|2.||Gastroesophageal Reflux (GERD)
|4.||Peptic Ulcer (Peptic Ulcers)
|1.||Talley, N J: 28 articles (03/2012 - 05/2000)|
|2.||Talley, Nicholas J: 26 articles (11/2015 - 05/2002)|
|3.||Moayyedi, P: 24 articles (07/2009 - 01/2000)|
|4.||Forman, D: 22 articles (10/2008 - 01/2000)|
|5.||Tack, J: 17 articles (06/2012 - 01/2000)|
|6.||Deeks, J: 17 articles (01/2006 - 01/2000)|
|7.||Tack, Jan: 16 articles (11/2015 - 05/2004)|
|8.||Delaney, B: 16 articles (01/2006 - 01/2000)|
|9.||Soo, S: 15 articles (01/2006 - 01/2000)|
|10.||Moayyedi, Paul: 14 articles (08/2015 - 09/2004)|
|1.||Cisapride (Propulsid)FDA Link
05/01/1994 - "At the end of cisapride treatment, the most frequently reported symptoms of functional dyspepsia were significantly improved. "
04/01/1995 - "We were unable to show major differences in the short-term efficacy of cisapride and placebo in functional dyspepsia. "
01/01/1993 - "A double-blind, placebo-controlled trial was performed to determine the therapeutic efficacy of cisapride in patients with refractory functional dyspepsia. "
01/01/1989 - "Chronic idiopathic dyspepsia Cisapride has been shown to be effective in both improving symptoms and also delayed gastric emptying in a six week study. "
06/01/1995 - "Cisapride is also effective in improving symptoms in patients with functional dyspepsia. "
|2.||Omeprazole (Esomeprazole)FDA LinkGeneric
11/01/2004 - "Omeprazole (Prilosec) 20 mg is highly effective for the treatment of acid-related dyspepsia. "
05/01/2003 - "Omeprazole was effective in the short term for uninvestigated dyspepsia."
10/01/2000 - "In dyspepsia the identification of potential responders to omeprazole can be improved by considering certain patient characteristics and symptoms associated with the omeprazole response. "
05/24/2003 - "To compare the efficacy of a "Helicobacter pylori test and treat" strategy with that of an empirical trial of omeprazole in the non-endoscopic management by empirical prescribing of young patients with dyspepsia. "
11/01/1998 - "Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies)."
|3.||Proton Pump InhibitorsIBA
05/01/2010 - "It is still controversial which drugs, proton pump inhibitors (PPI) or histamine-2 receptor antagonists (H2RA), are more effective for dyspepsia in the Japanese population. "
04/01/2007 - "Proton pump inhibitors: effective first-line treatment for management of dyspepsia."
01/01/2003 - "Proton pump inhibitors appear to be effective in this subset of patients with dyspepsia. "
11/01/1998 - "The efficacy of H2-receptor antagonists in functional dyspepsia is equivocal and the therapeutic place of proton pump inhibitors in functional dyspepsia is unknown. "
10/01/2013 - "The efficacy of proton pump inhibitors (PPIs) for treating functional dyspepsia (FD) is not well established. "
|4.||Proton Pumps (Proton Pump)IBA
01/01/2015 - "This study aimed to test the efficacy of empirical proton pump inhibitor use and Helicobacter pylori therapy for uninvestigated dyspepsia in a population with a high prevalence of H. "
06/01/2004 - "The efficacy of proton pump inhibitor therapy for symptom resolution in patients with functional dyspepsia remains controversial. "
11/01/1998 - "To evaluate the efficacy of proton pump inhibitor therapy in functional dyspepsia. "
03/22/2008 - "Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial)."
09/01/2006 - "The etiologies of functional dyspepsia (FD) are unclear, but in some studies, treatment with a proton pump inhibitor has been beneficial. "
04/01/2011 - "Both the medical device and domperidone significantly improved gastrointestinal symptoms and quality of life in subjects with functional dyspepsia, not showing significant difference in efficacy."
12/01/1988 - "Although domperidone therapy had no significant effect on motility, it appears to be an effective drug for the treatment of the symptoms of nonulcer dyspepsia."
01/01/2015 - "Clinical symptom scores combined with real-time ultrasonography is effective in evaluating the therapeutic effect of domperidone in patients with functional dyspepsia. "
04/01/2011 - "The aim of the study was to evaluate the efficacy of a new medical device in respect to domperidone in patients with functional dyspepsia. "
04/01/2011 - "In a cross-over, randomized trial, 36 patients with functional dyspepsia ingested two daily doses of a medical device (Digerfast) or domperidone (Peridon) for 21 days. "
|6.||Ranitidine (Zantac)FDA LinkGeneric
02/15/1994 - "It is concluded that in acid-related functional dyspepsia ranitidine is superior to antacid in relieving symptoms. "
08/28/1993 - "[Ranitidine therapeutically effective in functional dyspepsia with reflux-like symptoms]."
02/15/1994 - "In the present study, the influence of a four-week-treatment with ranitidine (twice 150/d, n = 346) in comparison with an antacid (40 mmol/d, n = 340) on the severity and course of symptoms in patients suffering from an acid-related functional dyspepsia was investigated. "
03/08/1986 - "Patients who presented to their family doctors with previously uninvestigated dyspepsia of at least two weeks' duration were recruited into a placebo controlled trial of treatment with ranitidine (150 mg twice daily) for six weeks. "
05/01/1999 - "Patients receiving ranitidine should be warned about this rebound dyspepsia and advised not to immediately resume treatment, as rebound symptoms are likely to improve within a few days."
06/01/2012 - "Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography."
06/01/2010 - "Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. "
09/01/2011 - "In clinical trials, acotiamide hydrochloride (acotiamide: Z-338) has been reported to be useful in the treatment of functional dyspepsia. "
03/01/2011 - "Acotiamide hydrochloride (acotiamide; N-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4-carboxamide monohydrochloride trihydrate, Z-338) has been reported to improve meal-related symptoms of functional dyspepsia in clinical studies. "
06/01/2012 - "Improvement in subjective symptoms has been reported in functional dyspepsia (FD) patients administered with acotiamide. "
|8.||bismuth tripotassium dicitrate (bismuth subcitrate)IBA
07/01/1992 - "We conclude that colloidal bismuth subcitrate is effective in the short term treatment of non-ulcer dyspepsia. "
11/01/1991 - "A study was undertaken to determine the role of Helicobacter pylori in non-ulcer dyspepsia (NUD) and to determine the efficacy of colloidal bismuth subcitrate (CBS) in the treatment of NUD. "
10/01/1988 - "This double blind randomised study tested the effectiveness of colloidal bismuth subcitrate (De-Nol) in non-ulcer dyspepsia (NUD) and if any benefit is associated with clearance of Campylobacter pylori (C pylori) from the gastric mucosa. "
09/01/1992 - "We have carried out a double blind placebo controlled trial to assess the effects of treatment with colloidal bismuth subcitrate in Helicobacter pylori associated non-ulcer dyspepsia. "
09/01/1992 - "Double blind trial of colloidal bismuth subcitrate versus placebo in Helicobacter pylori positive patients with non-ulcer dyspepsia."
|9.||Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/01/2009 - "Compared with t-NSAIDs, coxib use is associated with a small but significant reduction of dyspepsia. "
03/01/2004 - "The use of PPIs in combination with nonselective NSAIDs has also been found to be beneficial in patients at high risk for rebleeding and reduces the incidence of dyspepsia. "
05/01/2006 - "Meta-analysis of four studies comparing dyspepsia between the NSAID+PPI combination and NSAIDs alone revealed a 66% relative risk reduction for NSAID+PPI with an absolute risk reduction of 9%. "
11/01/2003 - "Measuring dyspepsia-related health in randomized trials: the Severity of Dyspepsia Assessment (SODA) and its use in treatment with NSAIDs and COX-2-specific inhibitors."
01/01/2003 - "The goals of this systematic review and meta-analysis were to ascertain whether studies of nonsteroidal anti-inflammatory drugs (NSAIDs) summarized in the FDA reviews are ultimately published, to compare the methodologic and population characteristics of studies summarized in the FDA reviews with those reported in peer reviewed literature, and to compare the pooled relative risk of dyspepsia from NSAIDs in each data source. "
|10.||lansoprazole (Prevacid)FDA LinkGeneric
04/01/2008 - "Is lansoprazole effective for the initial management of young patients with dyspepsia?"
12/01/2013 - "To examine the efficacy of lansoprazole for functional dyspepsia (FD) diagnosed with the Rome III criteria by the multicentre, double-blind, randomized, placebo-controlled study in Japan. "
06/01/2004 - "This study was designed to compare the efficacy of lansoprazole with placebo in relieving upper abdominal discomfort in patients with functional dyspepsia. "
10/01/2002 - "To evaluate the efficacy of different doses of lansoprazole for the treatment of functional dyspepsia in Chinese patients. "
12/01/2013 - "Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study): A multicentre, prospective, randomized, double-blind, placebo-controlled clinical trial."
04/01/2015 - "After treatment, the dyspepsia symptoms and the quality of life (QOL) of the patients in each group were significantly improved (p < 0.05) and there was insignificant difference in efficacy between the two groups (p > 0.05). "
10/01/1999 - "Dyspepsia scores also improved significantly after treatment. "
08/01/2010 - "In this extension to the study, we analysed dyspepsia consultations between two and 7 years after treatment. "
12/01/2004 - "Measurement of the severity of dyspepsia symptoms before and after treatment and determining what is a significant change is a major problem in designing dyspepsia treatment studies. "
01/01/2001 - "The aim of the study was to estimate clinical symptoms and gastric emptying in functional dyspepsia (f.d.) before and after treatment. "
04/01/1994 - "Re-evaluation in 18 of the 29 patients with dyspepsia, 3 months after cholecystectomy, revealed complete disappearance of symptoms in three, improvement in 11 and no change in four patients. "
01/01/2013 - "We advise consideration of cholecystectomy for chronic biliary dyspepsia where repeat ultrasonography fails to demonstrate a gallbladder."
01/01/2013 - "In children with symptomatic biliary dyspepsia, the decision to proceed to cholecystectomy is made difficult if choleliths are not seen on ultrasonography. "
12/01/2002 - "Increased amounts of DGR may further be of clinical importance in patients with reflux disease or nonulcer dyspepsia and following cholecystectomy."
05/12/1997 - "Dyspepsia alone is not an indication for cholecystectomy. "
|3.||Drug Therapy (Chemotherapy)
03/01/2011 - "Review article: endpoints used in functional dyspepsia drug therapy trials."
11/01/2004 - "Little progress has been made in pharmacotherapy of functional dyspepsia, but exploratory studies show interesting new options. "
03/01/1998 - "Patients in most trials of pharmacotherapy for nonorganic dyspepsia have been groups referred selectively for endoscopy, which could have led to a selection bias of nonresponders, explaining the negative outcome of most controlled treatment trials in nonorganic dyspepsia. "
07/01/1994 - "The study confirms the classification into dyspepsia-subtypes as a useful tool in selecting the most appropriate drug therapy."
09/25/2014 - "The impact of sleep disorder, Helicobacter pylori-associated dyspepsia, and the emerging drug therapies in functional dyspepsia will also be discussed in this article."
|4.||Renal Dialysis (Hemodialysis)
02/01/2009 - "We report a 78-year-old hemodialysis patient who was admitted because of intractable dyspepsia. "
11/01/2000 - "In conclusion, there is a high prevalence of dysmotility-like dyspepsia in hemodialysis patients. "
01/01/1996 - "pylori and hypergastrinaemia was significant (P = 0.00038), after adjustment by multiple regression analysis for sex, age, smoking, alcohol, months on dialysis, renal function, drugs, and dyspepsia. "
02/01/2005 - "We consecutively enrolled in the study 50 dyspeptic patients with chronic kidney failure (mean age 52 +/- 5 years), of whom 11 were on hemodialysis treatment (HD), and 93 subjects (mean age 54 +/- 7 years) with chronic dyspepsia and normal renal function (NRF). "
01/01/2013 - "We assessed the association of dyspepsia with gastric emptying time in ESRD patients undergoing hemodialysis (HD). "
|5.||Acupuncture Points (Acupuncture Point)
03/01/2012 - "Acupuncture is effective in the treatment of functional dyspepsia, and is superior to non-acupoint puncture. "
04/01/2015 - "To investigate the similarities and differences in cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia (FD). "
04/01/2015 - "Cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia."
01/01/2015 - "In order to investigate the therapeutic potential of acupuncture on patients with functional dyspepsia (FD), patients were randomized to receive acupuncture at classic acupoints with manipulations (treatment group) versus acupuncture at nonacupoints without manipulation (control group) once every other day, three times a week, for one month and were followed up for three months. "
08/01/2012 - "To compare the clinical efficacy differences among acupuncture at special acupoints, nonspecific acupoints and non acupoints in Foot Yangming Meridian for functional dyspepsia (FD) at different time points. "