Ependymoma
564
relevant articles (9 outcomes,
63 trials/studies)
found for this Disease
Description:
Glioma derived from ependymocytes that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Also Known As:
Anaplastic Ependymoma; Cellular Ependymoma; Clear Cell Ependymoma; Papillary Ependymoma; Anaplastic Ependymomas; Cellular Ependymomas; Clear Cell Ependymomas; Ependymoma, Anaplastic; Ependymoma, Cellular; Ependymoma, Clear Cell; Ependymomas; Ependymomas, Anaplastic; Ependymomas, Cellular; Ependymomas, Clear Cell; Ependymomas, Myxopapillary; Ependymomas, Papillary; Myxopapillary Ependymoma; Myxopapillary Ependymomas; Papillary Ependymomas; Ependymoma, Myxopapillary; Ependymoma, Papillary
Relationship Network
Disease Context: Research Results
Related Diseases
Experts
| 1. | Genitori, Lorenzo:
3 articles
(05/2008 - 04/2004)
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| 2. | Sandri, Alessandro:
3 articles
(05/2008 - 04/2004)
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| 3. | Chi, Susan N:
2 articles
(09/2008 - 07/2007)
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| 4. | den Boer, Monique L:
2 articles
(08/2008 - 06/2007)
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| 5. | Reddingius, Roel E:
2 articles
(08/2008 - 06/2007)
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| 6. | Pieters, Rob:
2 articles
(08/2008 - 06/2007)
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| 7. | de Bont, Judith M:
2 articles
(08/2008 - 06/2007)
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| 8. | Passier, Monique M C J:
2 articles
(08/2008 - 06/2007)
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| 9. | Gunhan, O:
2 articles
(09/2006 - 11/2003)
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| 10. | Onguru, O:
2 articles
(09/2006 - 11/2003)
|
Drugs and Biologics
Drugs and Important Biological Agents (IBA) related to Ependymoma:
| 1. | Etoposide (VP 16)FDA LinkGeneric
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| 2. | Carboplatin (JM8)FDA LinkGeneric
07/01/2007
- " Protocol III (carboplatin and vincristine) in 3 children with medulloblastoma, ependymoma and glioblastoma multiformae" 02/01/1992
- " Neither drug demonstrated appreciable activity in the treatment of medulloblastoma (two of 26 responses to carboplatin, one of 14 responses to iproplatin), ependymoma (two of 17 responses to carboplatin, none of seven responses to iproplatin), high-grade glioma (two of 19 responses to carboplatin, one of 14 responses to iproplatin), or brain-stem tumors (one of 23 responses to carboplatin, none of 14 responses to iproplatin)" 07/01/1998
- " Following conventional chemotherapy with carboplatin/etoposide and after achieving complete or partial remission (CR or PR) 10 patients aged from 3.2 to 25.5 years (median, 10.3 years) with refractory or recurrent malignant brain tumors (anaplastic astrocytoma/glioblastoma, n = 2; medulloblastoma/PNET, n = 6; ependymoma, n = 1; plexus carcinoma, n = 1) received in a pilot study one course of HDCT with ABSCT" 05/01/1995
- " In this study, several courses of intensive chemotherapy (1 course: VP-16 300mg/m2 x 5 days + carboplatin 400-500mg/m2 x 3 days) and one course of ultra-high dose chemotherapy (1 course: VP-16 400mg/m2 x 8 days + carboplatin 800mg/m2 x 5 days + MCNU 250, 200mg/m2 x each day) with PBSC transfusion were applied in four cases of pediatric malignant brain tumors (2 cases of medulloblastoma, one case of pineoblastoma and anaplastic ependymoma) after surgical reduction"
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| 3. | Cisplatin (Platino)FDA LinkGeneric
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| 4. | temozolomide (Temodar)FDA Link
02/01/2006
- " A case report of a recurrent intracranial ependymoma treated with temozolomide in remission 10 years after completing chemotherapy." 07/01/1995
- " Temozolomide produced increases in median survival of 1285% (adult glioma D-54 MG), 323% (childhood glioma D-456 MG), and 68% (ependymoma D612 EP)" 07/01/1995
- " The activity of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin- 4(3H)-one (temozolomide) in the treatment of a panel of xenografts derived from ependymoma, medulloblastoma, and childhood and adult high-grade glioma was evaluated in athymic nude mice bearing s.c" 07/01/2001
- " 4-Demethyl-4-methoxyacetylpenclomedine showed inferior activity to current clinical brain tumor drugs against a glioma cell line, superior activity to temozolomide and procarbazine against the derived mismatch repair-deficient cell line, and superior activity to cyclophosphamide and carmustine but inferior activity to temozolomide against two ependymoma cell lines, all of which were implanted s.c"
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| 5. | Vincristine (Oncovin)FDA LinkGeneric
01/01/1984
- " The case of a girl with relapsing ependymoma is described, who received BCNU and vincristine treatment" 01/01/1990
- " It is concluded that the use of adjuvant chemotherapy with CCNU, vincristine, and cisplatinum does not improve progression-free survival in childhood ependymoma, and that the extent of surgical resection is a major determinant of outcome in this disease." 11/01/1978
- " Since 1975, the International Society of Paediatric Oncology has been carrying on a cooperative therapeutic trial, the aim of which is to find out whether adjuvant chemotherapy with vincristine and CCNU, added to standarized radiotherapy of the whole central nervous system, can improve life expectancy in medulloblastoma and high-grade ependymoma" 07/01/2007
- " Protocol III (carboplatin and vincristine) in 3 children with medulloblastoma, ependymoma and glioblastoma multiformae" 01/01/2003
- " The addition of postoperative chemotherapy with lomustine, vincristine and prednisone to cranio-spinal irradiation did not improve survival with respect to RT alone in a randomised phase III trial of children with infratentorial ependymoma"
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| 6. | Glial Fibrillary Acidic ProteinIBA
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| 7. | Lomustine (CCNU)FDA Link
10/01/2000
- " Short-term cell lines derived from ependymomas were considerably more resistant to VCR than other types of childhood brain tumours, while cultures derived from supratentorial primitive neuroectodermal tumour (PNET) displayed marked sensitivity to both lomustine and VCR" 10/01/2000
- " Cultures from ependymomas, medulloblastoma and astrocytic gliomas had similar sensitivity to lomustine and PCB as cultures derived from adult malignant astrocytoma." 01/01/1990
- " It is concluded that the use of adjuvant chemotherapy with CCNU, vincristine, and cisplatinum does not improve progression-free survival in childhood ependymoma, and that the extent of surgical resection is a major determinant of outcome in this disease." 11/01/1978
- " Since 1975, the International Society of Paediatric Oncology has been carrying on a cooperative therapeutic trial, the aim of which is to find out whether adjuvant chemotherapy with vincristine and CCNU, added to standarized radiotherapy of the whole central nervous system, can improve life expectancy in medulloblastoma and high-grade ependymoma" 03/01/1975
- " BCNU and CCNU have produced responses in patients with ependymoma, medulloblastoma, and brain stem glioma"
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| 8. | Proteins (Proteins, Gene)IBA
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