Myoclonic Epilepsies (Myoclonic Encephalopathy)

338  relevant articles (18 outcomes, 18 trials/studies) found for this Disease

Myoclonic Encephalopathy; Epilepsy, Myoclonus; Epilepsy, Myoclonic; Myoclonus Epilepsy; Myoclonic Epilepsy; Absence Epilepsy, Myoclonic; Epilepsies, Myoclonic; Benign Infantile Myoclonic Epilepsy; Cryptogenic Myoclonic Epilepsy; Early Childhood Epilepsy, Myoclonic; Early Childhood, Myoclonic Epilepsy; Encephalopathy, Myoclonic; Epilepsy, Early Childhood, Myoclonic; Epilepsy, Myoclonic, Early Childhood; Epilepsy, Myoclonic, Infantile; Epilepsy, Myoclonic, Infantile, Benign; Epilepsy, Myoclonic, Infantile, Severe; Infantile Severe Myoclonic Epilepsy; Myoclonic Astatic Epilepsy; Myoclonic Epilepsy, Benign Infantile; Myoclonic Epilepsy, Early Childhood; Myoclonic Epilepsy, Infantile, Benign; Myoclonic Epilepsy, Infantile, Severe; Myoclonic Epilepsy, Severe Infantile; Myoclonic Seizure Disorder; Severe Infantile Myoclonic Epilepsy; Severe Myoclonic Epilepsy, Infantile; Absence Epilepsies, Myoclonic; Astatic Epilepsies, Myoclonic; Astatic Epilepsy, Myoclonic; Cryptogenic Myoclonic Epilepsies; Disorder, Myoclonic Seizure; Disorders, Myoclonic Seizure; Encephalopathies, Myoclonic; Epilepsies, Cryptogenic Myoclonic; Epilepsies, Idiopathic Myoclonic; Epilepsies, Myoclonic Absence; Epilepsies, Myoclonic Astatic; Epilepsies, Symptomatic Myoclonic; Epilepsy, Cryptogenic Myoclonic; Epilepsy, Idiopathic Myoclonic; Epilepsy, Myoclonic Absence; Epilepsy, Myoclonic Astatic; Epilepsy, Symptomatic Myoclonic; Idiopathic Myoclonic Epilepsies; Myoclonic Absence Epilepsies; Myoclonic Astatic Epilepsies; Myoclonic Encephalopathies; Myoclonic Epilepsies, Cryptogenic; Myoclonic Epilepsies, Idiopathic; Myoclonic Epilepsies, Symptomatic; Myoclonic Epilepsy, Cryptogenic; Myoclonic Epilepsy, Idiopathic; Myoclonic Seizure Disorders; Myoclonus Epilepsies; Seizure Disorder, Myoclonic; Seizure Disorders, Myoclonic; Symptomatic Myoclonic Epilepsies; Idiopathic Myoclonic Epilepsy; Myoclonic Absence Epilepsy; Symptomatic Myoclonic Epilepsy

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Syndrome
2.	Infantile Spasms (West Syndrome)
3.	Epilepsy (Aura)
4.	Absence Epilepsy (Absence Seizure)
5.	Seizures (Seizure)

Experts

1.	Yu, Frank H: 3 articles (12/2007 - 09/2006)
2.	Catterall, William A: 3 articles (12/2007 - 09/2006)
3.	Westenbroek, Ruth E: 2 articles (10/2007 - 09/2006)
4.	Kalume, Franck: 2 articles (10/2007 - 09/2006)
5.	Scheuer, Todd: 2 articles (10/2007 - 09/2006)
6.	Veggiotti, Pierangelo: 2 articles (01/2006 - 03/2002)
7.	Osawa, M: 2 articles (01/2005 - 10/2001)
8.	Yamamoto, T: 2 articles (09/2003 - 03/2001)
9.	Tommerup, Niels: 1 article (06/2008)
10.	Schneider, Lizette M: 1 article (06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myoclonic Epilepsies:

1.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 10/01/2002 - "She was diagnosed as having benign myoclonic epilepsy of infancy at 3.5 months of age and treated with valproic acid" 07/01/1987 - "A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy" 09/01/2008 - "In 5 pediatric patients with severe myoclonic epilepsy and valproic acid-induced liver failure, we identified 1 novel and 4 previously described pathogenic mutations in the linker region of this enzyme" 02/01/1977 - "Sodium valproate alone controlled all fits in four children with absences, in 18 with absences with automatisms, 10 with tonic-clonic seizures and 22 with myoclonic epilepsy" 11/10/1978 - "Valproic acid, a new anticonvulsant, is most effective in absence seizures (simple and complex), but it has produced improvement in tonicclonic seizures, mixed absence with tonic-clonic seizures, and myoclonic epilepsy" Order ALL the reference details at left...
2.	clobazam (HR 376)IBA 11/01/1999 - "Ten of the 20 children with severe myoclonic epilepsy in infancy also responded with clobazam (CLB) as comedication" 01/01/2007 - "Whereas the studies in adult patients were disappointing, the trials conducted in pediatric populations demonstrated a specific efficacy of STP in severe myoclonic epilepsy in infancy, Dravet syndrome, when combined with valproate and clobazam" 07/01/2005 - "Although the studies in adult patients were disappointing, the trials conducted in paediatric populations demonstrated a specific efficacy of STP in a severe form of early childhood epilepsy, Dravet syndrome (severe myoclonic epilepsy in infancy), when combined with valproate and clobazam" 04/01/2006 - "A metabolic interaction between stiripentol (STP), an anticonvulsant agent that inhibits the activity of several cytochromes P450 (P450s), and clobazam (CLB), a 1,5-benzodiazepine, used in association with STP in severe myoclonic epilepsy in infancy was observed in vivo" 04/01/2005 - "6) The stiripentol dose strengths currently available in France are unsuitable for infants weighing less than 10 kg. (7) In practice, given the severity of this type of myoclonic epilepsy of infancy, the addition of stiripentol to ongoing but ineffective valproate-clobazam combination therapy is justified, even though the treatment is somewhat difficult to manage and has not yet been fully evaluated." Order ALL the reference details at left...
3.	stiripentolIBA 08/01/2001 - "Stiripentol can be effective in severe myoclonic epilepsy in infancy" 11/11/2000 - "Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial" 04/01/2006 - "A metabolic interaction between stiripentol (STP), an anticonvulsant agent that inhibits the activity of several cytochromes P450 (P450s), and clobazam (CLB), a 1,5-benzodiazepine, used in association with STP in severe myoclonic epilepsy in infancy was observed in vivo" 04/01/2005 - "6) The stiripentol dose strengths currently available in France are unsuitable for infants weighing less than 10 kg. (7) In practice, given the severity of this type of myoclonic epilepsy of infancy, the addition of stiripentol to ongoing but ineffective valproate-clobazam combination therapy is justified, even though the treatment is somewhat difficult to manage and has not yet been fully evaluated." 11/01/2002 - "OBJECTIVE: To describe the long term efficacy and tolerance of stiripentol associated with valproate and clobazam in an exhaustive cohort of patients with severe myoclonic epilepsy of infancy (Dravet's syndrome), in which short term efficacy of such a treatment has recently been demonstrated in a placebo-controlled trial" Order ALL the reference details at left...
4.	BismuthIBA 07/01/1975 - "Polygraphic study of bismuth-induced myoclonic encephalopathy]" 12/01/2002 - "Myoclonic encephalopathy caused by chronic bismuth abuse." 02/01/1990 - "Myoclonic encephalopathy caused by bismuth]" 03/01/1989 - "Myoclonic encephalopathy caused by bismuth]" 07/01/1982 - "faecalis, which do not darken in the presence of Bismuth in vitro, and which had been previously isolated from faeces of patients having presented bismuthic myoclonic encephalopathy, were implanted in the digestive tract of axenic rats" Order ALL the reference details at left...
5.	Anticonvulsants (Antiepileptic Drugs)IBA 03/01/1983 - "An infant with histidinemia had a myoclonic seizure disorder that was unresponsive to therapy with anticonvulsants" 02/01/2008 - "Severe myoclonic epilepsy in infancy (SMEI) is a rare, but severe disorder with seizures typically resistant to conventional antiepileptic drugs" 06/01/2006 - "Myoclonic-astatic epilepsy in early childhood is one of the malignant epilepsy syndromes that often proves refractory to antiepileptic drugs treatment" 01/01/1993 - "All patients receiving VPA in mono- or polytherapy had a higher activity than those receiving other anticonvulsants (16.4 +/- 8.4 vs. 9.9 +/- 3.9 pmol/min/mg, P < 0.001), the activity in Lennox syndrome and myoclonic epilepsies being significantly higher than in those with absences and partial epilepsy" 04/01/1998 - "Finally, the interaction of the non-NMDA receptor antagonist with antiepileptic drugs does not seem promising in the pentetrazol test, recognized as a model of human myoclonic epilepsy." Order ALL the reference details at left...
6.	etiracetam (levetiracetam)FDA Link 07/17/2007 - "OBJECTIVE: To conduct an open-label, add-on trial on safety and efficacy of levetiracetam in severe myoclonic epilepsy of infancy (SMEI)" 07/17/2007 - "An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy." 07/17/2007 - "CONCLUSION: Levetiracetam add-on is effective and well tolerated in severe myoclonic epilepsy of infancy" 09/01/2006 - "We report on a 3-year-old boy with myoclonic-astatic epilepsy who developed myoclonic status epilepticus with continuous twitching of the face and unresponsiveness under monotherapy with levetiracetam" 09/01/2006 - "Levetiracetam-induced myoclonic status epilepticus in myoclonic-astatic epilepsy: a case report." Order ALL the reference details at left...
7.	SaltsIBA 06/03/1989 - "Myoclonic encephalopathy caused by bismuth salts" 05/01/1980 - "Research conducted by INSERM on myoclonic encephalopathies induced by the insoluble salts of bismuth used in gastroenterology]" 06/01/1977 - "Acute myoclonic encephalopathy related to the ingestion of bismuth salts has been known for 3 years and would appear to be reversible" 07/24/1976 - "Myoclonic encephalopathy due to bismuth salts" 02/01/1976 - "Iatrogenic myoclonic encephalopathies caused by bismuth salts]" Order ALL the reference details at left...
8.	lamotrigine (Lamictal)FDA LinkGeneric 09/01/1995 - "Lamotrigine can be helpful for severe myoclonic epilepsy and myoclonic absences" 03/01/2000 - "In severe myoclonic epilepsy of infancy, there is a nearly constant aggravating effect of lamotrigine" 01/01/1998 - "Recent evidence indicates that lamotrigine is inappropriate in severe myoclonic epilepsy" 01/01/1998 - "Severe myoclonic epilepsy of infants usually worsens with lamotrigine, but occasionally, children improve" 05/01/1998 - "Lamotrigine and seizure aggravation in severe myoclonic epilepsy." Order ALL the reference details at left...
9.	VigabatrinIBA 06/01/1997 - "These occurred most often in patients with nonprogressive myoclonic epilepsy; therefore vigabatrin should be used with particular caution in such patients." 11/01/1993 - "Vigabatrin has been shown to aggravate "nonprogressive myoclonic epilepsies." Vigabatrin has been well tolerated in children, with mild drowsiness and agitation being the most commonly reported side effects." 01/01/2006 - "Vigabatrin caused rapidly progressive deterioration in two cases with early myoclonic encephalopathy associated with nonketotic hyperglycinemia." 11/01/1999 - "CONCLUSIONS: STP seems to be a promising add-on drug, particularly when combined with CBZ in patients with partial childhood epilepsy refractory to vigabatrin (VGB) and with CLB in patients with severe myoclonic epilepsy in infancy." 12/01/1993 - "Vigabatrin is also effective in infantile spasms, but seems to have negative effects on myoclonic epilepsies and absence seizures" Order ALL the reference details at left...
10.	Clonazepam (Rivotril)FDA LinkGeneric 01/01/1973 - "Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy" 11/01/1995 - "Clonazepam prophylaxis and busulfan-related myoclonic epilepsy in autografted acute leukemia patients." 11/01/1976 - "Clonazepam is also at least as effective as current treatment in psychomotor and myoclonic epilepsies, but seems unlikely to replace phenytoin and the barbiturates in the treatment of grand mal or focal motor seizures except in patients resistant to standard therapy" 07/01/1987 - "Myoclonic epilepsy is considered resistant to antiepileptic drugs other than clonazepam and valproate, but two of our patients responded well to clobazam." 07/01/1981 - "In the hyperkinetic syndromes (Huntington's chorea, idiopathic tremor, myoclonic epilepsy, hyperkinetic torsion dystonia) preparations of phenothiazine, butyrophenone and new drugs active on the GABAergic system (Baclophen, Lyoresal, Pantogam) and diazepine (Clonazepam) were used" Order ALL the reference details at left...

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 11/18/1981 - "Chronological study of signs of myoclonic encephalopathy in hemodialysis patients (author's transl)]" Order ALL the reference details at left...
2.	High-Frequency Ventilation 01/01/1999 - "Somatosensory evoked high-frequency oscillation in Parkinson's disease and myoclonus epilepsy." 08/01/2003 - "To evaluate recovery function of and effects of hyperventilation (HV) on high-frequency oscillations (HFOs) of median nerve somatosensory evoked potential (SEP), we recorded SEPs in 8 Parkinson's disease (PD) patients with enlarged HFOs, 4 myoclonus epilepsy (ME) patients and 10 healthy volunteers (N)" 08/01/2003 - "Recovery function of and effects of hyperventilation on somatosensory evoked high-frequency oscillation in Parkinson's disease and myoclonus epilepsy." 05/01/2000 - "Modulation of high-frequency oscillations versus electric and magnetic N20, N20 (m), primary response by a wake-sleep cycle, by attention or interference, by aging, and in central nervous system diseases such as Parkinson's disease and myoclonus epilepsy are also presented" Order ALL the reference details at left...
3.	Psychosurgery (Lobotomy) 07/01/1957 - "The possible focal cortical genesis of some types of myoclonic epilepsy disclosed by performing a prefrontal lobotomy.]" 01/01/1954 - "Applications of psychosurgery to the treatment of dyskinesias; case of myoclonus epilepsy with continuous rhythmic clonus of the upper extremities.]" Order ALL the reference details at left...
4.	Withholding Treatment 01/01/1986 - "After cessation of treatment in 28 seizure-free patients, no recurrence was observed in absence epilepsy, benign myoclonic epilepsy, infantile spasms or benign partial epilepsy, whereas two thirds of the patients with generalized tonic-clonic seizures on awakening relapsed in the year following the cessation of the treatment." Order ALL the reference details at left...
5.	Exercise (Aerobic Exercise) 02/01/1989 - "31P-NMR spectra were obtained from the quadriceps femoris muscle (at rest and after aerobic exercise) of the 7 cases of mitochondrial myopathies (2 cases of mitochondrial encephalomyopathy and lactic acidosis(MELA), 1 case of myoclonus epilepsy with regged red fiber, 1 case of Kearns-Sayre syndrome, 3 cases of progressive external ophthalmoplegia), using superconducting whole body MR (Magnetom, Siemens)" Order ALL the reference details at left...