Absence Epilepsy (Absence Seizure)

708  relevant articles (67 outcomes, 103 trials/studies) found for this Disease

Absence Seizure; Childhood Absence Epilepsy; Absence Seizures; Epilepsy, Juvenile Absence; Seizure, Absence; Pyknolepsy; Epilepsy, Absence; Absence Seizure Disorder; Atonic Absence Seizures; Epilepsy, Absence, Atypical; Epilepsy, Petit Mal; Juvenile Absence Epilepsy; Petit Mal Convulsion; Pykno-Epilepsy; Seizure Disorder, Absence; Absence Epilepsies, Childhood; Absence Epilepsies, Juvenile; Absence Epilepsy, Childhood; Absence Epilepsy, Juvenile; Absence Seizure Disorders; Absence Seizure, Atonic; Absence Seizures, Atonic; Atonic Absence Seizure; Childhood Absence Epilepsies; Convulsion, Petit Mal; Epilepsies, Childhood Absence; Epilepsies, Juvenile Absence; Epilepsy, Childhood Absence; Juvenile Absence Epilepsies; Minor Epilepsies; Minor Epilepsy; Petit Mal Epilepsies; Petit Mal, Akinetic; Pykno Epilepsy; Pykno-Epilepsies; Pyknolepsies; Seizure Disorders, Absence; Seizure, Atonic Absence; Seizures, Atonic Absence; Akinetic Petit Mal; Epilepsy, Minor; Petit Mal Epilepsy

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Seizures (Seizure)
2.	Absence Epilepsy (Absence Seizure)
3.	Syndrome
4.	Epilepsy (Aura)
5.	Partial Epilepsies (Epilepsy, Partial)

Experts

1.	van Luijtelaar, Gilles: 6 articles (05/2007 - 07/2003)
2.	Nehlig, Astrid: 5 articles (09/2008 - 03/2002)
3.	Cortez, Miguel A: 5 articles (05/2007 - 01/2002)
4.	O'Brien, Terence J: 5 articles (02/2007 - 06/2004)
5.	Snead, O C: 5 articles (11/2004 - 01/2000)
6.	Vergnes, M: 5 articles (01/2002 - 02/2000)
7.	Russo, Emilio: 4 articles (09/2008 - 09/2005)
8.	De Sarro, Giovambattista: 4 articles (09/2008 - 09/2005)
9.	Aker, Rezzan Gülhan: 4 articles (07/2008 - 02/2002)
10.	Onat, Filiz Yilmaz: 4 articles (07/2008 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Absence Epilepsy:

1.	lamotrigine (Lamictal)FDA LinkGeneric 04/27/2004 - "There is also evidence that lamotrigine is effective for newly diagnosed absence seizures in children" 07/01/1999 - "PURPOSE: To investigate whether lamotrigine (LTG) monotherapy is effective and safe for newly diagnosed typical absence seizures in children and adolescents (aged 3-15 years, n = 45)" 11/01/1997 - "Early data from ambulatory encephalographic (EEG) recordings in patients with previously refractory absence seizures, and from controlled studies on patients with newly diagnosed typical absence seizures, appear to confirm the efficacy of lamotrigine in those patients" 01/01/2004 - "Lamotrigine as first-line drug in childhood absence epilepsy: a clinical and neurophysiological study." 07/01/2003 - "Another 7-year-old boy who started on lamotrigine for suspected absence seizures developed abnormalities of eye movement with associated cognitive decline, which also resolved on discontinuing the medication" Order ALL the reference details at left...
2.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 07/01/1999 - "In conclusion LTG appears to be effective in resistant absence seizures in combination with valproic acid" 09/01/1988 - "Valproate in the treatment of absence epilepsy in children: a study of dose-response relationships." 06/01/1982 - "Valproic acid in the treatment of intractable absence seizures in children: a single-blind clinical and quantitative EEG study." 01/01/1980 - "Analytic study of epileptic absence seizures and effect of sodium valproate treatment." 02/01/2007 - "Juvenile absence epilepsy exacerbated by valproic acid." Order ALL the reference details at left...
3.	Anticonvulsants (Antiepileptic Drugs)IBA 01/01/1989 - "The mechanisms of action of antiepileptic drugs effective against generalized absence seizures (antiabsence AEDs) remain uncertain" 01/01/1989 - "Antiepileptic drugs (AEDs) vary in their efficacy against generalized tonic-clonic, myoclonic, and absence seizures, suggesting different mechanisms of action" 06/01/2006 - "Studies with antiepileptic drugs demonstrated that compounds used to treat absence epilepsy blocked the convulsive effects of nonpeptidic delta-opioid agonists" 10/01/1980 - "On the basis of behavioral experiments and studies employing single doses of antiepileptic drugs, FEAD has been proposed as a model of the absence seizure" 11/01/1978 - "Such a relationship, if substantiated by further studies, might indicate that anticonvulsant drugs used to treat petit mal epilepsy have a dopaminergic mode of action." Order ALL the reference details at left...
4.	Ethosuximide (Zarontin)FDA LinkGeneric 12/01/1996 - "Ethosuximide is effective against absence seizures" 10/30/2007 - "Mice heterozygous for the mutation demonstrated behavioral arrest associated with 6-to 7-Hz spike-and-wave discharges, which are blocked by ethosuximide, a first-line treatment for absence epilepsy in man" 02/01/1976 - "A study was conducted in 9 children with petit mal epilepsy to compare the plasma levels of ethosuximide after divided daily administration with those after single daily administration" 12/01/2005 - "Ethosuximide is a drug used for the treatment of absence seizures" 09/01/2005 - "Ethosuximide is a chiral drug substance primarily indicated for the treatment of absence seizures" Order ALL the reference details at left...
5.	Pentylenetetrazole (Metrazol)IBA 07/15/2000 - "The DMF ternary complex was also found to be effective in the subcutaneous injection of metrazol model of petit mal epilepsy" 10/01/1980 - "It is concluded that FEAD is a valid absence seizure model with a pharmacological predictive value that is at least as good as the metrazol model." 09/01/1953 - "Intracarotid and intravertebral metrazol in petit mal epilepsy." 04/01/1997 - "PURPOSE: Traditional methods of preclinical screening have predicted the effects of a putative antiepileptic drug (AED) against human absence seizures by testing its efficacy against clonic seizures in the high-dose pentylenetetrazole (PTZ) model" 11/15/2007 - "Pentylenetetrazol (PTZ)-induced kindling in rodents is considered a model of human absence epilepsy and myoclonic, generalized tonic-clonic seizure" Order ALL the reference details at left...
6.	Phenytoin (Dilantin)FDA LinkGeneric 02/01/1983 - "In contrast, phenytoin at 5, 10, 30, or 60 mg/kg produced no significant reduction in the incidence of absence seizures" 08/01/2006 - "Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy." 10/01/1986 - "This response is unusual since phenytoin is considered ineffective in controlling petit mal epilepsy." 10/01/1996 - "1. Phenytoin has been used with much clinical success against all types of epileptiform seizures, except petit mal epilepsy, for over 50 years" 01/01/2001 - "In conclusion, this case is peculiar for several reasons: 1) late onset of absence epilepsy, 2) epigastric sensation at onset of absence seizures, 3) recognition of brief "phantom" absences and 4) presumable adverse effects of phenytoin." Order ALL the reference details at left...
7.	Carbamazepine (Tegretol)FDA LinkGeneric 10/01/2008 - "Six months after stopping carbamazepine, however, he developed deja vu phenomena and absence seizures with EEG abnormality" 11/01/2006 - "The mechanism of carbamazepine aggravation of absence seizures." 03/01/2005 - "The lack of difference in cFos activation patterns between carbamazepine and vehicle-treated animals suggests that the mechanism for carbamazepine aggravation of absence seizures may not involve neuronal activation but rather enhanced neuronal synchronization" 03/01/2005 - "The mechanisms underlying carbamazepine aggravation of absence seizures are uncertain but are thought to involve enhancement of neuronal activity within the thalamocortical circuitry" 03/01/2005 - "Aggravation of absence seizures by carbamazepine in a genetic rat model does not induce neuronal c-Fos activation." Order ALL the reference details at left...
8.	zonisamide (Zonegran)FDA LinkGeneric 07/01/1994 - "It is suggested that zonisamide monotherapy may be effective against absence seizures with focal paroxysmal discharges." 03/01/2005 - "These data support the efficacy of zonisamide in treating absence seizures." 03/01/2005 - "This chart review investigated the efficacy and safety of zonisamide in 45 patients aged < or = 18 years with absence seizures" 03/01/2005 - "Zonisamide for absence seizures." 07/01/1994 - "We report two cases of absence seizures, in which zonisamide monotherapy was effective" Order ALL the reference details at left...
9.	gamma-Aminobutyric Acid (GABA)IBA 07/24/2007 - "We combined immunocytochemistry and high-resolution ImmunoGold electron microscopy to study cellular and subcellular localization of GABA(A)R alpha1, alpha3, and beta2/beta3 subunits in ventral posterior nucleus (VP) and reticular nucleus (RTN) of control rats and WAG/Rij rats, a genetic model of absence epilepsy" 03/01/2006 - "CONCLUSIONS: This study confirms the potential of GABA(B) antagonists in contrasting seizure absence in rodent models and suggests the application of drugs with a similar mechanism in humans" 10/01/1995 - "Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study." 06/01/2008 - "Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy." 10/01/2007 - "The properties of reticular thalamic neuron GABA(A) IPSCs of absence epilepsy rats lead to enhanced network excitability." Order ALL the reference details at left...
10.	Clonazepam (Rivotril)FDA LinkGeneric 01/01/1983 - "Although effective in controlling absence seizures, clonazepam is not favored in this indication because of a high incidence of side effects and the development of tolerance" 03/01/1975 - "This preliminary study shows clonazepam to be useful in the treatment of absence seizures in children and to merit further study." 10/01/1996 - "4. The elevated efficacy of clonazepam (CNZ) in NRT neurons relative to thalamic and cortical neurons, particularly in neurons isolated from adult (> p58) rats, is consistent with the anticonvulsant profile of this drug in controlling Generalized Absence epilepsy" 04/01/1997 - "Because the lh/lh genetic model of absence seizures correctly predicted effects of ESM, clonazepam, VPA, PHT, CBZ, and PB against human absence seizures, we performed this study to test the predictive utility of the lh/lh model for LTG, VGB, TGB, GBP, and TPM" 11/12/2004 - "Sensitivity of thalamic GABAergic currents to clonazepam does not differ between control and genetic absence epilepsy rats." Order ALL the reference details at left...

Therapies and Procedures

1.	Electrodes (Electrode) 02/08/2005 - "In this study, adult male Genetic Absence Epilepsy Rats of Strasbourg (GAERS) were implanted with extradural electrodes and an intracerebroventricular (icv) cannula" 08/14/2003 - "To that end, WAG/Rij rats which are an animal model for absence epilepsy, were provided with cortical electrodes for the registration of the electroencephalogram (EEG)" 02/01/2002 - "METHODS: Nonepileptic Wistar rats and genetic absence epilepsy rats from Strasbourg (GAERS) were instrumented with a guide cannula for drug injection and extradural electrodes for EEG recording" 01/01/2002 - "Transverse topographical analysis revealed that the first spike component of the spike-wave burst of absence seizure always showed phase reversal on the right anterior temporal electrode" 11/01/1999 - "METHODS: Five children with 25 absence seizures were investigated with an expanded electrode array" Order ALL the reference details at left...
2.	Exercise (Aerobic Exercise) 08/01/1991 - "The aim of this study was to compare the effects of a physical exercise test and of voluntary hyperventilation between controls and children with absence epilepsy" 08/01/1991 - "Physical exercise and voluntary hyperventilation in childhood absence epilepsy." Order ALL the reference details at left...
3.	Ovariectomy (Oophorectomy) 05/01/2007 - "The present study examined whether chronic progesterone exposure would induce tolerance for the occurrence of absence seizures and whether reduction in gonadal steroids (via ovariectomy) would alter the number of basal and stress induced absence seizures in WAG/Rij rats, a genetic model for absence epilepsy" Order ALL the reference details at left...
4.	Induced Hypothermia 11/28/1997 - "In this study we investigated the relationship between penicillin-induced hypothermia and petit mal epilepsy induced by this proconvulsant antibiotic" 11/28/1997 - "The connection between absence-like seizures and hypothermia induced by penicillin: possible implication on other animal models of petit mal epilepsy." Order ALL the reference details at left...
5.	Drug Therapy (Chemotherapy) 12/01/1997 - "The patient was suffering from atypical absence seizures, repeating daily in spite of antiepileptic drug therapy, since age 7 years" 09/01/1954 - "Combined drug therapy in petit mal epilepsy." 09/01/1996 - "RESULTS: Sixteen (27%) of 59 patients with AE reported accidental injury during an absence seizure, with risk of injury being 9% per person-year of AE. Most injuries (81%) occurred during anti-epileptic drug therapy" 07/01/1986 - "With respect to treatment, although effective drug therapy (valproic acid, ethosuximide) exists for the "pure" form of absence epilepsy, other forms, in which there is an admixture of grand mal seizures, are less amenable to pharmacotherapy" Order ALL the reference details at left...