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Ergot Alkaloids

Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists.
Also Known As:
Clavine Alkaloids; Alkaloids, Clavine; Alkaloids, Ergot
Networked: 208 relevant articles (13 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Diener, H C: 5 articles (12/2004 - 01/2001)
2. Panaccione, Daniel G: 4 articles (11/2021 - 01/2017)
3. Katsarava, Z: 4 articles (12/2004 - 01/2001)
4. Duckett, S K: 3 articles (12/2021 - 02/2015)
5. Limmroth, V: 3 articles (12/2004 - 01/2001)
6. Britt, J L: 2 articles (12/2021 - 10/2020)
7. Blakley, Barry: 2 articles (02/2021 - 01/2021)
8. Wipf, Peter: 2 articles (01/2021 - 07/2016)
9. Klotz, James L: 2 articles (10/2020 - 01/2015)
10. Tolosa, Jorge E: 2 articles (01/2019 - 10/2013)

Related Diseases

1. Vomiting
02/11/1982 - "It is very effective against emesis induced by apomorphine and dihydrogenated ergot alkaloids in dogs. "
04/18/2007 - "Ergot alkaloids increased the risk of vomiting (RR 11.81, 95% CI 1.78 to 78.28), elevation of blood pressure (RR 2.60, 95% CI 1.03 to 6.57) and pain after birth requiring analgesia (RR 2.53, 95% CI 1.34 to 4.78). "
04/18/2007 - "Prophylactic intramuscular or intravenous injections of ergot alkaloids are effective in reducing blood loss and postpartum haemorrhage, but adverse effects include vomiting, elevation of blood pressure and pain after birth requiring analgesia, particularly with the intravenous route of administration."
10/30/2013 - "Use of prophylactic oxytocin was associated with fewer side effects compared with use of ergot alkaloids; including decreased nausea between delivery of the baby and discharge from the labour ward (RR 0.18; 95% CI 0.06 to 0.53; three trials, 1091 women; T² = 0.41, I² = 41%) and vomiting between delivery of the baby and discharge from the labour ward (RR 0.07; 95% CI 0.02 to 0.25; three trials, 1091 women; T² = 0.45, I² = 30%). "
01/01/2018 - "Ergot alkaloids increased the risk of elevated blood pressure (average RR 2.60, 95% CI 1.03 to 6.57: women = 2559; studies = 3; low-quality evidence) and pain after birth requiring analgesia (RR 2.53, 95% CI 1.34 to 4.78: women = 1429; studies = 1; moderate-quality evidence) but there were no differences between groups in vomiting, nausea, headache or eclamptic fit.Results"
2. Migraine Disorders (Migraine)
3. Pain (Aches)
01/01/2018 - "Ergot alkaloids may also decrease the use of therapeutic uterotonics, but adverse effects may include elevated blood pressure and pain after birth requiring analgesia. "
04/18/2007 - "Ergot alkaloids increased the risk of vomiting (RR 11.81, 95% CI 1.78 to 78.28), elevation of blood pressure (RR 2.60, 95% CI 1.03 to 6.57) and pain after birth requiring analgesia (RR 2.53, 95% CI 1.34 to 4.78). "
04/18/2007 - "Prophylactic intramuscular or intravenous injections of ergot alkaloids are effective in reducing blood loss and postpartum haemorrhage, but adverse effects include vomiting, elevation of blood pressure and pain after birth requiring analgesia, particularly with the intravenous route of administration."
01/01/1993 - "Accordingly, this chapter will review the consequences of trigeminovascular activation to pain and meningeal inflammation, and will summarize emerging molecular and pharmacological data suggesting that ergot alkaloids and sumatriptan alleviate pain primarily via activation of pre-junctional 5-HT1 heteroreceptors residing on primary afferent trigeminovascular fibers."
01/01/2018 - "Ergot alkaloids increased the risk of elevated blood pressure (average RR 2.60, 95% CI 1.03 to 6.57: women = 2559; studies = 3; low-quality evidence) and pain after birth requiring analgesia (RR 2.53, 95% CI 1.34 to 4.78: women = 1429; studies = 1; moderate-quality evidence) but there were no differences between groups in vomiting, nausea, headache or eclamptic fit.Results"
4. Cerebrovascular Disorders (Cerebrovascular Occlusion)
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. Sumatriptan (Imigran)
2. Apomorphine
3. buflomedil (Lofton)
4. Analgesics (Analgesic Drugs)
5. Anticonvulsants (Antiepileptic Drugs)
6. Antidepressive Agents (Antidepressants)
7. Sympatholytics
8. Piribedil (Trivastal)
9. Lipids
10. DEAE-Dextran (Pulsar)

Related Therapies and Procedures

1. Therapeutics
2. Analgesia
3. Drug Therapy (Chemotherapy)
4. Intravenous Injections
5. Topical Administration