Echovirus Infections

Infectious disease processes, including meningitis, diarrhea, and respiratory disorders, caused by echoviruses.

Also Known As:

Echo Virus Infections; Infections, Echo Virus; Infections, Echovirus; Echo Virus Infection; Echovirus Infection; Infection, Echo Virus; Infection, Echovirus

Networked: 28 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Infections: 526564
- Virus Diseases: 41777
  - RNA Virus Infections: 303
    - Picornaviridae Infections: 82
      - Enterovirus Infections: 341
        Echovirus Infections: 28
        Herpangina: 27
        Echo Virus 11 Sensitivity

Related Diseases

1.	Infections
2.	Virus Diseases (Viral Diseases)
3.	Rhabdomyosarcoma
4.	Aseptic Meningitis
5.	Myocarditis (Carditis)

Experts

1.	Coyne, Carolyn B: 3 articles (01/2022 - 01/2019)
2.	Wells, Alexandra I: 3 articles (01/2022 - 01/2019)
3.	Ammendolia, Maria Grazia: 2 articles (03/2007 - 02/2006)
4.	Pietrantoni, Agostina: 2 articles (03/2007 - 02/2006)
5.	Superti, Fabiana: 2 articles (03/2007 - 02/2006)
6.	Tinari, Antonella: 2 articles (03/2007 - 02/2006)
7.	Valenti, Piera: 2 articles (03/2007 - 02/2006)
8.	Fukushima, Wakaba: 1 article (11/2022)
9.	Hirota, Yoshio: 1 article (11/2022)
10.	Kase, Tetsuo: 1 article (11/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Echovirus Infections:

1.	Proteins (Proteins, Gene)FDA Link 01/01/2020 - "Additionally, our results suggest that Hsp70 could be a useful therapeutic host protein target for echovirus infection." 05/01/2000 - "Echovirus infection of rhabdomyosarcoma cells is inhibited by antiserum to the complement control protein CD59." 01/01/2020 - "Further, evaluation of the function of Hsp70 using siRNA and quercetin, an inhibitor of Hsp70, showed that Hsp70 was necessary for the infection of echovirus type 9. This study revealed that echovirus infection could cause the differential expression of a series of host proteins, which is helpful to reveal the pathogenesis of viral infection and identify therapeutic drug targets. "
2.	LactoferrinIBA 02/01/2006 - "In the present study, we have investigated both the role of tryptic fragments of bovine lactoferrin and the mechanism of lactoferrin effect on echovirus infection. " 03/01/2007 - "Recently, we have shown that bovine lactoferrin prevents the early phases of echovirus infection and also acts as a survival factor inhibiting viral-induced apoptosis. "
3.	Small Interfering RNA (siRNA)IBA 01/01/2020 - "Further, evaluation of the function of Hsp70 using siRNA and quercetin, an inhibitor of Hsp70, showed that Hsp70 was necessary for the infection of echovirus type 9. This study revealed that echovirus infection could cause the differential expression of a series of host proteins, which is helpful to reveal the pathogenesis of viral infection and identify therapeutic drug targets. "
4.	QuercetinIBA 01/01/2020 - "Further, evaluation of the function of Hsp70 using siRNA and quercetin, an inhibitor of Hsp70, showed that Hsp70 was necessary for the infection of echovirus type 9. This study revealed that echovirus infection could cause the differential expression of a series of host proteins, which is helpful to reveal the pathogenesis of viral infection and identify therapeutic drug targets. "
5.	Complement System Proteins (Complement)IBA 05/01/1961 - "Observations on the complement-fixing antibody response to poliovirus in patients with certain Coxsackie and ECHO virus infections." 06/01/1989 - "Disseminated echovirus infection in a patient with multiple myeloma and a functional defect in complement. " 05/01/2000 - "Echovirus infection of rhabdomyosarcoma cells is inhibited by antiserum to the complement control protein CD59."
6.	Neutralizing AntibodiesIBA 01/01/1993 - "The epidemiologic features of type 22 echovirus infections with regard to age and seasonal distribution, contagiousness and a relative lack of protection by neutralizing antibodies differed from most enterovirus infections." 01/01/1987 - "All investigated myocarditis patients suffered from Coxsackie B or Echo-virus infections which were confirmed using virus neutralizing antibody test and haemagglutination inhibition test, respectively. "
7.	EnzymesIBA 12/31/1964 - "[ON THE BEHAVIOR OF SOME SERUM ENZYME ACTIVITIES (GOT, GPT, ALDOLASE) IN A GROUP OF SUBJECTS WITH ECHO VIRUS INFECTIONS]." 03/01/2002 - "[Establishment of an indirect enzyme-linked immunosorbent assay for detecting the specific IgM antibodies in patients with echovirus infection]."
8.	AlbuminsIBA 02/01/1999 - "Serum and interstitial albumin concentrations may limit echovirus infection in vivo and thereby act as an extracellular determinant for echovirus tropism." 01/01/2020 - "Importantly, FcRn, by protecting IgG from intracellular degradation, results in an approximately 21-day circulating IgG half-life and high plasma levels; similarly, FcRn recycles albumin and is the portal of entry for enteric cytopathic human orphan (echo) virus infection. "
9.	Interferon LambdaIBA 01/01/2022 - "In contrast, type III IFNs limit echovirus infection in the intestinal epithelium, and mice lacking this pathway exhibit extended epithelial replication. " 01/01/2022 - "Together, this work establishes an in vivo model of aseptic meningitis associated with echovirus infections that delineates the differential roles of type I and type III IFNs in echovirus-associated neuronal disease and defines the specificity of echoviral infections within the meninges. "
10.	Integrin beta3 (GPIIIa)IBA 09/01/1999 - "Since E9/Barty does not replicate or replicates only poorly in mice older than about 5 days, and expression of the vitronectin receptor is reported to be down-regulated in striated muscle tissue during development, it is suggested that susceptibility of mice to this echovirus infection is controlled by the availability of alpha(v)beta3 integrin."

Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 11/01/1997 - "Disseminated echovirus infection after allogeneic bone marrow transplantation." 04/01/1990 - "Disseminated echovirus infection complicating bone marrow transplantation." 11/01/1997 - "Disseminated enteric human cytopathogenic orphan (echo) virus infection after allogeneic bone marrow transplantation has been reported once previously: a patient developed a fatal infection with the virus being isolated from brain, lung and heart. "
2.	Therapeutics 01/01/2006 - "There are no therapies for echovirus infections. " 09/01/1985 - "This mode of therapy and the electron microscopic features noted in echovirus infections are discussed."