|1.||Gorelick, Fred S: 10 articles (09/2012 - 03/2002)|
|2.||Kolodecik, Thomas R: 5 articles (09/2012 - 02/2005)|
|3.||Thrower, Edwin C: 4 articles (09/2012 - 02/2005)|
|4.||Steer, Michael L: 3 articles (06/2007 - 02/2005)|
|5.||Perides, George: 3 articles (06/2007 - 02/2005)|
|6.||Petersen, Ole H: 2 articles (08/2013 - 01/2003)|
|7.||Grant, Wayne M: 2 articles (11/2009 - 10/2005)|
|8.||Husain, Sohail Z: 2 articles (11/2009 - 10/2005)|
|9.||Lerch, Markus M: 2 articles (01/2007 - 02/2002)|
|10.||Steer, M L: 2 articles (10/2005 - 11/2001)|
03/11/2003 - "The zymogen positioning of both the 180s and autolysis loops are synergistic structural elements that appear to prevent premature proteolysis by chymase and, quite possibly, by other dipeptide zymogens."
03/25/1986 - "The native or unautolyzed forms of these enzymes appear to be proenzymes that can be activated by autolysis."
08/15/2015 - "Bio Basic DNase stock solution (in Tris-HCl buffer [pH 8.0] containing 5mM CaCl2) was first incubated at 50 °C to generate autolysis of proteases and zymogens, leading to a significant reduction in protease activity while preserving DNase activity. "
01/01/2013 - "Calpains are generated as inactive proenzymes which are activated by N-terminal autolysis induced by calcium-ions. "
11/01/2002 - "Ca(2+)-dependent autolysis of enteropeptidase heavy chain and of trypsin were compared; the second one serves as the natural defense mechanism against the undesirable premature proenzymes activation in pancreas leading to pancreatitis. "
01/01/2014 - "Acute pancreatitis occurs as a result of autodigestive activation of pancreatic proenzymes, within the parenchyma of the glands. "
09/15/2012 - "The premature activation of digestive enzyme zymogens in the pancreatic acinar cell is an important initiating event in acute pancreatitis. "
08/01/2010 - "Pancreatitis caused by activation of digestive zymogens in the exocrine pancreas is a serious chronic health problem in alcoholic patients. "
11/01/2009 - "Activation of zymogens within the acinar cell and an inhibition of secretion are critical, but poorly understood, early pancreatitis events. "
05/01/2006 - "Pathological activation of digestive zymogens within the pancreatic acinar cell initiates acute pancreatitis. "
05/01/1980 - "Electron-dense granules, which appeared as zymogens, were observed in the tumor tissue, in cancer cells in the peritoneal fluid (from which the present cell line had been derived), and in cultured cells in early passages. "
08/01/2015 - "The results suggest that tumor development shifts the proportion between active MMP and proenzymes in the tumor, lungs with metastasis, and spleen without metastasis."
01/01/2009 - "Although some proteases directly regulate these events, it is now evident that some proteases indirectly contribute to cancer development by regulating posttranslational activation of latent zymogens that then directly impart regulatory information. "
12/01/2008 - "In vitro and in vivo analyses show that vitamin K-dependent coagulation zymogens mediate tumor transduction and that the elimination of these factors abrogates tumor transduction. "
01/01/2001 - "Tumor cell variants that are deficient in expression of effector caspase zymogens or are capable to suppress the extrinsic and intrinsic activation mechanisms of effector caspase zymogens and the activity of effector caspases have a significant survival advantage in environments of various death stimuli. "
|4.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/07/1993 - "The purpose of this study was to examine the expression and activation of 92-kd and 72-kd proenzymes in non-small-cell lung carcinoma. "
04/07/1993 - "These results demonstrate elevated expression of the activated forms of both the 92-kd and 72-kd proenzymes in non-small-cell lung carcinoma tissue relative to adjacent uninvolved tissue. "
04/01/1982 - "Thus, the CDE-induced pancreatic necrosis results from a sequence of events: blockade of exocytosis evolves to crinophagy and autophagy, which might lead to lysosomal activation of zymogens."
08/06/2013 - "The sustained [Ca(2+)]i elevation activates intracellular digestive proenzymes resulting in necrosis and inflammation. "
01/01/2007 - "These activated zymogens then cause acinar cell injury and necrosis, a characteristic of pancreatitis. "
08/01/2002 - "Leakage of proenzymes occurs in acute pancreatitis, irrespective of severity, while development of pancreatic necrosis occurs only when there is activation of the proenzymes."
10/01/2009 - "Membrane-anchored ADAM proteins are best known for their role in activating zymogens--including tumour necrosis factor-alpha, epidermal growth factor (EGF) and amyloid precursor protein (APP). "
|1.||Peptide Hydrolases (Proteases)
|10.||Intercellular Signaling Peptides and Proteins (Growth Factors)