Etazolate

A potent phosphodiesterase inhibitor proposed as an antipsychotic agent.

Also Known As:

Etazolate Hydrochloride; SQ-20009; Hydrochloride, Etazolate; SQ 20009; SQ20009; 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester

Networked: 12 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Nicotinic Acids: 13
      - Etazolate: 12
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - Etazolate: 12

Experts

1.	Jafarian-Tehrani, Mehrnaz: 3 articles (10/2021 - 04/2013)
2.	Alzoubi, Karem H: 3 articles (01/2019 - 10/2017)
3.	Carrete, Alex: 2 articles (10/2021 - 01/2018)
4.	Meffre, Delphine: 2 articles (10/2021 - 01/2018)
5.	Simon, Anne: 2 articles (10/2021 - 01/2018)
6.	Al Subeh, Zeinab Y: 2 articles (01/2019 - 10/2017)
7.	Khabour, Omar F: 2 articles (01/2019 - 10/2017)
8.	Llufriu-Dabén, Gemma: 2 articles (01/2018 - 04/2013)
9.	Bhatt, Shvetank: 2 articles (12/2017 - 06/2013)
10.	Barrot, Michel: 1 article (01/2022)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2022 - "Mechanical hypersensitivity, evaluated using von Frey filaments, was relieved by sustained treatment with the non-selective PDEi theophylline and ibudilast (AV-411), with PDE4i rolipram, etazolate and YM-976, and with PDE5i sildenafil, zaprinast and MY-5445, but not by treatments with PDE1i vinpocetine, PDE2i EHNA or PDE3i milrinone. "
2.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 10/01/2017 - "The current study was done to evaluate the role of etazolate in preventing PTSD induced memory impairment, anxiety and depression-like symptoms. " 01/01/2019 - "We have previously shown that PTSD induced-memory impairment, anxiety and depression were prevented via the administration of etazolate. " 10/01/2017 - "In conclusion, our data suggests that memory impairment, anxiety, and depression symptoms that are induced by PTSD can be prevented using etazolate." 10/01/2017 - "The PTSD was associated with short- and long-term memory impairment, which was prevented by etazolate administration. " 10/01/2017 - "Evaluating the protective effect of etazolate on memory impairment, anxiety- and depression-like behaviors induced by post traumatic stress disorder."
3.	Demyelinating Diseases (Demyelinating Disease) 10/01/2021 - "Altogether, this study shows that the beneficial effect of etazolate upon demyelination does not occur at the gene expression level at the time points studied. " 10/01/2021 - "To this end, we have employed two protocols which consists of administering etazolate (10 mg/kg/d) for a period of 2 weeks either during (Protocol #1) or after (Protocol #2) 5-weeks of CPZ-induced demyelination. " 01/01/2018 - "In conclusion, etazolate-induced sAPPα release protects myelinated axons from demyelination while also promoting remyelination. " 01/01/2018 - "We also performed ex vivo studies to decipher etazolate's mechanism of action in a lysolecithin-induced demyelination model using organotypic culture of cerebellar slices. " 10/01/2021 - "In continuation of this work, here we have further investigated the effects of etazolate treatment after acute cuprizone-induced demyelination at the molecular level (expression of myelin genes Plp, Mbp and Mag and inflammatory markers Il-1β, Tnf-α) and at the functional level (locomotor and spatial memory skills) in vivo. "
4.	Parkinson Disease (Parkinson's Disease) 01/01/2018 - "Beneficial effect of etazolate on depression-like behavior and, learning, and memory impairment in a model of Parkinson's disease." 01/01/2018 - "The aim of this study was to evaluate etazolate against depression-like behavior and, learning and memory impairment induced by 6- hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD). "
5.	Alzheimer Disease (Alzheimer's Disease) 03/01/2011 - "EHT0202 (etazolate hydrochloride) is a new compound exhibiting both potential disease-modifying and symptomatic treatment properties in Alzheimer's Disease increasing alpha-secretase activity and sAPP alpha secretion, as well as acting as a GABA-A receptor modulator and as a PDE-4 inhibitor. " 05/25/2010 - "Etazolate is a phosphodiesterase 4 (PDE4) inhibitor and GABAA receptor modulator that also stimulates alpha-secretase activity and neurotrophic soluble amyloid precursor protein (sAPPalpha) production, currently developed as a possible Alzheimer's disease therapeutic. "

Related Drugs and Biologics

1.	Rolipram
2.	Milrinone (Primacor)
3.	Theophylline (Theon)
4.	Sildenafil Citrate (Viagra)
5.	YM 976
6.	MY 5445
7.	ibudilast
8.	vinpocetine
9.	zaprinast
10.	9-(2-hydroxy-3-nonyl)adenine (EHNA)