Generalized Epilepsy

639  relevant articles (32 outcomes, 85 trials/studies) found for this Disease

Epilepsy, Generalized; Convulsive Seizure Disorder, Generalized; Epilepsy, Akinetic; Epilepsy, Atonic; Generalized Convulsive Epilepsy; Generalized Nonconvulsive Epilepsy; Generalized Onset Seizure Disorder; Generalized Seizure Disorder, Convulsive; Generalized Seizure Disorder, Nonconvulsive; Nonconvulsive Generalized Seizure Disorder; Nonconvulsive Seizure Disorder, Generalized; Seizure Disorder, Convulsive, Generalized; Seizure Disorder, Generalized Nonconvulsive; Seizure Disorder, Generalized Onset; Seizure Disorder, Generalized, Convulsive; Seizure Disorder, Nonconvulsive Generalized; Symptomatic Generalized Epilepsy; Akinetic Epilepsies; Akinetic Epilepsy; Atonic Epilepsies; Atonic Epilepsy; Convulsive Epilepsies, Generalized; Convulsive Epilepsy, Generalized; Epilepsies, Akinetic; Epilepsies, Atonic; Epilepsies, Generalized; Epilepsies, Generalized Convulsive; Epilepsies, Tonic; Epilepsy, Generalized Convulsive; Epilepsy, Generalized Nonconvulsive; Epilepsy, Symptomatic Generalized; Generalized Convulsive Epilepsies; Generalized Epilepsies; Generalized Epilepsy, Symptomatic; Generalized Seizure Disorder; Generalized Seizure Disorders; Nonconvulsive Epilepsy, Generalized; Seizure Disorders, Generalized; Tonic Epilepsies; Tonic Epilepsy; Convulsive Generalized Seizure Disorder; Epilepsy, Tonic; Generalized Nonconvulsive Seizure Disorder; Seizure Disorder, Generalized

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Seizures (Seizure)
2.	Partial Epilepsies (Epilepsy, Partial)
3.	Syndrome
4.	Epilepsy (Aura)
5.	Febrile Seizures (Febrile Seizure)

Experts

1.	Sander, T: 7 articles (02/2005 - 04/2000)
2.	Sander, Thomas: 5 articles (04/2006 - 04/2002)
3.	Berkovic, S F: 4 articles (10/2007 - 04/2001)
4.	Heils, Armin: 4 articles (04/2006 - 04/2002)
5.	Heils, A: 4 articles (02/2005 - 04/2000)
6.	Boehrer, Any: 3 articles (03/2008 - 01/2003)
7.	Nehlig, Astrid: 3 articles (03/2008 - 01/2003)
8.	Scheffer, I E: 3 articles (08/2007 - 04/2001)
9.	Wallace, R H: 3 articles (08/2007 - 04/2001)
10.	Mulley, J C: 3 articles (08/2007 - 04/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Generalized Epilepsy:

1.	lamotrigine (Lamictal)FDA LinkGeneric 10/01/2002 - "Lamotrigine is effective in the treatment of partial and generalized seizure disorders and often prescribed by neurologists and pediatricians because of its effectiveness in children with idiopathic, resistant generalized seizure disorders; it lacks cognitive impairment" 04/01/2002 - "Lamotrigine administered as monotherapy or adjunctive therapy for an average of 2 years (96.7 weeks) was well tolerated and effective in pediatric patients with partial or generalized epilepsy" 05/01/1998 - "The efficacy of lamotrigine in children and adolescents with refractory generalized epilepsy: a randomized, double-blind, crossover study." 10/01/2008 - "Imaging the cortical effect of lamotrigine in patients with idiopathic generalized epilepsy: A low-resolution electromagnetic tomography (LORETA) study." 04/01/1997 - "Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy." Order ALL the reference details at left...
2.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 01/01/2003 - "Depakine is concluded to be an effective medication for the treatment of idiopathic generalized epilepsy." 08/01/2002 - "METHODS: Eligible patients were between the ages of 12 and 65 years with primary generalized epilepsy, which was controlled over the month prior to study enrollment with divalproex or valproic acid 1000 mg to 2000 mg/day" 11/01/1988 - "A double blind cross over trial of Sodium Valproate (Na VPA) vs Magnesium Valproate (Mg VPA) was performed in 122 patients affected by focal or generalized epilepsies" 04/01/2008 - "Valproate decreases EEG synchronization in a use-dependent manner in idiopathic generalized epilepsy." 07/01/2007 - "Valproate selectively reduces EEG activity in anterior parts of the cortex in patients with idiopathic generalized epilepsy" Order ALL the reference details at left...
3.	topiramate (Topamax)FDA Link 08/01/1998 - "Limited open label trials have shown that topiramate has broad spectrum activity and may be effective in patients with primary generalized epilepsies" 01/01/2003 - "PURPOSE: The antiepileptic effects of topiramate (TPM) were assessed in two models of genetically determined generalized epilepsy" 01/01/2003 - "Effects of topiramate in two models of genetically determined generalized epilepsy, the GAERS and the Audiogenic Wistar AS." 01/01/2000 - "Use of topiramate in childhood generalized seizure disorders." 04/01/1997 - "Preliminary data suggest that topiramate may be effective also in generalized epilepsies, but this needs to be confirmed in prospective studies" Order ALL the reference details at left...
4.	zonisamide (Zonegran)FDA LinkGeneric 12/01/2004 - "This case report suggests that zonisamide may be effective in the treatment of medication-resistant idiopathic generalized epilepsy and that it may lead to a significant improvement of the EEG." 06/01/2008 - "Zonisamide decreases cortical excitability in patients with idiopathic generalized epilepsy." 01/01/2007 - "Nine hundred twenty-eight children and 584 adult (ages 1 month to 79 years), including 372 newly-diagnosed patients, received zonisamide for partial and generalized epilepsies" 12/01/2004 - "Zonisamide, a newer antiepileptic drug (AED) with multiple mechanisms of action, has been increasingly used in patients with generalized epilepsies" 12/01/2004 - "Nine hundred twenty-eight children and 584 adults (ages 1 month to 79 years), including 372 newly-diagnosed patients, received zonisamide for partial and generalized epilepsies" Order ALL the reference details at left...
5.	Anticonvulsants (Antiepileptic Drugs)IBA 05/01/2006 - "In total, 44 men with generalized epilepsy were included in this study, their ages between 18 and 48 years (29.2+/-9.9) and duration of illness between 2 and 35 years (11.2+/-7.4); 34 patients were treated with conventional antiepileptic drugs (AEDs)" 01/01/2005 - "Further randomized controlled trials of older antiepileptic drugs are recommended to solidify the evidence-based treatment of the idiopathic generalized epilepsies." 03/01/2008 - "Taken together, these results support the concept that SV2A protein is an important target for both partial and generalized epilepsies and thereby relevant for the generation of new antiepileptic drugs with potential broad-spectrum efficacy." 09/01/2007 - "Old and new antiepileptic drugs for the treatment of idiopathic generalized epilepsies." 06/01/2007 - "Antiepileptic drugs have been reduced, and generalized epilepsy was the most sensitive" Order ALL the reference details at left...
6.	etiracetam (levetiracetam)FDA Link 02/01/2005 - "Most studies suggest that levetiracetam is effective against partial and generalized epilepsy" 09/01/2005 - "Clinical experience in open-label studies and anectodal reports suggest that levetiracetam is effective in generalized epilepsy" 01/01/2008 - "Levetiracetam efficacy in idiopathic generalized epilepsy: long suspected and now confirmed in randomized clinical trials." 10/30/2007 - "Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy." 09/01/2006 - "Levetiracetam reduces frequency and duration of epileptic activity in patients with refractory primary generalized epilepsy." Order ALL the reference details at left...
7.	Immunoglobulin E (IgE)IBA 01/01/2005 - "The aim of the study was to evaluate efficacy of antiepileptic therapy (AT) in patients with juvenile types of idiopathic generalized epilepsy (IGE) and to elucidate factors that may reduce it" 07/15/2008 - "Subsequently, an association study was conducted for all discovered variants in a case-control sample comprising 459 German patients with idiopathic generalized epilepsy (IGE) and 462 population controls" 01/01/2008 - "In the present study we describe the mutation analysis of HCN1 and HCN2 in 84 unrelated patients with idiopathic generalized epilepsy (IGE)" 10/01/2006 - "Five SNPs, including A118G, were investigated by association studies in a sample of 240 probands with idiopathic generalized epilepsy (IGE), including 110 with IAE, and 257 controls" 07/15/2006 - "Recent studies have demonstrated thalamic and cortical fMRI signal changes in association with GSW in idiopathic generalized epilepsy (IGE)" Order ALL the reference details at left...
8.	Carbamazepine (Tegretol)FDA LinkGeneric 05/01/1999 - "Carbamazepine is used to manage generalized tonic-clonic, partial, and mixed partial and generalized seizure disorders in children" 01/01/2008 - "Some drugs, such as carbamazepine when used to treat primary generalized epilepsy, can exacerbate certain seizure types" 08/01/2005 - "We describe two patients with idiopathic generalized epilepsy in whom nonconvulsive status epilepticus, aggravated by carbamazepine, was misdiagnosed as psychiatric disorder" 10/01/2001 - "Patients with generalized epilepsy (p = 0.01), who were not receiving carbamazepine (CBZ; p = 0.02) were more likely to become seizure-free" 09/01/1994 - "Carbamazepine (CBZ) therapy was associated with development of absence seizures in 4 adults with generalized epilepsy" Order ALL the reference details at left...
9.	BenzodiazepinesIBA 01/01/2000 - "PET: central benzodiazepine neuroreceptor mapping in generalized epilepsies." 07/09/2004 - "The present results are also consistent with recent findings that mutation of the gamma2 subunit of the GABAA receptor changes benzodiazepine modulation in families with generalized epilepsy syndromes." 01/01/1983 - "Both our personal experience and the findings of others indicate that the benzodiazepines (a) are the drugs of first choice for control of status epilepticus occurring in patients with primary generalized epilepsy (90%-100% effective) or control of hemiclonic convulsions in children without brain lesions, (b) are effective in approximately 60% of cases of status epilepticus occurring in partial epilepsy, (c) are effective in only 15% to 59% of cases of tonic status or various types of absence status occurring in secondary generalized epilepsy (but no other drug is more effective), (d) are helpful in status epilepticus occurring in nonepileptic patients if there is no overt brain lesion (but give only temporary relief when status is the result of a severe organic brain lesion), and (e) are generally safe drugs." 02/01/1995 - "Benzodiazepine-GABAA receptors in idiopathic generalized epilepsy measured with [11C]flumazenil and positron emission tomography." 01/01/1988 - "Secondary generalized epilepsy in childhood: EEG patterns and correlation with responsiveness to benzodiazepines or ACTH (preliminary note)." Order ALL the reference details at left...
10.	mexidolIBA 05/01/2005 - "Using Depakin in combination with Mexidol in the study group of patients with generalized epilepsy, improvement of clinical picture of disease and normalization of EEG patterns in 93% of cases has been observed" 05/01/2005 - "Mexidol titrated to the target doze of 5mg/kg may be effective in combination with Depakin for treatment of patients with generalized epilepsy and as monotherapy in patients with first episode of febrile seizures." 05/01/2005 - "Mexidol in treatment of children with generalized epilepsy and febrile seizures]" Order ALL the reference details at left...

Therapies and Procedures

1.	Hypnosis (Mesmerism) 01/01/1991 - "A study was made of brain bioelectric activity in patients with secondarily generalized epilepsy under hypnosis" Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 03/01/2006 - "Teenage onset, coexistent spontaneous seizure, and associated idiopathic generalized epilepsies were crucial factors in the determination of antiepileptic drug therapy" 05/01/1999 - "These factors include: (1) diagnosis of generalized seizure disorder, (2) diagnosis of organic mental disorder, (3) concurrent pharmacotherapy with medications implicated in lowering the seizure threshold, and (4) abrupt change in pharmacotherapy" 06/01/1990 - "Factors that were found likely to interfere with a reduction in antiepileptic drug therapy to one drug modality included: symptomatic etiology, prolonged duration of illness, low age at onset and secondary generalized epilepsy with a large number of seizures in combination, for generalized epilepsies; symptomatic etiology, prolonged duration of illness, low age at onset, other than occipital lobe origin, complex partial seizure with secondary generalization, temporal lobe epilepsy with associated automatisms, elementary sensorimotor seizure and high frequency of seizures, for partial epilepsies" 12/01/2004 - "In 50 patients with generalized epilepsies, and 19 with undetermined epilepsies and specific syndromes, seizure frequency was reduced by >50% with monotherapy or two-drug therapy with zonisamide" Order ALL the reference details at left...
3.	Electrodes (Electrode) 08/01/2000 - "Outcomes using ESCM for generalized epilepsy were better in patients in whom anatomic and electrophysiological confirmation of electrode placement was correct than in those in whom the target was missed bilaterally (P < 0.001)" 09/01/1991 - "Eight rats of the WAG/Rij strain, an animal model for idiopathic generalized epilepsy of the absence type, which were equipped with cortical EEG and nuchal EMG electrodes, served as subjects" 12/01/1997 - "METHODS: Simultaneous registrations of scalp electroencephalograms, with electrodes placed according to the 10-20 System, and transcranial Doppler recordings of both middle cerebral arteries were performed in 27 patients (9 with primary generalized epilepsy, 18 with focal epilepsy)" Order ALL the reference details at left...
4.	Anterior Temporal Lobectomy 11/01/2008 - "Fifteen patients with well-characterized unilateral hippocampal sclerosis, 15 patients who had undergone unilateral anterior temporal lobectomy (ATL), and a comparison group consisting of 15 patients with idiopathic generalized epilepsy and 25 neurologically healthy participants explored a novel virtual environment" 10/01/1991 - "The subjects consisted of: (i) a control group of patients with primary generalized epilepsy; (ii) patients who had undergone either a left or a right anterior temporal lobectomy; (iii) unoperated patients with either left or right unilateral temporal lobe epilepsy" 11/01/2008 - "Performance of temporal lobe epilepsy (TLE) patients (either unilateral hippocampal sclerosis or anterior temporal lobectomy) on the different spatial memory variables, namely navigation, object location and plan drawing, was significantly worse relative to the comparison groups (either idiopathic generalized epilepsy or controls)" Order ALL the reference details at left...
5.	Split-Brain Procedure (Split-Brain) 06/01/1982 - "Telencephalic theory of generalized epilepsy: observations in split-brain patients." Order ALL the reference details at left...