Estramustine

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618 relevant articles (47 outcomes, 195 trials/studies) found for this Drug

Description: A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

Also Known As:

Emcyt; Estracyt; Estramustin Phosphate; Estramustine Phosphate Sodium; Leo-275; NSC-89199; Leo 275; Leo275; NSC 89199; NSC89199; Phosphate Sodium, Estramustine; Phosphate, Estramustin; Estramustinphosphate; Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-(bis(2-chloroethyl)carbamate)

Relationship Network

Drug Context: Research Results

Experts

1.	Small, Eric J: 7 articles (09/2008 - 12/2003)
2.	Kelly, W Kevin: 5 articles (09/2008 - 11/2003)
3.	Smith, David C: 5 articles (06/2007 - 04/2003)
4.	Hussain, Maha: 5 articles (03/2005 - 12/2002)
5.	Urakami, Shinji: 4 articles (01/2008 - 12/2002)
6.	Igawa, Mikio: 4 articles (01/2008 - 12/2002)
7.	Shiina, Hiroaki: 4 articles (01/2008 - 12/2002)
8.	Vaughn, David J: 3 articles (05/2008 - 02/2004)
9.	Logothetis, Christopher J: 3 articles (11/2007 - 09/2004)
10.	Dunn, Rodney L: 3 articles (06/2007 - 07/2003)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/1996 - "CONCLUSIONS: With now over 10 years mean follow-up for this series of patients, we conclude that adjuvant estramustine is beneficial for prostate cancer patients receiving definitive irradiation. " 02/01/1993 - "Adjuvant estramustine phosphate was beneficial in patients with prostate cancer and pelvic node involvement who received irradiation as definitive treatment." 03/01/1984 - "Estracyt Research Group in Japan concluded that Estracyt was effective in 38% of reactivated prostatic cancer patients (15% (I-C, I-B), 23% (I-A, O-B, O-C]. " 05/01/1988 - "[Stage D1 prostatic cancer benefited by a single regimen of Estracyt]" 01/31/1982 - "[Total remission of prostatic cancer following treatment with Estracyt]" Order ALL the reference details at left...
2.	Carcinoma (Carcinomatosis) 01/01/1991 - "Estracyt was effective for untreated prostatic carcinoma but the problems such as recurrence of progression and side effects require further examination." 04/01/1976 - "Estramustine phosphate has been useful in the treatment of advanced carcinoma of the prostate. " 01/01/1985 - "We conclude that estramustine phosphate retards the growth of various cells, and that studies of other potential fields of application of the drug (aside from prostatic carcinoma) is justified." 01/01/1980 - "A preliminary report is presented of prospective, randomized study with continuous and intermittent oral Estracyt treatment in patients with prostatic carcinoma. " 03/01/1979 - "Estracyt in advanced carcinoma of the breast: a phase II study." Order ALL the reference details at left...
3.	Neoplasms (Cancer) 11/01/2007 - "In phase II trials of patients with cancer, response to microtubule inhibitors increases when these drugs are combined with estramustine. " 07/01/2000 - "The present study revealed that estramustine acts as a radio sensitising agent on the human renal cell cancer cell lines, A498 and CAKI-2. " 11/01/1987 - "Immunofluorescent studies of the anti-microtubule effects of the anti-cancer drug estramustine." 12/01/1985 - "Fluorescence-microscopic studies with dansylated estramustine (DnsEM) has permitted investigation of the mechanism of estramustine (EM) uptake in live human prostatic tumor cells (DU 145). " 12/01/2005 - "Evaluation of lipophilins as determinants of tumor cell response to estramustine." Order ALL the reference details at left...
4.	Pain (Aches) 07/01/1995 - "In addition to producing similar objective response rates to other established agents, estramustine phosphate improves the subjective status of many patients and has been shown to reduce the intensity of pain and improve the performance status of patients.(ABSTRACT TRUNCATED AT 250 WORDS)" 11/01/1986 - "In this study, Estracyt showed 80% improvement of dysuria, 60% of nykturia, 35% of pain and 55% of general condition. " 04/01/2000 - "Re: Estramustine phosphate withdrawal syndrome with dramatic pain relief." 09/01/1999 - "Estramustine phosphate withdrawal syndrome with dramatic pain relief." 06/01/2002 - "Two of the available studies examining the use of docetaxel with and without estramustine for treatment of androgen-independent prostate cancer include a detailed prospective analysis of pain and quality of life. " Order ALL the reference details at left...
5.	Glioma (Gliomas) 07/01/2006 - "In conclusion, this first randomized study did not demonstrate any significant improvement of using estramustine in addition to conventional radiotherapy, however, a trend for a positive response for the estramustine group was found in patients with grade III glioma." 01/01/2002 - "In this study, the effect of irradiation, alone and in combination with the antimicrotubule drug estramustine (EaM), was investigated in vitro using the BT4C rat glioma cell line, and in vivo the BT4C rat intracerebral glioma model was used. " 04/01/2000 - "Drug-induced apoptosis by anti-microtubule agent, estramustine phosphate on human malignant glioma cell line, U87MG; in vitro study." 04/01/1999 - "This study investigated the effects of fractionated radiotherapy and estramustine on angiogenesis in malignant glioma. " 01/01/1999 - "Serotoninergic modulation of cell volume response to estramustine: an image-analysis study on perifused individual glioma cells." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Hormones
2.	docetaxel (Taxotere)
3.	Paclitaxel (Taxol)
4.	Carboplatin (JM8)
5.	Etoposide (VP 16)
6.	Taxoids
7.	Estramustine
8.	Vinblastine (Vinblastine Sulfate)
9.	Prednisone (Sone)
10.	Mitoxantrone (Novantrone)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Castration
4.	Oral Administration
5.	Orchiectomy (Orchidectomy)

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