06/01/1984 - "Studies of ethchlorvynol (ECV)-induced pulmonary edema were undertaken for determination of the structural basis of increased microvascular permeability. "
11/01/1987 - "Ethchlorvynol-induced pulmonary edema: a chronically instrumented, awake sheep model mimicking human disease."
11/01/1986 - "Two cases of intravenous ethchlorvynol-induced pulmonary edema are presented. "
11/01/1986 - "Pulmonary edema induced by intravenous ethchlorvynol."
06/01/1985 - "Ethchlorvynol (ECV), an agent which produces reversible pulmonary edema, was studied for its effects on cultured bovine pulmonary artery endothelial cell (BPAE) and human umbilical vein endothelial cell (HUVE) monolayers. "
|2.||Acute Lung Injury
02/01/1993 - "Seven sheep were ventilated with a tidal volume of 10-12 ml.kg-1 with end-tidal CO2 of 40 +/- 5 mmHg (5.3 +/- 0.7 kPa) after acute lung injury was induced with up to 30 mg kg-1 of ethchlorvynol (ECV). "
05/01/1984 - "Ethchlorvynol (ECV) was used to induce unilateral acute lung injury in anesthetized dogs. "
05/01/1984 - "Unilateral acute lung injury induced by ethchlorvynol in anesthetized dogs."
09/01/1995 - "Inhibition of nitric oxide synthesis improves arterial oxygenation in ethchlorvynol-induced acute lung injury in dogs."
07/01/1991 - "The effect of three chemically dissimilar cyclooxygenase inhibitors on ethchlorvynol-(ECV) induced acute lung injury was studied in isolated buffer-perfused rat and blood-perfused rabbit lungs. "
|3.||Sleep Initiation and Maintenance Disorders (Insomnia)
12/01/1983 - "Death, the ultimate cure for insomnia--Placidyl overdose."
02/01/1990 - "After lung injury with ethchlorvynol (ECV), animals were bled 40% blood volume over 40 min. Mean cardiac output decreased 7.0 to 2.2 L/min (p less than .05) accompanied by a decrease in mean Qsp/Qt from 0.28 to 0.14 (p less than .05) and an increase in mean VD/VT from 0.39 to 0.54 (p less than .05). "
07/01/1992 - "Effect of tidal volume and PEEP in ethchlorvynol-induced asymmetric lung injury."
09/01/1989 - "Pleural effusions associated with ethchlorvynol lung injury result from visceral pleural leak."
03/01/1992 - "Ibuprofen reduces ethchlorvynol lung injury: possible role of blood flow distribution."
02/01/1993 - "The effects of amrinone and calcium chloride on pulmonary vasculature and biventricular function in ethchlorvynol-induced lung injury in sheep."
03/01/1980 - "Identification of low levels of a metabolite of unaltered skeletal structure, 1-chloro-3-ethynylpent-1-en-3,4-diol (VII), detected in biological specimens of both nonfatal and fatal poisonings with DL-1-chloro-3-ethylpent-1-en-4-yn-3-ol (ethchlorvynol, la), has been achieved by high-resolution GC/MS. Corroborative evidence for the assigned structure (VII) was provided by synthesis, the design of which included as a central objective, concurrent access to 1-chloro-3-ethynyl-3,4-epoxy-1-pentene (VI), the putative direct precursor of VII. The diastereomeric epoxide mixture (VI) is mutagenic toward Escherichia coli WP2 try-hcr-, a UV-deficient repair strain. "
09/01/1974 - "Letter: Placidyl poisoning or withdrawal?"
01/01/1967 - "On special traits of acute ethchlorvynol poisoning."
06/11/1978 - "Analysis of chlormethiazole, ethchlorvynol and trichloroethanol in biological fluids by gas-liquid chromatography as an aid to the diagnosis of acute poisoning."
11/01/1980 - "A haemoperfusion column containing activated charcoal coated with cellulose acetate was used to treat 7 patients with barbiturate or ethchlorvynol poisoning. "
|3.||Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
|8.||barbituric acid (barbiturate)
|2.||Positive-Pressure Respiration (PEEP)