|1.||Schmidt-Wolf, Ingo G H: 4 articles (10/2014 - 01/2009)|
|2.||Yuan, Fan: 4 articles (10/2012 - 08/2004)|
|3.||Czuczwar, Stanisław J: 3 articles (01/2013 - 12/2009)|
|4.||Łukawski, Krzysztof: 3 articles (01/2013 - 12/2009)|
|5.||Zhao, Guisen: 3 articles (12/2012 - 08/2007)|
|6.||Wang, Rui: 3 articles (12/2012 - 08/2007)|
|7.||Jing, Yongkui: 3 articles (12/2012 - 08/2007)|
|8.||Roarke, Michael C: 2 articles (12/2015 - 07/2010)|
|9.||Nguyen, Ba D: 2 articles (12/2015 - 07/2010)|
|10.||Miller, Jamie L: 2 articles (08/2014 - 01/2014)|
01/01/1992 - "Therefore, ethacrynic acid may potentially prove useful in the treatment of glaucoma."
03/01/2010 - "To improve the drug delivery, a mathematical model was developed to numerically simulate the transport process of ethacrynic acid (ECA), a potential drug for glaucoma treatment, in the anterior segment of a typical human eye. "
06/01/2009 - "Poor topical bioavailability and ocular irritation have impeded the development of the diuretic, ethacrynic acid (ECA) as a clinically useful ocular hypotensive for the treatment of glaucoma. "
08/01/2004 - "Ethacrynic acid (ECA) is a potential glaucoma drug that can reduce intraocular pressure. "
05/01/1993 - "The effect of ethacrynic acid, a potential outflow agent for the treatment of glaucoma, was studied in a series of 25 pairs of human eyes in perfusion organ culture. "
01/01/1971 - "Diuretic treatment in congestive heart failure with Uregyt (ethacrynic acid)."
10/12/1968 - "This technique of direct transfusion with ethacrynic acid is simple, and it may well replace exchange transfusion as a means of treating patients with anaemic heart failure."
10/12/1968 - "Parenteral ethacrynic acid was added to the blood for transfusion in 20 patients, seven of whom were in anaemic heart failure on admission. "
08/01/1968 - "The use of ethacrynic acid in infants and children with congestive heart failure."
04/01/1968 - "Hemodynamic effects of diuresis by ethacrynic acid in normal subjects and in patients with congestive heart failure."
01/01/2009 - "Most side effects of ethacrynic acid can be attributed to its effectiveness (volume depletion); however, it may cause metabolic alkalosis that is preventable by KCl replacement. "
01/01/1987 - "Water and NaCl reabsorption remaining during ethacrynic acid infusion is almost equally inhibited by alkalosis and by an osmotic effect of unreabsorbed NaHCO3."
05/01/1968 - "Metabolic alkalosis was induced in dogs by administering ethacrynic acid and sustained by feeding a chloride-deficient diet. "
05/01/1965 - ""CONTRACTION" ALKALOSIS AFTER DIURESIS OF EDEMATOUS PATIENTS WITH ETHACRYNIC ACID."
12/01/1981 - "Examinations in five dogs over a wide range of glomerular filtration rates (GFR) during ethacrynic acid infusion showed that bicarbonate reabsorption at equal filtered load and equal plasma pH of 7.5 was not significantly changed by increasing PHCO3 from 30.2 +/- 0.4 to 55.2 +/- 0.6 mM and PCO2 from 33.8 +/- 0.7 to 74.1 +/- 2.1 mm Hg. Examinations during respiratory and metabolic alkalosis in five dogs at plasma pH of 7.8 showed that bicarbonate reabsorption at equal filtered load was not significantly different at a PCO2 of 20.2 +/- 0.8 and 36.8 +/- 0.8 mm Hg. Finally, in five dogs that did not receive ethacrynic acid, plasma pH was lowered by inducing respiratory acidosis at a PHCO3 of 30 mM and raised during progressive respiratory and metabolic alkalosis, Bicarbonate reabsorption was linearly related to plasma pH within the range 7.1 to 7.85 (r = 0.92). "
11/01/2003 - "Ethacrynic acid can be effective for refractory congestive heart failure and ascites."
06/01/1967 - "[Effect of ethacrynic acid on diuresis, salidiuresis and electrolyte concentration of the plasma in liver cirrhosis patients with ascites]."
11/01/1965 - "The use of ethacrynic acid in patients with cirrhosis and ascites."
11/01/2003 - "However, in our clinical experience, ethacrynic acid can alleviate acute congestive heart failure and ascites resistant to other diuretics. "
01/01/1993 - "Ethacrynic acid has been shown to be highly effective in the treatment of ascites, even in patients refractory to other diuretics, but its use is associated with a high incidence of hypokalemia and hypochloremic alkalosis. "
01/15/1996 - "Ethacrynic acid: a novel radiation enhancer in human carcinoma cells."
01/01/1992 - "Subpopulations of HT 29 human colon carcinoma cells (HT/M and HT/S) were selected for resistance to the glutathione S-transferase (GST) inhibitor ethacrynic acid (EA). "
05/01/2005 - "Because BSO, ethacrynic acid and indomethacin caused a partial recovery of resistance in the cisplatin-resistant cell line, further studies are needed to investigate their efficacy for treating patients with metastatic bladder carcinoma resistant to cisplatin."
06/01/1994 - "Human colon carcinoma HT29 cells sensitive (WT) and resistant (HT/M and HT/S) to ethacrynic acid (EA) were used to investigate the role of NAD(P)H:quinone oxidoreductase1 (NQO1) in drug resistance. "
06/01/1994 - "Inhibition of NAD(P)H:quinone oxidoreductase1 in ethacrynic acid-resistant human colon carcinoma cells."
|3.||Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
|7.||NF-kappa B (NF-kB)