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Peptic Esophagitis (Reflux Esophagitis)

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INFLAMMATION of the ESOPHAGUS that is caused by the reflux of GASTRIC JUICE with contents of the STOMACH and DUODENUM.

Also Known As:

Reflux Esophagitis; Esophagitis, Peptic; Esophagitides, Peptic; Esophagitides, Reflux; Peptic Esophagitides; Reflux Esophagitides; Esophagitis, Reflux

Networked: 786 relevant articles (104 outcomes, 113 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 30
- Gastrointestinal Diseases: 1201

Related Diseases

1.	Stomach Ulcer (Gastric Ulcer)
2.	Duodenal Ulcer (Curling's Ulcer)
3.	Peptic Ulcer (Peptic Ulcers)
4.	Esophagitis
5.	Ulcer

Experts

1.	Kinoshita, Yoshikazu: 9 articles (05/2009 - 12/2003)
2.	Miwa, Hiroto: 7 articles (12/2009 - 08/2004)
3.	Adachi, Kyoichi: 7 articles (01/2009 - 12/2003)
4.	Li, Yan: 6 articles (08/2009 - 01/2007)
5.	Yanaga, Katsuhiko: 6 articles (01/2009 - 12/2006)
6.	Yano, Fumiaki: 5 articles (01/2009 - 12/2006)
7.	Tsuboi, Kazuto: 5 articles (01/2009 - 12/2006)
8.	Omura, Nobuo: 5 articles (01/2009 - 12/2006)
9.	Kashiwagi, Hideyuki: 5 articles (01/2009 - 12/2006)
10.	Ishihara, Shunji: 5 articles (12/2008 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Peptic Esophagitis:

1.	Omeprazole (Esomeprazole)FDA LinkGeneric 04/01/2000 - "CONCLUSIONS: Long-term omeprazole therapy (up to 11 years) is highly effective and safe for control of reflux esophagitis." 10/01/1988 - "Omeprazole is a highly effective treatment for peptic esophagitis. " 02/01/1992 - "In doses ranging from 20-60 mg once daily, omeprazole has proved to be effective in the short-term treatment of reflux esophagitis, even in patients resistant to treatment with H2-receptor antagonists. " 05/01/1991 - "It is concluded that omeprazole maintenance treatment in severe reflux esophagitis is an effective and safe therapy." 09/01/2003 - "This study compared the efficacy of esomeprazole 40 mg and omeprazole 20 mg for starting on-demand therapy for grade A and B reflux esophagitis. " Order ALL the reference details at left...
2.	Ranitidine (Zantac)FDA LinkGeneric 09/01/2001 - "Only scattered erosions were observed in antioxidant pre-treated group, but acid suppression by ranitidine was not so effective in decreasing the severity of reflux esophagitis. " 01/01/1997 - "CONCLUSIONS: Ranitidine 150 mg bid and 300 mg bid are safe and effective treatments in the prevention of reflux esophagitis relapse." 01/01/1997 - "OBJECTIVE: To compare the efficacy and safety of long term use of ranitidine 150 mg bid, 300 mg bid and placebo in prevention of endoscopic and symptomatic relapse of reflux esophagitis in an international, double-blind, placebo controlled, parallel group study. " 01/01/1997 - "Prevention of relapse in reflux esophagitis: a placebo controlled study of ranitidine 150 mg bid and 300 mg bid." 08/01/1986 - "In a randomized multicentre study 96 patients with mild to moderate types of reflux esophagitis (stages I and II according to Savary-Miller) the effect of 150 mg ranitidine b.i.d. " Order ALL the reference details at left...
3.	lansoprazole (Prevacid)FDA LinkGeneric 02/01/1998 - "CONCLUSIONS: Lansoprazole was safe and effective for the treatment of reflux esophagitis in this trial. " 08/01/2009 - "Long-term efficacy of lansoprazole in preventing relapse of erosive reflux esophagitis." 01/01/2008 - "The demographic characteristics and health-related quality of life in a large cohort of reflux esophagitis patients in Japan with reference to the effect of lansoprazole: the REQUEST study." 09/01/2001 - "[Complementary observational study of the efficacy, tolerance and safety of lansoprazole 15 mg as maintenance therapy of reflux esophagitis in daily medical practice in Belgium (record RU49749/R002]" 02/01/1998 - "This study indicates that the optimum daily dose of lansoprazole for reflux esophagitis is 30 mg." Order ALL the reference details at left...
4.	Sucralfate (Carafate)FDA LinkGeneric 09/28/1987 - "These data fail to establish that eight weeks of treatment with sucralfate suspension improves symptoms or heals lesions in reflux esophagitis at a rate significantly greater than placebo. " 06/09/1989 - "The purpose of this study was to determine the efficacy of sucralfate in the treatment of peptic esophagitis in children. " 09/28/1987 - "The efficacy of sucralfate suspension in the treatment of reflux esophagitis was assessed in a multicenter, randomized, double-blind, placebo-controlled trial. " 01/01/1989 - "Efficacy of sucralfate in refractory reflux esophagitis. " 09/28/1987 - "Clinical efficacy of sucralfate in reflux esophagitis. " Order ALL the reference details at left...
5.	Proton Pumps (Proton Pump)IBA 11/01/1997 - "Proton pump inhibitor (PPI) is very effective in the initial treatment of reflux esophagitis. " 01/01/2009 - "Reflux esophagitis, which was seen in five patients, was treated successfully with a proton pump inhibitor. " 03/01/2004 - "Administration of H2 receptor antagonist with proton pump inhibitor is effective for long-term control of refractory reflux esophagitis." 06/01/2004 - "CONCLUSION: Patients with non-erosive minimal esophageal lesions had similar reflux symptoms comparable to those with mild erosive reflux esophagitis, and reflux symptoms were improved with a short-term proton pump inhibitor. " 05/01/2009 - "Influences of CYP2C19 polymorphism on recurrence of reflux esophagitis during proton pump inhibitor maintenance therapy." Order ALL the reference details at left...
6.	Famotidine (Pepcid)FDA LinkGeneric 02/01/1992 - "Recent data also show that long-term treatment with famotidine seems to be effective in preventing recurrence in most patients with healed reflux esophagitis. " 09/01/1997 - "The results showed that maintenance therapy with famotidine 20 mg twice daily is effective in a large proportion of patients with healed reflux esophagitis, with few adverse effects reported." 12/01/1993 - "Efficacy of famotidine 20 mg twice a day versus 40 mg twice a day in the treatment of erosive or ulcerative reflux esophagitis." 01/01/1987 - "Further studies should be conducted to define the role of famotidine in the treatment of reflux esophagitis." 01/01/1987 - "An open-labeled study of once-daily administration of 40 mg famotidine was conducted in 24 patients with endoscopically confirmed reflux esophagitis. " Order ALL the reference details at left...
7.	pantoprazole (Protonix)FDA LinkGeneric 11/01/2000 - "Parenteral pantoprazole is effective in the treatment of reflux esophagitis. " 03/01/2005 - "Two hundred twenty-seven patients with endoscopically proven reflux esophagitis were treated for 8 weeks with pantoprazole, 40 mg daily. " 02/01/2003 - "CONCLUSIONS: Oral pantoprazole 20 mg daily provided gastric acid control in 15 pediatric patients with reflux esophagitis with partial clinical improvement of symptoms after 28 days of treatment. " 02/01/2003 - "OBJECTIVES: To investigate the efficacy and safety of oral pantoprazole, 20 mg (0.5 to 1.0 mg/kg/day) once daily for 28 days, in pediatric patients with reflux esophagitis. " 02/01/2003 - "Efficacy and safety of oral pantoprazole 20 mg given once daily for reflux esophagitis in children." Order ALL the reference details at left...
8.	Cimetidine (Biomet)FDA LinkGeneric 02/01/1989 - "We conclude that cimetidine is an effective agent for treatment of reflux esophagitis in children. " 01/01/1986 - "This combination is efficacious in the management of chronic reflux esophagitis but, because of frequent side effects, should be reserved for patients refractory to treatment with cimetidine alone." 05/01/1978 - "The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. " 09/01/1990 - "Efficacy of different doses of cimetidine in the treatment of reflux esophagitis. " 02/01/1989 - "Cimetidine treatment of reflux esophagitis in children: an Italian multicentric study." Order ALL the reference details at left...
9.	Proton Pump InhibitorsIBA 11/01/2003 - "In adult studies, proton pump inhibitors (PPIs) are highly effective in relieving reflux symptoms and healing reflux esophagitis. " 08/01/2002 - "SUMMARY BACKGROUND DATA: Medical therapy with proton pump inhibitors for endoscopically proven reflux esophagitis is a safe and effective treatment option. " 06/01/2001 - "Proton pump inhibitors are not more (and are sometimes even less) effective in non-erosive reflux disease than in reflux esophagitis. " 12/01/2003 - "The aim of the present study was to clarify whether there is any difference in the speed of symptom relief in patients with reflux esophagitis following the administration of these three proton pump inhibitors (PPI). " 02/28/2009 - "AIM: To clarify whether there is any difference in the symptom relief in patients with reflux esophagitis following the administration of four Proton pump inhibitors (PPIs). " Order ALL the reference details at left...
10.	rabeprazole (Aciphex)FDA Link 07/15/2001 - "When evaluated by decision analysis over a wide range of assumptions, rabeprazole was comparable to other PPIs in terms of cost and offered improved effectiveness for maintenance therapy of erosive reflux esophagitis." 11/01/2005 - "OBJECTIVE: To compare the health-related quality of life (HRQL) in the patients with reflux esophagitis (RE) and non-erosive reflux disease (NERD) treated with rabeprazole in the multi-center open study. " 09/01/2006 - "Therapeutic effects of 10 mg/day rabeprazole administration on reflux esophagitis was not influenced by the CYP2C19 polymorphism." 11/01/2005 - "[The impact of rabeprazole treatment on the quality of life in patients with reflux esophagitis and non-erosive reflux disease]" 01/01/2002 - "The article provides the data on 20 patients with erosive reflux esophagitis, who were treated with Pariet (rabeprazole). " Order ALL the reference details at left...

Therapies and Procedures

1.	Gastrectomy 01/01/1982 - "Experimental studies of reflux esophagitis following total gastrectomy in rats-pathogenesis and treatment." 01/01/1981 - "In this study, the effect of PANa on the chronic reflux esophagitis in rats induced by total gastrectomy followed by esophagojejunostomy was investigated. " 07/01/2008 - "CONCLUSION: Jejunal interposition helps prevent reflux esophagitis after proximal gastrectomy. " 07/01/2008 - "To date, only a few reports have compared the methods of reconstruction performed after proximal gastrectomy, and the method most likely to prevent postoperative reflux esophagitis remains undetermined. " 07/01/2008 - "BACKGROUND: Although proximal gastrectomy has been performed more as a function-preserving surgery, reflux esophagitis can occur postoperatively, resulting in poor postoperative quality of life. " Order ALL the reference details at left...
2.	Fundoplication 03/01/1993 - "Nissen fundoplication is effective in patients with reflux esophagitis who have adequate esophageal motility." 04/01/1974 - "Proceedings: Nissen fundoplication without crural repair: a cure for reflux esophagitis." 04/01/1993 - "OBJECTIVE: This study evaluates the clinical and endoscopic long-term results of Nissen fundoplication in reflux esophagitis. " 10/01/2009 - "Reflux esophagitis (preoperative rates: group 1, 74%; group 2, 59%) disappeared in all patients after fundoplication. " 12/01/2008 - "Thoracic aortic injury during laparoscopic fundoplication for reflux esophagitis." Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 03/01/2006 - "The authors concluded that although symptoms improved in more than half of infants with reflux esophagitis followed longitudinally, esophageal mucosal histology remained abnormal at the 1-yr evaluation in the absence of pharmacotherapy. " 03/01/2006 - "CONCLUSION: Although symptoms improved in more than half of the infants with reflux esophagitis followed longitudinally for 1 yr without pharmacotherapy, histology remained abnormal." 04/01/1991 - "Comparative efficacy of acid reflux inhibition by drug therapy in reflux esophagitis." 03/01/2006 - "Natural history of infant reflux esophagitis: symptoms and morphometric histology during one year without pharmacotherapy." 03/01/2005 - "Reflux esophagitis secondary to chemotherapy detected by serial FDG-PET." Order ALL the reference details at left...
4.	Gastroenterostomy 06/01/2006 - "Thus, duodenogastroesophageal reflux with low gastric acidity is one of the pathogeneses in the development of reflux esophagitis from the present clinical study with patients after distal gastrectomy reconstructed with Billroth I anastomosis." 05/01/2006 - "Reflux esophagitis in patients with partial gastrectomy and Billroth I or II reconstruction." 05/01/2006 - "BACKGROUND: Data on the occurrence of reflux esophagitis and Barrett's esophagus in patients with Billroth I or II resection is sparse. " 09/01/2002 - "Reflux esophagitis was not found in jejunal interposition, but two patients after Billroth I showed grade B esophagitis. " 05/01/1995 - "[Effects of gastric resection by the Billroth II technic on reflux esophagitis associated with duodenal or pyloric ulcer]" Order ALL the reference details at left...
5.	Gastroplasty (Vertical-Banded Gastroplasty) 02/01/1982 - "Patients with reflux esophagitis should not necessarily be excluded from consideration for gastroplasty." 02/01/1982 - "At present, only two have symptoms of reflux esophagitis and both were free of symptoms until reversal of the gastroplasty. " 02/01/1982 - "Gastroplasty in patients with symptoms of reflux esophagitis." 02/01/1981 - "A new gastroplasty for reflux esophagitis." 03/01/1973 - "Modified gastroplasty: a simple operation for reflux esophagitis with moderate degrees of shortening." Order ALL the reference details at left...

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