|1.||Stiborová, Marie: 1 article (01/2014)|
|2.||Frei, Eva: 1 article (01/2014)|
|3.||Sakoff, Jennette A: 1 article (02/2013)|
|4.||O'Sullivan, Elaine C: 1 article (02/2013)|
|5.||Maguire, Anita R: 1 article (02/2013)|
|6.||McCluskey, Adam: 1 article (02/2013)|
|7.||Gilbert, Jayne: 1 article (02/2013)|
|8.||McCarthy, Florence O: 1 article (02/2013)|
|9.||Deane, Fiona M: 1 article (02/2013)|
|10.||Hägg, Maria: 1 article (04/2004)|
|1.||Breast Neoplasms (Breast Cancer)
04/01/2004 - "In this study, we examined apoptosis induction by ellipticines, a class of cytotoxic plant alkaloids known to inhibit topoisomerase II. The potent ellipticine derivative 6-propanamine ellipticine (6-PA-ELL) induced rapid apoptosis in MDA-MB-231 breast cancer cells, preceded by a conformational change in Bak and cytochrome c release. "
01/01/2014 - "Cell cycle arrest was shown to result from DNA damage caused by a variety of tumor chemotherapeutic agents; this is also the case for ellipticines. "
02/28/2013 - "Synthesis and evaluation of novel ellipticines as potential anti-cancer agents."
06/24/1994 - "The ellipticines showed no significant subpanel specificity; however, the N-methylellipticinium compounds tested did exhibit specificity for the CNS tumor subpanel."
06/24/1994 - "The ellipticines and N-methylellipticinium derivatives were evaluated for in vitro antitumor activity against a panel of human tumors. "
01/01/2014 - "The aim of this review is to summarize our knowledge on the molecular mechanisms with the aim to explain the effectiveness of ellipticines as DNA-targeted chemotherapeutics in cancer cells. "
|3.||Brain Neoplasms (Brain Tumor)
11/01/1996 - "9-Methoxy-N2-methylellipticinium acetate (MMEA) is representative of a series of quaternized ellipticines that exhibited selective cytotoxicity for human brain tumor cell lines of glial origin in the in vitro primary screen of the U.S. "
07/08/1994 - "In contrast, 9-hydroxy-substituted ellipticiniums, as well as all nonquaternized ellipticines tested, were devoid of brain tumor specificity. "
05/16/1994 - "Cellular uptake as a determinant of cytotoxicity of quaternized ellipticines to human brain tumor cells."
|1.||Cytochromes c (Cytochrome c)
|2.||Type II DNA Topoisomerases (Topoisomerase II)
|5.||DNA (Deoxyribonucleic Acid)