Epidermal Cyst (Sebaceous Cyst)

Intradermal or subcutaneous saclike structure, the wall of which is stratified epithelium containing keratohyalin granules.

Also Known As:

Sebaceous Cyst; Sebaceous Cysts; Epidermoid Cyst; Cyst, Epidermal; Cyst, Epidermoid; Cyst, Pilar; Cyst, Sebaceous; Cysts, Epidermal; Cysts, Epidermoid; Cysts, Pilar; Cysts, Sebaceous; Epidermal Cysts; Epidermoid Cysts; Pilar Cysts; Pilar Cyst

Networked: 532 relevant articles (10 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 1324753
- Cysts: 25757
  - Epidermal Cyst: 532

Related Diseases

1.	Cysts
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
3.	Basal Cell Carcinoma (Rodent Ulcer)
4.	Infections
5.	Keloid

Experts

1.	Kim, Kyu Nam: 2 articles (01/2021 - 10/2019)
2.	Srinivasan, Visish M: 2 articles (01/2021 - 10/2019)
3.	Yoon, Chi Sun: 2 articles (01/2021 - 10/2019)
4.	Hu, Hui-Yong: 2 articles (02/2020 - 11/2018)
5.	Jiang, Hai-Yan: 2 articles (02/2020 - 11/2018)
6.	Wang, Hai-Rong: 2 articles (02/2020 - 11/2018)
7.	Xu, Yun-Feng: 2 articles (02/2020 - 11/2018)
8.	McDermott, Michael W: 2 articles (08/2019 - 04/2013)
9.	Sneed, Penny K: 2 articles (08/2019 - 04/2013)
10.	Xiao, Jianru: 2 articles (12/2017 - 03/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Epidermal Cyst:

1.	Carcinoembryonic AntigenIBA 06/01/1998 - "Epidermoid cyst of the spleen with CA19-9 or carcinoembryonic antigen productions: report of three cases." 03/01/1994 - "Multiple plantar epidermoid cysts harboring carcinoembryonic antigen and human papillomavirus DNA sequences." 12/01/1989 - "Carcinoembryonic antigen was immunohistochemically demonstrated in the center of the epidermoid cyst and the DAB reaction products took the shape of a circle resembling that of the sweat ducts in the horny layer." 02/01/1987 - "Carcinoembryonic antigen in epidermoid cyst fluid and plasma." 01/01/2010 - "Immunostaining for cytokeratin 17 and carcinoembryonic antigen showed strongly positive results in the Meibomian gland cysts and, by comparison, negative results in cutaneous epidermal cysts. "
2.	Imiquimod (Aldara)FDA LinkGeneric 03/01/2017 - "[Eruptive epidermoid cysts during topical imiquimod treatment]." 01/01/2007 - "Multiple and clustered eruptive epidermoid cysts following treatment with topical imiquimod." 07/01/2005 - "Eruptive epidermoid cysts resulting from treatment with imiquimod." 07/01/2005 - "The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy." 01/01/2009 - "As reported in the literature and as observed in our clinical experience, the occurrence of epidermoid cysts, after the topical treatment of basal cell carcinomas with imiquimod, may represent a local immune reaction that is drug-related and is a typical remission pattern in particular anatomical areas. "
3.	Keratin-17 (Keratin 17)IBA 03/01/2003 - "Mutation in the 1A domain of keratin 17 underlies the affected members' phenotype, PC-2 with early onset sebaceous cysts and late-onset thickened fingernails and toenails. " 03/01/2003 - "Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts." 01/01/2010 - "Immunostaining for cytokeratin 17 and carcinoembryonic antigen showed strongly positive results in the Meibomian gland cysts and, by comparison, negative results in cutaneous epidermal cysts. " 06/01/1997 - "We compared the patterns of keratin 10 (K10) and keratin 17 (K17) expression in epidermoid cysts, trichilemmal cysts, eruptive vellus hair cysts, and steatocystoma multiplex. "
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/10/2023 - "Patients with hypertrophic scars (HSs) or keloids occasionally have epidermoid cysts (ECs), and the effect of ECs on the effectiveness of intralesional corticosteroids (ILCs) treatment in these patients has not been reported. " 11/10/2023 - "Effect of Epidermoid Cysts on the Efficacy of Intralesional Corticosteroid Therapy for Hypertrophic Scars and Keloids: A Prospective Pilot Study." 08/01/2003 - "We describe the case of a patient with aseptic meningitis brought on by the rupture of an epidermoid cyst, which followed a subacute course and responded to corticoid therapy in a spectacular manner. "
5.	RetinoidsIBA 03/01/2014 - "We would like to recommend the possibility to administer retinoids in a squamous cell carcinoma, achieving very satisfactory results; in our case, a complete remission of malignant lesion and an improvement of epidermal cysts were made, without the development of side effects associated with retinoids. "
6.	ErbiumIBA 05/01/2015 - "Erbium:yttrium aluminum garnet laser fenestration might be a promising alternative to the surgical treatment of epidermal cysts, especially when the lesions are large or located in an aesthetically important area." 05/01/2015 - "To evaluate the safety and feasibility of erbium:yttrium aluminum garnet laser fenestration of epidermal cysts for patients concerned about scarring, from January 2010 to July 2013, 25 patients with cosmetic concerns underwent serial laser treatment using the fenestration technique to decompress the cyst contents. "
7.	yttrium-aluminum-garnetIBA 05/01/2015 - "Erbium:yttrium aluminum garnet laser fenestration might be a promising alternative to the surgical treatment of epidermal cysts, especially when the lesions are large or located in an aesthetically important area." 05/01/2015 - "To evaluate the safety and feasibility of erbium:yttrium aluminum garnet laser fenestration of epidermal cysts for patients concerned about scarring, from January 2010 to July 2013, 25 patients with cosmetic concerns underwent serial laser treatment using the fenestration technique to decompress the cyst contents. "
8.	bleomycetinIBA 01/01/2013 - "Efficacy of pingyangmycin injection for the treatment of cervical epidermoid cysts."
9.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 06/01/2020 - "Thus, we combined minimally invasive CO2 laser incision with PDT for epidermoid cysts with infection. " 06/01/2020 - "Our results demonstrate promise for the combination of minimally invasive CO2 laser incision with PDT as a safe and effective therapy for epidermoid cysts with infection. "
10.	Keratins (Keratin)IBA 12/01/2016 - "This study evaluated the clinical outcomes of the patients with facial sebaceous cyst enucleated by creating minimal elliptical incisions through a keratin-filled orifice. " 05/01/2023 - "A sebaceous cyst is a benign encapsulated, subepidermal nodule filled with keratin material. " 11/01/2020 - "Histopathology diagnosis was an epidermoid cyst, which was characterized by multilayers of keratin surrounded by stratified squamous epithelium. " 05/01/2020 - "Histopathological examination, which was similar in all 12 cases, showed multiple epidermal cysts containing an eosinophil lamellar keratin with a stratified wall without any visible hair, located in the superficial and mid dermis and appearing to be stacked on top of one another. " 01/01/2020 - "Pathologically, the lesion demonstrated a keratinized stratified squamous epithelium with keratin content without cutaneous attachments, thus confirming the diagnosis of an epidermoid cyst. "

Therapies and Procedures

1.	Therapeutics 01/01/1998 - "Contribution of one study case of testicular epidermoid cyst and discussion of issues on histogenesis, ultrasound diagnosis and therapy approaches." 08/06/2022 - "A 63-year-old Chinese male patient with a long-term history of excessive ultraviolet irradiation had received two surgeries for an "epidermal cyst" on his glabella and was presented to our hospital's Dermatology Department for further diagnosis and therapy of the lesion on his glabella. " 08/01/2019 - "A single-institution review of all recurrent epidermoid cysts treated with adjuvant therapy between 2000 and 2017 was performed. " 10/01/2018 - "Complete resection of epidermoid cysts should remain a high priority of therapy, but, in our opinion, preservation of CN function should be a primary goal, determining the extent of resection to provide patients with the highest quality of life possible following surgery." 01/01/2016 - "Instead, we recommend excision and pathology for all symptomatic epidermal cysts, or those that rapidly grow, or do not respond to medical therapy."
2.	Solid-State Lasers 02/01/2002 - "We report a case of a young man with several scrotum's sebaceous cysts, treated successfully with the use of a Nd-YAG laser." 09/01/2021 - "A pilot study of minimal invasion combined PDL/Nd:YAG laser in treating facial epidermoid cyst." 05/01/2015 - "Treatment of epidermal cysts with erbium: YAG laser fenestration: an alternative to surgical intervention." 02/01/2002 - "Until today, the use of de Nd-YAG laser for the management of the scrotum's sebaceous cysts as not been reported. " 09/01/2021 - "The treatment of minimal invasion and combined pulsed dye laser/Nd:YAG laser is effective and safe for medium-size facial epidermoid cysts. "
3.	Adjuvant Radiotherapy 12/01/2017 - "Our study highlights that incomplete excision has led to repeated recurrent epidermoid cyst, but its complete removal with adjuvant radiotherapy has achieved remission of symptoms. "
4.	Gas Lasers 06/01/2021 - "Epidermoid cyst removal with CO2 laser fenestration: A retrospective cohort study." 04/01/2019 - "For epidermal cysts measuring 2.2 cm or smaller, CO2 laser excision is recommended, especially when aesthetic outcome is considered important." 04/01/2019 - "This paper aimed to compare the results and postoperative complications associated with a CO2 laser-based excision against conventional surgical excision for epidermal cysts. " 04/01/2019 - "Comparison of complete surgical excision and minimally invasive excision using CO2 laser for removal of epidermal cysts on the face." 02/01/2016 - "Carbon Dioxide Laser: A Therapeutic Approach for Multiple Vulvar Epidermoid Cysts."
5.	Lasers (Laser) 06/01/2003 - "In cosmetically sensitive areas, laser marsipulization of epidermal cysts represents a viable alternative to conventional dissection." 07/01/2009 - "A new procedure for treating a sebaceous cyst: removal of the cyst content with a laser punch and the cyst wall with a minimal postponed excision." 06/01/2003 - "Laser marsipulization of epidermal cysts: avoiding linear scars." 05/01/2015 - "Erbium:yttrium aluminum garnet laser fenestration might be a promising alternative to the surgical treatment of epidermal cysts, especially when the lesions are large or located in an aesthetically important area." 05/01/2015 - "To evaluate the safety and feasibility of erbium:yttrium aluminum garnet laser fenestration of epidermal cysts for patients concerned about scarring, from January 2010 to July 2013, 25 patients with cosmetic concerns underwent serial laser treatment using the fenestration technique to decompress the cyst contents. "