|1.||Kim, J A: 3 articles (12/2001 - 04/2001)|
|2.||Lee, Y S: 3 articles (12/2001 - 04/2001)|
|3.||Krishnan, K S: 2 articles (09/2012 - 09/2001)|
|4.||Yesilada, Erdem: 2 articles (08/2010 - 06/2007)|
|5.||Kang, Y S: 2 articles (12/2001 - 04/2001)|
|6.||Szabo, S: 1 article (10/2015)|
|7.||Satoh, H: 1 article (10/2015)|
|8.||Park, In Soo: 1 article (06/2015)|
|9.||Chang, Woo-Jin: 1 article (06/2015)|
|10.||Lee, Sei-Young: 1 article (06/2015)|
10/01/2015 - "In male Sprague Dawley rats, ulcers were induced in the colon 6 cm from the anus by enema of 50 μl of 3% N-ethylmaleimide, a sulfhydryl alkylator. "
02/07/1989 - "The anti-ulcer effects of nitrendipine were not reversible with indomethacin, sodium meclofenamate or N-ethylmaleimide. "
10/25/1986 - "N-ethylmaleimide pretreatment of this gradient fraction uncovered a vesicle population with characteristics similar to the gastric H+,K+ATPase: proton transport was abolished by orthovanadate and the experimental anti-ulcer drug SCH 28080, was enhanced by potassium, and was not affected by chloride. "
06/01/2013 - "The present results show that HYDP reduced nociception in a dose-dependent manner in carrageenan and L5/L6 spinal nerve ligation, with efficacies of 72.6 and 57.1%, respectively, at doses of 100 and 562 mg/kg. HYDP also showed gastroprotective activity in the model of ethanol-induced gastric lesion, with a 75.59% maximum inhibition of ulcers at a dose of 100mg/kg. This gastroprotective effect was attenuated by N(G)-nitro-L-arginine methyl ester, indomethacin and N-ethylmaleimide, indicating that NO, prostaglandins and sulfhydryl groups are involved in the mechanisms of action. "
08/19/2010 - "The activity profile of the compound was investigated using several ulcerogenesis models such as indomethacin-, indomethacin plus HCl/EtOH-, cysteamine-, serotonin-, N(G)-nitro-L-arginine methyl ester plus EtOH-, diethyldithiocarbamate-, N-ethylmaleimide plus EtOH-, water immersion and restraint stress-, pyloric ligation-induced ulcers. "
|2.||Stomach Ulcer (Gastric Ulcer)
03/15/1991 - "N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats."
06/15/2006 - "Pretreatment with N-ethylmaleimide (NEM), a blocker of endogenous sulphydryl group, significantly abolished the protective effects of AD against ethanol-induced gastric ulcers (95% with saline versus 47% with NEM). "
01/01/2015 - "MEMM and quercitrin: i) significantly (p < 0.05) reduced the volume and acidity of gastric juice while increasing the pH and gastric wall mucus content.; ii) significantly (p < 0.05) increased the level of SOD, GTP and GTR while significantly (p < 0.05) reduced the level of CAT, MPO and TBARS activities.; iii) exerted gastroprotective activity when assessed using the ethanol-induced gastric ulcer assay, which was reversed by N(G)-nitro-L-arginine methyl esters (L-NAME; an inhibitor of NO synthase) and N-ethylmaleimide (NEM; a sulfhydryl (SH) blocker). "
03/01/1996 - "Blockade of endogenous sulfhydryls (SH) by N-ethylmaleimide (NEM) eliminated this adaptive cytoprotection but the suppression of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, by alpha-difluoro methylornithine (DFMO) failed to influence the protection and accompanying hyperemia afforded by NH4OH in low concentration. "
11/02/2001 - "Substitution of these residues to serine renders insensitivity to reduction, hypoxia and to the sulfhydryl-specific modifying agent, N-ethylmaleimide. "
07/28/1982 - "N-Ethylmaleimide inhibited the stimulation of sugar transport by 2,4-dinitrophenol and anoxia; this inhibitory effect appears to explain why N-ethylmaleimide itself did not stimulate sugar transport. "
07/01/2009 - "Monensin and N-ethylmaleimide (100 microM) attenuated the hypoxia-induced ATP release by up to 80%. "
06/22/2007 - "In cell lysates after hypoxia and treatment with N-ethylmaleimide (thiol alkylating agent), dithiothreitol (disulfide reducing agent) was not able to increase binding of p65-NFkappaB to DNA, suggesting that most sulfhydryls in p65-NFkappaB protein were in reduced and activated forms after hypoxia, thereby being blocked by N-ethylmaleimide. "
07/01/1984 - "A study was made of the influence of binding of endogenous nonprotein thiols (glutathione, GSH) by N-ethylmaleimide before or after irradiation (7 Gy) of Ehrlich ascites tumor cells on the radioprotective effect of anoxia (argon, 0.003% O2). "
06/01/2000 - "The purpose of this study was to examine whether N-ethylmaleimide (NEM) can enhance phosphatidylserine (PS) externalization on the outer surface of cancer cells, and PS-externalized cancer cells can be phagocytosed immediately by macrophages. "
03/01/1990 - "Treatment with the alkylating agent N-ethylmaleimide induced a disappearance of the high-affinity state of the D2 receptor in the adenoma and a reduction in receptor concentration, but did not have any effect on the affinity of receptors present in DA-resistant tumors. "
10/10/2003 - "Functional assays of KCl cotransport activation by osmotic swelling, staurosporine, and N-ethylmaleimide indicate that removal of the N-terminal 117 amino acids from KCC1 produces a dominant-negative loss-of-function phenotype for KCl cotransport in human cervical cancer cells. "
09/01/1991 - "Therefore, the catalase inhibitor 3-amino-1,2,4-triazole (AT) and the glutathione inhibitor N-ethylmaleimide (NE) were used to assess the role of each anti-oxidant in protecting the tumor target cells. "
12/15/1986 - "Partially purified reductases isolated by centrifugation of sodium-cholate-treated liver and LL tumor microsomes over a discontinuous sucrose gradient were also inhibited by the sulfhydryl reagent N-ethylmaleimide following their reduction by dithiothreitol. "
|1.||Ethanol (Ethyl Alcohol)
|2.||NG-Nitroarginine Methyl Ester (L-NAME)
|4.||Serotonin (5 Hydroxytryptamine)
|5.||Ditiocarb (Sodium Diethyldithiocarbamate)
|7.||Ornithine Decarboxylase (Decarboxylase, Ornithine)
|9.||Sulfhydryl Compounds (Thiols)
|10.||Glutathione (Reduced Glutathione)
|3.||Heterologous Transplantation (Xenotransplantation)