Amniotic Fluid Embolism

Blocking of maternal circulation by AMNIOTIC FLUID that is forced into uterine VEINS by strong UTERINE CONTRACTION near the end of pregnancy. It is characterized by the sudden onset of severe respiratory distress and HYPOTENSION that can lead to maternal DEATH.
Also Known As:
Embolism, Amniotic Fluid; Amniotic Fluid Embolisms; Embolisms, Amniotic Fluid
Networked: 186 relevant articles (6 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Disseminated Intravascular Coagulation
2. Shock
3. Eclampsia
4. Uterine Rupture
5. Sepsis (Septicemia)


1. Kanayama, Naohiro: 4 articles (07/2015 - 01/2011)
2. Knight, Marian: 4 articles (01/2013 - 05/2010)
3. Ikeda, Tomoaki: 3 articles (07/2015 - 01/2011)
4. Fineschi, Vittorio: 3 articles (01/2015 - 03/2009)
5. Kurinczuk, Jennifer J: 3 articles (01/2013 - 05/2010)
6. Karnad, Dilip R: 2 articles (10/2015 - 10/2005)
7. Guntupalli, Kalpalatha K: 2 articles (10/2015 - 10/2005)
8. Kobayashi, Takao: 2 articles (08/2015 - 05/2007)
9. Kobayashi, Hiroshi: 2 articles (08/2015 - 04/2014)
10. Itoh, Hiroaki: 2 articles (07/2015 - 06/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amniotic Fluid Embolism:
1. Heparin (Liquaemin)FDA LinkGeneric
2. Ibuprofen (Motrin)FDA LinkGeneric
3. fibrin fragment D (D-dimer)IBA
4. Tryptases (Tryptase)IBA
5. AntigensIBA
6. Acute fatty liver of pregnancyIBA
7. Complement C1 Inhibitor Protein (C1 Esterase Inhibitor)IBA
8. Fibrinogen (Factor I)FDA Link
9. BradykininIBA
10. Dacarbazine (DIC)FDA LinkGeneric

Therapies and Procedures

1. Cesarean Section (Caesarean Section)
2. Resuscitation
3. General Anesthesia
4. Hysterectomy
11/01/2015 - "Severe maternal morbidity (amniotic fluid embolism, placenta accreta, peripartum hysterectomy, eclampsia or pulmonary embolism). "
03/01/1996 - "From experiences in recent years and study of the literature the following recommendations can be summarized; (1) the need to understand (patho)physiologic changes in pregnancy, (2) cultivation of an anticipative attitude towards conditions with elevated risks, (3) adequate knowledge of diagnostic procedures, (4) the discipline to make a differential diagnosis, (5) experience with monitoring of (fetal and) maternal condition, (6) availability of management protocols for emergencies such as shock, eclampsia, uterine rupture, amniotic fluid embolism, thrombo-embolism, sepsis and diabetic ketoacidosis, (7) awareness of pitfalls with inspection of lesions and assessment of blood loss, (8) awareness that caesarean section without prior stabilization can be a life threatening procedure, (9) practice in life-saving measures such as uterine compression, packing, ligation of vessels, postpartum hysterectomy, (10) teaching of postoperative care, (11) insight into the cascade of events finally leading to multi-organ failure. "
12/01/2007 - "Composites of major morbidity possibly attributable to surgery:death, sepsis, cardiac arrest, shock, hypotension, ileus or bowel obstruction,major puerperal infection, septic or fat embolism, postpartum hemorrhage requiring hysterectomy, need for cardiopulmonary resuscitation, or another operation; and all major morbidity: major surgical morbidity, acute coronary syndrome, endocarditis, pulmonary edema, cerebrovascular disorder, pneumothorax, respiratory failure, amniotic fluid embolism, complications of anesthesia, deep vein thrombosis, pulmonary embolism, acute renal failure, and need for mechanical ventilation. "
01/01/2013 - "UKOSS studies from which data on case women were obtained included amniotic fluid embolism, acute fatty liver of pregnancy, eclampsia, peripartum hysterectomy, therapies for peripartum haemorrhage and uterine rupture. "
5. Postoperative Care