|3.||Absence Epilepsy (Absence Seizure)
|5.||Myoclonic Epilepsies (Myoclonic Encephalopathy)
|1.||van Luijtelaar, Gilles: 20 articles (07/2015 - 07/2003)|
|2.||De Sarro, Giovambattista: 20 articles (06/2015 - 08/2003)|
|3.||Citraro, Rita: 19 articles (06/2015 - 09/2005)|
|4.||Russo, Emilio: 19 articles (06/2015 - 09/2005)|
|5.||Snead, O Carter: 16 articles (08/2012 - 01/2002)|
|6.||Cortez, Miguel A: 16 articles (08/2012 - 01/2002)|
|7.||O'Brien, Terence J: 14 articles (04/2013 - 06/2004)|
|8.||Crunelli, Vincenzo: 12 articles (02/2015 - 05/2003)|
|9.||Nehlig, Astrid: 11 articles (02/2015 - 03/2002)|
|10.||Petrou, Steven: 10 articles (05/2015 - 11/2002)|
|1.||lamotrigine (Lamictal)FDA LinkGeneric
04/27/2004 - "There is also evidence that lamotrigine is effective for newly diagnosed absence seizures in children. "
07/01/1999 - "To investigate whether lamotrigine (LTG) monotherapy is effective and safe for newly diagnosed typical absence seizures in children and adolescents (aged 3-15 years, n = 45). "
11/01/1997 - "Early data from ambulatory encephalographic (EEG) recordings in patients with previously refractory absence seizures, and from controlled studies on patients with newly diagnosed typical absence seizures, appear to confirm the efficacy of lamotrigine in those patients. "
05/01/2012 - "In this study, we have compared WAG-Rij rats (genetically absence epileptic rats) with Wistar rats, in order to clarify if there is a deficient sensorimotor gating in absence epilepsy, and have examined the effects of lamotrigine (15, 30 mg/kg, i.p.) on this phenomenon. "
01/01/2004 - "Lamotrigine as first-line drug in childhood absence epilepsy: a clinical and neurophysiological study."
|2.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
12/01/2009 - "Valproic acid (VPA) is reported to be effective for the control of absence seizures in 75% of children. "
07/01/1999 - "In conclusion LTG appears to be effective in resistant absence seizures in combination with valproic acid. "
09/01/1988 - "Valproate in the treatment of absence epilepsy in children: a study of dose-response relationships."
06/01/1982 - "Valproic acid in the treatment of intractable absence seizures in children: a single-blind clinical and quantitative EEG study."
01/01/1980 - "Analytic study of epileptic absence seizures and effect of sodium valproate treatment."
|3.||Ethosuximide (Zarontin)FDA LinkGeneric
12/01/1996 - "Ethosuximide is effective against absence seizures. "
05/01/2014 - "Due to reduced side effects, ethosuximide remains the first line treatment for childhood absence epilepsy."
10/30/2007 - "Mice heterozygous for the mutation demonstrated behavioral arrest associated with 6-to 7-Hz spike-and-wave discharges, which are blocked by ethosuximide, a first-line treatment for absence epilepsy in man. "
07/01/2012 - "Ethosuximide is a minor antiepileptic drug, available in France since 1965, indicated in the epilepsy absence, whose interest was reassessed from recent clinical trials, showing that it was the first choice, in term of risk benefit relationship, in this indication. "
10/01/2015 - "T-type (Ca(V)3) channels are a target of ethosuximide, widely used in absence epilepsy. "
|4.||Anticonvulsants (Antiepileptic Drugs)IBA
01/01/1989 - "The mechanisms of action of antiepileptic drugs effective against generalized absence seizures (antiabsence AEDs) remain uncertain. "
02/01/2012 - "The results are of clinical interest creating a theoretical basis for improved diagnosis of absence epilepsy and selection of anticonvulsants."
01/01/1989 - "Antiepileptic drugs (AEDs) vary in their efficacy against generalized tonic-clonic, myoclonic, and absence seizures, suggesting different mechanisms of action. "
06/01/2006 - "Studies with antiepileptic drugs demonstrated that compounds used to treat absence epilepsy blocked the convulsive effects of nonpeptidic delta-opioid agonists. "
10/01/1980 - "On the basis of behavioral experiments and studies employing single doses of antiepileptic drugs, FEAD has been proposed as a model of the absence seizure. "
|5.||Lennox-Gastaut type Epileptic encephalopathyIBA
10/01/1998 - "Future outpatient studies of investigational anticonvulsant medications for patients with Lennox-Gastaut syndrome should consider parental counts of atypical absence seizures unreliable. "
08/01/2012 - "Atypical absence seizures are drug resistant in the majority of children with Lennox-Gastaut syndrome and herald a poor neurodevelopmental outcome. "
05/01/2012 - "Lennox Gastaut syndrome (LGS) is an epileptic encephalopathy characterized by tonic, atonic, and atypical absence seizures usually refractory to pharmacological treatment. "
07/10/2006 - "Chronic atypical absence seizures are a component of the Lennox-Gastaut syndrome, a disorder invariably associated with severe cognitive impairment in children. "
10/01/1998 - "We recommend that video/EEG monitoring be done on all Lennox-Gastaut syndrome patients with suspected atypical absence seizures not controlled by medication."
10/01/1980 - "It is concluded that FEAD is a valid absence seizure model with a pharmacological predictive value that is at least as good as the metrazol model."
09/01/1953 - "Intracarotid and intravertebral metrazol in petit mal epilepsy."
07/15/2000 - "The DMF ternary complex was also found to be effective in the subcutaneous injection of metrazol model of petit mal epilepsy. "
04/01/1997 - "Traditional methods of preclinical screening have predicted the effects of a putative antiepileptic drug (AED) against human absence seizures by testing its efficacy against clonic seizures in the high-dose pentylenetetrazole (PTZ) model. "
11/15/2007 - "Pentylenetetrazol (PTZ)-induced kindling in rodents is considered a model of human absence epilepsy and myoclonic, generalized tonic-clonic seizure. "
|7.||Phenytoin (Dilantin)FDA LinkGeneric
02/01/1983 - "In contrast, phenytoin at 5, 10, 30, or 60 mg/kg produced no significant reduction in the incidence of absence seizures. "
05/01/2010 - "3. Although the brain uptake of phenytoin was significantly reduced following PTZ administration, no changes were observed in phenytoin disposition in the genetic absence epilepsy model. "
08/01/2006 - "Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy."
10/01/1986 - "This response is unusual since phenytoin is considered ineffective in controlling petit mal epilepsy."
10/01/1996 - "1. Phenytoin has been used with much clinical success against all types of epileptiform seizures, except petit mal epilepsy, for over 50 years. "
|8.||zonisamide (Zonegran)FDA LinkGeneric
07/01/1994 - "It is suggested that zonisamide monotherapy may be effective against absence seizures with focal paroxysmal discharges."
03/01/2005 - "These data support the efficacy of zonisamide in treating absence seizures."
09/01/2014 - "To examine the clinical effect of zonisamide (ZNS) in patients with drug-resistant juvenile absence epilepsy (JAE). "
09/01/2014 - "Zonisamide for refractory juvenile absence epilepsy."
03/01/2014 - "After subsequently discontinuing zonisamide, absence seizures returned. "
|9.||gamma-Aminobutyric Acid (GABA)IBA
06/01/2014 - "In the present study, we used light-microscopic gamma-aminobutyric acid (GABA) immunocytochemistry to quantify the interneurons in the lateral geniculate (LGN), ventral posteromedial (VPM), and ventral posterolateral (VPL) thalamic nuclei, and compared the values from normal Wistar rats and genetic absence epilepsy rats from Strasbourg (GAERS). "
07/24/2007 - "We combined immunocytochemistry and high-resolution ImmunoGold electron microscopy to study cellular and subcellular localization of GABA(A)R alpha1, alpha3, and beta2/beta3 subunits in ventral posterior nucleus (VP) and reticular nucleus (RTN) of control rats and WAG/Rij rats, a genetic model of absence epilepsy. "
10/01/1995 - "Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study."
10/15/2015 - "Our findings show that there are changes in the levels of both phasic and tonic GABA(A)Rs in the VP thalamus; altered GABAergic inhibition within the VP could be one of many mechanisms contributing to the generation of absence seizures in this model."
10/01/2015 - "Facilitation of sub-maximal α1β2γ2, and α3β2γ2 GABA currents by CBZ may play a role in CBZ-induced GABA-mediated aggravation of absence seizures."
|10.||Carbamazepine (Tegretol)FDA LinkGeneric
10/01/2015 - "The aim of this study was to evaluate the effect of carbamazepine (CBZ) upon chemically induced absence seizures and in a genetic absence seizures model in the mouse. "
10/01/2015 - "Carbamazepine aggravates absence seizures in two dedicated mouse models."
10/01/2012 - "Eyelid myoclonia with absence seizure precipitated by carbamazepine therapy."
10/01/2008 - "Six months after stopping carbamazepine, however, he developed deja vu phenomena and absence seizures with EEG abnormality. "
11/01/2006 - "The mechanism of carbamazepine aggravation of absence seizures."
01/01/2000 - "Combined injections of low doses of a D1 and a D2 agonist in the core of the nucleus accumbens had an additive effect in absence seizures suppression. "
01/01/2000 - "Injections of mixed dopaminergic D1/D2 or of selective D1 or D2 agonists or antagonists in the dorsal parts of the striatum led to suppression of absence seizures associated with strong behavioral and electroencephalographic side-effects. "
04/01/1996 - "Second, inhibition of the subthalamic projection by bilateral injections of a GABAergic agonist in this structure similarly suppressed absence seizures. "
10/01/2002 - "Finally, bilateral injection of picrotoxin (33 pmol/side) appeared more effective in the superficial and intermediate layers of the caudal superior colliculus, whereas such injections had only weak effects on absence seizures when applied in the deep layers. "
11/01/1999 - "In the present study genetic absence epilepsy rats from Strasbourg (GAERS) were given single bilateral injections of pertussis toxin (PTx 0.4 microg), denatured-PTx or vehicle saline into the relay nuclei of the thalamus under anaesthesia. "
09/01/2009 - "These findings suggest GLUT1 deficiency underlies a significant proportion of early-onset absence epilepsy, which has both genetic counseling and treatment implications because the ketogenic diet is effective in GLUT1 deficiency."
12/01/2013 - "It is concluded that the paleolithic ketogenic diet was effective, safe and feasible in the treatment of this case of childhood absence epilepsy."
12/01/2013 - "Here, we present a case of a 7-year-old child with absence epilepsy successfully treated with the paleolithic ketogenic diet alone. "
12/01/2013 - "Childhood absence epilepsy successfully treated with the paleolithic ketogenic diet."
02/01/2011 - "Do patients with absence epilepsy respond to ketogenic diets?"
|3.||Vagus Nerve Stimulation
01/01/2005 - "The aim of this study was to evaluate the efficacy of acute and chronic vagus nerve stimulation (VNS) in genetic absence epilepsy rats from Strasbourg (GAERS). "
04/01/2004 - "We evaluated the efficacy of vagus nerve stimulation (VNS) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a validated model for absence epilepsy. "
05/01/2013 - "Vagus nerve stimulation for medically refractory absence epilepsy."
01/01/2005 - "The acute and chronic effect of vagus nerve stimulation in genetic absence epilepsy rats from Strasbourg (GAERS)."
04/01/2004 - "Acute vagus nerve stimulation does not suppress spike and wave discharges in genetic absence epilepsy rats from Strasbourg."
01/01/1986 - "After cessation of treatment in 28 seizure-free patients, no recurrence was observed in absence epilepsy, benign myoclonic epilepsy, infantile spasms or benign partial epilepsy, whereas two thirds of the patients with generalized tonic-clonic seizures on awakening relapsed in the year following the cessation of the treatment."
12/01/2013 - "We report a boy with absence seizures with onset at age 11 months, whose seizures increased in frequency after the introduction of valproic acid (VPA) treatment and substantially improved upon cessation of treatment. "
|5.||Carbohydrate-Restricted Diet (Low Carbohydrate Diet)