|3.||Partial Epilepsies (Epilepsy, Partial)
|4.||Absence Epilepsy (Absence Seizure)
|5.||Juvenile Myoclonic Epilepsy
|1.||Sander, Thomas: 28 articles (09/2015 - 04/2002)|
|2.||Berkovic, Samuel F: 23 articles (11/2015 - 02/2002)|
|3.||Lerche, Holger: 17 articles (09/2015 - 04/2003)|
|4.||Scheffer, Ingrid E: 16 articles (11/2015 - 02/2002)|
|5.||Stephani, Ulrich: 15 articles (09/2015 - 02/2006)|
|6.||Sander, T: 14 articles (02/2012 - 04/2000)|
|7.||Zara, Federico: 13 articles (10/2015 - 05/2002)|
|8.||Heils, Armin: 13 articles (04/2007 - 04/2002)|
|9.||Nürnberg, Peter: 12 articles (09/2015 - 04/2002)|
|10.||Berkovic, S F: 12 articles (08/2010 - 10/2000)|
|1.||Lennox-Gastaut type Epileptic encephalopathyIBA
05/01/2004 - "Limited evidence suggests that LTG and TPM also are effective for adjunctive treatment of idiopathic generalized epilepsy in adults and children, as well as treatment of the Lennox-Gastaut syndrome. "
06/01/2011 - "In the present study, we investigated whether iEEG source imaging is a useful supplementary tool for identifying extended epileptogenic sources in secondary generalized epilepsy such as Lennox-Gastaut syndrome (LGS). "
04/01/2012 - "Eight (50%) patients had generalized epilepsy including 4 with Lennox-Gastaut syndrome. "
02/01/2012 - "General (adult) neurologists are under the erroneous impression that Lennox-Gastaut syndrome is limited to childhood, and this common misconception indicates a lack of understanding of the group of generalized epilepsies. "
01/01/2012 - "Lennox-Gastaut syndrome (LGS) is a devastating and refractory generalized epilepsy affecting children and adolescents. "
|2.||lamotrigine (Lamictal)FDA LinkGeneric
10/01/2002 - "Lamotrigine is effective in the treatment of partial and generalized seizure disorders and often prescribed by neurologists and pediatricians because of its effectiveness in children with idiopathic, resistant generalized seizure disorders; it lacks cognitive impairment. "
04/01/2002 - "Lamotrigine administered as monotherapy or adjunctive therapy for an average of 2 years (96.7 weeks) was well tolerated and effective in pediatric patients with partial or generalized epilepsy. "
09/01/1999 - "Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study."
05/01/1998 - "The efficacy of lamotrigine in children and adolescents with refractory generalized epilepsy: a randomized, double-blind, crossover study."
10/01/2008 - "Imaging the cortical effect of lamotrigine in patients with idiopathic generalized epilepsy: a low-resolution electromagnetic tomography (LORETA) study."
|3.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
01/01/2003 - "Depakine is concluded to be an effective medication for the treatment of idiopathic generalized epilepsy."
06/01/2011 - "44 children with idiopathic, generalized epilepsy treated with valproic acid (VPA), and 40 control group children were included in this study. "
07/01/2009 - "In this study 27 patients with focal or generalized epilepsy receiving a single dosage of prolonged-release valproate given in the evening were included. "
08/01/2002 - "Eligible patients were between the ages of 12 and 65 years with primary generalized epilepsy, which was controlled over the month prior to study enrollment with divalproex or valproic acid 1000 mg to 2000 mg/day. "
11/01/1988 - "A double blind cross over trial of Sodium Valproate (Na VPA) vs Magnesium Valproate (Mg VPA) was performed in 122 patients affected by focal or generalized epilepsies. "
|4.||Anticonvulsants (Antiepileptic Drugs)IBA
12/01/2015 - "The aim of this study was to examine efficacy and tolerability of such a diet as an adjuvant therapy to antiepileptic drugs for adult patients with pharmacoresistant generalized epilepsy. "
05/01/2006 - "In total, 44 men with generalized epilepsy were included in this study, their ages between 18 and 48 years (29.2+/-9.9) and duration of illness between 2 and 35 years (11.2+/-7.4); 34 patients were treated with conventional antiepileptic drugs (AEDs). "
01/01/2005 - "Further randomized controlled trials of older antiepileptic drugs are recommended to solidify the evidence-based treatment of the idiopathic generalized epilepsies."
01/01/2015 - "Choice of Antiepileptic Drugs in Idiopathic Generalized Epilepsy: UAE Experience."
11/01/2011 - "Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? "
|5.||topiramate (Topamax)FDA LinkGeneric
08/01/1998 - "Limited open label trials have shown that topiramate has broad spectrum activity and may be effective in patients with primary generalized epilepsies. "
05/01/2011 - "[Short-term and long-term efficacy of topiramate in refractory generalized epilepsy of children]."
05/01/2011 - "Topiramate (TPM) was administered to 25 children with intractable generalized epilepsy. "
06/01/2010 - "We report the case of a 21-year-old man with idiopathic generalized epilepsy who ingested about 8,000 mg of topiramate (TPM) in a suicide attempt. "
12/01/2007 - "Topiramate in the treatment of partial and generalized epilepsy."
|6.||Immunoglobulin E (IgE)IBA
01/01/2005 - "The aim of the study was to evaluate efficacy of antiepileptic therapy (AT) in patients with juvenile types of idiopathic generalized epilepsy (IGE) and to elucidate factors that may reduce it. "
11/01/2015 - "Studies using quantitative neuroimaging have shown subtle abnormalities in patients with idiopathic generalized epilepsy (IGE). "
05/01/2015 - "Numerous resting-state fMRI studies have demonstrated altered functional connectivity within canonical intrinsic connectivity networks (ICNs) in patients with idiopathic generalized epilepsy (IGE). "
01/01/2015 - "Different studies have investigated by means of EEG-fMRI coregistration the brain networks related to generalized spike-and-wave discharges (GSWD) in patients with idiopathic generalized epilepsy (IGE). "
12/01/2014 - "Furthermore, clinical studies indicate that patients diagnosed with idiopathic generalized epilepsy (IGE) exhibit focal electroencephalographic abnormalities, which involve the thalamo-cortical circuitry. "
|7.||zonisamide (Zonegran)FDA LinkGeneric
12/01/2004 - "This case report suggests that zonisamide may be effective in the treatment of medication-resistant idiopathic generalized epilepsy and that it may lead to a significant improvement of the EEG."
03/01/2009 - "The objective of this study is to evaluate the efficacy and safety of zonisamide (ZNS) for the treatment of idiopathic generalized epilepsies (IGEs). "
03/30/2011 - "Our clinical experience with zonisamide in resistant generalized epilepsy syndromes."
03/01/2009 - "Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy."
06/01/2008 - "Zonisamide decreases cortical excitability in patients with idiopathic generalized epilepsy."
|8.||etiracetam (levetiracetam)FDA LinkGeneric
02/01/2005 - "Most studies suggest that levetiracetam is effective against partial and generalized epilepsy. "
09/01/2005 - "Clinical experience in open-label studies and anectodal reports suggest that levetiracetam is effective in generalized epilepsy. "
07/01/2009 - "Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: analysis of two randomized, double-blind, placebo-controlled studies."
03/01/2009 - "Aim of this study was to evaluate the effect of levetiracetam (LEV) on EDs, monitored with ambulatory EEG (A/EEG), in a limited series of patients with generalized epilepsy. "
01/01/2008 - "Levetiracetam efficacy in idiopathic generalized epilepsy: long suspected and now confirmed in randomized clinical trials."
|9.||Carbamazepine (Tegretol)FDA LinkGeneric
08/01/2009 - "Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation."
05/01/1999 - "Carbamazepine is used to manage generalized tonic-clonic, partial, and mixed partial and generalized seizure disorders in children. "
03/01/2014 - "Carbamazepine treatment of generalized tonic-clonic seizures in idiopathic generalized epilepsy."
01/01/2008 - "Some drugs, such as carbamazepine when used to treat primary generalized epilepsy, can exacerbate certain seizure types. "
08/01/2005 - "We describe two patients with idiopathic generalized epilepsy in whom nonconvulsive status epilepticus, aggravated by carbamazepine, was misdiagnosed as psychiatric disorder. "
01/01/2012 - "Lacosamide use in refractory idiopathic primary generalized epilepsy."
05/01/2007 - "This paper comprises a series of experiments in rodent models of partial and generalized epilepsy which were designed to describe the anti-convulsant profile of the functionalized amino acid lacosamide. "
04/01/2012 - "The role of lacosamide in treatment of idiopathic generalized epilepsy including juvenile myoclonic epilepsy is unknown. "
07/01/2013 - "The clinical use of lacosamide may broaden, pending results of trials evaluating its use as monotherapy for POS in adults, as treatment for epilepsy in pediatric subjects, and as adjunctive treatment for uncontrolled primary generalized tonic-clonic seizures in those with idiopathic generalized epilepsy. "
01/01/2012 - "Here we describe the cases of two young women with refractory idiopathic primary generalized epilepsy refractory to multiple antiepileptic drugs in monotherapy or combination before achieving a long-term remission with adjunctive lacosamide (LCS) treatment. "
02/01/2002 - "This initial experience with the ketogenic diet was effective in difficult-to-treat patients with partial and generalized epilepsies, though its efficacy dropped significantly by 9-12 months."
02/01/2002 - "This collaborative study by three Italian groups of child neuropsychiatrists was carried on to evaluate the efficacy and safety of the classic 4:1 ketogenic diet as add-on treatment in refractory partial or generalized epilepsy in children, adolescents and young adults. "
01/01/2015 - "Ketogenic diet therapy (KD) has been used to treat children with refractory generalized epilepsy. "
11/01/2011 - "We evaluated the ability of the ketogenic diet (KD) to improve thresholds to flurothyl-induced seizures in two mouse lines with Scn1a mutations: one that models Dravet syndrome (DS) and another that models genetic (generalized) epilepsy with febrile seizures plus (GEFS+). "
|2.||Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
02/01/2013 - "The modified Atkins diet (MAD) has been reported as effective for idiopathic generalized epilepsy and is increasingly being used in adolescents and adults. "
12/01/2015 - "A prospective study of the modified Atkins diet for adults with idiopathic generalized epilepsy."
12/01/2015 - "In conclusion, using a modified Atkins diet for 12weeks led to a clinically relevant reduction of seizure frequency in four of thirteen adult patients with pharmacoresistant generalized epilepsy. "
|3.||Deep Brain Stimulation
12/08/2009 - "These results may help to understand the clinical effect of deep brain stimulation within thalamic nuclei in intractable idiopathic generalized epilepsy patients."
01/01/2015 - "Thalamus, especially the mediodorsal nuclei, may serve as potential targets for deep brain stimulation to provide more effective treatment options for patients with drug-resistant generalized epilepsy. "
|4.||Vagus Nerve Stimulation
11/01/2013 - "A prospective long-term study on the outcome after vagus nerve stimulation at maximally tolerated current intensity in a cohort of children with refractory secondary generalized epilepsy."
11/01/2001 - "Although the use of vagus nerve stimulation in children has increased, including those younger than 12 years of age or those with generalized epilepsy, there has been no large controlled pediatric study to date. "
11/01/2013 - "We report the outcome after vagus nerve stimulation (VNS) in children with secondary generalized epilepsy. "
09/01/2012 - "Vagus nerve stimulation for partial and generalized epilepsy from infancy to adolescence."
03/01/2008 - "Vagus nerve stimulation for generalized epilepsy?...Show me the evidence!"
|5.||Palliative Care (Palliative Medicine)
01/01/2011 - "Prospective, randomized trials are needed for patients with generalized epilepsies and for younger children to potentially expand the number of patients who may benefit from this palliative treatment."
05/01/1998 - "Corpus callosotmy was introduced in 1940 as a palliative treatment for generalized epilepsies. "