|1.||Cuzzocrea, Salvatore: 42 articles (01/2014 - 05/2002)|
|2.||Mazzon, Emanuela: 30 articles (10/2015 - 05/2002)|
|3.||Belcaro, G: 29 articles (09/2015 - 10/2001)|
|4.||Thorlacius, Henrik: 29 articles (06/2015 - 02/2008)|
|5.||Küpeli, Esra: 27 articles (01/2009 - 08/2003)|
|6.||Di Paola, Rosanna: 26 articles (05/2012 - 12/2003)|
|7.||Cesarone, M R: 26 articles (09/2011 - 10/2001)|
|8.||Huang, Guan-Jhong: 24 articles (04/2015 - 11/2009)|
|9.||Cox, Charles S: 24 articles (02/2013 - 05/2002)|
|10.||Genovese, Tiziana: 24 articles (10/2012 - 12/2003)|
04/25/2014 - "Its average skin irritation scored 0.49 concluded to be non-irritant, safe for human use and in vivo studies revealed significantly greater extent of absorption and highly significant inhibition (%) of carrageenan induced paw edema. "
09/01/2013 - "The results showed a moderate antioxidant activity (40%), but potent anti-inflammatory activity (49.9%) on carrageenan-induced mice paw edema, and also as revealed by histopathologic examination, complete protection against AlCl₃-induced hepatic toxicity. "
01/01/2010 - "LA (25 and 50 μg/ml) was also very effective in inhibiting MPO released from stimulated human neutrophils, and significantly decreased the number of cells expressing iNOS activity in the paw of mice submitted to carrageenan-induced edema, suggesting a drug involvement with the NO system. "
06/01/2004 - "HAE and ASHAE-PPT presented antiinflammatory activity and were very effective in decreasing the mouse paw edema induced by carrageenan. "
09/01/2014 - "The HSM showed significant reduction of edema in carrageenan induced mice paw edema model at 1 h and 3 h for (78.03±15.54)% and (40.44±16.36)%, respectively. "
|2.||Dexamethasone (Maxidex)FDA LinkGeneric
06/01/2000 - "However, the patients receiving dexamethasone had a markedly smaller volume on day 3, but 9 of 11 experienced rebound edema with a volume on day 14 significantly greater than day 3. Because of the small number of patients evaluated, additional studies are essential to confirm these findings. "
01/01/2008 - "Dexamethasone treatment significantly improved gas exchange and reduced right-to-left pulmonary shunts, central venous pressure, and lung edema, whereas trend to more pronounced improvement in some parameters was observed after two doses of dexamethasone. "
11/01/2007 - "On the second postoperative day, facial edema showed a statistically significant reduction in both dexamethasone 4-mg and dexamethasone 8-mg groups compared with the control group, but no statistically significant differences were observed between the 2 dosage regimens of dexamethasone. "
10/01/2007 - "Results suggest that dexamethasone combination with serum therapy can be beneficial for treatment of inflammatory edema caused by B. "
01/01/1996 - "The control group showed significantly greater edema than the dexamethasone group. "
|3.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/01/2005 - "In contrast, a coapplication of Ang-1 and VEGF leads to a significant reduction of the ischemic and edema volumes by 50% and 42%, respectively, in comparison with VEGF-treated mice. "
05/01/2013 - "These preclinical findings suggest that available approaches to neutralize VEGF-A are prophylactic for PVR, and that anti-VEGF-based therapies may be effective for managing more than angiogenesis- and edema-driven pathological conditions."
01/01/2015 - "We questioned whether Compound 49b could decrease VEGF levels, suggesting that Compound 49b may be effective against edema. "
10/01/2015 - "This study aimed to elucidate axonal excitability properties and their relation to VEGF levels and nerve edema in POEMS neuropathy. "
01/01/2014 - "However, there is no study with regard to the correlation between pSTAT3 or VEGF and peritumoral edema. "
|4.||Adrenal Cortex Hormones (Corticosteroids)IBA
07/01/2007 - "This study suggests that both arnica and corticosteroids may be effective in reducing edema during the early postoperative period. "
09/01/2008 - "The findings of this study suggest that perioperative administration of corticosteroids produces a mild to moderate reduction in edema and improvement in range of motion after M3 removal."
01/01/2005 - "Corticosteroids were initiated with slow improvement in edema. "
08/01/2000 - "Treatment with systemic corticosteroids improved the rate of resolution of optic disc edema and vitreous cells, reducing median resolution times (P=0.042). "
08/01/2014 - "The advantages of limiting localized edema must be weighed against corticosteroids' disadvantageous inhibition of the normal growth factor profile production that is essential for would healing. "
01/01/1983 - "After clearance of the edema with diuretic therapy, total blood volume (TBV) was not significantly decreased; therefore, in the supine position the significant (2p less than 0.001) decrease of right atrial pressure, stroke volume, cardiac output, and cardiopulmonary blood volume (CBV) by the diuretics was due to an improvement in venous compliance which resulted in peripheral redistribution of CBV since the ratio CBV/TBV was decreased during diuretic therapy (2p less than 0.001). "
09/01/1962 - "Some further observations on the rapid quantitative method for determining efficacy of diuretics in bed-patients with edema."
01/01/2011 - "In 3 of 4 children remission of optic disc edema was observed after 8 weeks of treatment with diuretics - median global RNFL was 138 microm. "
11/01/1981 - "Both diuretics proved equally effective in reducing edema. "
08/15/1964 - "Its main therapeutic value, used either alone or in combination with other diuretics, is in the longterm management of chronic edema, especially in certain patients refractory to the currently used diuretics.No"
01/01/2015 - "The extract showed anti-inflammatory activity in the ear edema in mice test (34.3% inhibition), myeloperoxidase (MPO) activity was markedly reduced in animals administered with the extract: within 49.6% and 68.5%. "
11/18/2014 - "BBL was characterized, and its supplementation in situ led to significant decrease in paw edema, tissue myeloperoxidase activity, NO level, serum TNFα level and CINC 1 level as well as decrease in splenic CD4(+)/CD8(+) ratios and increase in level of Treg cells. "
07/01/2014 - "Paw diameter and tissue myeloperoxidase activity in the paws were evaluated as indices for edema and neutrophil infiltration into the tissue. "
06/27/2014 - "The anti-inflammatory activity of compounds 1-5 was determined using the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model, and the effect of compounds 1-4 on the recruitment of neutrophils was evaluated using the myeloperoxidase test. "
01/01/2014 - "Lethality rate, blood gas, myeloperoxidase (MPO) activity, lung edema and pathological changes were used to evaluate the degree of ALI. "
10/01/2014 - "First, the patient was treated by intravitreal applications of bevacizumab; after the first application, the edema from the macula subsided, and the best-corrected visual acuity improved to 4/12 (0.33). "
03/01/2013 - "Lesion/normal tissue ratios on (18)fluoride-labeled boronophenylalanine-positron emission tomography (P = 0.0084) and improvement in Karnofsky performance status after bevacizumab treatment (P = 0.0228) were significantly associated with reduced rates of perilesional edema. "
04/01/2015 - "When CSHRPE is found to have secondary vascular activity and associated macula edema, treatment of intravitreal bevacizumab may lead to improved visual and anatomical outcomes."
04/01/2015 - "The patient was treated with an off-label intravitreal bevacizumab injection to decrease the edema. "
01/01/2014 - "The PFS and the OS data are very encouraging as well as the symptomatic benefit due to bevacizumab's high capacity to provide a long-lasting decrease of perilesional edema."
11/01/1991 - "Urine volume, absolute and fractional sodium excretion were significantly decreased in the edema forming and proteinuric steady states as compared with those in remission, suggesting that sodium retention was present in both states of the disease although the change in these parameters was more profound in the edema forming state than in the proteinuric steady state. "
07/01/1996 - "The blockage of each of the passive sodium transporters improved the recovery of intracellular volumes at reperfusion, indicating that in the heart these pathways are responsible for the sustained reperfusion cellular edema. "
06/01/2009 - "AFC involves active transport mechanisms where sodium (Na(+)) is actively transported from the alveolar airspaces, across the alveolar epithelium, and into the pulmonary circulation, which creates an osmotic gradient that is responsible for the clearance of lung edema. "
01/01/1986 - "Improved forward cardiac flow and reduction of pulmonary congestion occur with reversal of vasoconstriction, so that relief of edema, due to enhanced sodium and water excretion, will occur. "
05/01/2014 - "Many studies published in the last decade reported that primary renal sodium retention was a major factor in edema formation. "
|9.||Prednisolone (Predate)FDA LinkGeneric
12/01/1982 - "Systemic administration of prednisolone dramatically reduced the occurrence of edema and reduced the intensity of the inflammatory response, which resolved in a shorter period of time than in untreated animals. "
08/01/1997 - "Prednisolone was increased from 2.5 mg to 10 mg daily with marked improvement in all the symptoms including the swelling and pitting edema. "
04/01/2014 - "Following treatment, the patient showed improvement and was continued on topical medications and oral prednisolone tapered over 3 weeks, after which VA OU improved, the AC showed no cells and flare and disc edema resolved. "
09/26/2014 - "Moreover, the formation of mouse ear edema was reduced at the highest dose tested compared to that in the control, and generated similar effects compared with prednisolone at 250mg/kg in mice ear edema evaluation test. "
01/01/2014 - "However, the patient was re-intubated due to his noisy breathing, and 10 mg prednisolone was given intravenously due to mild edema seen in the larynx during endotracheal intubation. "
07/01/2013 - "Steroids are effective for reducing disc edema in the acute stage in rNAION. "
02/01/1997 - "Steroids are effective for peripheral edema, and we have used them for inoperable patients over the long term. "
04/26/2014 - "Current treatment of SCI is limited to early administration of high dose steroids to mitigate the harmful effect of cord edema that occurs after SCI and to reduce the cascade of secondary delayed SCI. Recent evident-based clinical studies have cast doubt on the clinical benefit of steroids in SCI and intense focus on stem cell-based therapy has yielded some encouraging results. "
01/01/2009 - "This variable response demonstrates the need for a placebo-controlled randomized study to more accurately determine the effect of steroids on hydrops and CPAM growth rates. "
05/01/1985 - "In a study of 134 patients, it was found that a short course of systemic steroids was able to reduce the severity of post-cryosurgical edema. "
09/01/2009 - "The vascularized node transplants (n = 18) were associated with the greatest clinical improvement, with the magnitude of edema in these limbs exhibiting significantly lower levels of edema (p = 0.039) than nontreated limbs (n = 18). "
04/01/1999 - "However, this intervention did not result in a significant reduction of post-transplant lung edema or improvement of pulmonary hemodynamics. "
09/01/2006 - "In all cases, the new donor button adhered to and cleared the edema from the previous penetrating graft. "
09/01/2015 - "After 2 weeks of heparinization therapy, the edema disappeared and perfusion of the graft pancreas improved. "
03/01/2013 - "Bβ15-42 therapy was associated with improved graft lung function, including less edema, and improved oxygenation and airway pressure, particularly if Bβ15-42 was administered to both the donor and recipient. "
05/01/2009 - "After treatment, improvement in edema was statistically significant in the study group but not in the control group. "
01/01/2015 - "A significant reduction in bone marrow edema was observed after treatment (LPFH group, P = 0.007; non-LPFH group, P = 0.016). "
09/01/2000 - "Morphometric analysis demonstrated a significant reduction in both intramyelinic and interstitial edema in the white matter of the spinal cord (SC) of totally gastrectomized (TGX) rats after treatment. "
04/01/2008 - "We observerd the effect on the pathological change of spinal cord in rat, and found the tissue edema and inflammatory infiltration were relieved after treatment with different doses of antler polypeptide, especially in the dose of 15 mg antler polypeptide. "
07/01/1997 - "All patients in remission showed decrease in extent of synovial proliferation and bone marrow edema with no newly developed erosion after treatment, compared to baseline. "
03/01/2005 - "In both dose groups there was a progressive decrease in laser Doppler resting flux (RF), indicating improvement in microangiopathy and a significant decrease in capillary filtration (RAS) associated with a significant improvement in analogue scale line score (ASLS) and edema. "
03/01/2001 - "Subthreshold laser was less effective in promoting resolution of edema compared to threshold lesions, though the difference was not significant in this instance."
01/01/1992 - "In comparison to controls, statistically significant reduction in edema was seen only at the 24 hour time period after laser exposure for the steroid group (P less than .002) but not for the precooling group. "
07/01/2012 - "Though laser reduces the incidence of vision loss by 50%, few eyes with diffuse edema experience improved vision. "
04/01/1985 - "Sixty (67%) eyes improved anatomically post-laser, ie the amount of edema was less. "
01/01/1990 - "Thus E6123 was effective in inhibiting dose-dependently PAF-induced bronchoconstriction when administered orally or intravenously (IC50 1.0 and 1.3 micrograms/Kg, respectively, at 3 hr), and had a minimum effective dose of 10 micrograms/Kg and 3 micrograms/Kg, respectively, against PAF-induced hematoconcentration and edema at 3 hr after oral administration. "
06/01/2014 - "The oral administration of ascidian tunicate extracts alleviated paw edema and improved the histological hind leg cartilage status. "
01/01/2012 - "A significant inhibition of the paw edema formation was observed in healthy rats as well as in rats bearing early hepatocarcinogenic changes with oral administration of the decoction. "
01/01/2011 - "Oral administration of PWA, CWA and MWA (30 - 300 mg/kg) dose dependently reduced edema with maximal effects of 68.25±2.03%, 77.83±0.81% and 62.21±2.61% respectively. "
03/24/2010 - "In mouse ear edema model, oral administration of Saussurea laniceps, Saussurea involucrata and Saussurea medusa extract (400mg/kg) resulted in a significant inhibition of ear edema by 40.9%, 33.3%, and 9.1%, respectively. "
01/01/1989 - "Since an improvement in the visual acuity occurs only in 30% of the involved eyes, it is recommended to apply the photocoagulation treatment on arisal or deepening of the edema."
06/01/2002 - "These observations are consistent with the earlier theoretical study prediction that photocoagulation of efferent CNV vessels can be effective in reducing CNV-associated edema. "
01/01/1984 - "Perianeurysm photocoagulation was found to be effective, and is indicated in cases of deep exudate and edema that may threaten the fovea. "
10/01/2004 - "Three days after photocoagulation, edema of RPE cells and choroid was relieved. "
11/01/2000 - "After the photocoagulation therapy, the patient's vision improved, intraocular pressure increased, and the optic disc edema and macular folds had resolved. "