Endorphins

One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.

Also Known As:

Networked: 977 relevant articles (36 outcomes, 115 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Yong-Xiang: 14 articles (10/2021 - 04/2014)
2.	Urban-Kowalczyk, Małgorzata: 7 articles (01/2021 - 01/2015)
3.	Śmigielski, Janusz: 7 articles (01/2021 - 01/2015)
4.	Csaba, György: 7 articles (09/2014 - 03/2004)
5.	Sarkar, Dipak K: 6 articles (10/2020 - 10/2011)
6.	Al-Hakeim, Hussein Kadhem: 5 articles (12/2022 - 11/2019)
7.	Maes, Michael: 5 articles (12/2022 - 11/2019)
8.	Apryani, Evhy: 5 articles (01/2021 - 10/2018)
9.	Kotlicka-Antczak, Magdalena: 5 articles (01/2021 - 12/2018)
10.	Strzelecki, Dominik: 5 articles (01/2021 - 01/2016)

Related Diseases

1.	Pain (Aches) 01/01/2017 - "In conclusion, this pilot study showed a significant reduction in plasma β-endorphin levels and pain intensity at 6-24 months after TMJ surgery; plasma β-endorphin levels were correlated with time after surgery. " 02/04/1984 - "Pain relief from cryohypophysectomy is surmised to be due to the production of endorphins, but no proof of this is available." 01/01/2020 - "In the present study, we aimed to reveal the peripheral immunological mechanism of EA in relieving the pain of BPRA through the IL-17-CD4+ T lymphocyte-β-endorphin axis. " 01/01/2019 - "The purpose of this study was to investigate the relationship between resting plasma levels of β-endorphin and experimental pain sensitivity. " 12/19/2011 - "In this study, we determined the role of peripheral CB2Rs in the effects of EA on the expression of β-endorphin in inflamed skin tissues and inflammatory pain. "
2.	Respiratory Insufficiency (Respiratory Failure) 04/01/1982 - "Hypoxic ventilatory depression appears not to be mediated by endorphins in adults." 03/27/1982 - "These findings suggest that in acute respiratory failure there may be overproduction of, or increased sensitivity to, endorphins." 08/01/1987 - "We conclude that endorphins play a role in septic ventilatory depression and that naloxone is effective in ameliorating it." 11/01/1983 - "We hypothesized that this ventilatory depression, like some other central nervous system effects of ethanol, might be mediated via endorphins. " 07/01/1990 - "Naloxone, an endorphin antagonist, is widely used for the reversal of narcotic-induced respiratory depression but has not been shown to be clinically effective for either severely or moderately asphyxiated infants. "
3.	Schizophrenia (Dementia Praecox) 08/01/1992 - "The lack of efficacy of DE-gamma-E suggests that the theories that the endorphins have an important role in schizophrenia have to be revised. " 01/01/2021 - "The aim of the study was to identify the association between β-endorphin (BE) concentration and the outcome of short-term schizophrenia treatment. " 01/01/1986 - "The present study does not support the hypothesis of dysfunction of the endorphin system in schizophrenia." 01/01/1981 - "This attempt refers to studies which confirm any role of endorphins in the origin of schizophrenia. " 01/01/1981 - "Clinical studies on the role of endorphins in schizophrenia."
4.	Neuralgia (Stump Neuralgia) 05/01/2020 - "Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway." 07/15/2014 - "Thus, experimental findings indicate that electroacupuncture can attenuate neuropathic pain after brachial plexus injury through upregulating β-endorphin expression. " 01/01/2020 - "We, for the first time, showed that the neuropathic pain caused by BPRA was effectively relieved by EA treatment via IL-17-CD4+ T lymphocyte-β-endorphin mediated peripheral analgesic effect, providing scientific support for EA clinical application." 04/13/2019 - "This study aimed to elucidate the mechanisms underlying GPR40 activation-induced antinociception in neuropathic pain, particularly related to the spinal glial expression of IL-10 and subsequent β-endorphin. " 10/01/2021 - "Thalidomide alleviates neuropathic pain through microglial IL-10/β-endorphin signaling pathway."
5.	Psychotic Disorders (Schizoaffective Disorder) 01/01/1982 - "The therapeutic efficacy of these compounds lends support to the hypothesis that disorders of central endorphin metabolism may play a role in the pathogenesis of psychoses of the schizophrenic type." 05/01/2014 - "One plausible mechanism for alcohol seeking in schizophrenics with SUD, based on previous research, may be a deficiency of gamma type endorphins that has been linked to schizophrenic type psychosis. " 01/01/2006 - "This hypothesis predicts that: (1) anatomic position of endorphin production should mirror its presumed role in fetal-maternal conflict; (2) endorphin levels should co-vary positively with nutrient carrying capacity of maternal blood system; (3) postpartum psychological symptoms (postpartum blues, depression and psychosis) in humans are side-effects of this mechanism that can be interpreted as endorphin-deprivation symptoms; (4) shortly after parturition, placentophagia could play an adaptive role in decreasing the negative side-effects of fetal manipulation; (5) later, breast-feeding induced endorphin excretion of the maternal pituitary saves mother from further deprivation symptoms. " 01/01/1987 - "At the same time, distinct differences in concentrations of alpha- and gamma-endorphins in blood plasma were not found in groups of healthy donors and of patients with endogenous psychoses and pronounced depressive symptoms." 08/01/1985 - "Twenty 2- to 13-year-old infantile autistic children (16 boys and four girls) and four 4- to 13-year-old children (two boys and two girls) with other kinds of childhood psychoses were compared with eight 6-month-old to 6-year-old normal children with regard to cerebrospinal fluid contents of endorphin fractions I and II. The psychosis groups showed higher mean cerebrospinal fluid endorphin fraction II levels, and 11 (55%) of the 20 autistic patients showed values higher than the highest in the group of normal children. "

Related Drugs and Biologics

1.	Endorphins
2.	Opioid Analgesics (Opioids)
3.	Naloxone (Narcan)
4.	Opioid Receptors (Opioid Receptor)
5.	Analgesics (Analgesic Drugs)
6.	Opiate Alkaloids
7.	Opioid Peptides (Opioid Peptide)
8.	Neprilysin (Neutral Endopeptidase)
9.	Serotonin (5 Hydroxytryptamine)
10.	beta-Endorphin (Endorphin, beta)

Related Therapies and Procedures

1.	Therapeutics
2.	Moxibustion
3.	Transcutaneous Electric Nerve Stimulation (TENS)
4.	Transcranial Direct Current Stimulation
5.	Analgesia