle population with characteristics similar to the gastric H+,K+ATPase: proton transport was abolished by orthovanadate and the experimental anti-ulcer drug SCH 28080, was enhanced by potassium, and was not affected by chloride. "
06/01/2013 - "The present results show that HYDP reduced nociception in a dose-dependent manner in carrageenan and L5/L6 spinal nerve ligation, with efficacies of 72.6 and 57.1%, respectively, at doses of 100 and 562 mg/kg. HYDP also showed gastroprotective activity in the model of ethanol-induced gastric lesion, with a 75.59% maximum inhibition of ulcers at a dose of 100mg/kg. This gastroprotective effect was attenuated by N(G)-nitro-L-arginine methyl ester, indomethacin and N-ethylmaleimide, indicating that NO, prostaglandins and sulfhydryl groups are involved in the mechanisms of action. "
08/19/2010 - "The activity profile of the compound was investigated using several ulcerogenesis models such as indomethacin-, indomethacin plus HCl/EtOH-, cysteamine-, serotonin-, N(G)-nitro-L-arginine methyl ester plus EtOH-, diethyldithiocarbamate-, N-ethylmaleimide plus EtOH-, water immersion and restraint stress-, pyloric ligation-induced ulcers. "
3. Stomach Ulcer (Gastric Ulcer)
4. Hyperemia
5. Hypoxia (Hypoxemia)

Related Drugs and Biologics

1. Ethanol (Ethyl Alcohol)
2. NG-Nitroarginine Methyl Ester (L-NAME)
3. Acids
4. Indomethacin (Indometacin)
5. Enzymes
6. Serotonin (5 Hydroxytryptamine)
7. Metals
8. Cysteamine (Mercaptamine)
9. Doxorubicin (Adriamycin)
10. Ditiocarb (Sodium Diethyldithiocarbamate)

Related Therapies and Procedures

1. Ligation
2. Radiotherapy
3. Cholecystectomy
4. Therapeutics
5. Resuscitation