A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61)
Also Known As:
Thiodan; Thiodon; Thiotox; alpha-Endosulfan; beta-Endosulfan; alpha Endosulfan; beta Endosulfan; 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide
Networked: 142 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results


1. Dwivedi, Prabhaker: 3 articles (10/2008 - 03/2007)
2. Sharma, Anil K: 3 articles (10/2008 - 03/2007)
3. Kumar, Manoj: 3 articles (10/2008 - 03/2007)
4. Singh, Nittin D: 3 articles (10/2008 - 03/2007)
5. Patil, Rajendra D: 3 articles (10/2008 - 03/2007)
6. Eddleston, Michael: 3 articles (04/2008 - 01/2003)
7. Camadro, Elsa L: 2 articles (09/2014 - 06/2008)
8. Menone, Mirta L: 2 articles (09/2014 - 06/2008)
9. Pérez, Débora J: 2 articles (09/2014 - 06/2008)
10. Bernabò, Ilaria: 2 articles (10/2013 - 01/2009)

Related Diseases

1. Poisoning
2. Body Weight (Weight, Body)
3. Chromosome Aberrations (Chromosome Abnormalities)
4. Hepatocellular Carcinoma (Hepatoma)
5. Breast Neoplasms (Breast Cancer)
04/01/2011 - "Moreover, extracts of CN treated with endosulfan, dieldrin, or lindane induced cell proliferation in MCF-7 human breast cancer-derived cells, whereas only extracts of CGC treated with dieldrin induced MCF-7 cell proliferation. "
11/01/1997 - "Endosulfan and dieldrin showed no synergism in displacing 3H-E2 from rat uterine ER or in inducing the proliferation of MCF-7 breast cancer cells, an estrogen-dependent response. "
11/01/2001 - "The effects of simultaneous administration of some binary mixtures of seven natural and synthetic oestrogenic substances (17beta-estradiol, estrone, bisphenol A, butylbenzyl phthalate, endosulfan, methoxychlor and pentachlorophenol) on the cellular proliferation of human breast cancer MCF-7 cells in-vitro (a modified E-screen assay) have been measured. "
03/01/2014 - "Activity of the sinusoidal influx transporter OCT1 (organic cation transporter 1) was thus inhibited by endosulfan, chlordane, heptachlor, lindane, and dieldrine, but not by dichlorodiphenyltrichloroethane isomers, whereas those of the canalicular efflux pumps MRP2 (multidrug resistance-associated protein 2) and BCRP (breast cancer resistance protein) were blocked by endosulfan, chlordane, heptachlor, and chlordecone; this latter OC additionally inhibited the multidrug resistance gene 1 (MDR1)/P-glycoprotein (P-gp) activity. "
05/01/2008 - "This study investigated the effects of E2, diethylstilbestrol (DES), antiestrogens, the phytoestrogen resveratrol, and the xenoestrogens octylphenol (OP), nonylphenol (NP), endosulfan, kepone, 2,3,4,5-tetrachlorobiphenyl-4-ol (HO-PCB-Cl(4)), bisphenol-A (BPA), and 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) on induction of luciferase activity in breast cancer cells transfected with a construct (pSp1(3)) containing three tandem GC-rich Sp binding sites linked to luciferase and wild-type or variant ERalpha. "

Related Drugs and Biologics

1. Lindane (gamma-Hexachlorocyclohexane)
2. serum P-component (CIt)
3. Chlordecone (Kepone)
4. DNA (Deoxyribonucleic Acid)
5. bisphenol A
6. Phytoestrogens (Phytoestrogen)
7. Estrogen Receptor alpha
8. Estrogen Receptor Modulators (Antiestrogen)
9. Diethylstilbestrol (Stilbestrol)
10. Citrinin

Related Therapies and Procedures

1. Oral Administration
2. Artificial Respiration (Mechanical Ventilation)
3. Renal Replacement Therapy (Therapies, Renal Replacement)
4. Renal Dialysis (Hemodialysis)