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Ectromelia (Phocomelia)

Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, and phocomelia.
Also Known As:
Phocomelia; Sirenomelia; Hemimelia; Amelia
Networked: 335 relevant articles (4 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Infectious Ectromelia
3. Graft vs Host Disease (Graft-Versus-Host Disease)
4. Vaccinia
5. Cowpox

Experts

1. Buller, R Mark: 5 articles (06/2015 - 03/2009)
2. Hostetler, Karl Y: 4 articles (05/2011 - 10/2006)
3. Schriewer, Jill: 3 articles (11/2014 - 10/2005)
4. Beadle, James R: 3 articles (05/2011 - 10/2006)
5. Hembrador, Ed: 2 articles (11/2014 - 03/2009)
6. Painter, George: 2 articles (11/2014 - 03/2009)
7. Parker, Scott: 2 articles (11/2014 - 03/2009)
8. Ganesh, G Shankar: 2 articles (01/2014 - 07/2013)
9. Al Balwi, Mohammed: 2 articles (09/2013 - 03/2011)
10. Lietman, Steven A: 2 articles (07/2011 - 03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ectromelia:
1. cidofovir hexadecyloxypropyl esterIBA
2. Granzymes (Granzyme)IBA
3. cidofovir (Vistide)FDA Link
4. Interleukin-4 (Interleukin 4)IBA
5. Thalidomide (Thalomid)FDA Link
6. Caudal regression syndromeIBA
7. VACTERL associationIBA
8. Roberts SyndromeIBA
9. DNA (Deoxyribonucleic Acid)IBA
03/01/1997 - "DNA available for 6 of 8 Old World (cowpox, variola, monkeypox, camelpox, ectromelia and vaccinia viruses) and 3 New World (skunkpox, volepox, and raccoonpox) resulted in amplicons that ranged in size from 510 to 1673 base pairs depending on the species, except for raccoonpox virus DNA which did not amplify. "
08/01/2003 - "The assay was evaluated in a blinded study with 322 coded samples that included genomic DNA from 48 different isolates of variola virus; 25 different strains and isolates of camelpox, cowpox, ectromelia, gerbilpox, herpes, monkeypox, myxoma, rabbitpox, raccoonpox, skunkpox, vaccinia, and varicella-zoster viruses; and two rickettsial species at concentrations mostly ranging from 100 fg/ microl to 1 ng/ microl. "
08/01/1995 - "The initial identification step used a primer pair of consensus sequences for amplifying an HA DNA fragment from the three known North American orthopoxviruses (raccoonpox, skunkpox, and volepox viruses), and a second pair for amplifying virtually the entire HA open reading frame of the Eurasian-African orthopoxviruses (variola, vaccinia, cowpox, monkeypox, camelpox, ectromelia, and gerbilpox viruses). "
09/01/1993 - "Genes encoding virus-specific proteins with molecular masses of 36 kDa and 12 kDa were mapped in HindIII-P and HindIII-U DNA fragments of vaccinia strain LIVP and ectromelia strain K-1 viruses, respectively, by hybrid selection of RNA to cloned DNA fragments followed by in vitro translation. "
02/01/1985 - "Elevated rate of DNA synthesis and its correlation to cAMP-phosphodiesterase activity during induction of polydactyly in mouse embryos heterozygous for Hemimelia-extra toe (Hmx)."
10. VATER associationIBA

Therapies and Procedures

1. Ilizarov Technique
2. Amputation
3. External Fixators
4. Prostheses and Implants (Prosthesis)
5. Osteotomy