Emetine

The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.

Also Known As:

Networked: 408 relevant articles (21 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bakare, Oladapo: 5 articles (12/2017 - 09/2012)
2.	Akinboye, Emmanuel S: 4 articles (12/2017 - 09/2012)
3.	Denmeade, Samuel R: 4 articles (12/2017 - 09/2012)
4.	Lee, Sang Yeol: 3 articles (10/2021 - 11/2015)
5.	Möller, Maren: 3 articles (10/2007 - 10/2006)
6.	Wink, Michael: 3 articles (10/2007 - 10/2006)
7.	Li, Dan: 2 articles (11/2022 - 06/2022)
8.	Zhou, Yi: 2 articles (11/2022 - 01/2018)
9.	Funahashi, Makoto: 2 articles (11/2021 - 12/2020)
10.	Inui, Tadashi: 2 articles (11/2021 - 12/2020)

Related Diseases

1.	Amebiasis (Amoebiasis) 01/01/1962 - "[Colo-hepato-pulmonary amebiasis: complete clinical cure with 2-dehydro-emetine]." 12/01/1957 - "[Amebic abscess of right lobe apparently cured by emetine; value of gammagraphy & colored laparophotography]." 01/01/2021 - "Emetine is a FDA-approved drug for the treatment of amebiasis. " 11/27/2020 - "Emetine, in the past, has also been used in 10s to 100s of millions of people at a dose of ~60 mg daily to treat amoebiasis. " 03/21/2020 - "Furthermore, based on the relative EC50s of emetine towards the coronaviruses compared with Entamoeba histolytica, emetine could be much more effective as an anti-coronavirus agent than it is against amoebiasis. "
2.	Neoplasms (Cancer) 01/01/2023 - "In vivo anti-tumor efficacy of emetine was evaluated in the MGC803 xenograft model. " 06/22/2022 - "This study found that emetine may inhibit the entry and replication of SARS-CoV-2 and enhance tumor immunity by bounding to DDP4 and Mpro." 11/01/1973 - "Phase II study of emetine (NSC-33669) in the treatment of solid tumors." 05/01/1973 - "A phase I study of emetine hydrochloride (NSC 33669) in solid tumors." 01/01/2023 - "Emetine, a natural small molecule isolated from Psychotria ipecacuanha, has been broadly used for medicinal purposes including cancer treatment. "
3.	Infections 01/01/2021 - "Interestingly, emetine exhibited protective efficacy against lethal challenge with infectious bronchitis virus (IBV; a chicken coronavirus) in the embryonated chicken egg infection model. " 01/01/2018 - "Here, we show that emetine, an anti-protozoal agent, potently inhibits ZIKV and EBOV infection with a low nanomolar half maximal inhibitory concentration (IC50) in vitro and potent activity in vivo. " 01/01/2018 - "Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry." 01/01/2016 - "Irrespective of cell density, emetine induced RPS14 translocation into the nucleus during infection. " 06/22/2015 - "Emetine also blocked HIV-1 infection of RT M184V mutant. "
4.	Vomiting 04/01/2016 - "T-2 and HT-2 doses causing emesis in 50 % of treated animals (ED50s) were 0.05 and 0.02 mg/kg BW following IP and oral administration, respectively, whereas the ED50s for emetine were 2.0 and 1.0 mg/kg BW for IP and oral exposure, respectively. " 12/01/2020 - "The present study demonstrated a dose-responsive manner of emetine effects and emetine-induced upregulation of neuronal excitability in the area postrema and the NTS that form a part of the induction mechanisms of emetine-induced nausea and/or emesis." 12/01/2020 - "The aim of the present study was to demonstrate the effective dose of emetine for inducing nausea and/or emesis, and the effects of emetine on the excitability of central neurons in the area postrema (AP) and the nucleus tractus solitarius (NTS). " 12/01/2020 - "We also performed immunohistochemical analyses of c-Fos expression in the area postrema and the NTS, to examine changes in the excitability of brainstem neurons that may be responsible for emetine-induced nausea and/or emesis. " 04/01/2016 - "Taken together, the results suggest that T-2 and HT-2 were much more potent than emetine and that emesis induction by all three translational inhibitors co-occurred with increases in circulating levels of PYY3-36 and 5-HT."
5.	Poisoning 11/30/1958 - "[Eventual protective effects of KC1 on electrocardiographic changes in subacute emetine poisoning]." 12/01/2009 - "The emetine poisoning accident that occurred simultaneously in two different regions resulted from the Japanese colonial government's support. " 12/01/2009 - "Emetine poisoning had something to do with medical power's localization. " 12/01/2009 - "The emetine poisoning accident in Yeongheung and Haenam counties in 1927 occurred in this context. " 12/01/2009 - "[Research on endemic diseases and Japanese colonial rule: focusing on the emetine poisoning accident in Yeongheung and Haenam counties in 1927]."

Related Drugs and Biologics

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2.	Anti-Bacterial Agents (Antibiotics)
3.	Chlortetracycline (Aureomycin)
4.	Chloroquine (Aralen)
5.	Cycloheximide (Cicloheximide)
6.	Hypnotics and Sedatives (Sedatives)
7.	HU 211 (HU 210)
8.	Alkaloids
9.	cephaelin
10.	Ondansetron (Zofran)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration