Ethchlorvynol

06/01/1984 - "Studies of ethchlorvynol (ECV)-induced pulmonary edema were undertaken for determination of the structural basis of increased microvascular permeability. "
11/01/1987 - "Ethchlorvynol-induced pulmonary edema: a chronically instrumented, awake sheep model mimicking human disease."
11/01/1986 - "Two cases of intravenous ethchlorvynol-induced pulmonary edema are presented. "
11/01/1986 - "Pulmonary edema induced by intravenous ethchlorvynol."
06/01/1985 - "Ethchlorvynol (ECV), an agent which produces reversible pulmonary edema, was studied for its effects on cultured bovine pulmonary artery endothelial cell (BPAE) and human umbilical vein endothelial cell (HUVE) monolayers. "

02/01/1993 - "Seven sheep were ventilated with a tidal volume of 10-12 ml.kg-1 with end-tidal CO2 of 40 +/- 5 mmHg (5.3 +/- 0.7 kPa) after acute lung injury was induced with up to 30 mg kg-1 of ethchlorvynol (ECV). "
05/01/1984 - "Ethchlorvynol (ECV) was used to induce unilateral acute lung injury in anesthetized dogs. "
05/01/1984 - "Unilateral acute lung injury induced by ethchlorvynol in anesthetized dogs."
04/01/1996 - "The intravenous administration of ethchlorvynol (ECV), in dogs, resulted in an acute lung injury (ALI) characterized by a 200 +/- 80% increase in venous admixture and a 142 +/- 30% increase in extravascular lung water (EVLW). "
09/01/1995 - "Inhibition of nitric oxide synthesis improves arterial oxygenation in ethchlorvynol-induced acute lung injury in dogs."

12/01/1983 - "Death, the ultimate cure for insomnia--Placidyl overdose."
09/22/1979 - "Barbiturates and nonbarbiturate sedative hypnotics (e.g., ethchlorvynol, glutethimide, meprobamate, methaqualone and methyprylon) should not be prescribed for insomnia, acute reactive anxiety, chronic anxiety neurosis or depressive illnesses, since the safer and equally effective benzodiazepines, which are less associated with dependence, are available."

03/01/1989 - "Swine model of early adult respiratory distress syndrome induced by intravenous ethchlorvynol."
01/01/1980 - "A case of intravenous Placidyl injection is described which resulted in pulmonary pathophysiology consistent with adult respiratory distress syndrome (ARDS). "
01/01/1980 - "Adult respiratory distress syndrome after Placidyl abuse."
11/01/1987 - "Ethchlorvynol injection in humans leads to a clinical picture consistent with increased permeability pulmonary edema, ie, the adult respiratory distress syndrome. "
10/01/1982 - "Anesthetized rabbits were intravenously administered a bolus of 40 mg/kg of ethchlorvynol, a mild hypnotic known to induce respiratory distress syndrome in humans and laboratory animals when given intravenously. "

07/01/1992 - "Unilateral right lung edema was established in 10 animals by use of a selective infusion of ethchlorvynol. "
10/01/1982 - "Early tissue damage in ethchlorvynol-induced alveolar edema in rabbit lung."
09/01/1989 - "Intravenous ethchlorvynol (ECV), known to produce permeability edema in humans, was used to produce permeability pulmonary edema in rabbits. "
04/01/1990 - "In addition, leukotrienes were identified in edema fluid and in bronchoalveolar lavage fluid (BALF) both from patients with the adult respiratory distress syndrome (ARDS) and from dogs with ethchlorvynol-induced acute lung injury (ALI). "
01/01/1976 - "Injection of Placidyl (12 to 80 mg/kg of body weight) intravenously into dogs caused acute, severe, nonhemodynamic pulmonary edema (as evidenced by markedly elevated lung weights and microscopic evidence of intra-alveolar edema), hypotension with a relative bradycardia, and a decreased cardiac output. "