Endosulfan

A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61)

Also Known As:

Networked: 223 relevant articles (4 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sun, Yeqing: 8 articles (11/2022 - 03/2016)
2.	Xu, Dan: 8 articles (11/2022 - 03/2016)
3.	Banerjee, Basu Dev: 4 articles (11/2021 - 01/2013)
4.	Sun, Zhiwei: 4 articles (07/2020 - 01/2017)
5.	Wei, Jialiu: 4 articles (07/2020 - 01/2017)
6.	Zhang, Lianshuang: 4 articles (07/2020 - 01/2017)
7.	Zhou, Xianqing: 4 articles (07/2020 - 01/2017)
8.	Kumar, Neeraj: 4 articles (09/2016 - 08/2012)
9.	Ozmen, Ozlem: 4 articles (01/2016 - 12/2003)
10.	Guo, Yubing: 3 articles (11/2022 - 07/2018)

Related Diseases

1.	Cardiotoxicity 07/20/2020 - "These results suggest that endosulfan may induce cardiotoxicity by inducing myocardial apoptosis resulting from activation of mitochondria-mediated apoptosis pathway and inhibition of pro-survival signaling pathways, which might be helpful in elucidating the mechanism of cardiac dysfunction induced by endosulfan." 07/20/2020 - "In this study, we examined the cardiotoxicity induced by endosulfan using Wistar rats and human cardiomyocytes (AC16) cells. " 07/20/2020 - "Endosulfan induces cardiotoxicity through apoptosis via unbalance of pro-survival and mitochondrial-mediated apoptotic pathways." 06/01/2007 - "The protective effects of vitamin E was investigated on the cardiotoxicity induced by endosulfan administration. " 06/01/2007 - "Histopathological observations on protective effects of vitamin E on endosulfan induced cardiotoxicity in rats."
2.	Cardiovascular Diseases (Cardiovascular Disease) 07/01/2017 - "The results provide a new insight for mechanism of endosulfan-induced cardiovascular toxicity which will be helpful in future prevention of cardiovascular diseases induced by endosulfan." 07/01/2020 - "Cardiovascular diseases are related to vascular endothelial cell injury; our previous studies showed that endosulfan could cause hypercoagulation of blood by inducing endothelial cell injury. " 07/01/2017 - "Our previous study showed that endosulfan increases the risk of cardiovascular disease. " 04/01/2017 - "These findings suggest that endosulfan increased endothelial permeability by paracellular and transcellular pathways, implicating the potential correlation between endosulfan and cardiovascular diseases." 04/01/2017 - "Exposure to endosulfan increases endothelial permeability by transcellular and paracellular pathways in relation to cardiovascular diseases."
3.	B-Cell Lymphoma (Lymphoma, B Cell) 09/01/2016 - "The results showed that endosulfan significantly improved the expressions of cytochrome c and B-cell lymphoma 2 (Bcl-2)-associated X protein and increased the activities of caspases 9 and 3 as well as the downregulation of the expression of Bcl-2 in GC-1 spg cells. "
4.	Poisoning 10/01/2017 - "This study also investigated delayed neurologic sequelae in seizure-related endosulfan poisoning. " 05/01/2013 - "Characteristics of endosulfan poisoning: a study of 23 cases. " 07/01/2010 - "Among 34 patients hospitalized during this study period for alleged organochlorine poisoning, 16 patients with endosulfan poisoning were identified. " 12/01/2006 - "Characteristics of endosulfan poisoning: a study of 23 cases." 03/01/2000 - "The objective of the study is to identify the clinical profile of endosulfan poisoning and also to recognise any biochemical parameters which indicate clinical or subclinical dysfunction of organs so that the offending agent can be easily identified in a given case of poisoning and appropriate treatment instituted promptly. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2002 - "[Assessment of the estrogenicity of endosulfan and other chemicals with the in vitro proliferation of human breast cancer cell]" 04/30/2023 - "Molecular docking and molecular dynamics studies revealed a competitive affinity between endosulfan II and the thyroxine-binding site of TTR, pointing towards the significance of the competition between thyroxin and endosulfan, resulting in endocrine disruption leading to breast cancer. " 04/30/2023 - "Putative interactions between transthyretin and endosulfan II and its relevance in breast cancer." 01/01/2002 - "METHODS: The E-SCREEN test was developed based on proliferation of human breast cancer cells (MCF-7), and the estrogenicity of diethylstilbestrol, 4-hydrotamoxifen and endosulfan was assessed. " 01/01/2023 - "In this study, we discerned the toxic role of the pesticides atrazine, dichlorvos, and endosulfan in inducing breast cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Vitamin E
3.	Cytochromes c (Cytochrome c)
4.	Caspases
5.	GC 1 compound
6.	Pesticides
7.	Insecticides
8.	Hexachlorocyclohexane (gamma-Hexachlorocyclohexane)
9.	endosulfan sulfate
10.	serum P-component (CIt)

Related Therapies and Procedures

1.	Oral Administration
2.	Artificial Respiration (Mechanical Ventilation)
3.	Therapeutics
4.	Renal Dialysis (Hemodialysis)
5.	Continuous Renal Replacement Therapy