|2.||Neoplasm Metastasis (Metastasis)
|3.||Deglutition Disorders (Dysphagia)
|5.||Stomach Neoplasms (Stomach Cancer)
|1.||Doki, Yuichiro: 57 articles (12/2015 - 03/2002)|
|2.||Mori, Masaki: 46 articles (12/2015 - 01/2003)|
|3.||Miyata, Hiroshi: 42 articles (12/2015 - 05/2006)|
|4.||Takiguchi, Shuji: 41 articles (12/2015 - 07/2002)|
|5.||Ajani, Jaffer A: 41 articles (09/2015 - 01/2002)|
|6.||Kuwano, Hiroyuki: 40 articles (10/2015 - 11/2002)|
|7.||Kato, Hiroyuki: 39 articles (10/2015 - 11/2002)|
|8.||Yamasaki, Makoto: 38 articles (12/2015 - 09/2007)|
|9.||Miyazaki, Tatsuya: 35 articles (10/2015 - 11/2002)|
|10.||Nakajima, Masanobu: 33 articles (10/2015 - 11/2002)|
|1.||Cisplatin (Platino)FDA LinkGeneric
06/01/2015 - "This regimen is promising as neoadjuvant CRT for esophageal cancer and very useful as an alternative regimen for treating patients with esophageal cancer who cannot tolerate cisplatin."
06/01/2006 - "Chemoradiotherapy combined with S-1 and cisplatin may be a promising treatment option for advanced esophageal cancer."
01/01/2013 - "A phase II study was performed to investigate the safety and efficacy of concurrent chemoradiotherapy (CCRT) combined with an orally active fluoropyrimidine, S-1, plus cisplatin for locally advanced esophageal cancer (LAEC). "
06/01/2006 - "We prospectively analyzed the efficacy of concurrent chemoradiotherapy using oral fluoropyrimidine (S-1) and cisplatin for the treatment of advanced esophageal cancer. "
12/01/2014 - "This study thus investigated the role of autophagy in the anticancer activity of cisplatin in human esophageal cancer cells with acquired cisplatin resistance. "
|2.||Fluorouracil (Carac)FDA LinkGeneric
10/01/2002 - "Although the standard method of chemoradiotherapy is CDDP/5FU, it has been claimed that CDGP (a derivative of CDDP) alone is more effective than CDDP for the treatment of esophageal cancer due to its low nephro- and digestive toxicity. "
03/01/1996 - "[Improvement in the surgical outcome in esophageal cancer by multidisciplinary treatment--evaluation of pre-operative combined administration of CDDP and 5FU]."
10/01/2005 - "Three cases of advanced esophageal cancer and a case of relapsed esophageal cancer after administration of 5-FU and CDDP were enrolled in this pilot trial. "
11/01/2000 - "Recent studies have focused on biochemical modulation with the combined use of CDDP and 5-FU for esophageal cancer. "
04/01/1992 - "In esophageal cancer, two phase II studies with 5-FU/IFN reported seven (27%) objective remissions in 26 patients, indicating superiority of 5-FU/IFN over 5-FU monotherapy. "
|3.||Paclitaxel (Taxol)FDA LinkGeneric
01/01/2008 - "The present phase II study aimed to assess the feasibility and efficacy of a new paclitaxel-based neoadjuvant chemoradiation regimen followed by surgery in patients with stage II-III esophageal cancer. "
05/01/2007 - "The purpose of the study was to evaluate the efficacy of weekly paclitaxel (Taxol) in advanced esophageal cancer. "
06/01/2011 - "Weekly paclitaxel demonstrated efficacy and manageable toxicity in patients with advanced or recurrent esophageal cancer and may be a treatment option for this population."
04/01/2012 - "A Phase II study of a paclitaxel-based chemoradiation regimen with selective surgical salvage for resectable locoregionally advanced esophageal cancer: initial reporting of RTOG 0246."
02/01/2009 - "Phase 2: a dose-escalation study of OncoGel (ReGel/paclitaxel), a controlled-release formulation of paclitaxel, as adjunctive local therapy to external-beam radiation in patients with inoperable esophageal cancer."
|4.||docetaxel (Taxotere)FDA Link
08/01/2015 - "Antitumor Efficacy of Docetaxel-loaded Nanocarrier against Esophageal Cancer Cell Bearing Mice Model."
12/01/2011 - "We performed a phase II trial to evaluate a docetaxel-based regimen in locoregionally advanced esophageal cancer. "
12/01/2006 - "[A phase I/II study of docetaxel/TS-1 with radiation for esophageal cancer patients--step 1]."
06/01/2004 - "A phase II study of single-agent docetaxel in patients with metastatic esophageal cancer."
01/01/1998 - "Twenty-nine patients with advanced non-small-cell lung or esophageal cancer enrolled in this phase I study to evaluate escalating docetaxel doses at three schedules. "
12/01/2007 - "We evaluated the curative efficacy of PDT in superficial esophageal cancer in inoperable patients. "
05/01/2000 - "PDT is an effective regimen for early esophageal cancer, giving a CR rate of about 40%, long-term local control and favorable overall survival. "
03/01/2006 - "In selected patients, PDT may be useful in the treatment of persistent/recurrent mucosal esophageal cancer after incomplete response to CRT."
08/01/2003 - "PDT is an effective and safe treatment method in esophageal cancer. "
03/01/2014 - "A photosensitizing agent has also been developed that requires a shorter sun shade period after administration, and studies are currently underway to establish an esophageal cancer indication for this next-generation PDT in Japan. "
02/01/2000 - "The observations suggested that 254-S, which has little or no side effects including nephrotoxicity, can become the standard remedy for esophageal cancer instead of CDDP in future."
10/01/2002 - "[Clinical study of the combination of small amount of nedaplatin (CDGP)/5-FU with radiation for the treatment of esophageal cancer]."
09/01/2004 - "This is a report of a case with esophageal cancer in which pathological CR was obtained by neoadjvant chemoradiotherapy using a low-dose of nedaplatin (CDGP)/5-FU. "
02/01/1999 - "A 60-year-old male with type 2 advanced esophageal cancer, which was located in the upper part of the esophagus and had invaded adjacent organs, was treated with nedaplatin 150 mg/body (100 mg/m2) given intravenously every 4 weeks from January 6, 1991. "
04/01/1992 - "Based on these results, it was concluded that 254-S is a useful anticancer agent for the treatment of esophageal cancer."
|7.||titanium silicide (TS-1)IBA
12/01/2004 - "Chemoradiotherapy using TS-1 and weekly CDDP revealed their efficacy for esophageal cancer."
02/01/2005 - "This combined chemotherapy consisting of TS-1 and CDDP may prove effective for treating recurrent cases of esophageal cancer."
02/01/2004 - "TS-1 and CDDP therapy combined with radiotherapy appears to be effective in treating thoracic esophageal cancer."
03/01/2007 - "[Recurrent esophageal cancer with complete response to TS-1 chemotherapy]."
02/01/2004 - "Combined chemotherapy of TS-1 and CDDP with radiotherapy can be effective for advanced esophageal cancer."
|8.||Carboplatin (JM8)FDA LinkGeneric
02/01/2007 - "The regimen of paclitaxel, carboplatin, and radiation with or without surgery is well tolerated with promising efficacy for patients with esophageal cancer."
02/01/2007 - "A phase II study of paclitaxel, carboplatin, and radiation with or without surgery for esophageal cancer."
06/01/2004 - "This study was conducted to evaluate the efficacy and toxicity of combination carboplatin and paclitaxel in patients with esophageal cancer. "
06/01/2004 - "A phase II study of carboplatin and paclitaxel in esophageal cancer."
03/15/2004 - "A phase I and pharmacokinetic study of weekly paclitaxel and carboplatin in patients with metastatic esophageal cancer."
|9.||Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/01/2014 - "In this study, we investigated acquaporin-8 expression and signaling via epidermal growth factor receptor-extracellular signal-regulated kinases1/2 in human esophageal cancer Eca-109 cells by western blot, immunofluorescence and wound healing (scratch) assays. "
01/01/2014 - "This study was to evaluate antitumor activity of Ec-LDP-Hr-AE, a recently developed bispecific enediyne-energized fusion protein targeting both epidermal growth factor receptor (EGFR) and epidermal growth factor receptor 2 (HER2), on esophageal cancer. "
03/01/2015 - "Human epidermal growth factor receptor 2 (HER2) amplification is present in a subgroup of gastroo-esophageal cancers (GCs). "
10/01/2013 - "Further investigation of epidermal growth-factor-receptor-mediated pathways will push insight into the novel strategies of target therapy for esophageal cancer. "
10/01/2013 - "Epidermal growth factor receptor: an important target in esophageal cancer."
09/01/2010 - "The results suggest that proton-beam therapy is an effective treatment for patients with locally advanced esophageal cancer. "
01/01/2005 - "The results suggest that proton beam therapy is an effective treatment for patients with locally confined esophageal cancer. "
03/01/2015 - "Irrespective of the small sample size and short follow-up time of the study, proton beam therapy combined with chemo therapy seems to be feasible for esophageal cancer."
01/01/2013 - "This study quantifies pulmonary radiation toxicity in patients who received proton therapy for esophagus cancer. "
12/01/2011 - "In the present study, we compared the dosimetric parameters for photon IMRT with that for intensity-modulated proton therapy (IMPT) for unresectable, locally advanced, distal esophageal cancer. "
|1.||Drug Therapy (Chemotherapy)
09/01/2010 - "In sequential phase II/III trials involving locoregionally advanced esophageal cancer patients, preoperative C/RT was associated with improved overall and disease-free survival rates (p = 0.046 and p = 0.015, respectively) and increased pathologic complete response (p < 0.001) compared with preoperative chemotherapy."
11/01/2003 - "However, since esophageal cancer can hardly be cured by definitive chemotherapy alone, chemotherapy plays an important role in the multimodality therapy for esophageal cancer. "
09/01/2015 - "We report a case of far-advanced esophageal cancer in which induction chemotherapy followed by chemoradiotherapy achieved complete remission. "
01/01/2011 - "Induction chemotherapy may be beneficial for node-positive esophageal cancer, although the consensus has not yet been established. "
03/01/2002 - "Radiation therapy concurrent with chemotherapy is more effective than radiation therapy alone for patients with unresectable esophageal cancer. "
04/01/2012 - "Early detection of a second primary malignancy in the residual cervical esophagus followed by endoscopic resection is the best treatment strategy for patients who previously received subtotal esophagectomy for thoracic esophageal cancer. "
08/01/2005 - "Such a standardisation and the resulting improved quality most likely will result in a significant improvement of outcome of esophagectomy for cancer of the esophagus and GEJ. "
01/01/2003 - "Radical esophagectomy is a highly invasive operation for esophageal cancer, and improved techniques are being sought to reduce the invasiveness of this procedure. "
10/01/2012 - "Esophagectomy remains the gold standard curative therapy for the treatment of esophageal cancer. "
11/15/2010 - "The newly modified staging system of the World Esophageal Cancer Consortium has helped define the optimal number of lymph nodes to dissect during an esophagectomy. "
09/01/2013 - "Furthermore, curative treatment with surgery improved the survival of esophageal cancer patients more significantly compared with patients who undergo definite radiotherapy. "
12/01/2011 - "Oral medication with oral Fructus bruceae oil could effectively improve the efficacy of radiotherapy in esophageal cancer, including a reduction in esophageal obstruction, and also reduce the side effects of radiotherapy; thus it would be very promising for clinical application."
10/01/2005 - "A weekly administration of low dose DOC in combination with radiotherapy was very effective for advanced esophageal cancer. "
03/01/2005 - "Esophageal cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. "
10/01/1994 - "Chemo-radiotherapy seemed to be very effective for esophageal cancer patients, and it may provide a complete cure for them in the future."
|4.||Lymph Node Excision (Lymph Node Dissection)
01/01/2013 - "To date, however, this association of a more aggressive lymphadenectomy with improved outcome has remained elusive in most gastrointestinal malignancies, including esophageal cancer. "
09/01/2010 - "Surgical resection is the most effective treatment for patients with isolated esophageal cancer, but the 5-year survival rate is still very poor in spite of recent advances in early diagnosis and extended lymphadenectomy. "
02/01/2003 - "One of the most controversial aspects of surgery for esophageal cancer is the appropriate extent of lymphadenectomy to achieve the best outcome. "
12/01/2013 - "There have been many controversies about the optimal extent of lymphadenectomy for thoracic esophageal cancer, whether three-field lymphadenectomy is superior to two-field lymphadenectomy with respect to the 5-year survival rate and perioperative morbidities and mortality. "
10/01/2012 - "Extensive lymph node dissection (LND) is beneficial in primarily resected esophageal cancer patients. "
05/01/2007 - "Insertion of expandable metallic stents in esophageal cancer without fluoroscopy is safe and effective: a 5-year experience."
06/01/2015 - "To evaluate the clinical efficacy of temporary placement of a retrievable expandable metallic stent (REMS) during preoperative neoadjuvant chemoradiotherapy (CRT) in patients with resectable esophageal cancer. "
11/01/2011 - "The efficacy of stents with an antireflux valve for patients with distal esophageal cancer varies between different stent designs. "
07/01/2005 - "Does procedural volume matter in the efficacy of self-expanding stents in patients with esophageal cancer?"
03/01/2015 - "Study on the diagnosis of rabbit VX2 esophageal cancer and stent-therapy efficacy based on multiphoton microscopy."