|4.||Infantile Spasms (West Syndrome)
|5.||Temporal Lobe Epilepsy
|1.||Marson, Anthony G: 23 articles (08/2015 - 03/2007)|
|2.||Marson, A G: 15 articles (01/2008 - 01/2000)|
|3.||Ryvlin, Philippe: 13 articles (07/2015 - 09/2004)|
|4.||Perucca, Emilio: 11 articles (09/2015 - 03/2005)|
|5.||Brodie, Martin J: 10 articles (11/2015 - 01/2004)|
|6.||Verrotti, Alberto: 10 articles (01/2015 - 11/2005)|
|7.||Hutton, Jane L: 10 articles (09/2014 - 01/2008)|
|8.||Matsumoto, Riki: 9 articles (10/2015 - 05/2004)|
|9.||Schulze-Bonhage, A: 9 articles (04/2013 - 02/2000)|
|10.||Elger, C E: 9 articles (10/2012 - 02/2000)|
|1.||Carbamazepine (Tegretol)FDA LinkGeneric
04/01/2012 - "Arm A included patients for whom carbamazepine was considered the first-line treatment, most of whom were newly diagnosed with focal epilepsy. "
04/01/2014 - "Carbamazepine monotherapy may be a relatively safe and cost effective treatment option for women with focal epilepsy syndromes during pregnancy. "
06/01/2007 - "(1) The first-line treatment for patients with partial epilepsy is carbamazepine monotherapy. "
02/01/2009 - "The study population of 29 children (16 male, 13 female; age range, 3-12 years) diagnosed with partial epilepsy were enrolled within 14 days of starting carbamazepine. "
01/01/1998 - "Patients with newly diagnosed localization-related epilepsy who participated in a VGB-carbamazepine (CBZ) monotherapy trial were included. "
|2.||topiramate (Topamax)FDA LinkGeneric
06/01/2004 - "Topiramate has been proven to be effective in patients with refractory chronic partial epilepsies in short-term controlled clinical trials, but the long-term retention, long-term efficacy, and long-term side-effect profile have not been sufficiently investigated. "
01/01/2000 - "Topiramate has been shown to be safe and effective in refractory partial epilepsy in children. "
10/01/2004 - "(3) A dose-finding study of 48 patients with refractory partial epilepsy suggests that the efficacy of topiramate monotherapy is dose-dependent. "
06/01/1996 - "We conducted a multicenter, double-blind, randomized, parallel, placebo-controlled trial in 190 patients to evaluate the safety and efficacy of three dosages of topiramate (600, 800, and 1,000 mg/day) as adjunctive therapy for patients with refractory partial epilepsy. "
01/01/2001 - "The efficacy of topiramate was demonstrated in partial epilepsy, but the other indications remain to be précised. "
|3.||etiracetam (levetiracetam)FDA LinkGeneric
12/01/2000 - "Levetiracetam (LEV) is an interesting novel antiepileptic drug with proven efficacy in both animal models and patients with partial epilepsy. "
01/01/2010 - "The drug withdrawals due to side effects was 5,6% in group 1 and 8,2% in group 2. The results of the study suggest high efficacy of levetiracetam in treatment of partial epilepsy."
03/01/2006 - "This open-label non-controlled study suggests an early efficacy of levetiracetam as add-on therapy in patients with refractory partial epilepsy: these results appear to confirm previous indications of a rapid onset of action and seem to suggest first evaluation of the patient at the dose of 500 mg/day before increasing to the considered minimum standard dose of 1000 mg/day, as some patients could respond to the starting dose."
12/01/2002 - "Levetiracetam may be more effective for late-onset partial epilepsy."
07/01/2008 - "Levetiracetam (LEV) is a new antiepileptic drug that is clinically effective in generalized and partial epilepsy syndromes as sole or add-on medication. "
|4.||Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
01/01/1999 - "Valproate, when the proper therapeutic dosage was belatedly realized, was seen as a superior treatment for generalized and partial epilepsies. "
10/04/1994 - "There seems no doubt, in reviewing the literature from controlled randomized studies, that valproate is effective in the treatment of partial epilepsy. "
07/01/2015 - "(4) Valproate should not be prescribed as a first-line treatment for focal epilepsy. "
01/01/2007 - "In 23% of patients with symptomatic partial epilepsy, 100% efficacy of depakine in the monotherapy was achieved. "
01/01/2003 - "The efficacy of divalproex for partial epilepsies."
|5.||lamotrigine (Lamictal)FDA LinkGeneric
07/01/2005 - "The antiepileptic drug lamotrigine is effective in the treatment of focal epilepsies. "
05/01/1997 - "The new antiepileptic drug lamotrigine (LTG; 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine) has been shown to be effective in the treatment of focal epilepsies with or without secondary generalization. "
02/01/2014 - "Standard clinical data were modesty adequate to predict response to the initial trial of lamotrigine in adult patients with localization related epilepsy. "
10/01/2000 - "We evaluated the efficacy and safety of lamotrigine in 41 children and young adults (age range, 3-25 years; mean, 12 years) with drug-resistant, partial epilepsies, based on a prospective, add-on study. "
10/01/2000 - "Add-on lamotrigine treatment in children and young adults with severe partial epilepsy: an open, prospective, long-term study."
|6.||zonisamide (Zonegran)FDA LinkGeneric
08/01/2013 - "Adjunctive zonisamide treatment was shown to be effective and well tolerated in pediatric patients with partial epilepsy. "
02/01/2013 - "Zonisamide seems to be effective and safe in focal epilepsy. "
01/01/2012 - "The clinical efficacy of adjunctive zonisamide therapy has been established in four pivotal, phase III, randomized, double-blind, placebo-controlled trials, which together included approximately 850 patients, aged 12-77 years, with refractory partial epilepsy. "
01/01/2015 - "The safety and long-term efficacy of zonisamide as adjunctive therapy for focal epilepsy."
04/01/2014 - "To investigate the safety/tolerability and efficacy of long-term adjunctive zonisamide and its impact on growth and development in children (6-18 years) with partial epilepsy. "
|7.||Anticonvulsants (Antiepileptic Drugs)IBA
09/01/2007 - "The efficacy of the new antiepileptic drugs is not superior to that of the first-generation antiepileptic drugs for patients with partial epilepsy. "
06/01/2010 - "aEEG is useful for continuous monitoring in children with acute encephalopathy, may disclose subclinical seizures, and can contribute to an objective evaluation of the efficacy of antiepileptic drugs."
06/27/2000 - "OXC is safe and effective in the treatment of patients with partial epilepsy previously receiving treatment with other antiepileptic drugs. "
01/01/1996 - "Clinical efficacy of new antiepileptic drugs in refractory partial epilepsy: experience in the United States with three novel drugs."
12/01/2014 - "Assessment of placebo and nocebo effects and evaluation of background incidence of some predefined adverse effects (AEs) of antiepileptic drugs (AEDs) in placebo-treated paediatric patients recruited in randomized controlled studies (RCTs) of refractory focal epilepsies. "
|8.||gabapentin (Neurontin)FDA LinkGeneric
02/01/1998 - "To evaluate the safety and efficacy of high dose gabapentin (GBP) monotherapy (3,000-4,800 mg/day) in patients with medically refractory partial epilepsy. "
02/01/1996 - "Gabapentin (GBP) has been shown to be effective an add-on drug for the treatment of refractory partial epilepsy. "
11/01/1993 - "Gabapentin, administered as add-on therapy, was safe and effective in this 12-week, multicenter, placebo-controlled, parallel-group study in 306 patients with refractory partial epilepsy. "
11/01/1998 - "Gabapentin at 900 or 1,800 mg/day is effective and safe as monotherapy for patients with newly diagnosed partial epilepsy."
11/01/1998 - "To investigate the efficacy of gabapentin administered as monotherapy in patients with newly diagnosed partial epilepsy, a randomized double-blind trial was performed. "
|9.||oxcarbazepine (Trileptal)FDA LinkGeneric
05/01/2007 - "This study prospectively examined whether continued add-on treatment with oxcarbazepine (OXC) is associated with quantitative improvement in mood and anxiety symptoms in adult patients with partial epilepsy. "
01/01/2003 - "As a result, we found oxcarbazepine safe and effective in children with either generalized or partial epilepsy."
01/01/2008 - "The data on therapeutical efficacy of the new antiepileptic drug trileptal (oxcarbazepine) and results of the own observations of 38 patients with partial epilepsy who received trileptal as mono- or polytherapy are presented. "
07/01/2015 - "The objective of this study was to explore the efficacy of low dose of oxcarbazepine (OXC) in adult patients with newly diagnosed partial epilepsy in an actual clinical setting. "
07/01/2015 - "Efficacy of low to moderate doses of oxcarbazepine in adult patients with newly diagnosed partial epilepsy."
|10.||Phenytoin (Dilantin)FDA LinkGeneric
07/24/2000 - "In phenytoin nonresponders, LTG and FBM significantly increased ADT, which is in line with their proven efficacy in patients with refractory partial epilepsy in whom phenytoin has failed. "
04/01/2000 - "In PHT nonresponders, TPM significantly increased ADT, which is in line with its proven efficacy in patients with refractory partial epilepsy in whom phenytoin has failed. "
07/24/2000 - "The data in this study reveal that phenytoin nonresponders are a unique model for the search for new AEDs with improved efficacy in refractory partial epilepsy."
06/01/2000 - "The data of this study substantiate that phenytoin nonresponders are a unique model for the search of new AEDs with improved efficacy in refractory partial epilepsy."
09/01/2000 - "The aim of the present study was to document the frequency of subclinical seizure activity in a cohort of patients with ALF by using a cerebral function and activity monitor that allows continuous recording of electroencephalogram activity at the bedside and to determine whether the prophylactic administration of the antiepileptic agent phenytoin would reduce its occurrence. "
04/01/1989 - "Subdural electrodes may be effective in localizing the onset and spread of simple partial seizures, including those that arise from the medial temporal lobe."
04/23/2002 - "Remission of intractable partial epilepsy following implantation of intracranial electrodes."
10/23/2001 - "Remission of intractable partial epilepsy following implantation of intracranial electrodes."
08/01/1996 - "Intracerebral depth electrode monitoring in partial epilepsy: the morbidity and efficacy of placement using magnetic resonance image-guided stereotactic surgery."
11/01/2010 - "In this study, we evaluated 25 patients with drug-refractory focal epilepsy by stereotactically implanting at least one electrode into the insular cortex using an oblique approach (transfrontal or transparietal). "
|2.||Vagus Nerve Stimulation
04/01/2013 - "Clinical studies have proven the efficacy of vagus nerve stimulation and in recent years also of stimulation of the trigeminal nerve, the anterior nucleus of the thalamus and of the epileptic focus in treating focal epilepsy. "
09/28/2004 - "A retrospective review of the safety, tolerability, and efficacy of vagus nerve stimulation (VNS) in 48 patients with intractable partial epilepsy was performed. "
04/12/1999 - "Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy."
06/01/2014 - "The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: the PuLsE (Open Prospective Randomized Long-term Effectiveness) trial."
05/01/2013 - "The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. "
|3.||Drug Therapy (Chemotherapy)
08/01/2014 - "Pharmacotherapy of focal epilepsy."
04/01/2013 - "Pharmacotherapy of focal epilepsy in children: a systematic review of approved agents."
10/01/2011 - "Therefore, we aimed to confirm the association of ABCC2 variants with pharmacotherapy-resistance in Caucasians mainly affected by partial epilepsy. "
01/01/2010 - "Intracranial pharmacotherapy is a novel strategy to treat drug refractory, localization-related epilepsies not amenable to resective surgery. "
10/01/2005 - "Regional hypometabolism in FDG-PET is not significantly associated with a lower likelihood of successful anticonvulsant drug therapy in patients with nonrefractory partial epilepsy. "
12/01/1999 - "The ketogenic diet shows promise in both adult generalized and partial epilepsy. "
10/01/2014 - "Patients with focal epilepsy and PED should undergo genetic testing and can benefit from a ketogenic diet. "
03/01/2013 - "This review discusses the different types of ketogenic diet, proposed mechanism of actions and its evidence for use in children and adults with both generalized and focal epilepsies where surgery is not feasible. "
04/01/2009 - "From the 70 patients who received the ketogenic diet during a 3-year period at our institution, we retrospectively selected patients with focal epilepsy. "
04/01/2009 - "The ketogenic diet improves recently worsened focal epilepsy."
|5.||Psychology Biofeedback (Biofeedback)
01/01/2001 - "Measures of depression and locus of control were administered to 20 patients with refractory partial epilepsy before and after biofeedback treatment. "
10/01/1997 - "Sixteen patients with partial epilepsy learned to produce positive or negative slow cortical potential shifts in a biofeedback condition during 20 consecutive training sessions. "
11/01/1996 - "Twenty sessions of biofeedback training were carried out with 12 drug-resistant patients with focal epilepsy who learned to produce either negative or positive shifts of their slow cortical potentials (SCPs) at vertex. "
01/01/2011 - "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."
01/01/2010 - "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."